CA2291829A1 - Antagonistes de l'hormone de liberation de la gonadotrophine - Google Patents
Antagonistes de l'hormone de liberation de la gonadotrophine Download PDFInfo
- Publication number
- CA2291829A1 CA2291829A1 CA002291829A CA2291829A CA2291829A1 CA 2291829 A1 CA2291829 A1 CA 2291829A1 CA 002291829 A CA002291829 A CA 002291829A CA 2291829 A CA2291829 A CA 2291829A CA 2291829 A1 CA2291829 A1 CA 2291829A1
- Authority
- CA
- Canada
- Prior art keywords
- substituted
- alkyl
- aryl
- compound
- aralkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention concerne des composés de formule (I) et leurs sels pharmaceutiquement acceptables, qui sont des antagonistes de l'hormone de libération de la gonadotrophine (GnRH) et qui peuvent donc être utiles dans le traitement d'affections liées aux hormones sexuelles et d'autres affections chez l'homme et la femme.
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4863797P | 1997-06-05 | 1997-06-05 | |
US4863697P | 1997-06-05 | 1997-06-05 | |
US60/048,636 | 1997-06-05 | ||
US60/048,637 | 1997-06-05 | ||
GB9719839.4 | 1997-09-18 | ||
GBGB9719839.4A GB9719839D0 (en) | 1997-09-18 | 1997-09-18 | Antogonists of gonadotropin releasing hormone |
GB9800451.8 | 1998-01-09 | ||
GBGB9800451.8A GB9800451D0 (en) | 1998-01-09 | 1998-01-09 | Antagonists of gonadotropin releasing hormone |
PCT/US1998/011204 WO1998055119A1 (fr) | 1997-06-05 | 1998-06-01 | Antagonistes de l'hormone de liberation de la gonadotrophine |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2291829A1 true CA2291829A1 (fr) | 1998-12-10 |
Family
ID=27451701
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002291829A Abandoned CA2291829A1 (fr) | 1997-06-05 | 1998-06-01 | Antagonistes de l'hormone de liberation de la gonadotrophine |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1011667A4 (fr) |
JP (1) | JP2002503252A (fr) |
AU (1) | AU7806998A (fr) |
CA (1) | CA2291829A1 (fr) |
WO (1) | WO1998055119A1 (fr) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1027046A4 (fr) * | 1997-10-28 | 2002-04-03 | Merck & Co Inc | Antagonistes de l'hormone de liberation de la gonadothrophine |
EP1049472A4 (fr) * | 1997-10-28 | 2002-04-03 | Merck & Co Inc | Antagonistes de la gonadoliberine |
US6346534B1 (en) | 1998-09-23 | 2002-02-12 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
US6537998B1 (en) | 1999-10-15 | 2003-03-25 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
US6608197B2 (en) | 2000-01-25 | 2003-08-19 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
GB0022670D0 (en) | 2000-09-15 | 2000-11-01 | Astrazeneca Ab | Molecules |
SE0100566D0 (sv) | 2001-02-20 | 2001-02-20 | Astrazeneca Ab | Compounds |
SE0101692D0 (sv) | 2001-05-14 | 2001-05-14 | Astrazeneca Ab | Compounds |
EP1411945A1 (fr) | 2001-08-02 | 2004-04-28 | Neurocrine Biosciences, Inc. | Pyridin-4-ones substituees et leur utilisation en tant qu'antagonistes du recepteur de l'hormone de liberation de la gonadotrophine |
JP2005500352A (ja) | 2001-08-02 | 2005-01-06 | ニューロクライン バイオサイエンシーズ, インコーポレイテッド | ゴナドトロピン放出ホルモンレセプター(GnRH)アンタゴニストとしての1,2,4−トリアジン−3,5−ジオン |
EP1412363A1 (fr) | 2001-08-02 | 2004-04-28 | Neurocrine Biosciences, Inc. | Antagonistes du recepteur de l'hormone liberatrice de la gonadotropine |
AU2002324586B2 (en) | 2001-08-02 | 2008-04-24 | Neurocrine Biosciences, Inc. | 1,3,5-triazine-2,4,6-triones, preparation and use as gonadotropin-releasing hormone receptor antagonists |
AU2002321878A1 (en) | 2001-08-02 | 2003-02-17 | Neurocrine Biosciences, Inc. | Pyridinone and pyridazinone derivatives as gonadotropin-releasing hormone receptor antagonists |
DE60314158T2 (de) | 2002-08-21 | 2008-01-31 | Astrazeneca Ab | Pyrazolderivate als gnrh-inhibitoren |
TW200407127A (en) | 2002-08-21 | 2004-05-16 | Astrazeneca Ab | Chemical compounds |
TW200413351A (en) | 2002-08-21 | 2004-08-01 | Astrazeneca Ab | Chemical compounds |
GB0219472D0 (en) | 2002-08-21 | 2002-10-02 | Astrazeneca Ab | Chemical compounds |
DE60318716T2 (de) | 2002-08-21 | 2009-01-08 | Astrazeneca Ab | Thieno-pyrrole verbindungen als antagonisten der gonadotropin-freisetzenden hormonrezeptoren |
EA010370B1 (ru) | 2003-07-07 | 2008-08-29 | Ньюрокрайн Байосайенсиз, Инк. | Производные пиримидин-2,4-диона в качестве антагонистов рецептора гонадотропин-высвобождающего гормона |
CN101229165A (zh) | 2003-07-07 | 2008-07-30 | 纽罗克里生物科学有限公司 | 作为促性激素释放激素受体拮抗剂的嘧啶-2,4-二酮衍生物 |
JP4673847B2 (ja) | 2003-07-07 | 2011-04-20 | ニューロクライン バイオサイエンシーズ,インコーポレイテッド | 性腺刺激ホルモン放出ホルモンレセプターアンタゴニストおよびそれに関連する方法 |
WO2012175514A1 (fr) | 2011-06-21 | 2012-12-27 | Bayer Intellectual Property Gmbh | Dérivés de pyridinone et compositions pharmaceutiques les contenant |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA000829B1 (ru) * | 1995-12-14 | 2000-04-24 | Мерк Энд Ко., Инк. | Антагонисты гонадотропин-высвобождающего фактора |
-
1998
- 1998-06-01 AU AU78069/98A patent/AU7806998A/en not_active Abandoned
- 1998-06-01 WO PCT/US1998/011204 patent/WO1998055119A1/fr not_active Application Discontinuation
- 1998-06-01 JP JP50271499A patent/JP2002503252A/ja active Pending
- 1998-06-01 CA CA002291829A patent/CA2291829A1/fr not_active Abandoned
- 1998-06-01 EP EP98926171A patent/EP1011667A4/fr not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JP2002503252A (ja) | 2002-01-29 |
AU7806998A (en) | 1998-12-21 |
EP1011667A1 (fr) | 2000-06-28 |
WO1998055119A1 (fr) | 1998-12-10 |
EP1011667A4 (fr) | 2001-03-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU728988B2 (en) | Antagonists of gonadotropin releasing hormone | |
EP0873336B1 (fr) | Antagonistes de l'hormone de liberation de la gonadotropine | |
US6197975B1 (en) | Antagonists of gonadotropin releasing hormone | |
AU729752B2 (en) | Antagonists of gonadotropin releasing hormone | |
AU729663B2 (en) | Antagonists of gonadotropin releasing hormone | |
CA2291829A1 (fr) | Antagonistes de l'hormone de liberation de la gonadotrophine | |
US6156772A (en) | Antagonists of gonadotropin releasing hormone | |
AU760030B2 (en) | Antagonists of gonadotropin releasing hormone | |
US6077858A (en) | Antagonists of gonadotropin releasing hormone | |
CA2308069A1 (fr) | Antagonistes de la gonadoliberine | |
US6156767A (en) | Antagonists of gonadotropin releasing hormone | |
US6004984A (en) | Antagonists of gonadotropin releasing hormone | |
CA2318957A1 (fr) | Antagonistes de l'hormone de liberation de la gonadotrophine | |
CA2317451A1 (fr) | Antagonistes de l'hormone de liberation de la gonadotrophine | |
AU728811B2 (en) | Antagonists of gonadotropin releasing hormone | |
US5985901A (en) | Antagonists of gonadotropin releasing hormone | |
US6159975A (en) | Antagonists of gonadotropin releasing hormone |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |