CA2320040C - Cellules de souche mesenchymateuse servant a la prevention et au traitement des reponses immunitaires lors de la transplantation - Google Patents
Cellules de souche mesenchymateuse servant a la prevention et au traitement des reponses immunitaires lors de la transplantation Download PDFInfo
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- CA2320040C CA2320040C CA002320040A CA2320040A CA2320040C CA 2320040 C CA2320040 C CA 2320040C CA 002320040 A CA002320040 A CA 002320040A CA 2320040 A CA2320040 A CA 2320040A CA 2320040 C CA2320040 C CA 2320040C
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- mesenchymal stem
- stem cells
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/24—Interferons [IFN]
Abstract
L'invention concerne un procédé qui permet de réduire la réponse immunitaire du receveur à un transplant et qui consiste à traiter le receveur avec une certaine quantité de cellules de souche mésenchymateuse, efficace pour réduire ou pour inhiber le rejet du transplant par l'hôte. On peut administrer les cellules de souche mésenchymateuse avant, pendant ou après la transplantation. L'invention concerne également un procédé pour induire une réponse immunitaire limitée contre un hôte par un tissu étranger, par exemple, par la greffe vis-à-vis d'une maladie de l'hôte, au moyen du traitement avec des cellules de souche mésenchymateuse.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7846398P | 1998-03-18 | 1998-03-18 | |
| US60/078,463 | 1998-03-18 | ||
| US8996498P | 1998-06-19 | 1998-06-19 | |
| US60/089,964 | 1998-06-19 | ||
| PCT/US1999/005548 WO1999047163A2 (fr) | 1998-03-18 | 1999-03-12 | Cellules de souche mesenchymateuse servant a la prevention et au traitement des reponses immunitaires lors de la transplantation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2320040A1 CA2320040A1 (fr) | 1999-09-23 |
| CA2320040C true CA2320040C (fr) | 2007-05-22 |
Family
ID=26760560
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002320040A Expired - Lifetime CA2320040C (fr) | 1998-03-18 | 1999-03-12 | Cellules de souche mesenchymateuse servant a la prevention et au traitement des reponses immunitaires lors de la transplantation |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6328960B1 (fr) |
| EP (1) | EP1066052B1 (fr) |
| JP (1) | JP4740452B2 (fr) |
| AT (1) | ATE316795T1 (fr) |
| AU (1) | AU755888B2 (fr) |
| CA (1) | CA2320040C (fr) |
| DE (1) | DE69929681T2 (fr) |
| DK (1) | DK1066052T3 (fr) |
| ES (1) | ES2258329T3 (fr) |
| PT (1) | PT1066052E (fr) |
| WO (1) | WO1999047163A2 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101083910B (zh) * | 2004-09-10 | 2012-06-27 | 同源治疗公司 | 用于预防和治疗移植中的免疫应答的肝脏基质细胞 |
Families Citing this family (128)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999046366A1 (fr) * | 1998-03-13 | 1999-09-16 | Osiris Therapeutics, Inc. | Utilisations de cellules souches humaines mesenchymateuses non autologues |
| US7115417B1 (en) | 1998-05-01 | 2006-10-03 | Chancellor Michael B | Soft tissue and bone augmentation and bulking utilizing muscle-derived progenito compositions, and treatments thereof |
| US6866842B1 (en) | 1998-05-01 | 2005-03-15 | University Of Pittsburgh | Muscle-derived cells (MDCs) for treating muscle-or bone-related injury or dysfunction |
| US8147824B2 (en) | 1999-08-05 | 2012-04-03 | Athersys, Inc. | Immunomodulatory properties of multipotent adult progenitor cells and uses thereof |
| US6685936B2 (en) * | 1999-10-12 | 2004-02-03 | Osiris Therapeutics, Inc. | Suppressor cells induced by culture with mesenchymal stem cells for treatment of immune responses in transplantation |
| DE60129007T2 (de) | 2000-04-14 | 2008-02-28 | University Of Pittsburgh | Vermehrung des weich- sowie des knochengewebes anhand von aus muskeln stammenden vorläuferzellen, sowie damit verbundene zusammensetzungen und behandlungsformen |
