CA2250723C - Multiple epitope fusion protein - Google Patents
Multiple epitope fusion protein Download PDFInfo
- Publication number
- CA2250723C CA2250723C CA2250723A CA2250723A CA2250723C CA 2250723 C CA2250723 C CA 2250723C CA 2250723 A CA2250723 A CA 2250723A CA 2250723 A CA2250723 A CA 2250723A CA 2250723 C CA2250723 C CA 2250723C
- Authority
- CA
- Canada
- Prior art keywords
- epitope
- epitopes
- hcv
- mefa
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/653,226 US6514731B1 (en) | 1996-05-24 | 1996-05-24 | Methods for the preparation of hepatitis C virus multiple copy epitope fusion antigens |
| US08/653,226 | 1997-05-20 | ||
| US08/859,524 US6428792B1 (en) | 1996-05-24 | 1997-05-20 | Hepatitis C virus multiple copy epitope fusion antigens |
| US08/859,524 | 1997-05-20 | ||
| PCT/US1997/008950 WO1997044469A2 (en) | 1996-05-24 | 1997-05-23 | Multiple epitope fusion protein |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2250723A1 CA2250723A1 (en) | 1997-11-27 |
| CA2250723C true CA2250723C (en) | 2012-07-17 |
Family
ID=27096474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2250723A Expired - Lifetime CA2250723C (en) | 1996-05-24 | 1997-05-23 | Multiple epitope fusion protein |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0935662B1 (https=) |
| JP (2) | JP3945822B2 (https=) |
| AT (1) | ATE311463T1 (https=) |
| AU (1) | AU719929B2 (https=) |
| CA (1) | CA2250723C (https=) |
| DE (1) | DE69734776T2 (https=) |
| DK (1) | DK0935662T3 (https=) |
| ES (1) | ES2251028T3 (https=) |
| IL (1) | IL126460A (https=) |
| NZ (1) | NZ333431A (https=) |
| WO (1) | WO1997044469A2 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6322965B1 (en) * | 1997-02-10 | 2001-11-27 | Advanced Life Science Institute, Inc. | Chimera antigen peptide |
| AU9497998A (en) * | 1997-09-22 | 1999-04-12 | Chiron Corporation | Method for detecting antibodies in a sample |
| ATE417275T1 (de) | 1997-09-22 | 2008-12-15 | Novartis Vaccines & Diagnostic | Puffern zur stabilizierung von hcv antigenen |
| WO1999038880A1 (en) * | 1998-01-30 | 1999-08-05 | The General Hospital Corporation | Genetic immunization with nonstructural proteins of hepatitis c virus |
| BRPI9909678B8 (pt) | 1998-04-17 | 2021-05-25 | Fujirebio Europe N V | aperfeiçoados ensaios de imunodiagnóstico usando agentes redutores |
| WO1999058561A1 (fr) * | 1998-05-14 | 1999-11-18 | Pasteur Merieux Serums & Vaccins | Mimotopes du virus de l'hepatite c |
| US7052696B2 (en) * | 1998-07-10 | 2006-05-30 | The United States Of America As Represented By The Department Of Health And Human Services | Antigenic epitopes and mosaic polypeptides of hepatitis C virus proteins |
| US6379903B1 (en) * | 1999-10-08 | 2002-04-30 | Sigma-Aldrich Co. | Purification of recombinant proteins fused to multiple epitopes |
| CA2389206C (en) | 1999-10-27 | 2011-01-04 | Chiron Corporation | Activation of hcv-specific t cells |
| MXPA02006554A (es) * | 1999-12-28 | 2003-09-22 | Epimmune Inc | Minigenes optimizados y peptidos codificados por los mismos. |
| US7491808B2 (en) | 2000-06-15 | 2009-02-17 | Novartis Vaccines And Diagnostics, Inc. | HCV non-structural protein mutants and uses thereof |
| EP1829891B1 (en) | 2000-06-15 | 2012-12-26 | Novartis Vaccines and Diagnostics, Inc. | Immunoassays for Anti-HCV Antibodies |
| DK1354204T4 (da) * | 2000-06-15 | 2010-06-14 | Novartis Vaccines & Diagnostic | HCV-antigen/antistof-kombinationssay |
| WO2003008537A2 (en) * | 2001-04-06 | 2003-01-30 | Mannkind Corporation | Epitope sequences |
| AR045702A1 (es) | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
| ATE410693T1 (de) | 2002-09-09 | 2008-10-15 | Novartis Vaccines & Diagnostic | Hcv-test |
| WO2004039950A2 (en) * | 2002-10-25 | 2004-05-13 | Chiron Corporation | Activation of hcv-specific cells |
| US7731967B2 (en) | 2003-04-30 | 2010-06-08 | Novartis Vaccines And Diagnostics, Inc. | Compositions for inducing immune responses |
| ES2377978T3 (es) | 2004-08-27 | 2012-04-03 | Novartis Vaccines And Diagnostics, Inc. | Mutantes de proteínas no estructurales de VHC y usos de los mismos |
