CA2238829A1 - Methods and compositions for the diagnosis and treatment of cancer - Google Patents
Methods and compositions for the diagnosis and treatment of cancer Download PDFInfo
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- CA2238829A1 CA2238829A1 CA002238829A CA2238829A CA2238829A1 CA 2238829 A1 CA2238829 A1 CA 2238829A1 CA 002238829 A CA002238829 A CA 002238829A CA 2238829 A CA2238829 A CA 2238829A CA 2238829 A1 CA2238829 A1 CA 2238829A1
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- C07—ORGANIC CHEMISTRY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4746—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used p53
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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| AU732703B2 (en) * | 1996-11-20 | 2001-04-26 | Crucell Holland B.V. | An improved method for the production and purification of adenoviral vectors |
| US6689600B1 (en) * | 1998-11-16 | 2004-02-10 | Introgen Therapeutics, Inc. | Formulation of adenovirus for gene therapy |
| RU2219553C2 (ru) * | 2001-10-18 | 2003-12-20 | Ростовский научно-исследовательский онкологический институт | Способ определения эффективности аутогемохимиотерапии рака ректосигмоидного отдела прямой кишки и сигмовидной кишки, а также аутогемохимиотерапии в сочетании с свч-гипертермией рака прямой кишки |
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| WO2004020971A2 (en) * | 2002-08-28 | 2004-03-11 | Introgen Therapeutics Inc. | Chromatographic methods for adenovirus purification |
| US20050032728A1 (en) * | 2002-12-17 | 2005-02-10 | Sidney Kimmel Cancer Center | Tumor suppression through bicistronic co-expression of p53 and p14ARF |
| CA2511535A1 (en) * | 2002-12-27 | 2004-07-22 | Introgen Therapeutics, Inc. | P53 treatment of papillomavirus and carcinogen-transformed cells in hyperplastic lesions |
| US7534427B2 (en) * | 2002-12-31 | 2009-05-19 | Immunomedics, Inc. | Immunotherapy of B cell malignancies and autoimmune diseases using unconjugated antibodies and conjugated antibodies and antibody combinations and fusion proteins |
| RU2392319C2 (ru) * | 2003-03-06 | 2010-06-20 | Жаохи ПЕНГ | Рекомбинантный вирус, построенный с использованием вектора вируса и гена-подавителя опухоли человека, а также его применение |
| RU2234099C1 (ru) * | 2003-03-18 | 2004-08-10 | Российская медицинская академия последипломного образования | Способ дифференциальной диагностики стадий канцерогенеза |
| RU2242936C1 (ru) * | 2003-04-21 | 2004-12-27 | Ростовский научно-исследовательский онкологический институт | Способ лечения рака легкого |
| EP2228452B1 (en) * | 2004-02-23 | 2014-07-16 | Novartis AG | P53 wild-type as biomarker for the treatment with mtor inhibitors in combination with a cytotoxic agent |
| CA2557326A1 (en) * | 2004-02-24 | 2005-09-09 | Introgen Therapeutics, Inc. | Combination of ad-p53 and chemotherapy for the treatment of tumours |
| CN100333797C (zh) * | 2005-01-26 | 2007-08-29 | 彭朝晖 | 重组腺病毒p53制品在肿瘤治疗中的新用途 |
| RU2245551C1 (ru) * | 2004-04-23 | 2005-01-27 | Белохвостов Александр Сергеевич | Способ диагностики онкологических заболеваний |
| RU2263494C1 (ru) * | 2004-06-08 | 2005-11-10 | ГУ НИИ глазных болезней РАМН | Способ моделирования меланомы роговицы |
| RU2410098C2 (ru) * | 2004-08-31 | 2011-01-27 | Новартис Аг | Применение мидостаурина для лечения желудочно-кишечных стромальных опухолей |