| US7311905B2 (en) | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
| DK1349918T3 (da) | 2000-12-06 | 2014-11-10 | Anthrogenesis Corp | Fremgangsmåde til indsamling af stamceller fra moderkagen |
| KR100973615B1 (ko) | 2001-02-14 | 2010-08-02 | 안트로제네시스 코포레이션 | 산후 포유류의 태반, 이의 용도 및 태반 줄기세포 |
| EP2336299A1 (fr) * | 2001-02-14 | 2011-06-22 | Anthrogenesis Corporation | Placenta post-gravidique de mammifere, son utilisation et cellules souches placentaires correspondantes |
| US20020155096A1 (en) | 2001-02-23 | 2002-10-24 | Chancellor Michael B. | Rapid preparation of stem cell matrices for use in tissue and organ treatment and repair |
| US7682803B2 (en) | 2005-10-13 | 2010-03-23 | Anthrogenesis Corporation | Immunomodulation using placental stem cells |
| JP2005531507A (ja) * | 2002-03-02 | 2005-10-20 | ザ ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | ストローマ細胞前駆体による抗癌物質の局所的な産生および／または送達方法 |
| AU2004227342B2 (en) * | 2003-04-01 | 2011-01-20 | United States Of America Department Of Veteran's Affairs | Stem-cell, precursor cell, or target cell-based treatment of multi-organ failure and renal dysfunction |
| EP2289526B1 (fr) | 2003-04-25 | 2014-06-11 | The University of Pittsburgh | Cellules derivees de muscles favorisant et ameliorant la reparation et la regeneration des nerfs |
| US20080095749A1 (en) * | 2004-03-22 | 2008-04-24 | Sudeepta Aggarwal | Mesenchymal stem cells and uses therefor |
| ATE556134T1 (de) * | 2004-03-22 | 2012-05-15 | Osiris Therapeutics Inc | Mesenchymstammzellen und verwendungendafür |
| EP2298862B1 (fr) | 2004-03-22 | 2017-08-30 | Mesoblast International Sàrl | Cellules souches mésenchymateuses et utilisations associées |
| US7622108B2 (en) | 2004-04-23 | 2009-11-24 | Bioe, Inc. | Multi-lineage progenitor cells |
| DE602005027557D1 (de) | 2004-04-23 | 2011-06-01 | Bioe Llc | Mehrfachlinien-vorläuferzellen |
| ES2313805B1 (es) | 2004-10-04 | 2009-12-23 | Cellerix, S.L. | Identificacion y aislamiento de celulas multipotentes de tejido mesenquimal no osteocondral. |
| ES2264862B8 (es) * | 2004-08-25 | 2017-01-20 | Cellerix, S.L. | Biomaterial para sutura. |
| US8017395B2 (en) | 2004-12-17 | 2011-09-13 | Lifescan, Inc. | Seeding cells on porous supports |
| CA2512667A1 (fr) * | 2005-01-07 | 2006-07-07 | Takahiro Ochiya | Cellules semblables aux hepatocytes humains et utilisations connexes |
| CN101137292A (zh) * | 2005-01-11 | 2008-03-05 | 同源治疗公司 | 用于移植的神经干细胞的免疫保护的骨髓基质细胞 |
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- 1999-03-12 DE DE69929681T patent/DE69929681T2/de not_active Expired - Lifetime
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- 1999-03-12 DK DK99913876T patent/DK1066052T3/da active
- 1999-03-12 EP EP99913876A patent/EP1066052B1/fr not_active Expired - Lifetime
- 1999-03-12 WO PCT/US1999/005548 patent/WO1999047163A2/fr active IP Right Grant
- 1999-03-12 CA CA002320040A patent/CA2320040C/fr not_active Expired - Lifetime
- 1999-03-12 US US09/267,536 patent/US6328960B1/en not_active Expired - Lifetime
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101083910B (zh) * | 2004-09-10 | 2012-06-27 | 同源治疗公司 | 用于预防和治疗移植中的免疫应答的肝脏基质细胞 |
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| EP1066052A2 (fr) | 2001-01-10 |
| DK1066052T3 (da) | 2006-06-12 |
| PT1066052E (pt) | 2006-06-30 |
| AU3185699A (en) | 1999-10-11 |
| US6328960B1 (en) | 2001-12-11 |
| ATE316795T1 (de) | 2006-02-15 |
| ES2258329T3 (es) | 2006-08-16 |
| JP2002506831A (ja) | 2002-03-05 |
| AU755888B2 (en) | 2003-01-02 |
| CA2320040A1 (fr) | 1999-09-23 |
| JP4740452B2 (ja) | 2011-08-03 |
| DE69929681T2 (de) | 2006-10-26 |
| WO1999047163A2 (fr) | 1999-09-23 |
| DE69929681D1 (de) | 2006-04-13 |
| EP1066052B1 (fr) | 2006-02-01 |
| WO1999047163A3 (fr) | 1999-11-18 |
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