CA2293354A1 - Bone graft composites and spacers - Google Patents
Bone graft composites and spacers Download PDFInfo
- Publication number
- CA2293354A1 CA2293354A1 CA002293354A CA2293354A CA2293354A1 CA 2293354 A1 CA2293354 A1 CA 2293354A1 CA 002293354 A CA002293354 A CA 002293354A CA 2293354 A CA2293354 A CA 2293354A CA 2293354 A1 CA2293354 A1 CA 2293354A1
- Authority
- CA
- Canada
- Prior art keywords
- bone
- composition
- growth factor
- graft
- spacer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 251
- 125000006850 spacer group Chemical group 0.000 title claims abstract description 49
- 239000002131 composite material Substances 0.000 title description 14
- 239000000463 material Substances 0.000 claims abstract description 99
- 239000000203 mixture Substances 0.000 claims abstract description 52
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 43
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 43
- 230000008468 bone growth Effects 0.000 claims abstract description 32
- 102000008186 Collagen Human genes 0.000 claims abstract description 29
- 108010035532 Collagen Proteins 0.000 claims abstract description 29
- 229920001436 collagen Polymers 0.000 claims abstract description 29
- 238000000034 method Methods 0.000 claims abstract description 27
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 24
- 239000011707 mineral Substances 0.000 claims abstract description 24
- 239000003102 growth factor Substances 0.000 claims abstract description 18
- 239000011885 synergistic combination Substances 0.000 claims abstract description 7
- 238000001356 surgical procedure Methods 0.000 claims description 19
- 239000003937 drug carrier Substances 0.000 claims description 7
- 239000011159 matrix material Substances 0.000 claims description 7
- 241000283690 Bos taurus Species 0.000 claims description 6
- 238000002513 implantation Methods 0.000 claims description 6
- 230000006641 stabilisation Effects 0.000 claims description 3
- 238000011105 stabilization Methods 0.000 claims description 3
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims 2
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims 1
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
- 230000004927 fusion Effects 0.000 description 54
- 230000002188 osteogenic effect Effects 0.000 description 27
- 239000007943 implant Substances 0.000 description 22
- 230000001054 cortical effect Effects 0.000 description 21
- 229910052751 metal Inorganic materials 0.000 description 18
- 239000002184 metal Substances 0.000 description 18
- 235000010755 mineral Nutrition 0.000 description 18
- 239000000243 solution Substances 0.000 description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 18
- 230000002138 osteoinductive effect Effects 0.000 description 16
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 14
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 14
- 230000008901 benefit Effects 0.000 description 13
- 239000001506 calcium phosphate Substances 0.000 description 9
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 9
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 description 8
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 description 8
- 229940112869 bone morphogenetic protein Drugs 0.000 description 8
- 210000001519 tissue Anatomy 0.000 description 8
- 239000000919 ceramic Substances 0.000 description 7
- 239000012895 dilution Substances 0.000 description 7
- 238000010790 dilution Methods 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 239000003925 fat Substances 0.000 description 7
- 238000002360 preparation method Methods 0.000 description 7
- 239000008223 sterile water Substances 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 208000002193 Pain Diseases 0.000 description 6
- 230000035876 healing Effects 0.000 description 6
- 230000000921 morphogenic effect Effects 0.000 description 6
- 238000013459 approach Methods 0.000 description 5
- 208000037873 arthrodesis Diseases 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 210000003275 diaphysis Anatomy 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 238000002791 soaking Methods 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 5
- 229940078499 tricalcium phosphate Drugs 0.000 description 5
- 230000000735 allogeneic effect Effects 0.000 description 4
- 239000003462 bioceramic Substances 0.000 description 4
- 239000000872 buffer Substances 0.000 description 4
- 239000004068 calcium phosphate ceramic Substances 0.000 description 4
- 235000011010 calcium phosphates Nutrition 0.000 description 4
- 239000000969 carrier Substances 0.000 description 4
- 230000001413 cellular effect Effects 0.000 description 4
- 238000005520 cutting process Methods 0.000 description 4
- 125000004122 cyclic group Chemical group 0.000 description 4
- 238000010348 incorporation Methods 0.000 description 4
- 230000001939 inductive effect Effects 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 238000003780 insertion Methods 0.000 description 4
- 230000037431 insertion Effects 0.000 description 4
- 230000011164 ossification Effects 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- 239000010935 stainless steel Substances 0.000 description 4
- 229910001220 stainless steel Inorganic materials 0.000 description 4
- 239000008227 sterile water for injection Substances 0.000 description 4
- 238000012546 transfer Methods 0.000 description 4
- 235000019731 tricalcium phosphate Nutrition 0.000 description 4
- 208000035473 Communicable disease Diseases 0.000 description 3
- 206010016654 Fibrosis Diseases 0.000 description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
- 241001447056 Uristes Species 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000004761 fibrosis Effects 0.000 description 3
- 238000003306 harvesting Methods 0.000 description 3
- 230000002163 immunogen Effects 0.000 description 3
- 230000005847 immunogenicity Effects 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000033001 locomotion Effects 0.000 description 3
- 238000003754 machining Methods 0.000 description 3
- 230000005541 medical transmission Effects 0.000 description 3
- 230000004819 osteoinduction Effects 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 230000035882 stress Effects 0.000 description 3
- 238000006467 substitution reaction Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 2
- 241001546602 Horismenus Species 0.000 description 2
- 241000725303 Human immunodeficiency virus Species 0.000 description 2
- 208000028389 Nerve injury Diseases 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 229920002732 Polyanhydride Polymers 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 230000000975 bioactive effect Effects 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 230000002051 biphasic effect Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000002805 bone matrix Anatomy 0.000 description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical class [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 235000011132 calcium sulphate Nutrition 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 230000009849 deactivation Effects 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 229910003460 diamond Inorganic materials 0.000 description 2
- 239000010432 diamond Substances 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 235000012907 honey Nutrition 0.000 description 2
- -1 hydrogenophosphate ions Chemical class 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000002458 infectious effect Effects 0.000 description 2
- 210000002901 mesenchymal stem cell Anatomy 0.000 description 2
- 230000008764 nerve damage Effects 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 150000002978 peroxides Chemical class 0.000 description 2
- 235000021317 phosphate Nutrition 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 229920000747 poly(lactic acid) Polymers 0.000 description 2
- 230000002980 postoperative effect Effects 0.000 description 2
- 239000012460 protein solution Substances 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 238000007788 roughening Methods 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 102100028728 Bone morphogenetic protein 1 Human genes 0.000 description 1
- 108090000654 Bone morphogenetic protein 1 Proteins 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 241000701022 Cytomegalovirus Species 0.000 description 1
- 101100456896 Drosophila melanogaster metl gene Proteins 0.000 description 1
- 238000012286 ELISA Assay Methods 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 102100035368 Growth/differentiation factor 6 Human genes 0.000 description 1
- 101710204281 Growth/differentiation factor 6 Proteins 0.000 description 1
- HSRJKNPTNIJEKV-UHFFFAOYSA-N Guaifenesin Chemical compound COC1=CC=CC=C1OCC(O)CO HSRJKNPTNIJEKV-UHFFFAOYSA-N 0.000 description 1
- 208000031220 Hemophilia Diseases 0.000 description 1
- 208000009292 Hemophilia A Diseases 0.000 description 1
- 208000005176 Hepatitis C Diseases 0.000 description 1
- 101000762366 Homo sapiens Bone morphogenetic protein 2 Proteins 0.000 description 1
- 208000004044 Hypesthesia Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 102100026632 Mimecan Human genes 0.000 description 1
- 208000010428 Muscle Weakness Diseases 0.000 description 1
- 206010028372 Muscular weakness Diseases 0.000 description 1
- 101800002327 Osteoinductive factor Proteins 0.000 description 1
- 238000002944 PCR assay Methods 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
- 206010061363 Skeletal injury Diseases 0.000 description 1
- 208000020339 Spinal injury Diseases 0.000 description 1
- 229920001229 Starlite Polymers 0.000 description 1
- 101150027764 TECR gene Proteins 0.000 description 1
- 229910001069 Ti alloy Inorganic materials 0.000 description 1
- 208000024248 Vascular System injury Diseases 0.000 description 1
- 208000012339 Vascular injury Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 238000004873 anchoring Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 229940030225 antihemorrhagics Drugs 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 238000012865 aseptic processing Methods 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 238000010256 biochemical assay Methods 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000000515 collagen sponge Substances 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 238000002316 cosmetic surgery Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000003412 degenerative effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000035931 haemagglutination Effects 0.000 description 1
- 239000002874 hemostatic agent Substances 0.000 description 1
- 208000002672 hepatitis B Diseases 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 102000045896 human BMP2 Human genes 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 208000034783 hypoesthesia Diseases 0.000 description 1
- 230000000642 iatrogenic effect Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002969 morbid Effects 0.000 description 1
- 230000001002 morphogenetic effect Effects 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 210000000963 osteoblast Anatomy 0.000 description 1
- 230000000278 osteoconductive effect Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 231100001055 skeletal defect Toxicity 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 210000001032 spinal nerve Anatomy 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 235000012773 waffles Nutrition 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3695—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the function or physical properties of the final product, where no specific conditions are defined to achieve this
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/365—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/84—Bones; tendons; teeth; cartilage
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S606/00—Surgery
- Y10S606/907—Composed of particular material or coated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S606/00—Surgery
- Y10S606/907—Composed of particular material or coated
- Y10S606/908—Bioabsorbable material
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S606/00—Surgery
- Y10S606/907—Composed of particular material or coated
- Y10S606/909—Bone
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S606/00—Surgery
- Y10S606/907—Composed of particular material or coated
- Y10S606/912—Radiolucent material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Botany (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Sealing Material Composition (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/873,276 | 1997-06-11 | ||
| US08/873,276 US5972368A (en) | 1997-06-11 | 1997-06-11 | Bone graft composites and spacers |
| PCT/US1998/011611 WO1998056433A1 (en) | 1997-06-11 | 1998-06-11 | Bone graft composites and spacers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2293354A1 true CA2293354A1 (en) | 1998-12-17 |
Family
ID=25361316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002293354A Abandoned CA2293354A1 (en) | 1997-06-11 | 1998-06-11 | Bone graft composites and spacers |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US5972368A (enExample) |