| EP1679065A1 (en) | 2005-01-07 | 2006-07-12 | OctoPlus Sciences B.V. | Controlled release compositions for interferon based on PEGT/PBT block copolymers |
| MX2007008768A (es) * | 2005-01-21 | 2007-10-19 | Genentech Inc | Dosificacion fija de anticuerpos her. |
| WO2006081510A2 (en) * | 2005-01-27 | 2006-08-03 | Novartis Vaccines And Diagnostics Inc. | Methods for treating renal cell carcinoma |
| CN101163984A (zh) * | 2005-05-06 | 2008-04-16 | 奥索瑟夫特公司 | 用于跟踪对象的rf系统 |
| US20070231304A1 (en) * | 2006-01-30 | 2007-10-04 | Introgen Therapeutics, Inc. | Prognostic factors for anti-hyperproliferative disease gene therapy |
| EP2426142A3 (en) | 2006-10-16 | 2012-06-13 | Genelux Corporation | Modified vaccinia virus strains for use in a diagnostic and therapeutic method |
| WO2008106646A2 (en) * | 2007-03-01 | 2008-09-04 | Introgen Therapeutics, Inc | Methods and formulations for topical gene therapy |
| US20090081639A1 (en) * | 2007-05-31 | 2009-03-26 | Phil Hill | Assay for sensitivity to chemotherapeutic agents |
| RU2371202C2 (ru) * | 2007-07-30 | 2009-10-27 | Государственное учреждение научно-исследовательский институт онкологии Томского Научного центра Сибирского отделения Российской академии медицинских наук (ГУ НИИ онкологии ТНЦ СО РАМН) | Способ радионуклидной диагностики рака молочной железы |
| DK2245464T3 (en) | 2008-01-25 | 2017-02-20 | Multivir Inc | P53 BIOMARKETS |
| US8314068B2 (en) * | 2008-04-14 | 2012-11-20 | University Hospitals Of Cleveland | P2X7 inhibition of epithelial cancers and papillomas |
| EP2300023A2 (en) * | 2008-05-16 | 2011-03-30 | Genelux Corporation | Microorganisms for preventing and treating neoplasms accompanying cellular therapy |
| EP2370582B1 (en) | 2008-12-04 | 2017-05-10 | CuRNA, Inc. | Treatment of tumor suppressor gene related diseases by inhibition of natural antisense transcript to the gene |
| RU2384845C1 (ru) * | 2008-12-18 | 2010-03-20 | ФГУП Государственный научно-исследовательский институт особо чистых биопрепаратов ФМБА | Способ диагностики онкологических заболеваний |
| MX2011007980A (es) * | 2009-02-02 | 2011-08-17 | Okairos Ag | Secuencias de acido nucleico y aminoacido de adenovirus de simio, vectores que contienen los mismos y usos de las mismas. |
| US9050276B2 (en) | 2009-06-16 | 2015-06-09 | The Trustees Of Columbia University In The City Of New York | Autism-associated biomarkers and uses thereof |
| RU2395234C1 (ru) * | 2009-07-24 | 2010-07-27 | Учреждение Российской Академии Наук Институт Молекулярной Биологии Им. В.А. Энгельгардта Ран (Имб Ран) | ОПРЕДЕЛЕНИЕ СНИЖЕНИЯ УРОВНЯ мРНК ГЕНА ZG16 КАК СПОСОБ ДИАГНОСТИКИ РАКА ТОЛСТОЙ КИШКИ И НАБОР ДЛЯ ЕГО ОСУЩЕСТВЛЕНИЯ |
| CN108404115A (zh) | 2010-10-15 | 2018-08-17 | 纽约市哥伦比亚大学理事会 | 肥胖症-相关的基因和它们的蛋白和其用途 |
| EP2635299B1 (en) | 2010-11-02 | 2019-07-31 | The Trustees of Columbia University in the City of New York | Methods for treating hair loss disorders |
| WO2012142529A2 (en) | 2011-04-15 | 2012-10-18 | Genelux Corporation | Clonal strains of attenuated vaccinia viruses and methods of use thereof |
| CN102352368B (zh) * | 2011-09-29 | 2013-12-04 | 苏州大学 | Ing4与osm双基因共表达载体及其应用 |
| US9175312B2 (en) * | 2011-12-08 | 2015-11-03 | Virovek Incorporation | Vectors harboring toxic genes, methods and uses therefor |
| CN104169850B (zh) | 2012-01-12 | 2017-06-06 | 辛纳普蒂克斯公司 | 单层电容性成像传感器 |
| NZ627528A (en) * | 2012-02-15 | 2016-05-27 | Aileron Therapeutics Inc | Peptidomimetic macrocycles |
| US10039777B2 (en) | 2012-03-20 | 2018-08-07 | Neuro-Lm Sas | Methods and pharmaceutical compositions of the treatment of autistic syndrome disorders |
| KR102135601B1 (ko) | 2012-03-29 | 2020-07-20 | 더 트러스티스 오브 콜롬비아 유니버시티 인 더 시티 오브 뉴욕 | 탈모 질환의 치료 방법 |
| EP2968551B1 (en) | 2013-03-15 | 2021-05-05 | The Trustees of Columbia University in the City of New York | Fusion proteins and methods thereof |
| EP2978454A1 (en) * | 2013-03-27 | 2016-02-03 | Ge Healthcare As | Method and reagent for preparing a diagnostic composition |
| ES2878549T3 (es) * | 2013-06-18 | 2021-11-19 | Dnatrix Inc | Adenovirus oncolítico para su uso en el tratamiento del cáncer cerebral |
| US9542023B2 (en) | 2013-08-07 | 2017-01-10 | Synaptics Incorporated | Capacitive sensing using matrix electrodes driven by routing traces disposed in a source line layer |
| US20150091842A1 (en) | 2013-09-30 | 2015-04-02 | Synaptics Incorporated | Matrix sensor for image touch sensing |
| US9298325B2 (en) | 2013-09-30 | 2016-03-29 | Synaptics Incorporated | Processing system for a capacitive sensing device |
| US10042489B2 (en) | 2013-09-30 | 2018-08-07 | Synaptics Incorporated | Matrix sensor for image touch sensing |
| US9459367B2 (en) | 2013-10-02 | 2016-10-04 | Synaptics Incorporated | Capacitive sensor driving technique that enables hybrid sensing or equalization |
| US9274662B2 (en) | 2013-10-18 | 2016-03-01 | Synaptics Incorporated | Sensor matrix pad for performing multiple capacitive sensing techniques |
| US9081457B2 (en) | 2013-10-30 | 2015-07-14 | Synaptics Incorporated | Single-layer muti-touch capacitive imaging sensor |
| US9682123B2 (en) | 2013-12-20 | 2017-06-20 | The Trustees Of Columbia University In The City Of New York | Methods of treating metabolic disease |
| US9798429B2 (en) | 2014-02-28 | 2017-10-24 | Synaptics Incorporated | Guard electrodes in a sensing stack |
| CN104357408A (zh) * | 2014-03-13 | 2015-02-18 | 哈尔滨博翱生物医药技术开发有限公司 | 一种重组新城疫病毒及其应用 |
| US10133421B2 (en) | 2014-04-02 | 2018-11-20 | Synaptics Incorporated | Display stackups for matrix sensor |
| US9927832B2 (en) | 2014-04-25 | 2018-03-27 | Synaptics Incorporated | Input device having a reduced border region |
| US9690397B2 (en) | 2014-05-20 | 2017-06-27 | Synaptics Incorporated | System and method for detecting an active pen with a matrix sensor |
| PL3201234T3 (pl) | 2014-09-30 | 2019-04-30 | Diadem S R L | Przeciwciało wiążące liniowy epitop ludzkiego p53 i zastosowania diagnostyczne tego przeciwciała |
| US10175827B2 (en) | 2014-12-23 | 2019-01-08 | Synaptics Incorporated | Detecting an active pen using a capacitive sensing device |
| EP3925979A3 (en) | 2014-12-23 | 2022-03-23 | The Trustees of Columbia University in the City of New York | Fgfr-tacc fusion proteins and methods thereof |
| US10990148B2 (en) | 2015-01-05 | 2021-04-27 | Synaptics Incorporated | Central receiver for performing capacitive sensing |
| US9939972B2 (en) | 2015-04-06 | 2018-04-10 | Synaptics Incorporated | Matrix sensor with via routing |
| US10095948B2 (en) | 2015-06-30 | 2018-10-09 | Synaptics Incorporated | Modulation scheme for fingerprint sensing |
| US9715304B2 (en) | 2015-06-30 | 2017-07-25 | Synaptics Incorporated | Regular via pattern for sensor-based input device |
| US9720541B2 (en) | 2015-06-30 | 2017-08-01 | Synaptics Incorporated | Arrangement of sensor pads and display driver pads for input device |
| CN205028263U (zh) | 2015-09-07 | 2016-02-10 | 辛纳普蒂克斯公司 | 一种电容传感器 |
| US10037112B2 (en) | 2015-09-30 | 2018-07-31 | Synaptics Incorporated | Sensing an active device'S transmission using timing interleaved with display updates |
| US10067587B2 (en) | 2015-12-29 | 2018-09-04 | Synaptics Incorporated | Routing conductors in an integrated display device and sensing device |
| CN106933400B (zh) | 2015-12-31 | 2021-10-29 | 辛纳普蒂克斯公司 | 单层传感器图案和感测方法 |
| WO2018071814A1 (en) | 2016-10-14 | 2018-04-19 | The Trustees Of Columbia University In The City Of New York | Methods of treating alcohol abuse disorder |
| RU2760993C1 (ru) * | 2021-02-15 | 2021-12-02 | Сергей Александрович Никитин | Способ рентгеновской терапии рака легких |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4740463A (en) * | 1984-04-13 | 1988-04-26 | Massachusetts Institute Of Technology | Methods and artificial genes for antagonizing the function of an oncogene |
| ZA858044B (en) * | 1984-11-01 | 1987-05-27 | American Home Prod | Oral vaccines |
| US4748022A (en) * | 1985-03-25 | 1988-05-31 | Busciglio John A | Topical composition |
| US4822605A (en) * | 1986-02-18 | 1989-04-18 | Exovir, Inc. | Compositions and methods employing the same for the treatment of viral and cancerous skin lesions and the like |
| US5055400A (en) * | 1986-11-26 | 1991-10-08 | University Of Guelph | Leukotoxin gene of pasteurella haemolytica |
| US5166320A (en) * | 1987-04-22 | 1992-11-24 | University Of Connecticut | Carrier system and method for the introduction of genes into mammalian cells |
| US4980289A (en) * | 1987-04-27 | 1990-12-25 | Wisconsin Alumni Research Foundation | Promoter deficient retroviral vector |
| US5532220A (en) * | 1987-08-31 | 1996-07-02 | The Regents Of The University Of California | Genetic mechanisms of tumor suppression |
| US5017524A (en) * | 1989-02-13 | 1991-05-21 | Iscar Ltd. | Ceramic cutting tool |
| US5362623A (en) * | 1991-06-14 | 1994-11-08 | The John Hopkins University | Sequence specific DNA binding by p53 |
| US6800617B1 (en) * | 1989-03-29 | 2004-10-05 | The Johns Hopkins University | Methods for restoring wild-type p53 gene function |
| US5527676A (en) * | 1989-03-29 | 1996-06-18 | The Johns Hopkins University | Detection of loss of the wild-type P53 gene and kits therefor |
| US6677312B1 (en) * | 1989-03-29 | 2004-01-13 | The Johns Hopkins University | Methods for restoring wild-type p53 gene function |
| US5328470A (en) * | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| US5585362A (en) * | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| WO1992015680A1 (en) * | 1991-03-06 | 1992-09-17 | Board Of Regents, The University Of Texas System | Methods and compositions for the selective inhibition of gene expression |
| US6410010B1 (en) * | 1992-10-13 | 2002-06-25 | Board Of Regents, The University Of Texas System | Recombinant P53 adenovirus compositions |
| US5747469A (en) * | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| US5252479A (en) * | 1991-11-08 | 1993-10-12 | Research Corporation Technologies, Inc. | Safe vector for gene therapy |
