DK0935662T3 - Fusionsprotein med multiple epitoper - Google Patents

Fusionsprotein med multiple epitoper

Info

Publication number
DK0935662T3
DK0935662T3 DK97927767T DK97927767T DK0935662T3 DK 0935662 T3 DK0935662 T3 DK 0935662T3 DK 97927767 T DK97927767 T DK 97927767T DK 97927767 T DK97927767 T DK 97927767T DK 0935662 T3 DK0935662 T3 DK 0935662T3
Authority
DK
Denmark
Prior art keywords
epitopes
epitope
amino acid
acid sequence
sequences
Prior art date
Application number
DK97927767T
Other languages
Danish (da)
English (en)
Inventor
Pablo D T Valenzuela
David Ying Chien
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/653,226 external-priority patent/US6514731B1/en
Application filed by Chiron Corp filed Critical Chiron Corp
Application granted granted Critical
Publication of DK0935662T3 publication Critical patent/DK0935662T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK97927767T 1996-05-24 1997-05-23 Fusionsprotein med multiple epitoper DK0935662T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/653,226 US6514731B1 (en) 1996-05-24 1996-05-24 Methods for the preparation of hepatitis C virus multiple copy epitope fusion antigens
US08/859,524 US6428792B1 (en) 1996-05-24 1997-05-20 Hepatitis C virus multiple copy epitope fusion antigens

Publications (1)

Publication Number Publication Date
DK0935662T3 true DK0935662T3 (da) 2006-03-06

Family

ID=27096474

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97927767T DK0935662T3 (da) 1996-05-24 1997-05-23 Fusionsprotein med multiple epitoper

Country Status (11)

Country Link
EP (1) EP0935662B1 (https=)
JP (2) JP3945822B2 (https=)
AT (1) ATE311463T1 (https=)
AU (1) AU719929B2 (https=)
CA (1) CA2250723C (https=)
DE (1) DE69734776T2 (https=)
DK (1) DK0935662T3 (https=)
ES (1) ES2251028T3 (https=)
IL (1) IL126460A (https=)
NZ (1) NZ333431A (https=)
WO (1) WO1997044469A2 (https=)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0870830A3 (en) * 1997-02-10 2004-02-25 Advanced Life Science Institute, Inc. Chimera hepatitis C virus antigen
DE69837155T2 (de) * 1997-09-22 2007-06-21 Novartis Vaccines and Diagnostics, Inc., Emeryville Verfahren zum nachweiss von antikörpern in einer probe
AU9498098A (en) 1997-09-22 1999-04-12 Chiron Corporation Buffers for stabilizing antigens
AU746258B2 (en) * 1998-01-30 2002-04-18 General Hospital Corporation, The Genetic immunization with nonstructural proteins of hepatitis C virus
DK1071955T4 (da) 1998-04-17 2009-06-15 Innogenetics Nv Forbedrede immundiagnostiske assays, som anvender reduktionsmidler
AU3714499A (en) * 1998-05-14 1999-11-29 Pasteur Merieux Serums Et Vaccins Hepatitis c virus mimotopes
US7052696B2 (en) * 1998-07-10 2006-05-30 The United States Of America As Represented By The Department Of Health And Human Services Antigenic epitopes and mosaic polypeptides of hepatitis C virus proteins
US6379903B1 (en) * 1999-10-08 2002-04-30 Sigma-Aldrich Co. Purification of recombinant proteins fused to multiple epitopes
AU1236801A (en) 1999-10-27 2001-05-08 Chiron Corporation Activation of hcv-specific t cells
EP1242108B1 (en) * 1999-12-28 2007-07-11 Pharmexa Inc. Optimized minigenes and peptides encoded thereby
SI1354204T2 (sl) * 2000-06-15 2010-09-30 Novartis Vaccines & Diagnostic Hcv antigen antitelo kombinacijska analiza
US7491808B2 (en) 2000-06-15 2009-02-17 Novartis Vaccines And Diagnostics, Inc. HCV non-structural protein mutants and uses thereof
EP1829891B1 (en) 2000-06-15 2012-12-26 Novartis Vaccines and Diagnostics, Inc. Immunoassays for Anti-HCV Antibodies
WO2003008537A2 (en) * 2001-04-06 2003-01-30 Mannkind Corporation Epitope sequences
AR045702A1 (es) 2001-10-03 2005-11-09 Chiron Corp Composiciones de adyuvantes.
ES2312806T3 (es) 2002-09-09 2009-03-01 Novartis Vaccines And Diagnostics, Inc. Ensayo de vhc.
EP1576125A4 (en) * 2002-10-25 2008-09-03 Novartis Vaccines & Diagnostic ACTIVATION OF SPECIFIC HCV LYMPHOCYTES
US7731967B2 (en) 2003-04-30 2010-06-08 Novartis Vaccines And Diagnostics, Inc. Compositions for inducing immune responses
EP1802778B1 (en) 2004-08-27 2011-10-05 Novartis Vaccines and Diagnostics, Inc. Hcv multiple epitope fusion antigens with modified proteolytic cleavage sites and uses thereof
WO2006133911A2 (en) * 2005-06-17 2006-12-21 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Hepatitis c virus nucleic acid vaccine
ES2514316T3 (es) 2005-11-22 2014-10-28 Novartis Vaccines And Diagnostics, Inc. Partículas similares a virus (VLPs) de Norovirus y Sapovirus
EP3067048B1 (en) 2007-12-07 2018-02-14 GlaxoSmithKline Biologicals SA Compositions for inducing immune responses
EP2646459B1 (en) 2010-12-02 2020-01-08 Bionor Immuno AS Peptide scaffold design
JP6294076B2 (ja) 2011-01-06 2018-03-14 ビオノール イミュノ エーエスＢｉｏｎｏｒ Ｉｍｍｕｎｏ Ａｓ 多量体ペプチド
EP3494989B1 (en) * 2012-01-26 2025-07-16 Longhorn Vaccines and Diagnostics, LLC Composite antigenic sequences and vaccines
IN2014KN02769A (https=) 2012-06-06 2015-05-08 Bionor Immuno As
US11867696B2 (en) 2015-02-06 2024-01-09 Cell Idx, Inc. Antigen-coupled immunoreagents
CA2980718C (en) 2015-03-27 2021-06-01 Ortho-Clinical Diagnostics, Inc. Hcv ns4a/modified ns3 polypeptides and uses thereof
CN109716130B (zh) * 2016-07-18 2023-05-23 赛尔伊迪克斯公司 抗原偶联的杂交试剂
KR101813586B1 (ko) * 2016-12-29 2018-01-30 고려대학교 산학협력단 다양한 질병마커 인지 에피토프와 연결된 단백질 나노입자 및 이를 이용한 고민감도 질병마커 검출방법
CN110996986B (zh) 2017-07-27 2024-07-19 豪夫迈·罗氏有限公司 Hcv抗原的多表位融合蛋白及其用途
KR101871985B1 (ko) * 2017-08-14 2018-06-27 고려대학교 산학협력단 3차원 단백질 나노입자 프로브 기반 복수 질환의 동시검출 방법 및 키트
CN108794636B (zh) * 2018-06-28 2020-05-22 中国人民解放军军事科学院军事医学研究院 一种表位多肽串联混合物在抗立氏立克次体的免疫保护中的应用
KR102100813B1 (ko) * 2018-11-08 2020-04-16 주식회사 보레다바이오텍 C형 간염바이러스 유래 융합 단백질 및 이를 포함하는 진단키트

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2188583T3 (es) * 1991-06-24 2003-07-01 Chiron Corp Polipeptidos para el virus de la hepatitis c (hcv).
IL103456A (en) * 1991-10-16 2006-06-11 Merck Patent Gmbh Isolated peptides having t-cell stimulating activity
US5683695A (en) * 1993-02-10 1997-11-04 United Biomedical, Inc. Production of recombinant proteins containing multiple antigenic determinants linked by flexible hinge domains
US5744144A (en) * 1993-07-30 1998-04-28 University Of Pittsburgh University Patent Committee Policy And Procedures Synthetic multiple tandem repeat mucin and mucin-like peptides, and uses thereof
GB2294047A (en) * 1994-10-14 1996-04-17 Merck & Co Inc Synthetic peptides for use as epitopes specific for HIV

Also Published As

Publication number Publication date
DE69734776D1 (de) 2006-02-09
ATE311463T1 (de) 2005-12-15
EP0935662A2 (en) 1999-08-18
CA2250723C (en) 2012-07-17
WO1997044469A2 (en) 1997-11-27
JP2007127671A (ja) 2007-05-24
IL126460A0 (en) 1999-08-17
IL126460A (en) 2007-07-04
NZ333431A (en) 2000-05-26
DE69734776T2 (de) 2006-08-17
AU719929B2 (en) 2000-05-18
ES2251028T3 (es) 2006-04-16
WO1997044469A3 (en) 1997-12-31
EP0935662B1 (en) 2005-11-30
JP3945822B2 (ja) 2007-07-18
AU3214397A (en) 1997-12-09
JP2001500723A (ja) 2001-01-23
CA2250723A1 (en) 1997-11-27
WO1997044469A8 (en) 1999-07-22

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