CA2292880A1 - Antagonistes de l'hormone de liberation de la gonadotrophine - Google Patents

Antagonistes de l'hormone de liberation de la gonadotrophine Download PDF

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Publication number
CA2292880A1
CA2292880A1 CA002292880A CA2292880A CA2292880A1 CA 2292880 A1 CA2292880 A1 CA 2292880A1 CA 002292880 A CA002292880 A CA 002292880A CA 2292880 A CA2292880 A CA 2292880A CA 2292880 A1 CA2292880 A1 CA 2292880A1
Authority
CA
Canada
Prior art keywords
substituted
alkyl
aryl
compound
aralkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002292880A
Other languages
English (en)
Inventor
Mark Goulet
Matthew J. Wyvratt, Jr.
Lin Chu
Narindar N. Girotra
Peter Lin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9719840.2A external-priority patent/GB9719840D0/en
Priority claimed from GBGB9800454.2A external-priority patent/GB9800454D0/en
Application filed by Individual filed Critical Individual
Publication of CA2292880A1 publication Critical patent/CA2292880A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des composés de formule (I) et leurs sels pharmaceutiquement acceptables, qui sont des antagonistes de l'hormone de libération de la gonadotrophine (GnRH) et qui peuvent donc être utiles dans le traitement d'affections liées aux hormones sexuelles et d'autres affections chez l'homme et la femme.
CA002292880A 1997-06-05 1998-06-01 Antagonistes de l'hormone de liberation de la gonadotrophine Abandoned CA2292880A1 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US4864297P 1997-06-05 1997-06-05
US4863897P 1997-06-05 1997-06-05
US60/048,638 1997-06-05
US60/048,642 1997-06-05
GBGB9719840.2A GB9719840D0 (en) 1997-09-18 1997-09-18 Antagonists of gonadotropin releasing hormone
GB9719840.2 1997-09-18
GB9800454.2 1998-01-09
GBGB9800454.2A GB9800454D0 (en) 1998-01-09 1998-01-09 Antagonists of gonadatropin releasing hormone
PCT/US1998/011208 WO1998055123A1 (fr) 1997-06-05 1998-06-01 Antagonistes de l'hormone de liberation de la gonadotrophine

Publications (1)

Publication Number Publication Date
CA2292880A1 true CA2292880A1 (fr) 1998-12-10

Family

ID=27451702

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002292880A Abandoned CA2292880A1 (fr) 1997-06-05 1998-06-01 Antagonistes de l'hormone de liberation de la gonadotrophine

Country Status (5)

Country Link
EP (1) EP0994708A1 (fr)
JP (1) JP2002502428A (fr)
AU (1) AU728811B2 (fr)
CA (1) CA2292880A1 (fr)
WO (1) WO1998055123A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0022670D0 (en) 2000-09-15 2000-11-01 Astrazeneca Ab Molecules
SE0100566D0 (sv) 2001-02-20 2001-02-20 Astrazeneca Ab Compounds
SE0101692D0 (sv) 2001-05-14 2001-05-14 Astrazeneca Ab Compounds
TW200413351A (en) 2002-08-21 2004-08-01 Astrazeneca Ab Chemical compounds
US7253290B2 (en) 2002-08-21 2007-08-07 Astrazeneca Ab Pyrazole derivatives as GnRH inhibitors
GB0219472D0 (en) 2002-08-21 2002-10-02 Astrazeneca Ab Chemical compounds
TW200407127A (en) 2002-08-21 2004-05-16 Astrazeneca Ab Chemical compounds
AU2003267551A1 (en) 2002-08-21 2004-03-11 Astrazeneca Ab Thieno-pyrrole compounds as antagonists of gonadotropin releasing hormone

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
DE3821148A1 (de) * 1988-06-23 1989-12-28 Erwin Von Dr Angerer Aminoalkylindole, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
EA000992B1 (ru) * 1995-12-14 2000-08-28 Мерк Энд Ко., Инк. Антагонисты гормона, высвобождающего гонадотропин
CZ183298A3 (cs) * 1995-12-14 1998-09-16 Merck And Co., Inc. Nepeptidové deriváty, antagonizující hormon, uvolňující gonadotropin

Also Published As

Publication number Publication date
WO1998055123A1 (fr) 1998-12-10
JP2002502428A (ja) 2002-01-22
AU728811B2 (en) 2001-01-18
AU7807198A (en) 1998-12-21
EP0994708A1 (fr) 2000-04-26

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Legal Events

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FZDE Dead