CA2335505C - Novel triterpenoids and their use for the treatment and prevention of cancer, inflammatory disorders, and neurodegenerative disease - Google Patents
Novel triterpenoids and their use for the treatment and prevention of cancer, inflammatory disorders, and neurodegenerative disease Download PDFInfo
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- CA2335505C CA2335505C CA2335505A CA2335505A CA2335505C CA 2335505 C CA2335505 C CA 2335505C CA 2335505 A CA2335505 A CA 2335505A CA 2335505 A CA2335505 A CA 2335505A CA 2335505 C CA2335505 C CA 2335505C
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Classifications
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/47—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of rings being part of condensed ring systems
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
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- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
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- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9005398P | 1998-06-19 | 1998-06-19 | |
| US60/090,053 | 1998-06-19 | ||
| US09/335,003 US6326507B1 (en) | 1998-06-19 | 1999-06-17 | Therapeutic compounds and methods of use |
| US09/335,003 | 1999-06-17 | ||
| PCT/US1999/013635 WO1999065478A1 (en) | 1998-06-19 | 1999-06-18 | Therapeutic compositions and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2335505A1 CA2335505A1 (en) | 1999-12-23 |
| CA2335505C true CA2335505C (en) | 2010-06-15 |
Family
ID=22221055
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2335505A Expired - Lifetime CA2335505C (en) | 1998-06-19 | 1999-06-18 | Novel triterpenoids and their use for the treatment and prevention of cancer, inflammatory disorders, and neurodegenerative disease |
Country Status (10)
| Country | Link |
|---|---|
| US (7) | US6326507B1 (OSRAM) |
| EP (2) | EP1089724B1 (OSRAM) |
| JP (3) | JP4541548B2 (OSRAM) |
| AT (1) | ATE430563T1 (OSRAM) |
| CA (1) | CA2335505C (OSRAM) |
| CY (1) | CY1109256T1 (OSRAM) |
| DK (1) | DK1089724T3 (OSRAM) |
| ES (1) | ES2324966T3 (OSRAM) |
| PT (1) | PT1089724E (OSRAM) |
| WO (1) | WO1999065478A1 (OSRAM) |
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| US20080275104A1 (en) * | 1997-11-25 | 2008-11-06 | Musc Foundation For Research Development | Methods of treating juvenile type 1 diabetes mellitus |
| US20040072138A1 (en) * | 1997-11-25 | 2004-04-15 | Medical University Of South Carolina | Attenuation of ischemia/reperfusion injury |
| WO1999026657A1 (en) | 1997-11-25 | 1999-06-03 | Musc Foundation For Research Development | Inhibitors of nitric oxide synthase |
| US6326507B1 (en) * | 1998-06-19 | 2001-12-04 | Trustees Of Dartmouth College | Therapeutic compounds and methods of use |
| WO2001054688A1 (en) * | 2000-01-28 | 2001-08-02 | Merck & Co., Inc. | Treatment or prevention of prostate cancer with a cox-2 selective inhibiting drug |
| US7435755B2 (en) * | 2000-11-28 | 2008-10-14 | The Trustees Of Dartmouth College | CDDO-compounds and combination therapies thereof |
| WO2002047611A2 (en) * | 2000-11-28 | 2002-06-20 | Board Of Regents, The University Of Texas System | Cddo-compounds and combination therapies thereof |
| US6777004B1 (en) * | 2001-03-30 | 2004-08-17 | Council Of Scientific & Industrial Research | Composition containing novel compound corniculatonin having antifungi properties and a process for preparing the same |
| KR100464063B1 (ko) * | 2001-11-21 | 2005-01-06 | 한국생명공학연구원 | 세포사멸 유도작용을 갖는 트리테르펜 화합물 |
| US7176237B2 (en) | 2002-01-15 | 2007-02-13 | The Trustees Of Dartmouth College | Tricyclic-bis-enone derivatives and methods of use thereof |
| BR0309754A (pt) * | 2002-05-02 | 2007-03-13 | Univ Washington | métodos e composições para tratamento de distúrbios e doenças auto-imunes/inflamatórias mediados por célula t em indivìduos tendo uma deficiência de regulação de glicocorticóide |
| EP1507541A4 (en) * | 2002-05-13 | 2009-06-03 | Dartmouth College | HEMMER AND APPLICATION METHOD THEREFOR |
