CA2269502A1 - Tetraether lipid derivatives and liposomes and lipid agglomerates containing tetraetherlipid derivatives, and use thereof - Google Patents

Tetraether lipid derivatives and liposomes and lipid agglomerates containing tetraetherlipid derivatives, and use thereof

Info

Publication number
CA2269502A1
CA2269502A1 CA002269502A CA2269502A CA2269502A1 CA 2269502 A1 CA2269502 A1 CA 2269502A1 CA 002269502 A CA002269502 A CA 002269502A CA 2269502 A CA2269502 A CA 2269502A CA 2269502 A1 CA2269502 A1 CA 2269502A1
Authority
CA
Canada
Prior art keywords
derivatives
lipid
liposomes
tetraetherlipid
tetraether
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002269502A
Other languages
French (fr)
Other versions
CA2269502C (en
Inventor
H.-J. Freisleben
Emmanouil Antonopoulos
Maxim Balakirev
Larissa Balakirev
Klaus Hartmann
Felix Gropp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bernina Biosystems GmbH
Original Assignee
H.-J. Freisleben
Emmanouil Antonopoulos
Maxim Balakirev
Larissa Balakirev
Klaus Hartmann
Felix Gropp
Syrinx Therapeutika Gmbh
Bernina Biosystems Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H.-J. Freisleben, Emmanouil Antonopoulos, Maxim Balakirev, Larissa Balakirev, Klaus Hartmann, Felix Gropp, Syrinx Therapeutika Gmbh, Bernina Biosystems Gmbh filed Critical H.-J. Freisleben
Publication of CA2269502A1 publication Critical patent/CA2269502A1/en
Application granted granted Critical
Publication of CA2269502C publication Critical patent/CA2269502C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle

Abstract

Conventional liposomes which are used for transporting pharmaceutical active agents in eukaryotic cells or for lipofection can only be preserved for a limited period, are not acid-stable and require a number of set parameters in order to achieve satisfactory results. Less sensitive liposomes are therefore highly desirable. The inventive tetraetherlipid derivatives are very stable and are well suited to lipofection.
CA002269502A 1997-08-22 1998-08-19 Tetraether lipid derivatives and liposomes and lipid agglomerates containing tetraetherlipid derivatives, and use thereof Expired - Fee Related CA2269502C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19736592.2 1997-08-22
DE1997136592 DE19736592C2 (en) 1997-08-22 1997-08-22 Tetraether lipid derivative, one or more tetraether lipid derivatives containing liposome or lipid agglomerate and pharmaceutical composition
PCT/EP1998/005264 WO1999010337A1 (en) 1997-08-22 1998-08-19 Tetraether lipid derivatives and liposomes and lipid agglomerates containing tetraetherlipid derivatives, and use thereof

Publications (2)

Publication Number Publication Date
CA2269502A1 true CA2269502A1 (en) 1999-03-04
CA2269502C CA2269502C (en) 2003-07-29

Family

ID=7839862

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002269502A Expired - Fee Related CA2269502C (en) 1997-08-22 1998-08-19 Tetraether lipid derivatives and liposomes and lipid agglomerates containing tetraetherlipid derivatives, and use thereof

Country Status (5)

Country Link
EP (1) EP1005466A1 (en)
AU (1) AU9344398A (en)
CA (1) CA2269502C (en)
DE (1) DE19736592C2 (en)
WO (1) WO1999010337A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017212197A1 (en) 2016-06-09 2017-12-14 Université Pierre Et Marie Curie - Paris 6 (Upmc) Synthetic lipid archaeum diethers

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10065561A1 (en) * 2000-12-28 2002-07-11 Bernina Biosystems Gmbh Liposomes and lipid agglomerates containing tetraether lipid derivatives and tetraether lipid derivatives and their use
DE10204053A1 (en) * 2002-02-01 2003-08-14 Bernina Biosystems Gmbh New synthetic long-chain tetraether derivatives, useful as components of liposomes for nucleic acid transfection
DE10228857B4 (en) 2002-06-26 2006-11-16 Surface & Interface Technologies Gmbh Rosenhof Tetraether lipids with small head groups, their preparation and use
DE10249401A1 (en) * 2002-10-23 2004-05-13 Bernina Biosystems Gmbh Liposome forming composition
EP2711369A1 (en) 2012-09-20 2014-03-26 Bernina Plus GmbH Liposomes containing tetraether lipid derivatives
US10272041B2 (en) 2013-03-15 2019-04-30 The Penn State Research Foundation Acid stable liposomal compositions and methods for producing the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2122638C (en) * 1991-10-23 2001-05-08 G. Dennis Sprott Formation of stable liposomes from lipid extracts of archaeobacteria (archaea)
DE19607722A1 (en) * 1996-02-29 1997-09-04 Freisleben H J Dr Tetraether lipids and liposomes containing them and their use

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017212197A1 (en) 2016-06-09 2017-12-14 Université Pierre Et Marie Curie - Paris 6 (Upmc) Synthetic lipid archaeum diethers

Also Published As

Publication number Publication date
EP1005466A1 (en) 2000-06-07
DE19736592C2 (en) 2002-01-24
AU9344398A (en) 1999-03-16
DE19736592A1 (en) 1999-02-25
CA2269502C (en) 2003-07-29
WO1999010337A1 (en) 1999-03-04

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed