CA2232453A1 - Inhalation device - Google Patents
Inhalation device Download PDFInfo
- Publication number
- CA2232453A1 CA2232453A1 CA002232453A CA2232453A CA2232453A1 CA 2232453 A1 CA2232453 A1 CA 2232453A1 CA 002232453 A CA002232453 A CA 002232453A CA 2232453 A CA2232453 A CA 2232453A CA 2232453 A1 CA2232453 A1 CA 2232453A1
- Authority
- CA
- Canada
- Prior art keywords
- chamber
- dispersion chamber
- substance
- inhaler
- inhalation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000126 substance Substances 0.000 claims abstract description 56
- 239000012530 fluid Substances 0.000 claims abstract description 21
- 230000001105 regulatory effect Effects 0.000 claims abstract description 18
- 239000013543 active substance Substances 0.000 claims abstract description 9
- 239000006185 dispersion Substances 0.000 claims description 121
- 238000000034 method Methods 0.000 claims description 10
- 230000003213 activating effect Effects 0.000 claims description 9
- 230000007423 decrease Effects 0.000 claims description 5
- 229940112141 dry powder inhaler Drugs 0.000 claims description 5
- 230000001276 controlling effect Effects 0.000 claims 1
- 229940100563 gas for inhalation Drugs 0.000 claims 1
- 239000003570 air Substances 0.000 description 40
- 239000000843 powder Substances 0.000 description 10
- 239000002245 particle Substances 0.000 description 3
- 125000006850 spacer group Chemical group 0.000 description 3
- 230000004913 activation Effects 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- YPSXFMHXRZAGTG-UHFFFAOYSA-N 4-methoxy-2-[2-(5-methoxy-2-nitrosophenyl)ethyl]-1-nitrosobenzene Chemical compound COC1=CC=C(N=O)C(CCC=2C(=CC=C(OC)C=2)N=O)=C1 YPSXFMHXRZAGTG-UHFFFAOYSA-N 0.000 description 1
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 description 1
- 206010006458 Bronchitis chronic Diseases 0.000 description 1
- 241001137251 Corvidae Species 0.000 description 1
- 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 208000007451 chronic bronchitis Diseases 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 235000015108 pies Nutrition 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0086—Inhalation chambers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0013—Details of inhalators; Constructional features thereof with inhalation check valves
- A61M15/0016—Details of inhalators; Constructional features thereof with inhalation check valves located downstream of the dispenser, i.e. traversed by the product
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
- A61M15/0023—Mouthpieces therefor retractable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0086—Inhalation chambers
- A61M15/0088—Inhalation chambers with variable volume
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/07—General characteristics of the apparatus having air pumping means
- A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
- A61M2205/073—Syringe, piston type
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Nozzles (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9503344A SE9503344D0 (sv) | 1995-09-27 | 1995-09-27 | Inhalation device |
| SE9503344-5 | 1995-09-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2232453A1 true CA2232453A1 (en) | 1997-04-03 |
Family
ID=20399612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002232453A Abandoned CA2232453A1 (en) | 1995-09-27 | 1996-09-23 | Inhalation device |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6286506B1 (enExample) |
| EP (1) | EP0852508B1 (enExample) |
| JP (1) | JP3825051B2 (enExample) |
| CN (1) | CN1202117A (enExample) |
| AR (1) | AR003595A1 (enExample) |
| AT (1) | ATE228867T1 (enExample) |
| AU (1) | AU714995B2 (enExample) |
| BR (1) | BR9610693A (enExample) |
| CA (1) | CA2232453A1 (enExample) |
| CZ (1) | CZ92898A3 (enExample) |
| DE (1) | DE69625219T2 (enExample) |
| EE (1) | EE9800094A (enExample) |
| EG (1) | EG20990A (enExample) |
| HU (1) | HUP9802347A3 (enExample) |
| IL (1) | IL123612A0 (enExample) |
| IS (1) | IS4698A (enExample) |
| MY (1) | MY132402A (enExample) |
| NO (1) | NO981325L (enExample) |
| NZ (1) | NZ318915A (enExample) |