| EP (1) | EP0988070B1 (enExample) |
| JP (2) | JP2002503992A (enExample) |
| AT (1) | ATE275981T1 (enExample) |
| AU (1) | AU738218B2 (enExample) |
| CA (1) | CA2293354A1 (enExample) |
| DE (1) | DE69826273T2 (enExample) |
| ES (1) | ES2227842T3 (enExample) |
| WO (1) | WO1998056433A1 (enExample) |
Families Citing this family (273)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6150328A (en) | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
| US5962028A (en) | 1988-04-20 | 1999-10-05 | Norian Corporation | Carbonated hydroxyapatite compositions and uses |
| KR100259827B1 (ko) | 1991-11-04 | 2000-06-15 | 브루스 엠. 에이센, 토마스 제이 데스로저 | 재조합 골형태 형성 단백질 헤테로다이머, 그 조성물 및 사용방법 |
| US6291206B1 (en) | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
| ES2255059T3 (es) | 1993-12-07 | 2006-06-16 | Genetics Institute, Llc | Bmp-12, bmp-13 y composiciones suyas inductoras de tendon. |
| US20050165483A1 (en) * | 2004-01-27 | 2005-07-28 | Ray Eddie F.Iii | Bone grafts |
| US6037519A (en) * | 1997-10-20 | 2000-03-14 | Sdgi Holdings, Inc. | Ceramic fusion implants and compositions |
| US20080027552A1 (en) * | 1997-01-02 | 2008-01-31 | Zucherman James F | Spine distraction implant and method |
| US20080215058A1 (en) * | 1997-01-02 | 2008-09-04 | Zucherman James F | Spine distraction implant and method |
| US6033438A (en) * | 1997-06-03 | 2000-03-07 | Sdgi Holdings, Inc. | Open intervertebral spacer |
| US6296667B1 (en) | 1997-10-01 | 2001-10-02 | Phillips-Origen Ceramic Technology, Llc | Bone substitutes |
| US6977095B1 (en) | 1997-10-01 | 2005-12-20 | Wright Medical Technology Inc. | Process for producing rigid reticulated articles |
| US6511509B1 (en) | 1997-10-20 | 2003-01-28 | Lifenet | Textured bone allograft, method of making and using same |
| USRE38614E1 (en) * | 1998-01-30 | 2004-10-05 | Synthes (U.S.A.) | Intervertebral allograft spacer |
| US6986788B2 (en) | 1998-01-30 | 2006-01-17 | Synthes (U.S.A.) | Intervertebral allograft spacer |
| US6143033A (en) * | 1998-01-30 | 2000-11-07 | Synthes (Usa) | Allogenic intervertebral implant |
| US7087082B2 (en) * | 1998-08-03 | 2006-08-08 | Synthes (Usa) | Bone implants with central chambers |
| US7045141B2 (en) | 1998-02-27 | 2006-05-16 | Musculoskeletal Transplant Foundation | Allograft bone composition having a gelatin binder |
| US20030147860A1 (en) | 2002-02-07 | 2003-08-07 | Marchosky J. Alexander | Compositions and methods for forming and strengthening bone |
| DE69916280T2 (de) * | 1998-08-03 | 2005-05-25 | Synthes Ag Chur, Chur | Zwischenwirbel-allotransplantat-distanzstück |
| US6174311B1 (en) * | 1998-10-28 | 2001-01-16 | Sdgi Holdings, Inc. | Interbody fusion grafts and instrumentation |
| US6126688A (en) * | 1998-12-21 | 2000-10-03 | Surgical Dynamics Inc. | Apparatus for fusion of adjacent bone structures |
| US6547823B2 (en) * | 1999-01-22 | 2003-04-15 | Osteotech, Inc. | Intervertebral implant |
| US6727224B1 (en) | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
| DE60006356T2 (de) * | 1999-02-04 | 2004-09-09 | SDGI Holding, Inc., Wilmington | Hochmineralisierte osteogene schwammzusammensetzungen und ihre verwendung |
| US6241770B1 (en) | 1999-03-05 | 2001-06-05 | Gary K. Michelson | Interbody spinal fusion implant having an anatomically conformed trailing end |
| JP2003530131A (ja) | 1999-03-07 | 2003-10-14 | ディスクレ リミテッド | コンピューターを利用する手術方法及び装置 |
| US6485517B1 (en) | 1999-05-05 | 2002-11-26 | Gary K. Michelson | Nested interbody spinal fusion implants |
| US7371408B1 (en) * | 1999-06-07 | 2008-05-13 | Wright Medical Technology, Inc. | Bone graft substitute composition |
| WO2001000792A1 (en) | 1999-06-29 | 2001-01-04 | Marchosky J Alexander | Compositions and methods for forming and strengthening bone |
| AU6499800A (en) * | 1999-07-28 | 2001-02-19 | Regeneration Technologies, Inc. | Cartilage or bone matrix as a nucleic acid delivery vehicle |
| MXPA02000937A (es) * | 1999-07-28 | 2002-07-30 | Regeneration Tech Inc | Implantes de tejidos con antigenicidad reducida (tar). |
| US7435260B2 (en) * | 1999-08-13 | 2008-10-14 | Ferree Bret A | Use of morphogenetic proteins to treat human disc disease |
| US7201776B2 (en) | 1999-10-08 | 2007-04-10 | Ferree Bret A | Artificial intervertebral disc replacements with endplates |
| US20080311114A1 (en) * | 1999-08-13 | 2008-12-18 | Ferree Bret A | Use of morphogenic proteins to treat human disc disease |
| DK1207821T3 (da) * | 1999-08-27 | 2004-11-01 | Synthes Ag | Intervertebralimplantat |
| US6494883B1 (en) * | 2000-05-26 | 2002-12-17 | Bret A. Ferree | Bone reinforcers |
| US7060100B2 (en) | 1999-10-08 | 2006-06-13 | Ferree Bret A | Artificial disc and joint replacements with modular cushioning components |
| US7201774B2 (en) | 1999-10-08 | 2007-04-10 | Ferree Bret A | Artificial intervertebral disc replacements incorporating reinforced wall sections |
| US20040172019A1 (en) * | 1999-10-08 | 2004-09-02 | Ferree Bret A. | Reinforcers for artificial disc replacement methods and apparatus |
| JP4703926B2 (ja) | 1999-10-15 | 2011-06-15 | ジェネティクス インスティテュート,エルエルシー | 骨形成蛋白をデリバリーするためのヒアルロン酸の処方 |
| US6592624B1 (en) | 1999-11-24 | 2003-07-15 | Depuy Acromed, Inc. | Prosthetic implant element |
| WO2001049220A1 (en) | 1999-12-30 | 2001-07-12 | Osteotech, Inc. | Intervertebral implants |
| US7182781B1 (en) * | 2000-03-02 | 2007-02-27 | Regeneration Technologies, Inc. | Cervical tapered dowel |
| AR027685A1 (es) * | 2000-03-22 | 2003-04-09 | Synthes Ag | Forma de tejido y metodo para realizarlo |
| EP1142544B1 (de) * | 2000-04-04 | 2008-03-26 | Link Spine Group, Inc. | Zwischenwirbelkunststoffimplantat |
| US7462195B1 (en) | 2000-04-19 | 2008-12-09 | Warsaw Orthopedic, Inc. | Artificial lumbar interbody spinal implant having an asymmetrical leading end |
| US6350283B1 (en) | 2000-04-19 | 2002-02-26 | Gary K. Michelson | Bone hemi-lumbar interbody spinal implant having an asymmetrical leading end and method of installation thereof |
| US6579318B2 (en) | 2000-06-12 | 2003-06-17 | Ortho Development Corporation | Intervertebral spacer |
| USD493225S1 (en) | 2000-06-12 | 2004-07-20 | Ortho Development Corporation | Implant |
| US20020111680A1 (en) * | 2000-06-13 | 2002-08-15 | Michelson Gary K. | Ratcheted bone dowel |
| WO2001095837A1 (en) * | 2000-06-13 | 2001-12-20 | Michelson Gary K | Manufactured major long bone ring implant shaped to conform to a prepared intervertebral implantation space |
| US7018416B2 (en) * | 2000-07-06 | 2006-03-28 | Zimmer Spine, Inc. | Bone implants and methods |
| US7985247B2 (en) | 2000-08-01 | 2011-07-26 | Zimmer Spine, Inc. | Methods and apparatuses for treating the spine through an access device |
| US7056321B2 (en) | 2000-08-01 | 2006-06-06 | Endius, Incorporated | Method of securing vertebrae |
| US6761738B1 (en) | 2000-09-19 | 2004-07-13 | Sdgi Holdings, Inc. | Reinforced molded implant formed of cortical bone |
| US6432436B1 (en) | 2000-10-03 | 2002-08-13 | Musculoskeletal Transplant Foundation | Partially demineralized cortical bone constructs |
| JP4472925B2 (ja) | 2000-10-11 | 2010-06-02 | メイスン、マイケル・ディ | 骨移植を要しない脊椎固定機器 |
| US20030120274A1 (en) | 2000-10-20 | 2003-06-26 | Morris John W. | Implant retaining device |
| US6692498B1 (en) * | 2000-11-27 | 2004-02-17 | Linvatec Corporation | Bioabsorbable, osteopromoting fixation plate |
| US6752831B2 (en) | 2000-12-08 | 2004-06-22 | Osteotech, Inc. | Biocompatible osteogenic band for repair of spinal disorders |
| US20020114795A1 (en) | 2000-12-22 | 2002-08-22 | Thorne Kevin J. | Composition and process for bone growth and repair |
| US6520993B2 (en) | 2000-12-29 | 2003-02-18 | Depuy Acromed, Inc. | Spinal implant |
| US6986772B2 (en) * | 2001-03-01 | 2006-01-17 | Michelson Gary K | Dynamic lordotic guard with movable extensions for creating an implantation space posteriorly in the lumbar spine |
| AU2002244116A1 (en) * | 2001-02-16 | 2002-09-04 | Sulzer Spine-Tech Inc. | Bone implants and methods |
| US20020115742A1 (en) * | 2001-02-22 | 2002-08-22 | Trieu Hai H. | Bioactive nanocomposites and methods for their use |
| US20030045935A1 (en) * | 2001-02-28 | 2003-03-06 | Angelucci Christopher M. | Laminoplasty implants and methods of use |
| WO2002069891A2 (en) | 2001-03-01 | 2002-09-12 | Michelson Gary K | Dynamic lordotic guard with movable extensions for creating an implantation space posteriorly in the lumbar spine and method for use thereof |
| US6896680B2 (en) * | 2001-03-01 | 2005-05-24 | Gary K. Michelson | Arcuate dynamic lordotic guard with movable extensions for creating an implantation space posteriorly in the lumbar spine |
| US20060094112A1 (en) * | 2001-03-07 | 2006-05-04 | Omotunde Babalola | Biological scaffold |
| US7344539B2 (en) | 2001-03-30 | 2008-03-18 | Depuy Acromed, Inc. | Intervertebral connection system |
| US6989031B2 (en) | 2001-04-02 | 2006-01-24 | Sdgi Holdings, Inc. | Hemi-interbody spinal implant manufactured from a major long bone ring or a bone composite |
| US6749636B2 (en) | 2001-04-02 | 2004-06-15 | Gary K. Michelson | Contoured spinal fusion implants made of bone or a bone composite material |
| US6890355B2 (en) | 2001-04-02 | 2005-05-10 | Gary K. Michelson | Artificial contoured spinal fusion implants made of a material other than bone |
| US7695521B2 (en) * | 2001-05-01 | 2010-04-13 | Amedica Corporation | Hip prosthesis with monoblock ceramic acetabular cup |
| US20050177238A1 (en) * | 2001-05-01 | 2005-08-11 | Khandkar Ashok C. | Radiolucent bone graft |
| WO2002087475A1 (en) * | 2001-05-01 | 2002-11-07 | Amedica Corporation | Radiolucent bone graft |
| US7776085B2 (en) * | 2001-05-01 | 2010-08-17 | Amedica Corporation | Knee prosthesis with ceramic tibial component |
| US6719794B2 (en) | 2001-05-03 | 2004-04-13 | Synthes (U.S.A.) | Intervertebral implant for transforaminal posterior lumbar interbody fusion procedure |
| US6974480B2 (en) * | 2001-05-03 | 2005-12-13 | Synthes (Usa) | Intervertebral implant for transforaminal posterior lumbar interbody fusion procedure |
| US7226587B2 (en) | 2001-06-01 | 2007-06-05 | Wyeth | Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins |
| TWI267378B (en) * | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
| AU2002324443A1 (en) * | 2001-06-14 | 2003-01-02 | Amedica Corporation | Metal-ceramic composite articulation |
| US6814734B2 (en) * | 2001-06-18 | 2004-11-09 | Sdgi Holdings, Inc, | Surgical instrumentation and method for forming a passage in bone having an enlarged cross-sectional portion |
| US6558424B2 (en) | 2001-06-28 | 2003-05-06 | Depuy Acromed | Modular anatomic fusion device |
| SE519564C2 (sv) * | 2001-07-04 | 2003-03-11 | Nobel Biocare Ab | Implantat, t ex dentalt implantat, belagt med bentillväxtstimulerande medel |
| US6987136B2 (en) | 2001-07-13 | 2006-01-17 | Vita Special Purpose Corporation | Bioactive spinal implant material and method of manufacture thereof |
| US20030065397A1 (en) | 2001-08-27 | 2003-04-03 | Hanssen Arlen D. | Prosthetic implant support structure |
| US7892288B2 (en) | 2001-08-27 | 2011-02-22 | Zimmer Technology, Inc. | Femoral augments for use with knee joint prosthesis |
| US20040162619A1 (en) | 2001-08-27 | 2004-08-19 | Zimmer Technology, Inc. | Tibial augments for use with knee joint prostheses, method of implanting the tibial augment, and associated tools |
| US6635087B2 (en) | 2001-08-29 | 2003-10-21 | Christopher M. Angelucci | Laminoplasty implants and methods of use |
| JP4204772B2 (ja) * | 2001-08-30 | 2009-01-07 | 独立行政法人科学技術振興機構 | 生体内薬物徐放材料の製造方法 |
| US7371409B2 (en) | 2001-09-06 | 2008-05-13 | Wright Medical Technology, Inc. | Bone graft substitute composition |
| AU2002330148B2 (en) * | 2001-09-27 | 2007-11-01 | Zimmer Spine, Inc. | Modular spinal fusion device |
| WO2003030873A1 (en) * | 2001-10-09 | 2003-04-17 | Cellfactors Plc | Therapeutic biological product and method for formation of new vascularised bone |
| US20040131754A1 (en) * | 2001-10-24 | 2004-07-08 | Howmedica Osteonics Corp. | Antibiotic calcium phosphate coating |
| US6596338B2 (en) * | 2001-10-24 | 2003-07-22 | Howmedica Osteonics Corp. | Antibiotic calcium phosphate coating |
| US6855167B2 (en) | 2001-12-05 | 2005-02-15 | Osteotech, Inc. | Spinal intervertebral implant, interconnections for such implant and processes for making |
| US7238203B2 (en) | 2001-12-12 | 2007-07-03 | Vita Special Purpose Corporation | Bioactive spinal implants and method of manufacture thereof |
| US20030114930A1 (en) * | 2001-12-18 | 2003-06-19 | Lim Kit Yeng | Apparatus and method to stabilize and repair an intervertebral disc |
| AR038680A1 (es) | 2002-02-19 | 2005-01-26 | Synthes Ag | Implante intervertebral |
| US6730124B2 (en) * | 2002-03-08 | 2004-05-04 | Musculoskeletal Transplant Foundation | Bone-tendon-bone assembly with cancellous allograft bone block |
| US6890354B2 (en) * | 2002-03-08 | 2005-05-10 | Musculoskeletal Transplant Foundation | Bone-tendon-bone assembly with allograft bone block and method for inserting same |
| US6726720B2 (en) | 2002-03-27 | 2004-04-27 | Depuy Spine, Inc. | Modular disc prosthesis |
| WO2003082158A1 (en) | 2002-03-29 | 2003-10-09 | Wright Medical Technology, Inc. | Bone graft substitute composition |
