CA2282807A1 - Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics - Google Patents
Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics Download PDFInfo
- Publication number
- CA2282807A1 CA2282807A1 CA002282807A CA2282807A CA2282807A1 CA 2282807 A1 CA2282807 A1 CA 2282807A1 CA 002282807 A CA002282807 A CA 002282807A CA 2282807 A CA2282807 A CA 2282807A CA 2282807 A1 CA2282807 A1 CA 2282807A1
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- Prior art keywords
- mbi
- trp
- arg
- peptide
- lys
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 239000003242 anti bacterial agent Substances 0.000 title claims abstract description 158
- 229940088710 antibiotic agent Drugs 0.000 title claims abstract description 137
- 125000002091 cationic group Chemical group 0.000 title claims abstract description 105
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 104
- 208000015181 infectious disease Diseases 0.000 title claims abstract description 88
- 238000000034 method Methods 0.000 title claims abstract description 64
- 239000000203 mixture Substances 0.000 title claims abstract description 24
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- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims description 14
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- VAAUVRVFOQPIGI-SPQHTLEESA-N ceftriaxone Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1CSC1=NC(=O)C(=O)NN1C VAAUVRVFOQPIGI-SPQHTLEESA-N 0.000 claims description 14
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Classifications
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4064997P | 1997-03-10 | 1997-03-10 | |
| US08/915,314 US6180604B1 (en) | 1996-08-21 | 1997-08-20 | Compositions and methods for treating infections using analogues of indolicidin |
| US6009997P | 1997-09-26 | 1997-09-26 | |
| US60/060,099 | 1998-02-25 | ||
| US09/030,619 | 1998-02-25 | ||
| US08/915,314 | 1998-02-25 | ||
| US09/030,619 US6503881B2 (en) | 1996-08-21 | 1998-02-25 | Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics |
| US60/040,649 | 1998-02-25 | ||
| PCT/CA1998/000190 WO1998040401A2 (en) | 1997-03-10 | 1998-03-10 | Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2282807A1 true CA2282807A1 (en) | 1998-09-17 |
Family
ID=27487830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002282807A Abandoned CA2282807A1 (en) | 1997-03-10 | 1998-03-10 | Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US6503881B2 (enExample) |
| EP (1) | EP0966481B1 (enExample) |
| JP (1) | JP2002544759A (enExample) |
| AT (1) | ATE333464T1 (enExample) |
| AU (1) | AU6604798A (enExample) |
| CA (1) | CA2282807A1 (enExample) |
| DE (1) | DE69835279T2 (enExample) |
| ES (1) | ES2264198T3 (enExample) |
| WO (1) | WO1998040401A2 (enExample) |
Families Citing this family (147)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6180604B1 (en) * | 1996-08-21 | 2001-01-30 | Micrologix Biotech Inc. | Compositions and methods for treating infections using analogues of indolicidin |
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| US5359030A (en) | 1993-05-10 | 1994-10-25 | Protein Delivery, Inc. | Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same |
| JPH09502987A (ja) | 1993-09-22 | 1997-03-25 | ゾーマ コーポレイション | 殺菌性／浸透性が向上した（ｂｐｉ）タンパク質生成物および抗生物質の投与によるグラム陰性細菌感染の治療方法 |
| DE69527195T2 (de) | 1994-01-14 | 2003-03-06 | Xoma Technology Ltd., Berkeley | Anti gram positive bakterielle verfahren und mittel |
| US5574017A (en) * | 1994-07-05 | 1996-11-12 | Gutheil; William G. | Antibacterial agents |
| US5877274A (en) * | 1995-06-02 | 1999-03-02 | University Of British Columbia | Antimicrobial cationic peptides |
| JP3860838B2 (ja) * | 1995-08-23 | 2006-12-20 | ユニバーシティー オブ ブリティッシュ コロンビア | 抗微生物性陽イオン性ペプチドおよびそのスクリーニング方法 |
| US5994308A (en) | 1996-02-28 | 1999-11-30 | Board Of Trustees Of Southern Illinois University | Broad spectrum antimicrobial peptides containing a tryptophan triplet and methods of use |
| US6503881B2 (en) * | 1996-08-21 | 2003-01-07 | Micrologix Biotech Inc. | Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics |
| US6180604B1 (en) * | 1996-08-21 | 2001-01-30 | Micrologix Biotech Inc. | Compositions and methods for treating infections using analogues of indolicidin |
| US6551994B1 (en) | 1997-04-10 | 2003-04-22 | Mcgill University | Compounds and methods for inhibiting the interaction between α-catenin and β-catenin |
| AU2605099A (en) | 1998-02-25 | 1999-09-15 | Micrologix Biotech, Inc. | Indolicidin and cationic peptides conjugated with polymers |
-
1998
- 1998-02-25 US US09/030,619 patent/US6503881B2/en not_active Expired - Lifetime
- 1998-03-10 CA CA002282807A patent/CA2282807A1/en not_active Abandoned
- 1998-03-10 ES ES98907779T patent/ES2264198T3/es not_active Expired - Lifetime
- 1998-03-10 WO PCT/CA1998/000190 patent/WO1998040401A2/en not_active Ceased
- 1998-03-10 DE DE69835279T patent/DE69835279T2/de not_active Expired - Fee Related
- 1998-03-10 AT AT98907779T patent/ATE333464T1/de not_active IP Right Cessation
- 1998-03-10 EP EP98907779A patent/EP0966481B1/en not_active Expired - Lifetime
- 1998-03-10 JP JP53899798A patent/JP2002544759A/ja active Pending
- 1998-03-10 AU AU66047/98A patent/AU6604798A/en not_active Abandoned
-
2002
- 2002-10-18 US US10/277,233 patent/US7309759B2/en not_active Expired - Fee Related
-
2007
- 2007-11-15 US US11/940,653 patent/US20110150780A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP0966481B1 (en) | 2006-07-19 |
| ATE333464T1 (de) | 2006-08-15 |
| US7309759B2 (en) | 2007-12-18 |
| WO1998040401A2 (en) | 1998-09-17 |
| AU6604798A (en) | 1998-09-29 |
| DE69835279T2 (de) | 2007-07-12 |
| US20030232750A1 (en) | 2003-12-18 |
| US6503881B2 (en) | 2003-01-07 |
| DE69835279D1 (de) | 2006-08-31 |
| HK1025103A1 (en) | 2000-11-03 |
| WO1998040401A3 (en) | 1998-12-17 |
| ES2264198T3 (es) | 2006-12-16 |
| EP0966481A2 (en) | 1999-12-29 |
| US20020035061A1 (en) | 2002-03-21 |
| US20110150780A1 (en) | 2011-06-23 |
| JP2002544759A (ja) | 2002-12-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |