CA2250723C - Multiple epitope fusion protein - Google Patents
Multiple epitope fusion protein Download PDFInfo
- Publication number
- CA2250723C CA2250723C CA2250723A CA2250723A CA2250723C CA 2250723 C CA2250723 C CA 2250723C CA 2250723 A CA2250723 A CA 2250723A CA 2250723 A CA2250723 A CA 2250723A CA 2250723 C CA2250723 C CA 2250723C
- Authority
- CA
- Canada
- Prior art keywords
- epitope
- epitopes
- hcv
- mefa
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/653,226 US6514731B1 (en) | 1996-05-24 | 1996-05-24 | Methods for the preparation of hepatitis C virus multiple copy epitope fusion antigens |
| US08/653,226 | 1996-05-24 | ||
| US08/859,524 US6428792B1 (en) | 1996-05-24 | 1997-05-20 | Hepatitis C virus multiple copy epitope fusion antigens |
| US08/859,524 | 1997-05-20 | ||
| PCT/US1997/008950 WO1997044469A2 (en) | 1996-05-24 | 1997-05-23 | Multiple epitope fusion protein |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2250723A1 CA2250723A1 (en) | 1997-11-27 |
| CA2250723C true CA2250723C (en) | 2012-07-17 |
Family
ID=27096474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2250723A Expired - Lifetime CA2250723C (en) | 1996-05-24 | 1997-05-23 | Multiple epitope fusion protein |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0935662B1 (https=) |
| JP (2) | JP3945822B2 (https=) |
| AT (1) | ATE311463T1 (https=) |
| AU (1) | AU719929B2 (https=) |
| CA (1) | CA2250723C (https=) |
| DE (1) | DE69734776T2 (https=) |
| DK (1) | DK0935662T3 (https=) |
| ES (1) | ES2251028T3 (https=) |
| IL (1) | IL126460A (https=) |
| NZ (1) | NZ333431A (https=) |
| WO (1) | WO1997044469A2 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0870830A3 (en) * | 1997-02-10 | 2004-02-25 | Advanced Life Science Institute, Inc. | Chimera hepatitis C virus antigen |
| DE69837155T2 (de) * | 1997-09-22 | 2007-06-21 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Verfahren zum nachweiss von antikörpern in einer probe |
| AU9498098A (en) | 1997-09-22 | 1999-04-12 | Chiron Corporation | Buffers for stabilizing antigens |
| AU746258B2 (en) * | 1998-01-30 | 2002-04-18 | General Hospital Corporation, The | Genetic immunization with nonstructural proteins of hepatitis C virus |
| DK1071955T4 (da) | 1998-04-17 | 2009-06-15 | Innogenetics Nv | Forbedrede immundiagnostiske assays, som anvender reduktionsmidler |
| AU3714499A (en) * | 1998-05-14 | 1999-11-29 | Pasteur Merieux Serums Et Vaccins | Hepatitis c virus mimotopes |
| US7052696B2 (en) * | 1998-07-10 | 2006-05-30 | The United States Of America As Represented By The Department Of Health And Human Services | Antigenic epitopes and mosaic polypeptides of hepatitis C virus proteins |
| US6379903B1 (en) * | 1999-10-08 | 2002-04-30 | Sigma-Aldrich Co. | Purification of recombinant proteins fused to multiple epitopes |
| AU1236801A (en) | 1999-10-27 | 2001-05-08 | Chiron Corporation | Activation of hcv-specific t cells |
| EP1242108B1 (en) * | 1999-12-28 | 2007-07-11 | Pharmexa Inc. | Optimized minigenes and peptides encoded thereby |
| SI1354204T2 (sl) * | 2000-06-15 | 2010-09-30 | Novartis Vaccines & Diagnostic | Hcv antigen antitelo kombinacijska analiza |
| US7491808B2 (en) | 2000-06-15 | 2009-02-17 | Novartis Vaccines And Diagnostics, Inc. | HCV non-structural protein mutants and uses thereof |
| EP1829891B1 (en) | 2000-06-15 | 2012-12-26 | Novartis Vaccines and Diagnostics, Inc. | Immunoassays for Anti-HCV Antibodies |
| WO2003008537A2 (en) * | 2001-04-06 | 2003-01-30 | Mannkind Corporation | Epitope sequences |
| AR045702A1 (es) | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
| ES2312806T3 (es) | 2002-09-09 | 2009-03-01 | Novartis Vaccines And Diagnostics, Inc. | Ensayo de vhc. |
| EP1576125A4 (en) * | 2002-10-25 | 2008-09-03 | Novartis Vaccines & Diagnostic | ACTIVATION OF SPECIFIC HCV LYMPHOCYTES |
| US7731967B2 (en) | 2003-04-30 | 2010-06-08 | Novartis Vaccines And Diagnostics, Inc. | Compositions for inducing immune responses |
| EP1802778B1 (en) | 2004-08-27 | 2011-10-05 | Novartis Vaccines and Diagnostics, Inc. | Hcv multiple epitope fusion antigens with modified proteolytic cleavage sites and uses thereof |
| WO2006133911A2 (en) * | 2005-06-17 | 2006-12-21 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Hepatitis c virus nucleic acid vaccine |
| ES2514316T3 (es) | 2005-11-22 | 2014-10-28 | Novartis Vaccines And Diagnostics, Inc. | Partículas similares a virus (VLPs) de Norovirus y Sapovirus |
| EP3067048B1 (en) | 2007-12-07 | 2018-02-14 | GlaxoSmithKline Biologicals SA | Compositions for inducing immune responses |
| EP2646459B1 (en) | 2010-12-02 | 2020-01-08 | Bionor Immuno AS | Peptide scaffold design |
| JP6294076B2 (ja) | 2011-01-06 | 2018-03-14 | ビオノール イミュノ エーエスＢｉｏｎｏｒ Ｉｍｍｕｎｏ Ａｓ | 多量体ペプチド |
| EP3494989B1 (en) * | 2012-01-26 | 2025-07-16 | Longhorn Vaccines and Diagnostics, LLC | Composite antigenic sequences and vaccines |
| IN2014KN02769A (https=) | 2012-06-06 | 2015-05-08 | Bionor Immuno As | |
| US11867696B2 (en) | 2015-02-06 | 2024-01-09 | Cell Idx, Inc. | Antigen-coupled immunoreagents |
| CA2980718C (en) | 2015-03-27 | 2021-06-01 | Ortho-Clinical Diagnostics, Inc. | Hcv ns4a/modified ns3 polypeptides and uses thereof |
| CN109716130B (zh) * | 2016-07-18 | 2023-05-23 | 赛尔伊迪克斯公司 | 抗原偶联的杂交试剂 |
| KR101813586B1 (ko) * | 2016-12-29 | 2018-01-30 | 고려대학교 산학협력단 | 다양한 질병마커 인지 에피토프와 연결된 단백질 나노입자 및 이를 이용한 고민감도 질병마커 검출방법 |
| CN110996986B (zh) | 2017-07-27 | 2024-07-19 | 豪夫迈·罗氏有限公司 | Hcv抗原的多表位融合蛋白及其用途 |
| KR101871985B1 (ko) * | 2017-08-14 | 2018-06-27 | 고려대학교 산학협력단 | 3차원 단백질 나노입자 프로브 기반 복수 질환의 동시검출 방법 및 키트 |
| CN108794636B (zh) * | 2018-06-28 | 2020-05-22 | 中国人民解放军军事科学院军事医学研究院 | 一种表位多肽串联混合物在抗立氏立克次体的免疫保护中的应用 |
| KR102100813B1 (ko) * | 2018-11-08 | 2020-04-16 | 주식회사 보레다바이오텍 | C형 간염바이러스 유래 융합 단백질 및 이를 포함하는 진단키트 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2188583T3 (es) * | 1991-06-24 | 2003-07-01 | Chiron Corp | Polipeptidos para el virus de la hepatitis c (hcv). |
| IL103456A (en) * | 1991-10-16 | 2006-06-11 | Merck Patent Gmbh | Isolated peptides having t-cell stimulating activity |
| US5683695A (en) * | 1993-02-10 | 1997-11-04 | United Biomedical, Inc. | Production of recombinant proteins containing multiple antigenic determinants linked by flexible hinge domains |
| US5744144A (en) * | 1993-07-30 | 1998-04-28 | University Of Pittsburgh University Patent Committee Policy And Procedures | Synthetic multiple tandem repeat mucin and mucin-like peptides, and uses thereof |
| GB2294047A (en) * | 1994-10-14 | 1996-04-17 | Merck & Co Inc | Synthetic peptides for use as epitopes specific for HIV |
-
1997
- 1997-05-23 NZ NZ333431A patent/NZ333431A/xx not_active IP Right Cessation
- 1997-05-23 WO PCT/US1997/008950 patent/WO1997044469A2/en not_active Ceased
- 1997-05-23 CA CA2250723A patent/CA2250723C/en not_active Expired - Lifetime
- 1997-05-23 JP JP54284897A patent/JP3945822B2/ja not_active Expired - Lifetime
- 1997-05-23 EP EP97927767A patent/EP0935662B1/en not_active Expired - Lifetime
- 1997-05-23 DE DE69734776T patent/DE69734776T2/de not_active Expired - Lifetime
- 1997-05-23 AU AU32143/97A patent/AU719929B2/en not_active Expired
- 1997-05-23 IL IL126460A patent/IL126460A/en not_active IP Right Cessation
- 1997-05-23 AT AT97927767T patent/ATE311463T1/de active
- 1997-05-23 DK DK97927767T patent/DK0935662T3/da active
- 1997-05-23 ES ES97927767T patent/ES2251028T3/es not_active Expired - Lifetime
-
2007
- 2007-02-06 JP JP2007027374A patent/JP2007127671A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| DE69734776D1 (de) | 2006-02-09 |
| ATE311463T1 (de) | 2005-12-15 |
| EP0935662A2 (en) | 1999-08-18 |
| WO1997044469A2 (en) | 1997-11-27 |
| JP2007127671A (ja) | 2007-05-24 |
| IL126460A0 (en) | 1999-08-17 |
| IL126460A (en) | 2007-07-04 |
| NZ333431A (en) | 2000-05-26 |
| DE69734776T2 (de) | 2006-08-17 |
| AU719929B2 (en) | 2000-05-18 |
| ES2251028T3 (es) | 2006-04-16 |
| WO1997044469A3 (en) | 1997-12-31 |
| EP0935662B1 (en) | 2005-11-30 |
| JP3945822B2 (ja) | 2007-07-18 |
| DK0935662T3 (da) | 2006-03-06 |
| AU3214397A (en) | 1997-12-09 |
| JP2001500723A (ja) | 2001-01-23 |
| CA2250723A1 (en) | 1997-11-27 |
| WO1997044469A8 (en) | 1999-07-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20170523 |