| DE10220139A1 (de) * | 2002-05-06 | 2003-11-20 | Tutogen Medical Gmbh | Implantat aus Knochenmaterial |
| US20060204544A1 (en) * | 2002-05-20 | 2006-09-14 | Musculoskeletal Transplant Foundation | Allograft bone composition having a gelatin binder |
| US7166133B2 (en) * | 2002-06-13 | 2007-01-23 | Kensey Nash Corporation | Devices and methods for treating defects in the tissue of a living being |
| US6652887B1 (en) | 2002-06-24 | 2003-11-25 | Wright Medical Technology, Inc. | Bone graft substitute composition |
| US7291179B2 (en) * | 2002-06-24 | 2007-11-06 | Wright Medical Technology, Inc. | Bone graft substitute composition |
| WO2004000232A2 (en) | 2002-06-24 | 2003-12-31 | New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery | Complexed-acidic-phospholipid-collagen composites for bone induction |
| USD684693S1 (en) | 2002-08-22 | 2013-06-18 | Zimmer, Inc. | Prosthetic implant support structure |
| US7008226B2 (en) * | 2002-08-23 | 2006-03-07 | Woodwelding Ag | Implant, in particular a dental implant |
| AU2003268480A1 (en) * | 2002-09-06 | 2004-03-29 | Neville D. Alleyne | Seal for posterior lateral vertebral disk cavity |
| WO2004028045A1 (en) * | 2002-09-18 | 2004-04-01 | Incucomm, Inc. | Control processor for use with a transceiver in an optical wireless network |
| CA2501822C (en) | 2002-10-08 | 2012-02-21 | Osteotech, Inc. | Coupling agents for orthopedic biomaterials |
| US6695760B1 (en) * | 2002-10-11 | 2004-02-24 | Proxima Therapeutics | Treatment of spinal metastases |
| US7323011B2 (en) | 2002-10-18 | 2008-01-29 | Musculoskeletal Transplant Foundation | Cortical and cancellous allograft cervical fusion block |
| US7309361B2 (en) * | 2002-10-23 | 2007-12-18 | Wasielewski Ray C | Biologic modular tibial and femoral component augments for use with total knee arthroplasty |
| US7682392B2 (en) | 2002-10-30 | 2010-03-23 | Depuy Spine, Inc. | Regenerative implants for stabilizing the spine and devices for attachment of said implants |
| US20040098129A1 (en) * | 2002-11-13 | 2004-05-20 | Jo-Wen Lin | Spinal implant insertion adjustment instrument and implants for use therewith |
| US6761739B2 (en) | 2002-11-25 | 2004-07-13 | Musculoskeletal Transplant Foundation | Cortical and cancellous allograft spacer |
| US6994727B2 (en) * | 2002-12-17 | 2006-02-07 | Amedica Corporation | Total disc implant |
| US7141054B2 (en) * | 2003-02-03 | 2006-11-28 | Biomet, Inc. | Method and apparatus for intramedullary delivery of a material |
| US7507257B2 (en) * | 2003-02-04 | 2009-03-24 | Wright Medical Technology, Inc. | Injectable resorbable bone graft material, powder for forming same and methods relating thereto for treating bone defects |
| DE50313446D1 (de) | 2003-02-06 | 2011-03-10 | Synthes Gmbh | Zwischenwirbelimplantat |
| US20050008990A1 (en) * | 2003-02-26 | 2005-01-13 | Therics, Inc. | Method and system for repairing endosseous implants, such as with a bone graft implant |
| US20050021142A1 (en) * | 2003-02-26 | 2005-01-27 | Therics, Inc. | Method of manufacture, installation, and system for a sinus lift bone graft |
| US20050113930A1 (en) * | 2003-02-26 | 2005-05-26 | Therics, Inc. | Method of manufacture, installation, and system for an alveolar ridge augmentation graft |
| US7819903B2 (en) | 2003-03-31 | 2010-10-26 | Depuy Spine, Inc. | Spinal fixation plate |
| US7465304B1 (en) | 2003-04-14 | 2008-12-16 | Spine Design, Inc. | Anterior cervical facet discectomy surgery kit and method for its use |
| US7067123B2 (en) | 2003-04-29 | 2006-06-27 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
| US20050064042A1 (en) * | 2003-04-29 | 2005-03-24 | Musculoskeletal Transplant Foundation | Cartilage implant plug with fibrin glue and method for implantation |
| US7901457B2 (en) * | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
| US7488348B2 (en) | 2003-05-16 | 2009-02-10 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
| US20050020506A1 (en) * | 2003-07-25 | 2005-01-27 | Drapeau Susan J. | Crosslinked compositions comprising collagen and demineralized bone matrix, methods of making and methods of use |
| AU2003287021A1 (en) * | 2003-08-11 | 2005-03-10 | Musculoskeletal Transplant Foundation | Improved bone-tendon-bone assembly with cancellous allograft bone block |
| US7226482B2 (en) * | 2003-09-02 | 2007-06-05 | Synthes (U.S.A.) | Multipiece allograft implant |
| SI1675608T1 (sl) | 2003-09-12 | 2007-08-31 | Wyeth Corp | Injektibilne trdne paličice kalcijevega fosfata za dajanje osteogenih proteinov |
| US7182782B2 (en) | 2003-09-30 | 2007-02-27 | X-Spine Systems, Inc. | Spinal fusion system and method for fusing spinal bones |
| US8372152B2 (en) | 2003-09-30 | 2013-02-12 | X-Spine Systems, Inc. | Spinal fusion system utilizing an implant plate having at least one integral lock and ratchet lock |
| US7641701B2 (en) | 2003-09-30 | 2010-01-05 | X-Spine Systems, Inc. | Spinal fusion system and method for fusing spinal bones |
| US8062367B2 (en) | 2003-09-30 | 2011-11-22 | X-Spine Systems, Inc. | Screw locking mechanism and method |
| US8821553B2 (en) * | 2003-09-30 | 2014-09-02 | X-Spine Systems, Inc. | Spinal fusion system utilizing an implant plate having at least one integral lock |
| US9078706B2 (en) | 2003-09-30 | 2015-07-14 | X-Spine Systems, Inc. | Intervertebral fusion device utilizing multiple mobile uniaxial and bidirectional screw interface plates |
| CA2546250A1 (en) | 2003-11-20 | 2005-06-09 | Cytyc Corporation | Brachytherapy method and applicator for treatment of metastatic lesions in a load bearing region |
| US8012210B2 (en) * | 2004-01-16 | 2011-09-06 | Warsaw Orthopedic, Inc. | Implant frames for use with settable materials and related methods of use |
| NZ579516A (en) | 2004-01-27 | 2011-01-28 | Osteotech Inc | Stabilized bone graft |
| US20060045902A1 (en) * | 2004-09-01 | 2006-03-02 | Serbousek Jon C | Polymeric wrap for in vivo delivery of osteoinductive formulations |
| US7799081B2 (en) | 2004-09-14 | 2010-09-21 | Aeolin, Llc | System and method for spinal fusion |
| US8697139B2 (en) | 2004-09-21 | 2014-04-15 | Frank M. Phillips | Method of intervertebral disc treatment using articular chondrocyte cells |
| US20060069436A1 (en) * | 2004-09-30 | 2006-03-30 | Depuy Spine, Inc. | Trial disk implant |
| US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
| US7250550B2 (en) | 2004-10-22 | 2007-07-31 | Wright Medical Technology, Inc. | Synthetic bone substitute material |
| US20060111780A1 (en) * | 2004-11-22 | 2006-05-25 | Orthopedic Development Corporation | Minimally invasive facet joint hemi-arthroplasty |
| US8021392B2 (en) | 2004-11-22 | 2011-09-20 | Minsurg International, Inc. | Methods and surgical kits for minimally-invasive facet joint fusion |
| US20060111786A1 (en) * | 2004-11-22 | 2006-05-25 | Orthopedic Development Corporation | Metallic prosthetic implant for use in minimally invasive acromio-clavicular shoulder joint hemi-arthroplasty |
| US20060111779A1 (en) | 2004-11-22 | 2006-05-25 | Orthopedic Development Corporation, A Florida Corporation | Minimally invasive facet joint fusion |
| US20060166251A1 (en) * | 2005-01-26 | 2006-07-27 | Archambault Joanne M | Use of sFRPs as markers of BMP activity |
| JP4025827B2 (ja) * | 2005-02-10 | 2007-12-26 | フジコピアン株式会社 | 転写式感圧接着テープ |
| US8034080B2 (en) | 2005-02-17 | 2011-10-11 | Kyphon Sarl | Percutaneous spinal implants and methods |
| US20060184248A1 (en) * | 2005-02-17 | 2006-08-17 | Edidin Avram A | Percutaneous spinal implants and methods |
| US7993342B2 (en) | 2005-02-17 | 2011-08-09 | Kyphon Sarl | Percutaneous spinal implants and methods |
| US7998208B2 (en) * | 2005-02-17 | 2011-08-16 | Kyphon Sarl | Percutaneous spinal implants and methods |
| US8092459B2 (en) * | 2005-02-17 | 2012-01-10 | Kyphon Sarl | Percutaneous spinal implants and methods |
| US8096995B2 (en) | 2005-02-17 | 2012-01-17 | Kyphon Sarl | Percutaneous spinal implants and methods |
| US7927354B2 (en) | 2005-02-17 | 2011-04-19 | Kyphon Sarl | Percutaneous spinal implants and methods |
| US8029567B2 (en) | 2005-02-17 | 2011-10-04 | Kyphon Sarl | Percutaneous spinal implants and methods |
| US20070276373A1 (en) * | 2005-02-17 | 2007-11-29 | Malandain Hugues F | Percutaneous Spinal Implants and Methods |
| US8096994B2 (en) | 2005-02-17 | 2012-01-17 | Kyphon Sarl | Percutaneous spinal implants and methods |
| JP2006253316A (ja) * | 2005-03-09 | 2006-09-21 | Sony Corp | 固体撮像装置 |
| WO2006105359A2 (en) * | 2005-03-30 | 2006-10-05 | Wyeth | Methods for stimulating hair growth by administering bmps |
| CA2604622A1 (en) | 2005-04-15 | 2006-10-26 | Musculoskeletal Transplant Foundation | Vertebral disc repair |
| US9119901B2 (en) | 2005-04-28 | 2015-09-01 | Warsaw Orthopedic, Inc. | Surface treatments for promoting selective tissue attachment to medical impants |
| US8414907B2 (en) * | 2005-04-28 | 2013-04-09 | Warsaw Orthopedic, Inc. | Coatings on medical implants to guide soft tissue healing |
| US7727233B2 (en) * | 2005-04-29 | 2010-06-01 | Warsaw Orthopedic, Inc. | Spinous process stabilization devices and methods |
| US8506646B2 (en) * | 2005-04-29 | 2013-08-13 | Warsaw Orthopedic, Inc. | Multi-purpose medical implant devices |
| US8092548B2 (en) * | 2005-06-22 | 2012-01-10 | Warsaw Orthopedic, Inc. | Osteograft treatment to promote osteoinduction and osteograft incorporation |
| US7815926B2 (en) | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
| US20070074980A1 (en) * | 2005-09-02 | 2007-04-05 | Bankoski Brian R | Implant rehydration packages and methods of use |
| US8025903B2 (en) | 2005-09-09 | 2011-09-27 | Wright Medical Technology, Inc. | Composite bone graft substitute cement and articles produced therefrom |
| BRPI0617086B8 (pt) | 2005-09-09 | 2021-06-22 | Agnovos Healtcare Llc | cimento composto substituto de enxerto ósseo e artigos dele originados |
| WO2007035778A2 (en) | 2005-09-19 | 2007-03-29 | Histogenics Corporation | Cell-support matrix and a method for preparation thereof |
| WO2007044229A2 (en) * | 2005-09-28 | 2007-04-19 | Calcitec, Inc. | Surface treatments for calcium phosphate-based implants |
| US20070077267A1 (en) * | 2005-10-03 | 2007-04-05 | Sdgi Holdings, Inc. | Bioactive composite implants |
| GB2431408A (en) | 2005-10-19 | 2007-04-25 | Osta Technologies Cc | Bone material and a process for the preparation of bone material |
| US8690957B2 (en) | 2005-12-21 | 2014-04-08 | Warsaw Orthopedic, Inc. | Bone graft composition, method and implant |
| US8500778B2 (en) * | 2006-02-01 | 2013-08-06 | DePuy Synthes Products, LLC | Interspinous process spacer |
| US8252058B2 (en) * | 2006-02-16 | 2012-08-28 | Amedica Corporation | Spinal implant with elliptical articulatory interface |
| US20070198093A1 (en) * | 2006-02-17 | 2007-08-23 | Amedica Corporation | Spinal implant with offset keels |
| US20070198016A1 (en) * | 2006-02-21 | 2007-08-23 | Osteomed, L.P. | Compression stabilizing spacers |
| US8784477B2 (en) | 2011-01-05 | 2014-07-22 | Abbott Cardiovascular Systems Inc. | Stent graft with two layer ePTFE layer system with high plasticity and high rigidity |
| US7892577B2 (en) * | 2006-02-27 | 2011-02-22 | Globus Medical, Inc. | Bone graft materials derived from mineralized gelatin |
| WO2007098288A2 (en) | 2006-02-27 | 2007-08-30 | Synthes (U.S.A.) | Intervertebral implant with fixation geometry |
| US7985246B2 (en) * | 2006-03-31 | 2011-07-26 | Warsaw Orthopedic, Inc. | Methods and instruments for delivering interspinous process spacers |
| US8506983B2 (en) * | 2006-05-01 | 2013-08-13 | Warsaw Orthopedic, Inc. | Bone filler material |
| US7771741B2 (en) * | 2006-05-01 | 2010-08-10 | Warsaw Orthopedic, Inc | Demineralized bone matrix devices |
| US20100209470A1 (en) * | 2006-05-01 | 2010-08-19 | Warsaw Orthopedic, Inc. An Indiana Corporation | Demineralized bone matrix devices |
| US7838022B2 (en) * | 2006-05-01 | 2010-11-23 | Warsaw Orthopedic, Inc | Malleable implants containing demineralized bone matrix |
| US7959683B2 (en) | 2006-07-25 | 2011-06-14 | Musculoskeletal Transplant Foundation | Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation |
| US8043377B2 (en) | 2006-09-02 | 2011-10-25 | Osprey Biomedical, Inc. | Implantable intervertebral fusion device |
| US8506636B2 (en) | 2006-09-08 | 2013-08-13 | Theken Spine, Llc | Offset radius lordosis |
| US20080082170A1 (en) * | 2006-09-29 | 2008-04-03 | Peterman Marc M | Apparatus and methods for surgical repair |
| US20080177298A1 (en) * | 2006-10-24 | 2008-07-24 | St. Francis Medical Technologies, Inc. | Tensioner Tool and Method for Implanting an Interspinous Process Implant Including a Binder |
| AU2007328548A1 (en) * | 2006-12-08 | 2008-06-12 | Graftoss Limited | A medical preparation |
| US7955392B2 (en) | 2006-12-14 | 2011-06-07 | Warsaw Orthopedic, Inc. | Interspinous process devices and methods |
| US7718616B2 (en) | 2006-12-21 | 2010-05-18 | Zimmer Orthobiologics, Inc. | Bone growth particles and osteoinductive composition thereof |
| US8163028B2 (en) | 2007-01-10 | 2012-04-24 | Biomet Manufacturing Corp. | Knee joint prosthesis system and method for implantation |
| US8187280B2 (en) | 2007-10-10 | 2012-05-29 | Biomet Manufacturing Corp. | Knee joint prosthesis system and method for implantation |
| CN101646403B (zh) | 2007-01-10 | 2013-03-20 | 拜欧米特制造公司 | 用于移植的膝关节假体系统 |
| US8328873B2 (en) | 2007-01-10 | 2012-12-11 | Biomet Manufacturing Corp. | Knee joint prosthesis system and method for implantation |
| US8562616B2 (en) | 2007-10-10 | 2013-10-22 | Biomet Manufacturing, Llc | Knee joint prosthesis system and method for implantation |
| FR2911773B1 (fr) * | 2007-01-30 | 2009-03-27 | Tornier Sas | Methode et ensemble d'instrumentation chirurgicale pour poser une prothese totale d'epaule inversee,et prothese correspondante |
| US20090287309A1 (en) | 2007-01-30 | 2009-11-19 | Tornier Sas | Intra-articular joint replacement |
| WO2008100856A2 (en) | 2007-02-12 | 2008-08-21 | Osteotech, Inc. | Joint revision implant |
| US8435551B2 (en) | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
| US8114428B2 (en) * | 2007-03-08 | 2012-02-14 | Sbf Synthetic Bone Factory Gmbh | Methods for manufacturing a composition for treating bone and/or cartilage defects |
| US20080233203A1 (en) * | 2007-03-21 | 2008-09-25 | Jennifer Woodell-May | Porous orthapedic materials coated with demineralized bone matrix |
| US20090018659A1 (en) * | 2007-07-10 | 2009-01-15 | Malinin Theodore I | Invertebral spinal implant and method of making the same |
| US20100268339A1 (en) * | 2007-07-10 | 2010-10-21 | Malinin Theodore I | Intervertebral Spinal Implant and Method of Making the Same |
| US7963982B2 (en) * | 2007-07-16 | 2011-06-21 | X-Spine Systems, Inc. | Implant plate screw locking system and screw having a locking member |
| US8685099B2 (en) * | 2007-08-14 | 2014-04-01 | Warsaw Orthopedic, Inc. | Multiple component osteoimplant |
| US20090105824A1 (en) * | 2007-10-19 | 2009-04-23 | Jones Robert J | Spinal fusion device and associated methods |
| US9295564B2 (en) * | 2007-10-19 | 2016-03-29 | Spinesmith Partners, L.P. | Fusion methods using autologous stem cells |
| CA2705684A1 (en) | 2007-11-16 | 2009-05-22 | Synthes Usa, Llc | Low profile intervertebral implant |
| CA2717725A1 (en) | 2008-03-05 | 2009-09-11 | Musculoskeletal Transplant Foundation | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
| US20140031944A1 (en) * | 2008-03-18 | 2014-01-30 | Yoh Sawatari | Cylindrical graft and method for preparing a recipient site and implanting a cylindrical graft into alveolar jaw bone |
| TWI394597B (zh) * | 2008-06-24 | 2013-05-01 | Sunmax Biotechnology Co Ltd | 骨科用生物可分解性補綴物 |
| US8968373B2 (en) * | 2008-07-24 | 2015-03-03 | Warsaw Orthopedic, Inc. | Cortical tenting screw |
| US8114131B2 (en) | 2008-11-05 | 2012-02-14 | Kyphon Sarl | Extension limiting devices and methods of use for the spine |
| US20100145460A1 (en) | 2008-11-07 | 2010-06-10 | Mcdonough William P | Zero-profile interbody spacer and coupled plate assembly |
| US9192695B2 (en) * | 2008-11-20 | 2015-11-24 | Allosource | Allografts combined with tissue derived stem cells for bone healing |
| US7964208B2 (en) | 2009-02-25 | 2011-06-21 | Warsaw Orthopedic, Inc. | System and methods of maintaining space for augmentation of the alveolar ridge |
| US20110014587A1 (en) * | 2009-07-16 | 2011-01-20 | Warsaw Orthopedic, Inc. | System and methods of preserving an oral socket |
| US9539068B2 (en) * | 2009-07-24 | 2017-01-10 | Warsaw Orthopedic, Inc. | Implantable screw and system for socket preservation |
| US20110238183A1 (en) * | 2009-09-26 | 2011-09-29 | Maly Richard S | Interbody Fusion Device |
| US8535356B2 (en) | 2009-11-04 | 2013-09-17 | X-Spine Systems, Inc. | Screw implant and system and method for locking a screw in an implant plate |
| US9486263B2 (en) | 2009-11-04 | 2016-11-08 | X-Spine Systems, Inc. | Screw implant and system and method for locking a screw in an implant plate |
| US20140286911A1 (en) | 2013-03-15 | 2014-09-25 | Allosource | Cell repopulated collagen matrix for soft tissue repair and regeneration |
| US8147526B2 (en) | 2010-02-26 | 2012-04-03 | Kyphon Sarl | Interspinous process spacer diagnostic parallel balloon catheter and methods of use |
| US9408652B2 (en) | 2010-04-27 | 2016-08-09 | Tornier Sas | Intra-articular joint replacement and method |
| CN103313733A (zh) | 2010-11-15 | 2013-09-18 | 捷迈整形外科生物材料有限公司 | 骨空隙填充剂 |
| US9241809B2 (en) | 2010-12-21 | 2016-01-26 | DePuy Synthes Products, Inc. | Intervertebral implants, systems, and methods of use |
| WO2012088238A2 (en) | 2010-12-21 | 2012-06-28 | Synthes Usa, Llc | Intervertebral implants, systems, and methods of use |
| CA2836772C (en) | 2011-05-20 | 2020-03-10 | Zimmer, Inc. | Stabilizing prosthesis support structure |
| EP2731555B1 (en) | 2011-07-13 | 2018-11-07 | Vivex Biomedical, Inc. | Spinal implants with stem cells |
| US9237957B2 (en) | 2011-09-16 | 2016-01-19 | Globus Medical, Inc. | Low profile plate |
| US9149365B2 (en) | 2013-03-05 | 2015-10-06 | Globus Medical, Inc. | Low profile plate |
| US9398960B2 (en) | 2011-09-16 | 2016-07-26 | Globus Medical, Inc. | Multi-piece intervertebral implants |
| US10245155B2 (en) | 2011-09-16 | 2019-04-02 | Globus Medical, Inc. | Low profile plate |
| US10881526B2 (en) | 2011-09-16 | 2021-01-05 | Globus Medical, Inc. | Low profile plate |
| US8961606B2 (en) | 2011-09-16 | 2015-02-24 | Globus Medical, Inc. | Multi-piece intervertebral implants |
| US9848994B2 (en) | 2011-09-16 | 2017-12-26 | Globus Medical, Inc. | Low profile plate |
| US9539109B2 (en) | 2011-09-16 | 2017-01-10 | Globus Medical, Inc. | Low profile plate |
| US9204975B2 (en) | 2011-09-16 | 2015-12-08 | Globus Medical, Inc. | Multi-piece intervertebral implants |
| US9770340B2 (en) | 2011-09-16 | 2017-09-26 | Globus Medical, Inc. | Multi-piece intervertebral implants |
| US9681959B2 (en) | 2011-09-16 | 2017-06-20 | Globus Medical, Inc. | Low profile plate |
| WO2013075091A1 (en) | 2011-11-17 | 2013-05-23 | Allosource | Multi-piece machine graft systems and methods |
| US9585764B2 (en) * | 2012-07-26 | 2017-03-07 | Warsaw Orthopedic, Inc. | Bone implant device |
| CA2897855A1 (en) | 2013-03-07 | 2014-09-12 | Allosource | Consistent calcium content bone allograft systems and methods |
| US10327910B2 (en) | 2013-03-14 | 2019-06-25 | X-Spine Systems, Inc. | Spinal implant and assembly |
| EP3043727A1 (en) | 2013-09-13 | 2016-07-20 | X-spine Systems, Inc. | Screw implant and system and method for locking a screw in an implant plate |
| US9345589B2 (en) * | 2013-12-19 | 2016-05-24 | Ilion Medical, Inc. | Bone implants for orthopedic procedures and corresponding methods |
| WO2015175983A1 (en) | 2014-05-16 | 2015-11-19 | Allosource | Composite bone constructs and methods |
| US9867718B2 (en) | 2014-10-22 | 2018-01-16 | DePuy Synthes Products, Inc. | Intervertebral implants, systems, and methods of use |
| US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
| WO2016137983A1 (en) | 2015-02-24 | 2016-09-01 | X-Spine Systems, Inc. | Modular interspinous fixation system with threaded component |
| CN110191691B (zh) | 2017-01-20 | 2022-03-22 | 拜欧米特制造有限责任公司 | 模块化扩充部件 |
| US11364121B2 (en) | 2017-02-27 | 2022-06-21 | Vertical Spine LLC | Engineered bone graft implant and methods of using the same |
| US10376385B2 (en) | 2017-04-05 | 2019-08-13 | Globus Medical, Inc. | Decoupled spacer and plate and method of installing the same |
| US11452608B2 (en) | 2017-04-05 | 2022-09-27 | Globus Medical, Inc. | Decoupled spacer and plate and method of installing the same |
| EP3645066A1 (en) | 2017-06-30 | 2020-05-06 | Allosource | Cellular bone grafts, and methods of manufacture and use |
| KR102828408B1 (ko) * | 2024-01-05 | 2025-07-02 | 전북대학교병원 | 골결손 수복용 탄소소재 충전 연결부재 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2854490C2 (de) * | 1978-12-16 | 1981-04-09 | B. Braun Melsungen Ag, 3508 Melsungen | Knochenersatzmaterial mit verbesserter biologischer Stabilität auf Basis von Kollagen |
| US4294753A (en) * | 1980-08-04 | 1981-10-13 | The Regents Of The University Of California | Bone morphogenetic protein process |
| US4314380A (en) * | 1980-09-26 | 1982-02-09 | Koken Co., Ltd. | Artificial bone |
| US4472840A (en) * | 1981-09-21 | 1984-09-25 | Jefferies Steven R | Method of inducing osseous formation by implanting bone graft material |
| ATE31616T1 (de) * | 1983-10-20 | 1988-01-15 | Oscobal Ag | Knochenersatzmaterial auf der basis natuerlicher knochen. |
| US4888366A (en) * | 1984-10-24 | 1989-12-19 | Collagen Corporation | Inductive collagen-based bone repair preparations |
| GB8514055D0 (en) * | 1985-06-04 | 1985-07-10 | Geistlich Soehne Ag | Chemical substance |
| US5187076A (en) * | 1986-07-01 | 1993-02-16 | Genetics Institute, Inc. | DNA sequences encoding BMP-6 proteins |
| US5108922A (en) * | 1986-07-01 | 1992-04-28 | Genetics Institute, Inc. | DNA sequences encoding BMP-1 products |
| US5013649A (en) * | 1986-07-01 | 1991-05-07 | Genetics Institute, Inc. | DNA sequences encoding osteoinductive products |
| US5106748A (en) * | 1986-07-01 | 1992-04-21 | Genetics Institute, Inc. | Dna sequences encoding 5 proteins |
| US5366875A (en) * | 1986-07-01 | 1994-11-22 | Genetics Institute, Inc. | Methods for producing BMP-7 proteins |
| US4877864A (en) * | 1987-03-26 | 1989-10-31 | Genetics Institute, Inc. | Osteoinductive factors |
| DE3637314A1 (de) * | 1986-11-03 | 1988-05-11 | Lutz Biedermann | Platzhalter-implantat |
| US4834757A (en) * | 1987-01-22 | 1989-05-30 | Brantigan John W | Prosthetic implant |
| US4863732A (en) * | 1987-12-16 | 1989-09-05 | Collagen Corporation | Injectable composition for inductive bone repair |
| DE68929453T2 (de) * | 1988-04-08 | 2003-11-20 | Stryker Corp., Kalamazoo | Osteogene Vorrichtungen |
| US4975526A (en) * | 1989-02-23 | 1990-12-04 | Creative Biomolecules, Inc. | Bone collagen matrix for zenogenic implants |
| GB8813033D0 (en) * | 1988-06-02 | 1988-07-06 | Geistlich Soehne Ag | Chemical compound |
| US5015247A (en) * | 1988-06-13 | 1991-05-14 | Michelson Gary K | Threaded spinal implant |
| US5573771A (en) * | 1988-08-19 | 1996-11-12 | Osteomedical Limited | Medicinal bone mineral products |
| GB8819755D0 (en) * | 1988-08-19 | 1988-09-21 | Geistlich Soehne Ag | Chemical compound |
| US4961740B1 (en) * | 1988-10-17 | 1997-01-14 | Surgical Dynamics Inc | V-thread fusion cage and method of fusing a bone joint |
| DE8904664U1 (de) * | 1989-04-13 | 1989-06-01 | REHAU AG + Co, 8673 Rehau | Halteleiste für auswechselbare Informationsträger |
| FR2654625B1 (fr) * | 1989-11-22 | 1992-02-21 | Transphyto Sa | Procede de fabrication d'un materiau pour osteoplastie a partir d'un tissu osseux naturel et materiau obtenu par ce procede. |
| US5147402A (en) * | 1990-12-05 | 1992-09-15 | Sulzer Brothers Limited | Implant for ingrowth of osseous tissue |
| US5192327A (en) * | 1991-03-22 | 1993-03-09 | Brantigan John W | Surgical prosthetic implant for vertebrae |
| KR100255415B1 (ko) * | 1991-06-25 | 2000-05-01 | 브루스 엠. 에이센 | 비엠피-9 조성물 |
| EP0698094B1 (en) * | 1993-05-12 | 2004-02-04 | Genetics Institute, LLC | Bmp-11 compositions |
| JPH09501305A (ja) * | 1993-05-12 | 1997-02-10 | ジェネティックス・インスティテュート・インコーポレイテッド | Bmp−10組成物 |
| JPH07289626A (ja) * | 1994-04-27 | 1995-11-07 | Terumo Corp | 生体材料 |
| JP3881707B2 (ja) * | 1995-07-20 | 2007-02-14 | 学校法人松本歯科大学 | 骨形成促進剤の製造方法及び骨形成促進剤を用いた骨形成組成物の製造方法 |
| US5709683A (en) * | 1995-12-19 | 1998-01-20 | Spine-Tech, Inc. | Interbody bone implant having conjoining stabilization features for bony fusion |
-
1997
- 1997-06-11 US US08/873,276 patent/US5972368A/en not_active Expired - Lifetime
-
1998
- 1998-06-11 AU AU78185/98A patent/AU738218B2/en not_active Ceased
- 1998-06-11 CA CA002293354A patent/CA2293354A1/en not_active Abandoned
- 1998-06-11 DE DE69826273T patent/DE69826273T2/de not_active Expired - Lifetime
- 1998-06-11 AT AT98926323T patent/ATE275981T1/de not_active IP Right Cessation
- 1998-06-11 WO PCT/US1998/011611 patent/WO1998056433A1/en not_active Ceased
- 1998-06-11 JP JP50290599A patent/JP2002503992A/ja not_active Ceased
- 1998-06-11 ES ES98926323T patent/ES2227842T3/es not_active Expired - Lifetime
- 1998-06-11 EP EP98926323A patent/EP0988070B1/en not_active Expired - Lifetime
-
1999
- 1999-08-31 US US09/386,560 patent/US6261586B1/en not_active Expired - Lifetime
-
2010
- 2010-09-27 JP JP2010215347A patent/JP2011036690A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| DE69826273D1 (en) | 2004-10-21 |
| JP2011036690A (ja) | 2011-02-24 |
| US6261586B1 (en) | 2001-07-17 |
| WO1998056433A1 (en) | 1998-12-17 |
| EP0988070A1 (en) | 2000-03-29 |
| DE69826273T2 (de) | 2005-09-22 |
| JP2002503992A (ja) | 2002-02-05 |
| ES2227842T3 (es) | 2005-04-01 |
| AU738218B2 (en) | 2001-09-13 |
| ATE275981T1 (de) | 2004-10-15 |
| US5972368A (en) | 1999-10-26 |
| EP0988070B1 (en) | 2004-09-15 |
| AU7818598A (en) | 1998-12-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0988070B1 (en) | Bone graft composites and spacers | |
| EP0955961B1 (en) | Spinal spacer | |
| US20120071983A1 (en) | Bone grafts | |
| US7276081B1 (en) | Bone grafts | |
| CA2293758C (en) | Reinforced bone graft substitutes | |
| AU6499800A (en) | Cartilage or bone matrix as a nucleic acid delivery vehicle | |
| US20120310348A1 (en) | Bone grafts | |
| AU6499700A (en) | Reduced antigenicity tissue (rat) implants | |
| AU773116B2 (en) | Spinal spacer | |
| CA2547680A1 (en) | Spinal spacer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |