ATE311463T1 - Fusionsprotein mit multiplen epitopen - Google Patents

Fusionsprotein mit multiplen epitopen

Info

Publication number
ATE311463T1
ATE311463T1 AT97927767T AT97927767T ATE311463T1 AT E311463 T1 ATE311463 T1 AT E311463T1 AT 97927767 T AT97927767 T AT 97927767T AT 97927767 T AT97927767 T AT 97927767T AT E311463 T1 ATE311463 T1 AT E311463T1
Authority
AT
Austria
Prior art keywords
epitopes
epitope
amino acid
acid sequence
sequences
Prior art date
Application number
AT97927767T
Other languages
German (de)
English (en)
Inventor
Pablo D T Valenzuela
David Ying Chien
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/653,226 external-priority patent/US6514731B1/en
Application filed by Chiron Corp filed Critical Chiron Corp
Application granted granted Critical
Publication of ATE311463T1 publication Critical patent/ATE311463T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT97927767T 1996-05-24 1997-05-23 Fusionsprotein mit multiplen epitopen ATE311463T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/653,226 US6514731B1 (en) 1996-05-24 1996-05-24 Methods for the preparation of hepatitis C virus multiple copy epitope fusion antigens
US08/859,524 US6428792B1 (en) 1996-05-24 1997-05-20 Hepatitis C virus multiple copy epitope fusion antigens
PCT/US1997/008950 WO1997044469A2 (en) 1996-05-24 1997-05-23 Multiple epitope fusion protein

Publications (1)

Publication Number Publication Date
ATE311463T1 true ATE311463T1 (de) 2005-12-15

Family

ID=27096474

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97927767T ATE311463T1 (de) 1996-05-24 1997-05-23 Fusionsprotein mit multiplen epitopen

Country Status (11)

Country Link
EP (1) EP0935662B1 (https=)
JP (2) JP3945822B2 (https=)
AT (1) ATE311463T1 (https=)
AU (1) AU719929B2 (https=)
CA (1) CA2250723C (https=)
DE (1) DE69734776T2 (https=)
DK (1) DK0935662T3 (https=)
ES (1) ES2251028T3 (https=)
IL (1) IL126460A (https=)
NZ (1) NZ333431A (https=)
WO (1) WO1997044469A2 (https=)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6322965B1 (en) * 1997-02-10 2001-11-27 Advanced Life Science Institute, Inc. Chimera antigen peptide
AU9497998A (en) * 1997-09-22 1999-04-12 Chiron Corporation Method for detecting antibodies in a sample
ATE417275T1 (de) 1997-09-22 2008-12-15 Novartis Vaccines & Diagnostic Puffern zur stabilizierung von hcv antigenen
WO1999038880A1 (en) * 1998-01-30 1999-08-05 The General Hospital Corporation Genetic immunization with nonstructural proteins of hepatitis c virus
BRPI9909678B8 (pt) 1998-04-17 2021-05-25 Fujirebio Europe N V aperfeiçoados ensaios de imunodiagnóstico usando agentes redutores
WO1999058561A1 (fr) * 1998-05-14 1999-11-18 Pasteur Merieux Serums & Vaccins Mimotopes du virus de l'hepatite c
US7052696B2 (en) * 1998-07-10 2006-05-30 The United States Of America As Represented By The Department Of Health And Human Services Antigenic epitopes and mosaic polypeptides of hepatitis C virus proteins
US6379903B1 (en) * 1999-10-08 2002-04-30 Sigma-Aldrich Co. Purification of recombinant proteins fused to multiple epitopes
CA2389206C (en) 1999-10-27 2011-01-04 Chiron Corporation Activation of hcv-specific t cells
MXPA02006554A (es) * 1999-12-28 2003-09-22 Epimmune Inc Minigenes optimizados y peptidos codificados por los mismos.
US7491808B2 (en) 2000-06-15 2009-02-17 Novartis Vaccines And Diagnostics, Inc. HCV non-structural protein mutants and uses thereof
EP1829891B1 (en) 2000-06-15 2012-12-26 Novartis Vaccines and Diagnostics, Inc. Immunoassays for Anti-HCV Antibodies
DK1354204T4 (da) * 2000-06-15 2010-06-14 Novartis Vaccines & Diagnostic HCV-antigen/antistof-kombinationssay
WO2003008537A2 (en) * 2001-04-06 2003-01-30 Mannkind Corporation Epitope sequences
AR045702A1 (es) 2001-10-03 2005-11-09 Chiron Corp Composiciones de adyuvantes.
ATE410693T1 (de) 2002-09-09 2008-10-15 Novartis Vaccines & Diagnostic Hcv-test
WO2004039950A2 (en) * 2002-10-25 2004-05-13 Chiron Corporation Activation of hcv-specific cells
US7731967B2 (en) 2003-04-30 2010-06-08 Novartis Vaccines And Diagnostics, Inc. Compositions for inducing immune responses
ES2377978T3 (es) 2004-08-27 2012-04-03 Novartis Vaccines And Diagnostics, Inc. Mutantes de proteínas no estructurales de VHC y usos de los mismos
WO2006133911A2 (en) * 2005-06-17 2006-12-21 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Hepatitis c virus nucleic acid vaccine
CA2630220C (en) 2005-11-22 2020-10-13 Doris Coit Norovirus and sapovirus antigens
EP3067048B1 (en) 2007-12-07 2018-02-14 GlaxoSmithKline Biologicals SA Compositions for inducing immune responses
US9550811B2 (en) 2010-12-02 2017-01-24 Bionor Immuno As Peptide scaffold design
US9493514B2 (en) 2011-01-06 2016-11-15 Bionor Immuno As Dimeric scaffold proteins comprising HIV-1 GP120 and GP41 epitopes
WO2013112916A1 (en) * 2012-01-26 2013-08-01 Longhorn Vaccines And Diagnostics, Llc Composite antigenic sequences and vaccines
JP6310909B2 (ja) 2012-06-06 2018-04-11 ビオノール イミュノ エーエスＢｉｏｎｏｒ Ｉｍｍｕｎｏ Ａｓ 免疫原及び投薬反応物として使用するためのウイルスタンパク質に由来するペプチド
JP7297408B2 (ja) 2015-02-06 2023-06-26 セル アイディーエックス， インコーポレイテッド 抗原をカップリングさせた免疫試薬
WO2016160046A1 (en) 2015-03-27 2016-10-06 Ortho-Clinical Diagnostics, Inc. Hcv ns4a/modified ns3 polypeptides and uses thereof
CN109716130B (zh) * 2016-07-18 2023-05-23 赛尔伊迪克斯公司 抗原偶联的杂交试剂
KR101813586B1 (ko) * 2016-12-29 2018-01-30 고려대학교 산학협력단 다양한 질병마커 인지 에피토프와 연결된 단백질 나노입자 및 이를 이용한 고민감도 질병마커 검출방법
ES2961462T3 (es) * 2017-07-27 2024-03-12 Roche Diagnostics Gmbh Proteína de fusión multiepítopo de un antígeno del VHC y usos de la misma
KR101871985B1 (ko) * 2017-08-14 2018-06-27 고려대학교 산학협력단 3차원 단백질 나노입자 프로브 기반 복수 질환의 동시검출 방법 및 키트
CN108794636B (zh) * 2018-06-28 2020-05-22 中国人民解放军军事科学院军事医学研究院 一种表位多肽串联混合物在抗立氏立克次体的免疫保护中的应用
KR102100813B1 (ko) * 2018-11-08 2020-04-16 주식회사 보레다바이오텍 C형 간염바이러스 유래 융합 단백질 및 이를 포함하는 진단키트

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993000365A2 (en) * 1991-06-24 1993-01-07 Chiron Corporation Hepatitis c virus (hcv) polypeptides
NZ244782A (en) * 1991-10-16 1996-12-20 Immulogic Pharma Corp Isolated peptides having t-cell stimulating activity, pharmaceutical composition
US5683695A (en) * 1993-02-10 1997-11-04 United Biomedical, Inc. Production of recombinant proteins containing multiple antigenic determinants linked by flexible hinge domains
US5744144A (en) * 1993-07-30 1998-04-28 University Of Pittsburgh University Patent Committee Policy And Procedures Synthetic multiple tandem repeat mucin and mucin-like peptides, and uses thereof
GB2294047A (en) * 1994-10-14 1996-04-17 Merck & Co Inc Synthetic peptides for use as epitopes specific for HIV

Also Published As

Publication number Publication date
EP0935662A2 (en) 1999-08-18
EP0935662B1 (en) 2005-11-30
WO1997044469A2 (en) 1997-11-27
AU719929B2 (en) 2000-05-18
NZ333431A (en) 2000-05-26
WO1997044469A8 (en) 1999-07-22
WO1997044469A3 (en) 1997-12-31
ES2251028T3 (es) 2006-04-16
JP2007127671A (ja) 2007-05-24
AU3214397A (en) 1997-12-09
IL126460A (en) 2007-07-04
JP3945822B2 (ja) 2007-07-18
CA2250723C (en) 2012-07-17
DE69734776D1 (de) 2006-02-09
DK0935662T3 (da) 2006-03-06
CA2250723A1 (en) 1997-11-27
DE69734776T2 (de) 2006-08-17
JP2001500723A (ja) 2001-01-23
IL126460A0 (en) 1999-08-17

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