| WO2006133911A2 (en) * | 2005-06-17 | 2006-12-21 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Hepatitis c virus nucleic acid vaccine |
| CA2630220C (en) | 2005-11-22 | 2020-10-13 | Doris Coit | Norovirus and sapovirus antigens |
| EP3067048B1 (en) | 2007-12-07 | 2018-02-14 | GlaxoSmithKline Biologicals SA | Compositions for inducing immune responses |
| US9550811B2 (en) | 2010-12-02 | 2017-01-24 | Bionor Immuno As | Peptide scaffold design |
| US9493514B2 (en) | 2011-01-06 | 2016-11-15 | Bionor Immuno As | Dimeric scaffold proteins comprising HIV-1 GP120 and GP41 epitopes |
| WO2013112916A1 (en) * | 2012-01-26 | 2013-08-01 | Longhorn Vaccines And Diagnostics, Llc | Composite antigenic sequences and vaccines |
| JP6310909B2 (ja) | 2012-06-06 | 2018-04-11 | ビオノール イミュノ エーエスＢｉｏｎｏｒ Ｉｍｍｕｎｏ Ａｓ | 免疫原及び投薬反応物として使用するためのウイルスタンパク質に由来するペプチド |
| JP7297408B2 (ja) | 2015-02-06 | 2023-06-26 | セル アイディーエックス， インコーポレイテッド | 抗原をカップリングさせた免疫試薬 |
| WO2016160046A1 (en) | 2015-03-27 | 2016-10-06 | Ortho-Clinical Diagnostics, Inc. | Hcv ns4a/modified ns3 polypeptides and uses thereof |
| CN109716130B (zh) * | 2016-07-18 | 2023-05-23 | 赛尔伊迪克斯公司 | 抗原偶联的杂交试剂 |
| KR101813586B1 (ko) * | 2016-12-29 | 2018-01-30 | 고려대학교 산학협력단 | 다양한 질병마커 인지 에피토프와 연결된 단백질 나노입자 및 이를 이용한 고민감도 질병마커 검출방법 |
| ES2961462T3 (es) * | 2017-07-27 | 2024-03-12 | Roche Diagnostics Gmbh | Proteína de fusión multiepítopo de un antígeno del VHC y usos de la misma |
| KR101871985B1 (ko) * | 2017-08-14 | 2018-06-27 | 고려대학교 산학협력단 | 3차원 단백질 나노입자 프로브 기반 복수 질환의 동시검출 방법 및 키트 |
| CN108794636B (zh) * | 2018-06-28 | 2020-05-22 | 中国人民解放军军事科学院军事医学研究院 | 一种表位多肽串联混合物在抗立氏立克次体的免疫保护中的应用 |
| KR102100813B1 (ko) * | 2018-11-08 | 2020-04-16 | 주식회사 보레다바이오텍 | C형 간염바이러스 유래 융합 단백질 및 이를 포함하는 진단키트 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993000365A2 (en) * | 1991-06-24 | 1993-01-07 | Chiron Corporation | Hepatitis c virus (hcv) polypeptides |
| NZ244782A (en) * | 1991-10-16 | 1996-12-20 | Immulogic Pharma Corp | Isolated peptides having t-cell stimulating activity, pharmaceutical composition |
| US5683695A (en) * | 1993-02-10 | 1997-11-04 | United Biomedical, Inc. | Production of recombinant proteins containing multiple antigenic determinants linked by flexible hinge domains |
| US5744144A (en) * | 1993-07-30 | 1998-04-28 | University Of Pittsburgh University Patent Committee Policy And Procedures | Synthetic multiple tandem repeat mucin and mucin-like peptides, and uses thereof |
| GB2294047A (en) * | 1994-10-14 | 1996-04-17 | Merck & Co Inc | Synthetic peptides for use as epitopes specific for HIV |
-
1997
- 1997-05-23 CA CA2250723A patent/CA2250723C/en not_active Expired - Lifetime
- 1997-05-23 AU AU32143/97A patent/AU719929B2/en not_active Expired
- 1997-05-23 AT AT97927767T patent/ATE311463T1/de active
- 1997-05-23 EP EP97927767A patent/EP0935662B1/en not_active Expired - Lifetime
- 1997-05-23 DE DE69734776T patent/DE69734776T2/de not_active Expired - Lifetime
- 1997-05-23 IL IL126460A patent/IL126460A/en not_active IP Right Cessation
- 1997-05-23 ES ES97927767T patent/ES2251028T3/es not_active Expired - Lifetime
- 1997-05-23 JP JP54284897A patent/JP3945822B2/ja not_active Expired - Lifetime
- 1997-05-23 NZ NZ333431A patent/NZ333431A/xx not_active IP Right Cessation
- 1997-05-23 WO PCT/US1997/008950 patent/WO1997044469A2/en not_active Ceased
- 1997-05-23 DK DK97927767T patent/DK0935662T3/da active
-
2007
- 2007-02-06 JP JP2007027374A patent/JP2007127671A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP0935662A2 (en) | 1999-08-18 |
| EP0935662B1 (en) | 2005-11-30 |
| WO1997044469A2 (en) | 1997-11-27 |
| AU719929B2 (en) | 2000-05-18 |
| NZ333431A (en) | 2000-05-26 |
| WO1997044469A8 (en) | 1999-07-22 |
| WO1997044469A3 (en) | 1997-12-31 |
| ES2251028T3 (es) | 2006-04-16 |
| JP2007127671A (ja) | 2007-05-24 |
| ATE311463T1 (de) | 2005-12-15 |
| AU3214397A (en) | 1997-12-09 |
| IL126460A (en) | 2007-07-04 |
| JP3945822B2 (ja) | 2007-07-18 |
| DE69734776D1 (de) | 2006-02-09 |
| DK0935662T3 (da) | 2006-03-06 |
| CA2250723A1 (en) | 1997-11-27 |
| DE69734776T2 (de) | 2006-08-17 |
| JP2001500723A (ja) | 2001-01-23 |
| IL126460A0 (en) | 1999-08-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20170523 |