CA2268820A1 - Compositions antibiotiques stabilisees a base de carbapenem et procede de production - Google Patents

Compositions antibiotiques stabilisees a base de carbapenem et procede de production Download PDF

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Publication number
CA2268820A1
CA2268820A1 CA002268820A CA2268820A CA2268820A1 CA 2268820 A1 CA2268820 A1 CA 2268820A1 CA 002268820 A CA002268820 A CA 002268820A CA 2268820 A CA2268820 A CA 2268820A CA 2268820 A1 CA2268820 A1 CA 2268820A1
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CA
Canada
Prior art keywords
alkyl
group
substituted
unsubstituted
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002268820A
Other languages
English (en)
Inventor
Orn Almarsson
Michael J. Kaufman
John D. Strong
John M. Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9626211.8A external-priority patent/GB9626211D0/en
Application filed by Individual filed Critical Individual
Publication of CA2268820A1 publication Critical patent/CA2268820A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Cette invention a trait à une nouvelle forme stabilisée d'antibiotiques à base de carbapenem ainsi qu'à des compositions et à des techniques afférentes. Il est possible d'utiliser ces composés pour le traitement de maladies infectieuses, notamment des maladies provoquées par des bactéries aérobies et anaérobies, à Gram positif et à Gram négatif. Ces composés, qui ont une action bénéfique du point de vue pharmaceutique et qui se révèlent stable face aux bêta-lactamases, ont une durée d'activité notable.
CA002268820A 1996-10-28 1997-10-24 Compositions antibiotiques stabilisees a base de carbapenem et procede de production Abandoned CA2268820A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2952096P 1996-10-28 1996-10-28
US60/029,520 1996-10-28
GB9626211.8 1996-12-18
GBGB9626211.8A GB9626211D0 (en) 1996-12-18 1996-12-18 Carbapenem antibiotic, compositions and methods thereof
PCT/US1997/019336 WO1998018800A1 (fr) 1996-10-28 1997-10-24 Compositions antibiotiques stabilisees a base de carbapenem et procede de production

Publications (1)

Publication Number Publication Date
CA2268820A1 true CA2268820A1 (fr) 1998-05-07

Family

ID=26310661

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002268820A Abandoned CA2268820A1 (fr) 1996-10-28 1997-10-24 Compositions antibiotiques stabilisees a base de carbapenem et procede de production

Country Status (5)

Country Link
EP (1) EP0937079A4 (fr)
JP (1) JP2000508343A (fr)
AU (1) AU725298B2 (fr)
CA (1) CA2268820A1 (fr)
WO (1) WO1998018800A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6548492B1 (en) * 1999-10-29 2003-04-15 Merck & Co., Inc. Process for formulation of carbapenem antibiotic compositions
EP1244444B1 (fr) * 1999-10-29 2004-12-29 Merck & Co., Inc. Procede de preparation de compositions antibiotiques a base de carbapenem
US8293895B2 (en) * 2007-06-28 2012-10-23 Kbp Biosciences Co., Ltd. Carbapenem derivatives
JPWO2009075309A1 (ja) 2007-12-12 2011-04-28 大日本住友製薬株式会社 製剤組成物
US8691803B2 (en) * 2011-01-24 2014-04-08 Savior Lifetec Corporation Process for the preparation of antibiotic compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1283906C (fr) * 1983-05-09 1991-05-07 Makoto Sunagawa COMPOSE DE .beta.-LACTAM ET PROCEDE DE PRODUCTION
KR880006244A (ko) * 1986-11-24 1988-07-22 후지사와 도모 기찌 로 3-피롤리디닐티오-1-아자바이스클로[3.2.0]햅트2-엔-2-카르복실산 화합물 및 이의 제조방법
JPS6425779A (en) * 1987-04-11 1989-01-27 Lederle Japan Ltd (1r,5s,6s)-2-substituted-thio-6-((r)-1-hydroxyethyl)-1-methyl -carbapenem-3-carboxylic acid derivative
GB9202298D0 (en) * 1992-02-04 1992-03-18 Ici Plc Antibiotic compounds
JP2783683B2 (ja) * 1992-12-21 1998-08-06 ジョン グン ダン コーポレーション ２−（２−置換されたピロリジン−４−イル）チオ−カバペネム誘導体
HRP970281B1 (en) * 1996-05-28 2002-04-30 Merck & Co Inc Carbapenem antibiotic, composition and method of preparation

Also Published As

Publication number Publication date
EP0937079A4 (fr) 2001-01-24
JP2000508343A (ja) 2000-07-04
AU725298B2 (en) 2000-10-12
AU5088198A (en) 1998-05-22
EP0937079A1 (fr) 1999-08-25
WO1998018800A1 (fr) 1998-05-07

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