CA2258559A1 - Derives de l'indoline utiles comme antagonistes des recepteurs 5ht-2c - Google Patents
Derives de l'indoline utiles comme antagonistes des recepteurs 5ht-2c Download PDFInfo
- Publication number
- CA2258559A1 CA2258559A1 CA002258559A CA2258559A CA2258559A1 CA 2258559 A1 CA2258559 A1 CA 2258559A1 CA 002258559 A CA002258559 A CA 002258559A CA 2258559 A CA2258559 A CA 2258559A CA 2258559 A1 CA2258559 A1 CA 2258559A1
- Authority
- CA
- Canada
- Prior art keywords
- pyridin
- hydrogen
- formula
- compound
- ylmethyloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
L'invention concerne des composés hétérocycliques de formule (I), dans laquelle R<1> est hydrogène ou alkyle C1-C6, et les groupes R<2>, R<3> et R<4> sont indépendamment hydrogène, halogène ou alkyle C1-C6 éventuellement substitués par un ou plusieurs atomes de fluor, et leurs sels, ces composés ayant une activité pharmacologique. L'invention concerne également des procédés permettant de les préparer et des compositions les contenant, ainsi que leur utilisation dans le traitement des troubles du système nerveux central tels que l'angoisse.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9612885.5 | 1996-06-20 | ||
| GBGB9612885.5A GB9612885D0 (en) | 1996-06-20 | 1996-06-20 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2258559A1 true CA2258559A1 (fr) | 1997-12-24 |
Family
ID=10795577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002258559A Abandoned CA2258559A1 (fr) | 1996-06-20 | 1997-06-16 | Derives de l'indoline utiles comme antagonistes des recepteurs 5ht-2c |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US6313145B1 (fr) |
| EP (1) | EP0912556B1 (fr) |
| JP (1) | JP2000512644A (fr) |
| KR (1) | KR20040101563A (fr) |
| CN (1) | CN1147485C (fr) |
| AR (1) | AR008244A1 (fr) |
| AT (1) | ATE196766T1 (fr) |
| AU (1) | AU718000B2 (fr) |
| BR (1) | BR9709982A (fr) |
| CA (1) | CA2258559A1 (fr) |
| CO (1) | CO4870758A1 (fr) |
| CZ (1) | CZ289799B6 (fr) |
| DE (1) | DE69703242T2 (fr) |
| DK (1) | DK0912556T3 (fr) |
| ES (1) | ES2152682T3 (fr) |
| GB (1) | GB9612885D0 (fr) |
| GR (1) | GR3034847T3 (fr) |
| HK (1) | HK1019744A1 (fr) |
| HU (1) | HUP9903480A3 (fr) |
| IL (1) | IL127304A (fr) |
| NO (1) | NO316756B1 (fr) |
| NZ (1) | NZ332840A (fr) |
| PL (1) | PL186885B1 (fr) |
| PT (1) | PT912556E (fr) |
| TR (1) | TR199802552T2 (fr) |
| TW (1) | TW360650B (fr) |
| WO (1) | WO1997048700A1 (fr) |
| ZA (1) | ZA975416B (fr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9710523D0 (en) * | 1997-05-23 | 1997-07-16 | Smithkline Beecham Plc | Novel compounds |
| AU3030899A (en) * | 1998-02-25 | 1999-09-15 | Smithkline Beecham Plc | Process(es) for the preparation of 6-trifluoromethyl-indoline derivatives |
| GB0019950D0 (en) * | 2000-08-12 | 2000-09-27 | Smithkline Beecham Plc | Compounds |
| US20030008880A1 (en) * | 2001-05-02 | 2003-01-09 | Pfizer Inc. | 4-(2-Pyridyl) piperizines having 5HT7 receptor agonist activity |
| MXPA04005151A (es) | 2001-11-28 | 2004-08-11 | Upjohn Co | Compuestos terapeuticos. |
| GB0200283D0 (en) * | 2002-01-08 | 2002-02-20 | Smithkline Beecham Plc | Compounds |
| WO2003076426A2 (fr) | 2002-03-04 | 2003-09-18 | Pharmacia & Upjohn Company | Composes therapeutiques |
| EP1497265B1 (fr) * | 2002-04-19 | 2009-02-18 | Glaxo Group Limited | Composes presentant une affinite avec le recepteur 5ht2c et utilisation therapeutique de ceux-ci |
| GB0305024D0 (en) * | 2003-03-05 | 2003-04-09 | Glaxo Group Ltd | Compounds |
| GB0305553D0 (en) * | 2003-03-11 | 2003-04-16 | Glaxo Group Ltd | Compounds |
| KR101062376B1 (ko) * | 2008-04-10 | 2011-09-06 | 한국화학연구원 | 신규 인돌 카르복실산 비스피리딜 카르복사마이드 유도체,이의 제조방법 및 이를 유효성분으로 함유하는 조성물 |
| KR20110114664A (ko) | 2009-01-16 | 2011-10-19 | 메사추세츠 인스티튜트 오브 테크놀로지 | 자폐 스펙트럼 장애의 진단 및 치료 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08500580A (ja) | 1992-08-20 | 1996-01-23 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ５ｈｔ▲下２ｃ▼および５ｈｔ▲下２ｂ▼拮抗薬用縮合インドール誘導体 |
| GB9313913D0 (en) * | 1993-07-06 | 1993-08-18 | Smithkline Beecham Plc | Novel compounds |
| ATE197300T1 (de) * | 1995-02-02 | 2000-11-15 | Smithkline Beecham Plc | Indolderivate als 5-ht rezeptorantagoniste |
| JPH10513443A (ja) | 1995-02-02 | 1998-12-22 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ５ＨＴ▲下２ｃ▼レセプターアンタゴニスト活性を有する複素環化合物 |
| GB9607219D0 (en) | 1996-04-04 | 1996-06-12 | Smithkline Beecham Plc | Novel compounds |
| US6028055A (en) | 1996-10-22 | 2000-02-22 | Genetech, Inc. | Receptor selective BNP |
-
1996
- 1996-06-20 GB GBGB9612885.5A patent/GB9612885D0/en active Pending
-
1997
- 1997-06-16 TR TR1998/02552T patent/TR199802552T2/xx unknown
- 1997-06-16 IL IL12730497A patent/IL127304A/xx not_active IP Right Cessation
- 1997-06-16 ES ES97929202T patent/ES2152682T3/es not_active Expired - Lifetime
- 1997-06-16 PL PL97330708A patent/PL186885B1/pl not_active IP Right Cessation
- 1997-06-16 DK DK97929202T patent/DK0912556T3/da active
- 1997-06-16 DE DE69703242T patent/DE69703242T2/de not_active Expired - Fee Related
- 1997-06-16 WO PCT/EP1997/003157 patent/WO1997048700A1/fr active IP Right Grant
- 1997-06-16 HU HU9903480A patent/HUP9903480A3/hu not_active Application Discontinuation
- 1997-06-16 PT PT97929202T patent/PT912556E/pt unknown
- 1997-06-16 BR BR9709982A patent/BR9709982A/pt not_active Application Discontinuation
- 1997-06-16 US US09/202,772 patent/US6313145B1/en not_active Expired - Fee Related
- 1997-06-16 EP EP97929202A patent/EP0912556B1/fr not_active Expired - Lifetime
- 1997-06-16 CN CNB971955395A patent/CN1147485C/zh not_active Expired - Fee Related
- 1997-06-16 AT AT97929202T patent/ATE196766T1/de not_active IP Right Cessation
- 1997-06-16 AU AU33396/97A patent/AU718000B2/en not_active Ceased
- 1997-06-16 NZ NZ332840A patent/NZ332840A/xx unknown
- 1997-06-16 CZ CZ19984204A patent/CZ289799B6/cs not_active IP Right Cessation
- 1997-06-16 JP JP10502260A patent/JP2000512644A/ja not_active Ceased
- 1997-06-16 CA CA002258559A patent/CA2258559A1/fr not_active Abandoned
- 1997-06-16 KR KR10-2004-7017304A patent/KR20040101563A/ko active IP Right Grant
- 1997-06-18 AR ARP970102675A patent/AR008244A1/es active IP Right Grant
- 1997-06-19 TW TW086108550A patent/TW360650B/zh active
- 1997-06-19 ZA ZA975416A patent/ZA975416B/xx unknown
- 1997-06-20 CO CO97034433A patent/CO4870758A1/es unknown
-
1998
- 1998-12-18 NO NO19985970A patent/NO316756B1/no unknown
-
1999
- 1999-11-02 HK HK99104963A patent/HK1019744A1/xx not_active IP Right Cessation
-
2000
- 2000-11-14 GR GR20000402536T patent/GR3034847T3/el not_active IP Right Cessation
-
2001
- 2001-09-06 US US09/948,289 patent/US20020035134A1/en not_active Abandoned
Also Published As
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| US6369060B1 (en) | Indoline derivatives useful as 5-HT-2C receptor antagonists | |
| US20060052384A1 (en) | Aryl piperidine derivatives as inducers of ldl-receptor expression for the treatment of hypercholesterolemia | |
| WO1998052943A1 (fr) | Derives d'indoline comme antagonistes du recepteur 5ht¿2c? | |
| US5039687A (en) | N-(pyrrol-1-yl)pyridinamine compounds having enhancing activity | |
| KR100486795B1 (ko) | 5-ht-2c수용체길항제로유용한인돌린유도체 | |
| US4900742A (en) | N-(pyrrol-1-yl)pyridinamine compounds having memory enhancing properties |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |