CA2247580A1 - Process for preparing chiral succinic acid derivatives - Google Patents

Process for preparing chiral succinic acid derivatives Download PDF

Info

Publication number
CA2247580A1
CA2247580A1 CA002247580A CA2247580A CA2247580A1 CA 2247580 A1 CA2247580 A1 CA 2247580A1 CA 002247580 A CA002247580 A CA 002247580A CA 2247580 A CA2247580 A CA 2247580A CA 2247580 A1 CA2247580 A1 CA 2247580A1
Authority
CA
Canada
Prior art keywords
formula
compound
benzyl
accordance
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002247580A
Other languages
English (en)
French (fr)
Inventor
Hans Hilpert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2247580A1 publication Critical patent/CA2247580A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/608—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a ring other than a six-membered aromatic ring in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA002247580A 1997-10-03 1998-09-15 Process for preparing chiral succinic acid derivatives Abandoned CA2247580A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97117191 1997-10-03
EP97117191.3 1997-10-03

Publications (1)

Publication Number Publication Date
CA2247580A1 true CA2247580A1 (en) 1999-04-03

Family

ID=8227435

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002247580A Abandoned CA2247580A1 (en) 1997-10-03 1998-09-15 Process for preparing chiral succinic acid derivatives

Country Status (5)

Country Link
US (2) US5952507A (zh)
JP (1) JP2986464B2 (zh)
KR (2) KR100303376B1 (zh)
CN (2) CN1515561A (zh)
CA (1) CA2247580A1 (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6222039B1 (en) 1998-07-13 2001-04-24 Hoffman-La Roche Inc. Process for the preparation of chiral lactones
JO2258B1 (en) 1999-05-11 2004-10-07 اف . هوفمان لاروش ايه جي Method for preparing hydroxamic acids
EP1200390B1 (de) * 1999-07-29 2008-08-27 Speedel Pharma AG Herstellung von n-substituierten 2,7-dialkyl-4-hydroxy-5-amino-8-aryl-octanoylamiden
CN107032992A (zh) * 2017-04-05 2017-08-11 华东师范大学 一种(r)‑4‑(叔丁氧基)‑2‑(环戊基甲基)‑4‑氧代丁酸的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2942606A1 (de) * 1979-10-22 1981-04-30 Helmut Dipl.-Chem. Aigner Verfahren zur herstellung von saeureamiden und anwendung des verfahrens
GB9501737D0 (en) * 1994-04-25 1995-03-22 Hoffmann La Roche Hydroxamic acid derivatives
EP0816341A1 (de) * 1996-07-04 1998-01-07 F. Hoffmann-La Roche Ag Verfahren zur Herstellung von chiralen Bernsteinsäurederivaten

Also Published As

Publication number Publication date
JP2986464B2 (ja) 1999-12-06
JPH11180959A (ja) 1999-07-06
KR19990036858A (ko) 1999-05-25
CN1515561A (zh) 2004-07-28
US5952507A (en) 1999-09-14
KR100293391B1 (ko) 2001-06-15
KR100303376B1 (ko) 2002-07-18
KR20010021487A (ko) 2001-03-15
CN1213663A (zh) 1999-04-14
US6197995B1 (en) 2001-03-06

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued