CA2231050A1 - Systeme permettant de rendre biodisponibles des agents bioalterants sensiblement non solubles - Google Patents

Systeme permettant de rendre biodisponibles des agents bioalterants sensiblement non solubles Download PDF

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Publication number
CA2231050A1
CA2231050A1 CA 2231050 CA2231050A CA2231050A1 CA 2231050 A1 CA2231050 A1 CA 2231050A1 CA 2231050 CA2231050 CA 2231050 CA 2231050 A CA2231050 A CA 2231050A CA 2231050 A1 CA2231050 A1 CA 2231050A1
Authority
CA
Canada
Prior art keywords
bio
composition
agent
water
soluble polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2231050
Other languages
English (en)
Inventor
Robert K. Yang
Andrea Blake
Steven Frisbee
Richard C. Fuisz
Garry L. Myers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BIOVAIL INTERNATIONAL Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2231050A1 publication Critical patent/CA2231050A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
    • A01N25/10—Macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne un procédé permettant de préparer un système pour administrer un agent bioaltérant et la composition ainsi préparée. L'invention consiste à former une dispersion solide de l'agent bioaltérant dans un état d'énergie accrue dans un polymère soluble à l'eau, qui est compatible avec l'agent bioaltérant. La transformation de l'agent bioaltérant en un état d'énergie accrue, et sa congélation dans cet état dans un polymère soluble à l'eau, se traduit par la disponibilité (biodisponibilité) d'un agent bioaltérant pour un biosystème lors de la dissolution du polymère. Ce procédé et cette composition se sont avérés extrêmement efficaces pour administrer des produits sensiblement non solubles et d'autres ingrédients bioaltérants.
CA 2231050 1995-09-07 1996-09-09 Systeme permettant de rendre biodisponibles des agents bioalterants sensiblement non solubles Abandoned CA2231050A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52453195A 1995-09-07 1995-09-07
US08/524,531 1995-09-07

Publications (1)

Publication Number Publication Date
CA2231050A1 true CA2231050A1 (fr) 1997-03-13

Family

ID=24089609

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2231050 Abandoned CA2231050A1 (fr) 1995-09-07 1996-09-09 Systeme permettant de rendre biodisponibles des agents bioalterants sensiblement non solubles

Country Status (5)

Country Link
EP (1) EP0952770A4 (fr)
JP (1) JPH11514979A (fr)
AU (1) AU7106996A (fr)
CA (1) CA2231050A1 (fr)
WO (1) WO1997008950A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU9587198A (en) * 1997-10-07 1999-04-27 Fuisz Technologies Ltd. Immediate release drug delivery forms
US6013280A (en) * 1997-10-07 2000-01-11 Fuisz Technologies Ltd. Immediate release dosage forms containing microspheres
US6350786B1 (en) * 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers
FR2795326B1 (fr) † 1999-06-28 2001-08-31 Adir Composition pharmaceutique solide thermoformable a liberation controlee
JP2001247408A (ja) * 2000-03-08 2001-09-11 Hodogaya Chem Co Ltd 酸溶解性ポリマーを用いた摂食性害虫駆除剤組成物
FR2818552B1 (fr) * 2000-12-26 2003-02-07 Servier Lab Compositions pharmaceutique solide thermoformable pour la liberation controlee d'ivabradine
DE60233874D1 (de) * 2001-06-22 2009-11-12 Pfizer Prod Inc Pharmazeutische zusammensetzungen enthaltend dispersionen aus arzneistoffen und neutralen polymeren
US8912174B2 (en) 2003-04-16 2014-12-16 Mylan Pharmaceuticals Inc. Formulations and methods for treating rhinosinusitis
US7811606B2 (en) 2003-04-16 2010-10-12 Dey, L.P. Nasal pharmaceutical formulations and methods of using the same
US9808471B2 (en) 2003-04-16 2017-11-07 Mylan Specialty Lp Nasal pharmaceutical formulations and methods of using the same
PT1748756E (pt) * 2004-03-10 2009-07-20 Bayer Schering Pharma Ag Composições compreendendo drospirenona molecularmente dispersa
WO2005117834A1 (fr) * 2004-05-27 2005-12-15 Janssen Pharmaceutica N.V. Dispersions solides d'un compose medicamenteux basique et d'un polymere renfermant des groupes acides
EP2054042B8 (fr) * 2006-06-30 2020-06-10 iCeutica Pty Ltd Procédés de préparation de composés biologiquement actifs sous forme de nanoparticules
JO3002B1 (ar) 2009-08-28 2016-09-05 Irm Llc مركبات و تركيبات كمثبطات كيناز بروتين
JP5953646B2 (ja) * 2009-11-24 2016-07-20 大正製薬株式会社 イブプロフェン含有固形製剤
PL2782557T3 (pl) * 2011-11-23 2019-03-29 Array Biopharma, Inc. Formulacje farmaceutyczne

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3146167A (en) * 1961-10-05 1964-08-25 Smith Kline French Lab Method of preparing sustained release pellets and products thereof
US3829564A (en) * 1970-07-17 1974-08-13 Commw Scient Ind Res Org Coated products for veterinary use
DE3612212A1 (de) * 1986-04-11 1987-10-15 Basf Ag Verfahren zur herstellung von festen pharmazeutischen formen
US4755397A (en) * 1986-12-24 1988-07-05 National Starch And Chemical Corporation Starch based particulate encapsulation process
FR2634397B2 (fr) * 1986-12-31 1991-04-19 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une proteine sous forme de nanoparticules
US4855326A (en) * 1987-04-20 1989-08-08 Fuisz Pharmaceutical Ltd. Rapidly dissoluble medicinal dosage unit and method of manufacture
US4948586A (en) * 1987-11-02 1990-08-14 Lim Technology Laboratories, Inc. Microencapsulated insecticidal pathogens
PL170554B1 (pl) * 1991-12-17 1996-12-31 Fuisz Technologies Ltd Sposób wytwarzania kompozycji przeciwwrzodowej PL PL PL
GB9200607D0 (en) * 1992-01-13 1992-03-11 Ethical Pharma Ltd Pharmaceutical compositions containing nifedipine and process for the preparation thereof
US5518730A (en) * 1992-06-03 1996-05-21 Fuisz Technologies Ltd. Biodegradable controlled release flash flow melt-spun delivery system
JPH08291063A (ja) * 1995-04-21 1996-11-05 Maruho Kk 易吸収性製剤及びその製造法

Also Published As

Publication number Publication date
EP0952770A1 (fr) 1999-11-03
JPH11514979A (ja) 1999-12-21
EP0952770A4 (fr) 1999-12-22
AU7106996A (en) 1997-03-27
WO1997008950A1 (fr) 1997-03-13

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