| PL (1) | PL325826A1 (enExample) |
| RU (1) | RU2181058C2 (enExample) |
| SE (1) | SE9503344D0 (enExample) |
| SG (2) | SG90046A1 (enExample) |
| SK (1) | SK39398A3 (enExample) |
| TR (2) | TR199900011T2 (enExample) |
| TW (1) | TW343925B (enExample) |
| WO (1) | WO1997011732A1 (enExample) |
| ZA (1) | ZA967805B (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9503344D0 (sv) | 1995-09-27 | 1995-09-27 | Astra Ab | Inhalation device |
| SE9700935D0 (sv) * | 1997-03-14 | 1997-03-14 | Astra Ab | Inhalation device |
| US6192876B1 (en) | 1997-12-12 | 2001-02-27 | Astra Aktiebolag | Inhalation apparatus and method |
| GEP20043260B (en) * | 1998-03-16 | 2004-06-25 | Nectar Therapeutics | Aerosolized Active Agent Delivery and Device for Realization Thereof |
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| SE0000935D0 (sv) * | 2000-03-21 | 2000-03-21 | Astrazeneca Ab | An inhalation device |
| US6705316B2 (en) | 2002-03-11 | 2004-03-16 | Battelle Pulmonary Therapeutics, Inc. | Pulmonary dosing system and method |
| JP4681231B2 (ja) | 2002-03-20 | 2011-05-11 | マンカインド コーポレイション | 吸入装置 |
| ATE486064T1 (de) | 2004-08-20 | 2010-11-15 | Mannkind Corp | Katalyse der diketopiperazinsynthese |
| HUE025151T2 (en) | 2004-08-23 | 2016-01-28 | Mannkind Corp | Diceto-piperazine salts for drug delivery |
| MX373000B (es) | 2005-09-14 | 2020-05-21 | Mannkind Corp | Metodo para formulacion de farmaco basado en el aumento de la afinidad de agentes activos hacia las superficies de microparticulas cristalinas. |
| DE102006007495A1 (de) * | 2006-02-17 | 2007-08-23 | Siegfried Generics International Ag | Dispergiereinheit |
| CN104383546B (zh) | 2006-02-22 | 2021-03-02 | 曼金德公司 | 用于改善包含二酮哌嗪和活性剂的微粒的药物性质的方法 |
| GB2479842B (en) | 2007-05-18 | 2012-03-14 | Malvern Instr Ltd | Method and apparatus for dispersing a sample of particulate material |
| EP2534957B1 (en) | 2007-12-14 | 2015-05-27 | AeroDesigns, Inc | Delivering aerosolizable products |
| US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
| MY155524A (en) | 2008-06-13 | 2015-10-30 | Mannkind Corp | A dry powder inhaler and system for drug delivery |
| EP2609954B1 (en) | 2008-06-20 | 2021-12-29 | MannKind Corporation | An interactive apparatus for real-time profiling of inhalation efforts |
| TWI494123B (zh) | 2008-08-11 | 2015-08-01 | Mannkind Corp | 超快起作用胰島素之用途 |
| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| US8538707B2 (en) | 2009-03-11 | 2013-09-17 | Mannkind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
| AU2010259943C1 (en) | 2009-06-12 | 2016-03-03 | Mannkind Corporation | Diketopiperazine microparticles with defined specific surface areas |
| JP5784622B2 (ja) | 2009-11-03 | 2015-09-24 | マンカインド コーポレ−ション | 吸入活動をシミュレートするための装置及び方法 |
| RU2531455C2 (ru) | 2010-06-21 | 2014-10-20 | Маннкайнд Корпорейшн | Системы и способы доставки сухих порошковых лекарств |
| MX353285B (es) | 2011-04-01 | 2018-01-05 | Mannkind Corp | Paquete de blister para cartuchos farmaceuticos. |
| WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
| HK1201475A1 (en) | 2011-10-24 | 2015-09-04 | Mannkind Corporation | Methods and compositions for treating pain |
| AU2013289957B2 (en) | 2012-07-12 | 2017-02-23 | Mannkind Corporation | Dry powder drug delivery systems and methods |
| WO2014066856A1 (en) | 2012-10-26 | 2014-05-01 | Mannkind Corporation | Inhalable influenza vaccine compositions and methods |
| BR112015023168B1 (pt) | 2013-03-15 | 2021-08-10 | Mannkind Corporation | Composição de 3,6-bis(n-fumaril-4-aminobutil)-2,5-dicetopiperazina cristalina, método de produção de partículas de 3,6-bis(n-fumaril-4-aminobutil)-2,5-dicetopiperazina e uso de uma composição de dicetopiperazina cristalina |
| US10286162B2 (en) | 2013-03-15 | 2019-05-14 | Christopher V. CIANCONE | Inhaler spacer and storage apparatus |
| BR122019026637B1 (pt) | 2013-07-18 | 2023-09-26 | Mannkind Corporation | Formulações farmacêuticas de pó seco e método para a fabricação de uma formulação de pó seco |
| CA2920488C (en) | 2013-08-05 | 2022-04-26 | Mannkind Corporation | Insufflation apparatus and methods |
| US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
| US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
| EP3693044A1 (en) | 2019-02-07 | 2020-08-12 | Koninklijke Philips N.V. | Breath actuated inhalers |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US523992A (en) * | 1894-08-07 | End post for wire fences | ||
| CA699313A (en) * | 1964-12-08 | G. Cheney Ralph | Atomizer | |
| US3636949A (en) * | 1969-08-08 | 1972-01-25 | Armstrong Kropp Dev Corp | Inhalation-initiated aerosol dispenser |
| SE411705B (sv) | 1976-11-09 | 1980-02-04 | Draco Ab | Anordning for generering av en avskermad, vesentligen drivmedelsfri aerosol |
| EP0069715B1 (en) | 1981-07-08 | 1986-11-05 | Aktiebolaget Draco | Powder inhalator |
| DE3429389C1 (de) * | 1984-08-09 | 1986-03-13 | Brugger, Inge, geb. Ritzau, 8130 Starnberg | Inhalator |
| SE453566B (sv) | 1986-03-07 | 1988-02-15 | Draco Ab | Anordning vid pulverinhalatorer |
| IT1217890B (it) * | 1988-06-22 | 1990-03-30 | Chiesi Farma Spa | Dispositivo per l'inalazione di aerosol dosati |
| GB9004781D0 (en) * | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
| DE4027749A1 (de) * | 1990-09-01 | 1992-03-05 | Pfeiffer Erich Gmbh & Co Kg | Austragvorrichtung fuer medien |
| SE9002895D0 (sv) | 1990-09-12 | 1990-09-12 | Astra Ab | Inhalation devices for dispensing powders i |
| RU2095092C1 (ru) | 1990-09-12 | 1997-11-10 | Бисгорд Ханс | Ингаляторное устройство для вдыхания активного порошкообразного или жидкого вещества |
| FR2676929B1 (fr) * | 1991-05-30 | 1994-02-11 | Aerosols Bouchage Ste Fse | Inhalateur de poudres. |
| US5341801A (en) * | 1991-12-03 | 1994-08-30 | Sandoz Ltd. | Inhaler |
| DE4237568C1 (de) | 1992-11-06 | 1994-05-11 | Dieter Dipl Ing Dr Med Koehler | Verfahren und Vorrichtung zum Erzeugen eines Aerosols |
| DE4239402A1 (de) | 1992-11-24 | 1994-05-26 | Bayer Ag | Pulverinhalator |
| SE9404439D0 (sv) | 1994-12-21 | 1994-12-21 | Astra Ab | Inhalation device |
| US5823183A (en) * | 1995-08-02 | 1998-10-20 | Innovative Devices | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
| SE9503344D0 (sv) | 1995-09-27 | 1995-09-27 | Astra Ab | Inhalation device |
-
1995
- 1995-09-27 SE SE9503344A patent/SE9503344D0/xx unknown
-
1996
- 1996-09-16 TW TW085111277A patent/TW343925B/zh active
- 1996-09-16 AR ARP960104371A patent/AR003595A1/es unknown
- 1996-09-16 ZA ZA967805A patent/ZA967805B/xx unknown
- 1996-09-23 CN CN96198415A patent/CN1202117A/zh active Pending
- 1996-09-23 US US08/836,777 patent/US6286506B1/en not_active Expired - Fee Related
- 1996-09-23 TR TR1999/00011T patent/TR199900011T2/xx unknown
- 1996-09-23 CZ CZ98928A patent/CZ92898A3/cs unknown
- 1996-09-23 HU HU9802347A patent/HUP9802347A3/hu unknown
- 1996-09-23 SG SG9901561A patent/SG90046A1/en unknown
- 1996-09-23 SK SK393-98A patent/SK39398A3/sk unknown
- 1996-09-23 AT AT96932123T patent/ATE228867T1/de not_active IP Right Cessation
- 1996-09-23 EE EE9800094A patent/EE9800094A/xx unknown
- 1996-09-23 AU AU71025/96A patent/AU714995B2/en not_active Ceased
- 1996-09-23 PL PL96325826A patent/PL325826A1/xx unknown
- 1996-09-23 NZ NZ318915A patent/NZ318915A/xx unknown
- 1996-09-23 SG SG9901558A patent/SG90045A1/en unknown
- 1996-09-23 RU RU98107243/14A patent/RU2181058C2/ru active
- 1996-09-23 BR BR9610693A patent/BR9610693A/pt unknown
- 1996-09-23 TR TR1998/00570T patent/TR199800570T2/xx unknown
- 1996-09-23 EP EP96932123A patent/EP0852508B1/en not_active Expired - Lifetime
- 1996-09-23 CA CA002232453A patent/CA2232453A1/en not_active Abandoned
- 1996-09-23 JP JP51334497A patent/JP3825051B2/ja not_active Expired - Lifetime
- 1996-09-23 IL IL12361296A patent/IL123612A0/xx unknown
- 1996-09-23 DE DE69625219T patent/DE69625219T2/de not_active Expired - Lifetime
- 1996-09-23 WO PCT/SE1996/001184 patent/WO1997011732A1/en not_active Ceased
- 1996-09-25 EG EG85896A patent/EG20990A/xx active
- 1996-09-27 MY MYPI96004009A patent/MY132402A/en unknown
-
1998
- 1998-03-24 IS IS4698A patent/IS4698A/is unknown
- 1998-03-24 NO NO981325A patent/NO981325L/no not_active Application Discontinuation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |