CA2258753A1 - Derives piperidine de l'acide acetique et leur utilisation dans le traitement des troubles thrombotiques - Google Patents

Derives piperidine de l'acide acetique et leur utilisation dans le traitement des troubles thrombotiques Download PDF

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Publication number
CA2258753A1
CA2258753A1 CA002258753A CA2258753A CA2258753A1 CA 2258753 A1 CA2258753 A1 CA 2258753A1 CA 002258753 A CA002258753 A CA 002258753A CA 2258753 A CA2258753 A CA 2258753A CA 2258753 A1 CA2258753 A1 CA 2258753A1
Authority
CA
Canada
Prior art keywords
piperidin
formula
compound
indazol
acetic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002258753A
Other languages
English (en)
Inventor
David George Allen
Colin David Eldred
Brian David Judkins
William Leonard Mitchell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9613095.0A external-priority patent/GB9613095D0/en
Priority claimed from GBGB9613018.2A external-priority patent/GB9613018D0/en
Priority claimed from GBGB9613017.4A external-priority patent/GB9613017D0/en
Application filed by Individual filed Critical Individual
Publication of CA2258753A1 publication Critical patent/CA2258753A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne les composés de la formule (I), ou un sel, un solvate, ou un dérivé physiologiquement fonctionnel de ces derniers, où X représente CH¿2?-CH¿2? ou CH=CH; Y représente un groupe de la formule (a) ou (b) où R?0¿ représente SO¿2?Me ou CONH¿2? et R?1¿ représente SO¿2?Me. L'invention traite aussi de procédés pour leur préparation, de compositions pharmaceutiques contenant ces composés et de leur utilisation en médecine, en particulier, pour traiter les troubles thrombotiques.
CA002258753A 1996-06-21 1997-06-19 Derives piperidine de l'acide acetique et leur utilisation dans le traitement des troubles thrombotiques Abandoned CA2258753A1 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB9613017.4 1996-06-21
GBGB9613095.0A GB9613095D0 (en) 1996-06-21 1996-06-21 Therapeutic piperidines
GB9613095.0 1996-06-21
GBGB9613018.2A GB9613018D0 (en) 1996-06-21 1996-06-21 Therapeutic indazoles
GB9613018.2 1996-06-21
GBGB9613017.4A GB9613017D0 (en) 1996-06-21 1996-06-21 Therapeutic compounds

Publications (1)

Publication Number Publication Date
CA2258753A1 true CA2258753A1 (fr) 1997-12-31

Family

ID=27268341

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002258753A Abandoned CA2258753A1 (fr) 1996-06-21 1997-06-19 Derives piperidine de l'acide acetique et leur utilisation dans le traitement des troubles thrombotiques

Country Status (17)

Country Link
EP (1) EP0912555A1 (fr)
JP (1) JP2000512648A (fr)
KR (1) KR20000022041A (fr)
AP (1) AP9801417A0 (fr)
AR (1) AR008245A1 (fr)
AU (1) AU3261197A (fr)
BR (1) BR9709930A (fr)
CA (1) CA2258753A1 (fr)
CZ (1) CZ424698A3 (fr)
EA (1) EA199801015A1 (fr)
ID (1) ID17052A (fr)
IL (1) IL127464A0 (fr)
IS (1) IS4924A (fr)
NO (1) NO985974L (fr)
PL (1) PL330797A1 (fr)
TR (1) TR199802665T2 (fr)
WO (1) WO1997049699A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7642278B2 (en) 2001-07-03 2010-01-05 Novartis Vaccines And Diagnostics, Inc. Indazole benzimidazole compounds
WO2003004488A1 (fr) 2001-07-03 2003-01-16 Chiron Corporation Composes d'indazole benzimidazole utilises comme inhibiteurs de tyrosine et de serine/threonine kinase
TW200401641A (en) * 2002-07-18 2004-02-01 Wyeth Corp 1-Heterocyclylalkyl-3-sulfonylindole or-indazole derivatives as 5-hydroxytryptamine-6 ligands
RU2347780C2 (ru) * 2003-02-14 2009-02-27 Уайт Гетероциклил-3-сульфонилиндазолы в качестве лигандов 5-гидрокситриптамина-6
MX2008012824A (es) 2006-04-05 2008-10-15 Wyeth Corp Derivados de sulfonil-3-heterociclilindazol como ligandos de 5-hidroxitriptamina-6.
KR101132577B1 (ko) 2007-01-10 2012-04-05 에프. 호프만-라 로슈 아게 키마아제 억제제로서의 술폰아미드 유도체
CN113655155A (zh) * 2021-07-28 2021-11-16 任贤金 一种测定sph3127有关物质的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4124942A1 (de) * 1991-07-27 1993-01-28 Thomae Gmbh Dr K 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
TW221996B (fr) * 1991-11-14 1994-04-01 Glaxo Group Ltd
GB9208740D0 (en) * 1992-04-23 1992-06-10 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
AR008245A1 (es) 1999-12-29
KR20000022041A (ko) 2000-04-25
IS4924A (is) 1998-12-15
BR9709930A (pt) 1999-08-10
JP2000512648A (ja) 2000-09-26
CZ424698A3 (cs) 1999-05-12
EP0912555A1 (fr) 1999-05-06
NO985974L (no) 1999-02-17
ID17052A (id) 1997-12-04
WO1997049699A1 (fr) 1997-12-31
AU3261197A (en) 1998-01-14
TR199802665T2 (xx) 1999-03-22
EA199801015A1 (ru) 1999-08-26
AP9801417A0 (en) 1998-12-31
PL330797A1 (en) 1999-06-07
NO985974D0 (no) 1998-12-18
IL127464A0 (en) 1999-10-28

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Legal Events

Date Code Title Description
FZDE Discontinued