| WO2005034958A1 (en) * | 2003-10-10 | 2005-04-21 | Sk Chemicals, Co., Ltd. | Triterpene compounds which are effective on improvement of brain function |
| US20050208151A1 (en) * | 2003-10-30 | 2005-09-22 | Entelos, Inc. | Treatment of rheumatoid arthritis with FLIP antagonists |
| US7551346B2 (en) * | 2003-11-05 | 2009-06-23 | E Ink Corporation | Electro-optic displays, and materials for use therein |
| EP1711197A4 (en) * | 2003-12-23 | 2008-11-05 | Musc Found For Res Dev | METHOD AND COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF INFLAMMATORY DISEASES OR CONDITIONS |
| US7638331B2 (en) | 2004-01-02 | 2009-12-29 | The Administration of the Tulane Rducation Fund | Directed apoptosis in COX-2 overexpressing cancer cells through expression targeted gene delivery |
| WO2006006152A2 (en) * | 2004-07-08 | 2006-01-19 | Ramot At Tel-Aviv University Ltd | Treatment of disorders and diseases of the colon |
| CA2600276C (en) * | 2005-03-08 | 2013-01-08 | Mitsui Norin Co., Ltd | Polyphenol coxib combinations and methods |
| US20100190735A1 (en) * | 2006-03-28 | 2010-07-29 | Myrex Pharmaceuticals Inc. | Mouthwash and Method of Using Same for the Treatment of Mucositis or Stomatitis |
| US7714012B2 (en) | 2006-11-17 | 2010-05-11 | Trustees Of Dartmouth University | Synthesis and biological activities of new tricyclic-bis-enones (TBEs) |
| WO2008064132A2 (en) * | 2006-11-17 | 2008-05-29 | Trustees Of Dartmouth College | Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth |
| US8921340B2 (en) | 2006-11-17 | 2014-12-30 | Trustees Of Dartmouth College | Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions |
| US20080227846A1 (en) * | 2007-03-13 | 2008-09-18 | Musc Foundation For Research Development | Methods of treating juvenile type 1 diabetes mellitus |
| US8088824B2 (en) | 2007-08-15 | 2012-01-03 | Reata Pharmaceuticals Inc. | Forms of CDDO methyl ester |
| US20090048205A1 (en) * | 2007-08-15 | 2009-02-19 | Colin Meyer | Combination therapy with synthetic triterpenoids and gemcitabine |
| US7879369B2 (en) | 2007-09-18 | 2011-02-01 | Selvamedica, Llc | Combretum laurifolium Mart. extract and methods of extracting and using such extract |
| US9012439B2 (en) * | 2007-10-29 | 2015-04-21 | University Of Rochester | Use of electrophilic compounds for inducing platelet production or maintaining platelet function |
| LT2252283T (lt) | 2008-01-11 | 2019-03-25 | Reata Pharmaceuticals, Inc. | Sintetiniai triterpenoidai ir jų panaudojimo būdai gydant ligą |
| ES2326065B1 (es) * | 2008-03-28 | 2010-07-08 | Consejo Superior De Investigaciones Cientificas (Csic) | Utilizacion de un triterpeno pentaciclico para la preparacion de una composicion farmaceutica destinada al tratamiento de la esclerosis multiple. |
| CA2721665C (en) | 2008-04-18 | 2017-01-24 | Reata Pharmaceuticals, Inc. | Compounds including an anti-inflammatory pharmacore and methods of use |
| HUE033288T2 (en) | 2008-04-18 | 2017-11-28 | Reata Pharmaceuticals Inc | Antioxidant inflammation modulators: C-17 homologated oleic acid derivatives |
| WO2009129545A1 (en) | 2008-04-18 | 2009-10-22 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the c-ring |
| WO2009146216A2 (en) * | 2008-04-18 | 2009-12-03 | Reata Pharmaceuticals. Inc. | Antioxidant inflammation modulators: novel derivatives of oleanolic acid |
| KR101735807B1 (ko) | 2008-04-18 | 2017-05-15 | 리타 파마슈티컬스 잉크. | Ｃ-17에 아미노 및 기타 변형을 갖는 올레아놀산 유도체를 포함하는 항산화 염증 조절제 |
| AU2009274037B2 (en) * | 2008-07-22 | 2015-07-09 | Trustees Of Dartmouth College | Monocyclic cyanoenones and methods of use thereof |
| ES2646816T3 (es) | 2009-02-13 | 2017-12-18 | Reata Pharmaceuticals, Inc. | Composiciones de dosificaciones orales de liberación retardada que contienen CDDO-Me amorfo |
| JP5687690B2 (ja) * | 2009-04-30 | 2015-03-18 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 針リムーバ及び針を除去する方法 |
| MY163031A (en) | 2010-04-12 | 2017-07-31 | Reata Pharmaceuticals Inc | Method of treating obesity using antioxidant inflammation modulators |
