CA2246751A1 - Human metabotropic glutamate receptor - Google Patents
Human metabotropic glutamate receptor Download PDFInfo
- Publication number
- CA2246751A1 CA2246751A1 CA002246751A CA2246751A CA2246751A1 CA 2246751 A1 CA2246751 A1 CA 2246751A1 CA 002246751 A CA002246751 A CA 002246751A CA 2246751 A CA2246751 A CA 2246751A CA 2246751 A1 CA2246751 A1 CA 2246751A1
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- Prior art keywords
- nucleic acid
- amino acid
- seq
- sequence
- metabotropic glutamate
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Psychology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polyamides (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/604,298 | 1996-02-21 | ||
| US08/604,298 US6084084A (en) | 1996-02-21 | 1996-02-21 | Human metabotropic glutamate receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2246751A1 true CA2246751A1 (en) | 1997-12-24 |
Family
ID=24419059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002246751A Abandoned CA2246751A1 (en) | 1996-02-21 | 1997-02-20 | Human metabotropic glutamate receptor |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US6084084A (enExample) |
| EP (1) | EP0882065B1 (enExample) |
| JP (1) | JP2000506392A (enExample) |
| AT (1) | ATE369385T1 (enExample) |
| AU (1) | AU719841B2 (enExample) |
| CA (1) | CA2246751A1 (enExample) |
| DE (1) | DE69737990T2 (enExample) |
| ES (1) | ES2292193T3 (enExample) |
| IL (2) | IL125711A0 (enExample) |
| WO (1) | WO1997048724A2 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5521297A (en) * | 1993-06-04 | 1996-05-28 | Salk Institute Biotechnology/Industrial Associates | Nucleic acids encoding human metabotropic glutamate receptors |
| US5981195A (en) * | 1995-07-26 | 1999-11-09 | Nps Pharmaceuticals, Inc. | Chimeric receptors and methods for identifying compounds active at metabotropic glutamate receptors |
| US6221609B1 (en) * | 1996-07-03 | 2001-04-24 | Eli Lilly And Company | Isolate nucleic acid encoding human MGLUR8 |
| US7262280B1 (en) | 1998-04-03 | 2007-08-28 | Nps Pharmaceuticals, Inc. | G-protein fusion receptors and constructs encoding same |
| EP1066325A1 (en) * | 1998-04-03 | 2001-01-10 | Nps Pharmaceuticals, Inc. | G-protein fusion receptors and chimeric gaba b? receptors |
| EP1662255A3 (en) * | 1998-08-18 | 2006-09-13 | The Johns Hopkins University School Of Medicine | Homer interacting proteins |
| EP1105734A4 (en) * | 1998-08-18 | 2005-04-13 | Univ Johns Hopkins Med | PROTEINS WITH INTERACTION OF THE HOMER FAMILY |
| IL141691A0 (en) * | 1998-08-31 | 2002-03-10 | Trinity College Dublin | Polypeptides and polynucleotides from coagulase-negative staphylococci |
| US20030166554A1 (en) * | 2001-01-16 | 2003-09-04 | Genset, S.A. | Treatment of CNS disorders using D-amino acid oxidase and D-aspartate oxidase antagonists |
| US20030185754A1 (en) * | 2001-01-16 | 2003-10-02 | Genset, S.A. | Treatment of CNS disorders using D-amino acid oxidase and D-aspartate oxidase antagonists |
| US6620850B2 (en) * | 2001-09-19 | 2003-09-16 | University Of Florida | Materials and methods for treatment of neurological disorders involving overactivation of glutamatergic ionotropic receptors |
| US20050233321A1 (en) * | 2001-12-20 | 2005-10-20 | Hess John W | Identification of novel polymorphic sites in the human mglur8 gene and uses thereof |
| CA2472472A1 (en) * | 2002-01-10 | 2003-07-24 | Osteotrophin Llc | Treatment of bone disorders with skeletal anabolic drugs |
| WO2004050858A2 (en) * | 2002-12-04 | 2004-06-17 | Diadexus, Inc. | Compositions, splice variants and methods relating to colon specific genes and proteins |
| US20050186658A1 (en) * | 2003-10-17 | 2005-08-25 | Nps Pharmaceuticals, Inc. | Chimeric metabotropic glutamate receptors and uses thereof |
| WO2005073730A1 (en) * | 2004-01-31 | 2005-08-11 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with human metabotropic glutamate receptor 8 (mglur8) |
| AU2005295655A1 (en) * | 2004-10-14 | 2006-04-27 | Carnegie Institution Of Washington | Neurotransmitter sensors and methods of using the same |
| AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
| US8889950B2 (en) * | 2006-07-28 | 2014-11-18 | The George Washington University | Repression of AtGLR3.2 increases plant biomass |
| US7424876B2 (en) * | 2006-10-06 | 2008-09-16 | Ford Global Technologies, Llc | Pushrod engine with multiple independent lash adjusters for each pushrod |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| PL2203439T3 (pl) | 2007-09-14 | 2011-06-30 | Addex Pharmaceuticals Sa | 1',3'-dipodstawione-4-fenylo-3,4,5,6-tetrahydro-2H, 1'H-[1, 4']bipirydynylo-2'-ketony |
| CA2707309A1 (en) * | 2007-12-18 | 2009-06-25 | Acumen Pharmaceuticals, Inc. | Novel addl receptor polypeptides, polynucleotides and host cells for recombinant production |
| AU2009274482A1 (en) * | 2008-05-20 | 2010-01-28 | Eos Neuroscience, Inc. | Vectors for delivery of light-sensitive proteins and methods of use |
| JP5547194B2 (ja) | 2008-09-02 | 2014-07-09 | ジャンセン ファーマシューティカルズ， インコーポレイテッド． | 代謝型グルタミン酸受容体の調節因子としての３−アザビシクロ［３．１．０］ヘキシル誘導体 |
| RU2512283C2 (ru) | 2008-11-28 | 2014-04-10 | Янссен Фармасьютикалз, Инк. | Производные индола и бензоксазина в качестве модуляторов метаботропных глутаматных рецепторов |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| KR101753826B1 (ko) | 2009-05-12 | 2017-07-04 | 얀센 파마슈티칼즈, 인코포레이티드 | 1,２,４―트리아졸로［４,３―ａ］피리딘 유도체 및 신경정신 질환의 치료 또는 예방을 위한 이들의 용도 |
| AU2010246607B2 (en) | 2009-05-12 | 2012-09-27 | Addex Pharma S.A. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
| CN103261195B (zh) | 2010-11-08 | 2015-09-02 | 杨森制药公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
| CA2815002C (en) | 2010-11-08 | 2019-10-22 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| AU2011328194B2 (en) | 2010-11-08 | 2015-04-16 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| LT3431106T (lt) | 2014-01-21 | 2021-02-10 | Janssen Pharmaceutica Nv | Deriniai, apimantys 2 potipio metabotropinio glutamaterginio receptoriaus teigiamus alosterinius moduliatorius arba ortosterinius agonistus, ir jų panaudojimas |
| SI3431106T1 (sl) | 2014-01-21 | 2021-03-31 | Janssen Pharmaceutica Nv | Kombinacije, ki vsebujejo pozitivne alosterične modulatorje metabotropnega glutamatergičnega receptorja podtipa 2 in njihova uporaba |
| NZ739721A (en) | 2015-08-07 | 2019-09-27 | Imaginab Inc | Antigen binding constructs to target molecules |
| WO2018147960A1 (en) | 2017-02-08 | 2018-08-16 | Imaginab, Inc. | Extension sequences for diabodies |
| CA3060443A1 (en) | 2017-04-19 | 2018-10-25 | Board Of Regents, The University Of Texas System | Immune cells expressing engineered antigen receptors |
| JP7273421B2 (ja) | 2018-02-21 | 2023-05-15 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | ナチュラルキラー細胞の活性化および拡大のための方法ならびにその使用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3829583A (en) * | 1971-02-20 | 1974-08-13 | Hayashibara Ken | Mixture of maltobionic acid and monosodium glutamate as a food seasoning |
| US4945050A (en) * | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US5177011A (en) * | 1988-08-18 | 1993-01-05 | Calgene, Inc. | Plant elongation factor promoters, coding sequences and uses |
| JP2944721B2 (ja) * | 1990-08-22 | 1999-09-06 | 生化学工業株式会社 | エンドトキシンの測定剤 |
| NZ240921A (en) * | 1990-12-12 | 1994-06-27 | Zymogenetics Inc | G protein coupled glutamate receptor (neurotransmitters), recombinant production |
| WO1995011221A1 (en) * | 1991-08-23 | 1995-04-27 | Nps Pharmaceuticals, Inc. | Calcium receptor-active arylalkyl amines |
| RU2147574C1 (ru) * | 1991-08-23 | 2000-04-20 | Эн-Пи-Эс Фармасьютикалз, Инк. | Арилалкиламины, композиции, способы лечения и диагностики, способы идентификации соединения |
| IL105587A0 (en) * | 1992-05-08 | 1993-09-22 | Lilly Co Eli | Human metabotropic glutamate receptor and related dna compounds |
| JPH08500481A (ja) * | 1992-05-11 | 1996-01-23 | リボザイム・ファーマシューティカルズ・インコーポレーテッド | ウイルスの複製を阻害するための方法および薬剤 |
| ATE283916T1 (de) * | 1993-09-20 | 2004-12-15 | Novartis Pharma Gmbh | Menschliche metabotropische glutamatrezeptor untertype hmglur7 und verwandte dns-verbindungen |
| US6274330B1 (en) * | 1993-12-30 | 2001-08-14 | Zymogenetics, Inc. | L-AP4 sensitive glutamate receptors |
| WO1995031539A1 (en) * | 1994-05-16 | 1995-11-23 | Human Genome Sciences, Inc. | Neurotransmitter transporter |
| US5981195A (en) * | 1995-07-26 | 1999-11-09 | Nps Pharmaceuticals, Inc. | Chimeric receptors and methods for identifying compounds active at metabotropic glutamate receptors |
-
1996
- 1996-02-21 US US08/604,298 patent/US6084084A/en not_active Expired - Fee Related
-
1997
- 1997-02-20 AU AU37156/97A patent/AU719841B2/en not_active Ceased
- 1997-02-20 AT AT97933988T patent/ATE369385T1/de not_active IP Right Cessation
- 1997-02-20 IL IL12571197A patent/IL125711A0/xx active IP Right Grant
- 1997-02-20 ES ES97933988T patent/ES2292193T3/es not_active Expired - Lifetime
- 1997-02-20 CA CA002246751A patent/CA2246751A1/en not_active Abandoned
- 1997-02-20 EP EP97933988A patent/EP0882065B1/en not_active Expired - Lifetime
- 1997-02-20 DE DE69737990T patent/DE69737990T2/de not_active Expired - Fee Related
- 1997-02-20 WO PCT/US1997/009025 patent/WO1997048724A2/en not_active Ceased
- 1997-02-20 JP JP9540300A patent/JP2000506392A/ja active Pending
- 1997-03-24 US US08/823,110 patent/US6077675A/en not_active Expired - Fee Related
- 1997-03-24 US US08/823,437 patent/US6051688A/en not_active Expired - Fee Related
-
1998
- 1998-08-09 IL IL125711A patent/IL125711A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU719841B2 (en) | 2000-05-18 |
| EP0882065B1 (en) | 2007-08-08 |
| WO1997048724A2 (en) | 1997-12-24 |
| ES2292193T3 (es) | 2008-03-01 |
| EP0882065A2 (en) | 1998-12-09 |
| JP2000506392A (ja) | 2000-05-30 |
| DE69737990T2 (de) | 2008-09-11 |
| IL125711A (en) | 2006-09-05 |
| AU3715697A (en) | 1998-01-07 |
| US6077675A (en) | 2000-06-20 |
| ATE369385T1 (de) | 2007-08-15 |
| IL125711A0 (en) | 1999-04-11 |
| US6051688A (en) | 2000-04-18 |
| WO1997048724A3 (en) | 1998-03-26 |
| DE69737990D1 (de) | 2007-09-20 |
| US6084084A (en) | 2000-07-04 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Discontinued |