IL126460A - Multiple epitope fusion protein - Google Patents

Multiple epitope fusion protein

Info

Publication number
IL126460A
IL126460A IL126460A IL12646097A IL126460A IL 126460 A IL126460 A IL 126460A IL 126460 A IL126460 A IL 126460A IL 12646097 A IL12646097 A IL 12646097A IL 126460 A IL126460 A IL 126460A
Authority
IL
Israel
Prior art keywords
epitopes
epitope
mefa
hcv
virus
Prior art date
Application number
IL126460A
Other languages
English (en)
Other versions
IL126460A0 (en
Original Assignee
Novartis Vaccines & Diagnostic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/653,226 external-priority patent/US6514731B1/en
Application filed by Novartis Vaccines & Diagnostic filed Critical Novartis Vaccines & Diagnostic
Publication of IL126460A0 publication Critical patent/IL126460A0/xx
Publication of IL126460A publication Critical patent/IL126460A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
IL126460A 1996-05-24 1997-05-23 Multiple epitope fusion protein IL126460A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/653,226 US6514731B1 (en) 1996-05-24 1996-05-24 Methods for the preparation of hepatitis C virus multiple copy epitope fusion antigens
US08/859,524 US6428792B1 (en) 1996-05-24 1997-05-20 Hepatitis C virus multiple copy epitope fusion antigens
PCT/US1997/008950 WO1997044469A2 (en) 1996-05-24 1997-05-23 Multiple epitope fusion protein

Publications (2)

Publication Number Publication Date
IL126460A0 IL126460A0 (en) 1999-08-17
IL126460A true IL126460A (en) 2007-07-04

Family

ID=27096474

Family Applications (1)

Application Number Title Priority Date Filing Date
IL126460A IL126460A (en) 1996-05-24 1997-05-23 Multiple epitope fusion protein

Country Status (11)

Country Link
EP (1) EP0935662B1 (https=)
JP (2) JP3945822B2 (https=)
AT (1) ATE311463T1 (https=)
AU (1) AU719929B2 (https=)
CA (1) CA2250723C (https=)
DE (1) DE69734776T2 (https=)
DK (1) DK0935662T3 (https=)
ES (1) ES2251028T3 (https=)
IL (1) IL126460A (https=)
NZ (1) NZ333431A (https=)
WO (1) WO1997044469A2 (https=)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0870830A3 (en) * 1997-02-10 2004-02-25 Advanced Life Science Institute, Inc. Chimera hepatitis C virus antigen
DE69837155T2 (de) * 1997-09-22 2007-06-21 Novartis Vaccines and Diagnostics, Inc., Emeryville Verfahren zum nachweiss von antikörpern in einer probe
AU9498098A (en) 1997-09-22 1999-04-12 Chiron Corporation Buffers for stabilizing antigens
AU746258B2 (en) * 1998-01-30 2002-04-18 General Hospital Corporation, The Genetic immunization with nonstructural proteins of hepatitis C virus
DK1071955T4 (da) 1998-04-17 2009-06-15 Innogenetics Nv Forbedrede immundiagnostiske assays, som anvender reduktionsmidler
AU3714499A (en) * 1998-05-14 1999-11-29 Pasteur Merieux Serums Et Vaccins Hepatitis c virus mimotopes
US7052696B2 (en) * 1998-07-10 2006-05-30 The United States Of America As Represented By The Department Of Health And Human Services Antigenic epitopes and mosaic polypeptides of hepatitis C virus proteins
US6379903B1 (en) * 1999-10-08 2002-04-30 Sigma-Aldrich Co. Purification of recombinant proteins fused to multiple epitopes
AU1236801A (en) 1999-10-27 2001-05-08 Chiron Corporation Activation of hcv-specific t cells
EP1242108B1 (en) * 1999-12-28 2007-07-11 Pharmexa Inc. Optimized minigenes and peptides encoded thereby
SI1354204T2 (sl) * 2000-06-15 2010-09-30 Novartis Vaccines & Diagnostic Hcv antigen antitelo kombinacijska analiza
US7491808B2 (en) 2000-06-15 2009-02-17 Novartis Vaccines And Diagnostics, Inc. HCV non-structural protein mutants and uses thereof
EP1829891B1 (en) 2000-06-15 2012-12-26 Novartis Vaccines and Diagnostics, Inc. Immunoassays for Anti-HCV Antibodies
WO2003008537A2 (en) * 2001-04-06 2003-01-30 Mannkind Corporation Epitope sequences
AR045702A1 (es) 2001-10-03 2005-11-09 Chiron Corp Composiciones de adyuvantes.
ES2312806T3 (es) 2002-09-09 2009-03-01 Novartis Vaccines And Diagnostics, Inc. Ensayo de vhc.
EP1576125A4 (en) * 2002-10-25 2008-09-03 Novartis Vaccines & Diagnostic ACTIVATION OF SPECIFIC HCV LYMPHOCYTES
US7731967B2 (en) 2003-04-30 2010-06-08 Novartis Vaccines And Diagnostics, Inc. Compositions for inducing immune responses
EP1802778B1 (en) 2004-08-27 2011-10-05 Novartis Vaccines and Diagnostics, Inc. Hcv multiple epitope fusion antigens with modified proteolytic cleavage sites and uses thereof
WO2006133911A2 (en) * 2005-06-17 2006-12-21 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Hepatitis c virus nucleic acid vaccine
ES2514316T3 (es) 2005-11-22 2014-10-28 Novartis Vaccines And Diagnostics, Inc. Partículas similares a virus (VLPs) de Norovirus y Sapovirus
EP3067048B1 (en) 2007-12-07 2018-02-14 GlaxoSmithKline Biologicals SA Compositions for inducing immune responses
EP2646459B1 (en) 2010-12-02 2020-01-08 Bionor Immuno AS Peptide scaffold design
JP6294076B2 (ja) 2011-01-06 2018-03-14 ビオノール イミュノ エーエスＢｉｏｎｏｒ Ｉｍｍｕｎｏ Ａｓ 多量体ペプチド
EP3494989B1 (en) * 2012-01-26 2025-07-16 Longhorn Vaccines and Diagnostics, LLC Composite antigenic sequences and vaccines
IN2014KN02769A (https=) 2012-06-06 2015-05-08 Bionor Immuno As
US11867696B2 (en) 2015-02-06 2024-01-09 Cell Idx, Inc. Antigen-coupled immunoreagents
CA2980718C (en) 2015-03-27 2021-06-01 Ortho-Clinical Diagnostics, Inc. Hcv ns4a/modified ns3 polypeptides and uses thereof
CN109716130B (zh) * 2016-07-18 2023-05-23 赛尔伊迪克斯公司 抗原偶联的杂交试剂
KR101813586B1 (ko) * 2016-12-29 2018-01-30 고려대학교 산학협력단 다양한 질병마커 인지 에피토프와 연결된 단백질 나노입자 및 이를 이용한 고민감도 질병마커 검출방법
CN110996986B (zh) 2017-07-27 2024-07-19 豪夫迈·罗氏有限公司 Hcv抗原的多表位融合蛋白及其用途
KR101871985B1 (ko) * 2017-08-14 2018-06-27 고려대학교 산학협력단 3차원 단백질 나노입자 프로브 기반 복수 질환의 동시검출 방법 및 키트
CN108794636B (zh) * 2018-06-28 2020-05-22 中国人民解放军军事科学院军事医学研究院 一种表位多肽串联混合物在抗立氏立克次体的免疫保护中的应用
KR102100813B1 (ko) * 2018-11-08 2020-04-16 주식회사 보레다바이오텍 C형 간염바이러스 유래 융합 단백질 및 이를 포함하는 진단키트

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2188583T3 (es) * 1991-06-24 2003-07-01 Chiron Corp Polipeptidos para el virus de la hepatitis c (hcv).
IL103456A (en) * 1991-10-16 2006-06-11 Merck Patent Gmbh Isolated peptides having t-cell stimulating activity
US5683695A (en) * 1993-02-10 1997-11-04 United Biomedical, Inc. Production of recombinant proteins containing multiple antigenic determinants linked by flexible hinge domains
US5744144A (en) * 1993-07-30 1998-04-28 University Of Pittsburgh University Patent Committee Policy And Procedures Synthetic multiple tandem repeat mucin and mucin-like peptides, and uses thereof
GB2294047A (en) * 1994-10-14 1996-04-17 Merck & Co Inc Synthetic peptides for use as epitopes specific for HIV

Also Published As

Publication number Publication date
DE69734776D1 (de) 2006-02-09
ATE311463T1 (de) 2005-12-15
EP0935662A2 (en) 1999-08-18
CA2250723C (en) 2012-07-17
WO1997044469A2 (en) 1997-11-27
JP2007127671A (ja) 2007-05-24
IL126460A0 (en) 1999-08-17
NZ333431A (en) 2000-05-26
DE69734776T2 (de) 2006-08-17
AU719929B2 (en) 2000-05-18
ES2251028T3 (es) 2006-04-16
WO1997044469A3 (en) 1997-12-31
EP0935662B1 (en) 2005-11-30
JP3945822B2 (ja) 2007-07-18
DK0935662T3 (da) 2006-03-06
AU3214397A (en) 1997-12-09
JP2001500723A (ja) 2001-01-23
CA2250723A1 (en) 1997-11-27
WO1997044469A8 (en) 1999-07-22

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