| FR2688514A1 (fr) * | 1992-03-16 | 1993-09-17 | Centre Nat Rech Scient | Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant. |
| US5496731A (en) * | 1993-03-25 | 1996-03-05 | Xu; Hong-Ji | Broad-spectrum tumor suppressor genes, gene products and methods for tumor suppressor gene therapy |
| TW442569B (en) * | 1993-10-25 | 2001-06-23 | Canji Inc | Recombinant adenoviral vector |
| WO1995034671A1 (en) * | 1994-06-10 | 1995-12-21 | Genvec, Inc. | Complementary adenoviral vector systems and cell lines |
-
1996
- 1996-11-27 SK SK705-98A patent/SK70598A3/sk unknown
- 1996-11-27 KR KR1019980704074A patent/KR19990071795A/ko not_active Ceased
- 1996-11-27 PL PL96327009A patent/PL186018B1/pl unknown
- 1996-11-27 RU RU98111928/14A patent/RU2174409C2/ru active
- 1996-11-27 EP EP96942100A patent/EP0863984B1/en not_active Expired - Lifetime
- 1996-11-27 CN CNA2007100051249A patent/CN101028523A/zh active Pending
- 1996-11-27 AU AU11263/97A patent/AU722042B2/en not_active Expired
- 1996-11-27 JP JP9520700A patent/JP2000501394A/ja not_active Ceased
- 1996-11-27 CN CNB961995858A patent/CN1308450C/zh not_active Expired - Lifetime
- 1996-11-27 NZ NZ324168A patent/NZ324168A/en not_active IP Right Cessation
- 1996-11-27 CA CA002238829A patent/CA2238829A1/en not_active Abandoned
- 1996-11-27 AT AT96942100T patent/ATE325872T1/de active
- 1996-11-27 DE DE69636120T patent/DE69636120T2/de not_active Expired - Lifetime
- 1996-11-27 CZ CZ0165798A patent/CZ296810B6/cs not_active IP Right Cessation
- 1996-11-27 ES ES96942100T patent/ES2264145T3/es not_active Expired - Lifetime
- 1996-11-27 HU HU9902068A patent/HUP9902068A3/hu unknown
- 1996-11-27 DK DK96942100T patent/DK0863984T3/da active
- 1996-11-27 WO PCT/US1996/019083 patent/WO1997020047A1/en not_active Ceased
-
1998
- 1998-05-29 NO NO19982481A patent/NO982481L/no not_active Application Discontinuation
-
2001
- 2001-10-01 US US09/968,958 patent/US20020077313A1/en not_active Abandoned
-
2003
- 2003-03-24 US US10/395,864 patent/US20030166603A1/en not_active Abandoned
-
2005
- 2005-08-09 US US11/200,527 patent/US20060035857A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20060035857A1 (en) | 2006-02-16 |
| US20020077313A1 (en) | 2002-06-20 |
| PL186018B1 (pl) | 2003-09-30 |
| CN1207771A (zh) | 1999-02-10 |
| SK70598A3 (en) | 1999-04-13 |
| RU2174409C2 (ru) | 2001-10-10 |
| AU722042B2 (en) | 2000-07-20 |
| CZ296810B6 (cs) | 2006-06-14 |
| NO982481D0 (no) | 1998-05-29 |
| JP2000501394A (ja) | 2000-02-08 |
| DE69636120T2 (de) | 2006-11-30 |
| DE69636120D1 (de) | 2006-06-14 |
| PL327009A1 (en) | 1998-11-09 |
| CN1308450C (zh) | 2007-04-04 |
| CN101028523A (zh) | 2007-09-05 |
| HUP9902068A3 (en) | 2001-02-28 |
| EP0863984A1 (en) | 1998-09-16 |
| EP0863984B1 (en) | 2006-05-10 |
| WO1997020047A1 (en) | 1997-06-05 |
| NO982481L (no) | 1998-07-29 |
| US20030166603A1 (en) | 2003-09-04 |
| ES2264145T3 (es) | 2006-12-16 |
| ATE325872T1 (de) | 2006-06-15 |
| DK0863984T3 (da) | 2006-08-28 |
| KR19990071795A (ko) | 1999-09-27 |
| NZ324168A (en) | 2004-11-26 |
| HUP9902068A2 (hu) | 1999-10-28 |
| CZ165798A3 (cs) | 1998-12-16 |
| AU1126397A (en) | 1997-06-19 |
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| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Discontinued |