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| HUE038046T2 (hu) | 2010-12-17 | 2018-09-28 | Reata Pharmaceuticals Inc | Antioxidáns gyulladáscsökkentõ pirazolil és pirimidinil triciklusos enonok |
| CN103619866B (zh) | 2011-03-11 | 2016-06-22 | 里亚塔医药公司 | C4-一甲基三萜系化合物的衍生物及其使用方法 |
| GB201120860D0 (en) | 2011-12-05 | 2012-01-18 | Cambridge Entpr Ltd | Cancer immunotherapy |
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| US8921419B2 (en) | 2012-05-08 | 2014-12-30 | Trustees Of Dartmouth College | Triterpenoids and compositions containing the same |
| US8981144B2 (en) | 2012-05-08 | 2015-03-17 | Trustees Of Dartmouth College | Method for synthesizing 2-cyano-3,12-dioxoolean-1, 9(11)-dien-28-oic acid methyl ester and derivatives thereof |
| US9556222B2 (en) | 2012-06-15 | 2017-01-31 | Reata Pharmaceuticals, Inc. | A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof |
| US8791067B2 (en) | 2012-07-24 | 2014-07-29 | Morehouse School Of Medicine | Method for treating malaria |
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| US20140073700A1 (en) * | 2012-09-10 | 2014-03-13 | Abbvie Inc. | Glycyrrhetinic acid derivatives and methods of use thereof |
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| KR102237364B1 (ko) * | 2012-09-10 | 2021-04-06 | 리아타 파마슈티컬즈, 아이엔씨. | 올레아놀산의 ｃ１７―헤테로아릴 유도체 및 그의 사용 방법 |
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-
1999
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- 1999-06-18 EP EP99928731A patent/EP1089724B1/en not_active Expired - Lifetime
- 1999-06-18 AT AT99928731T patent/ATE430563T1/de active
- 1999-06-18 DK DK99928731T patent/DK1089724T3/da active
- 1999-06-18 CA CA2335505A patent/CA2335505C/en not_active Expired - Lifetime
- 1999-06-18 WO PCT/US1999/013635 patent/WO1999065478A1/en not_active Ceased
- 1999-06-18 JP JP2000554358A patent/JP4541548B2/ja not_active Expired - Lifetime
- 1999-06-18 PT PT99928731T patent/PT1089724E/pt unknown
- 1999-06-18 EP EP09154222A patent/EP2062577A1/en not_active Withdrawn
- 1999-06-18 ES ES99928731T patent/ES2324966T3/es not_active Expired - Lifetime
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2001
- 2001-08-09 US US09/927,081 patent/US6552075B2/en not_active Expired - Lifetime
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- 2003-03-24 US US10/395,372 patent/US7288568B2/en not_active Expired - Lifetime
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- 2007-10-29 US US11/927,418 patent/US8034955B2/en not_active Expired - Fee Related
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- 2009-06-05 JP JP2009136739A patent/JP5210971B2/ja not_active Expired - Lifetime
- 2009-07-15 CY CY20091100756T patent/CY1109256T1/el unknown
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- 2012-04-27 JP JP2012102499A patent/JP2012144574A/ja not_active Withdrawn
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| DK1089724T3 (da) | 2009-07-27 |
| ES2324966T3 (es) | 2009-08-20 |
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| EP1089724A4 (en) | 2004-06-09 |
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| US20130237721A1 (en) | 2013-09-12 |
| CA2335505A1 (en) | 1999-12-23 |
| US6326507B1 (en) | 2001-12-04 |
| EP1089724A1 (en) | 2001-04-11 |
| JP2009242409A (ja) | 2009-10-22 |
| ATE430563T1 (de) | 2009-05-15 |
| US20080234368A9 (en) | 2008-09-25 |
| US8586775B2 (en) | 2013-11-19 |
| US20140275618A1 (en) | 2014-09-18 |
| EP1089724B1 (en) | 2009-05-06 |
| WO1999065478A1 (en) | 1999-12-23 |
| JP4541548B2 (ja) | 2010-09-08 |
| JP2002530272A (ja) | 2002-09-17 |
| US8034955B2 (en) | 2011-10-11 |
| US7863327B2 (en) | 2011-01-04 |
| US20050288363A1 (en) | 2005-12-29 |
| PT1089724E (pt) | 2009-07-20 |
| US20080220057A1 (en) | 2008-09-11 |
| US7288568B2 (en) | 2007-10-30 |
| US20030236303A1 (en) | 2003-12-25 |
| CY1109256T1 (el) | 2014-07-02 |
| JP5210971B2 (ja) | 2013-06-12 |
| US20020042535A1 (en) | 2002-04-11 |
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