CA2269502C - Tetraether lipid derivatives and liposomes and lipid agglomerates containing tetraetherlipid derivatives, and use thereof - Google Patents

Tetraether lipid derivatives and liposomes and lipid agglomerates containing tetraetherlipid derivatives, and use thereof Download PDF

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Publication number
CA2269502C
CA2269502C CA002269502A CA2269502A CA2269502C CA 2269502 C CA2269502 C CA 2269502C CA 002269502 A CA002269502 A CA 002269502A CA 2269502 A CA2269502 A CA 2269502A CA 2269502 C CA2269502 C CA 2269502C
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CA
Canada
Prior art keywords
lipid
tetraether
liposomes
derivative
liposome
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002269502A
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English (en)
French (fr)
Other versions
CA2269502A1 (en
Inventor
H.-J. Freisleben
Emmanouil Antonopoulos
Maxim Balakirev
Larissa Balakirev
Klaus Hartmann
Felix Gropp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bernina Biosystems GmbH
Original Assignee
Bernina Biosystems GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bernina Biosystems GmbH filed Critical Bernina Biosystems GmbH
Publication of CA2269502A1 publication Critical patent/CA2269502A1/en
Application granted granted Critical
Publication of CA2269502C publication Critical patent/CA2269502C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA002269502A 1997-08-22 1998-08-19 Tetraether lipid derivatives and liposomes and lipid agglomerates containing tetraetherlipid derivatives, and use thereof Expired - Fee Related CA2269502C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1997136592 DE19736592C2 (de) 1997-08-22 1997-08-22 Tetraetherlipidderivat, ein oder mehrere Tetraetherlipidderivate enthaltendes Liposom oder Lipidagglomerat und pharmazeutische Zusammensetzung
DE19736592.2 1997-08-22
PCT/EP1998/005264 WO1999010337A1 (de) 1997-08-22 1998-08-19 Tetraetherlipidderivate und tetraetherlipidderivate enthaltende liposomen und lipidagglomerate sowie deren verwendung

Publications (2)

Publication Number Publication Date
CA2269502A1 CA2269502A1 (en) 1999-03-04
CA2269502C true CA2269502C (en) 2003-07-29

Family

ID=7839862

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002269502A Expired - Fee Related CA2269502C (en) 1997-08-22 1998-08-19 Tetraether lipid derivatives and liposomes and lipid agglomerates containing tetraetherlipid derivatives, and use thereof

Country Status (5)

Country Link
EP (1) EP1005466A1 (de)
AU (1) AU9344398A (de)
CA (1) CA2269502C (de)
DE (1) DE19736592C2 (de)
WO (1) WO1999010337A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10065561A1 (de) * 2000-12-28 2002-07-11 Bernina Biosystems Gmbh Tetraetherlipidderivate und Tetraetherlipidderivate enthaltende Liposomen und Lipidagglomerate sowie deren Verwendung
DE10204053A1 (de) * 2002-02-01 2003-08-14 Bernina Biosystems Gmbh Synthetische Tetraether und Herstellungsverfahren dafür
DE10228857B4 (de) 2002-06-26 2006-11-16 Surface & Interface Technologies Gmbh Rosenhof Tetraetherlipide mit kleinen Kopfgruppen, deren Herstellung und Verwendung
DE10249401A1 (de) * 2002-10-23 2004-05-13 Bernina Biosystems Gmbh Liposomen formende Zusammensetzung
EP2711369A1 (de) 2012-09-20 2014-03-26 Bernina Plus GmbH Liposome mit Tetraetherlipidderivaten
EP2968147A4 (de) 2013-03-15 2017-02-22 The Penn State Research Foundation Säurestabile liposomale zusammensetzungen
FR3052361B1 (fr) 2016-06-09 2019-08-23 Centre National De La Recherche Scientifique Diethers d’archaea lipides synthetiques

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69221496T2 (de) * 1991-10-23 1997-12-11 National Research Council Of Canada, Ottawa, Ontario Formierung von stabilen Liposomen aus Lipidextrakten von Archaeobakterien.
DE19607722A1 (de) * 1996-02-29 1997-09-04 Freisleben H J Dr Tetraetherlipide und diese enthaltende Liposomen sowie deren Verwendung

Also Published As

Publication number Publication date
WO1999010337A1 (de) 1999-03-04
CA2269502A1 (en) 1999-03-04
AU9344398A (en) 1999-03-16
DE19736592A1 (de) 1999-02-25
DE19736592C2 (de) 2002-01-24
EP1005466A1 (de) 2000-06-07

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