CA2230228C - Fluorescence lifetime-based imaging and spectroscopy in tissues and other random media - Google Patents

Fluorescence lifetime-based imaging and spectroscopy in tissues and other random media Download PDF

Info

Publication number
CA2230228C
CA2230228C CA002230228A CA2230228A CA2230228C CA 2230228 C CA2230228 C CA 2230228C CA 002230228 A CA002230228 A CA 002230228A CA 2230228 A CA2230228 A CA 2230228A CA 2230228 C CA2230228 C CA 2230228C
Authority
CA
Canada
Prior art keywords
tissue
fluorescence
emission
light
values
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002230228A
Other languages
English (en)
French (fr)
Other versions
CA2230228A1 (en
Inventor
Eva M. Sevick-Muraca
Dilip Y. Paithankar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Texas A&M University
Original Assignee
Texas A&M University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Texas A&M University filed Critical Texas A&M University
Publication of CA2230228A1 publication Critical patent/CA2230228A1/en
Application granted granted Critical
Publication of CA2230228C publication Critical patent/CA2230228C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G01J3/4406—Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
CA002230228A 1995-08-24 1996-08-23 Fluorescence lifetime-based imaging and spectroscopy in tissues and other random media Expired - Lifetime CA2230228C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US274695P 1995-08-24 1995-08-24
US60/002,746 1995-08-24
PCT/US1996/013658 WO1997008538A1 (en) 1995-08-24 1996-08-23 Fluorescence lifetime-based imaging and spectroscopy in tissues and other random media

Publications (2)

Publication Number Publication Date
CA2230228A1 CA2230228A1 (en) 1997-03-06
CA2230228C true CA2230228C (en) 2006-11-14

Family

ID=21702295

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002230228A Expired - Lifetime CA2230228C (en) 1995-08-24 1996-08-23 Fluorescence lifetime-based imaging and spectroscopy in tissues and other random media

Country Status (9)

Country Link
US (1) US5865754A (enExample)
EP (1) EP0846262A4 (enExample)
JP (1) JP3819032B2 (enExample)
CN (1) CN1200174A (enExample)
AU (1) AU1130797A (enExample)
CA (1) CA2230228C (enExample)
MX (1) MX9801351A (enExample)
NO (1) NO980750L (enExample)
WO (1) WO1997008538A1 (enExample)

Families Citing this family (267)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5353799A (en) * 1991-01-22 1994-10-11 Non Invasive Technology, Inc. Examination of subjects using photon migration with high directionality techniques
US6304771B1 (en) * 1993-10-29 2001-10-16 The Trustees Of The University Of Pennsylvania Systems and methods for imaging fluorophores
US5919140A (en) * 1995-02-21 1999-07-06 Massachusetts Institute Of Technology Optical imaging using time gated scattered light
US7328059B2 (en) * 1996-08-23 2008-02-05 The Texas A & M University System Imaging of light scattering tissues with fluorescent contrast agents
US6766183B2 (en) 1995-11-22 2004-07-20 Medtronic Minimed, Inc. Long wave fluorophore sensor compounds and other fluorescent sensor compounds in polymers
US6571119B2 (en) 1996-03-06 2003-05-27 Fuji Photo Film Co., Ltd. Fluorescence detecting apparatus
JP3796635B2 (ja) * 1996-03-06 2006-07-12 富士写真フイルム株式会社 蛍光検出装置
US6525862B2 (en) * 1996-10-30 2003-02-25 Photogen, Inc. Methods and apparatus for optical imaging
AU5253098A (en) 1996-11-08 1998-05-29 Purdue Research Foundation Particle analysis system and method
US5952664A (en) * 1997-01-17 1999-09-14 Imaging Diagnostic Systems, Inc. Laser imaging apparatus using biomedical markers that bind to cancer cells
US5963658A (en) * 1997-01-27 1999-10-05 University Of North Carolina Method and apparatus for detecting an abnormality within a host medium
US7865230B1 (en) 1997-02-07 2011-01-04 Texas A&M University System Method and system for detecting sentinel lymph nodes
US6208886B1 (en) * 1997-04-04 2001-03-27 The Research Foundation Of City College Of New York Non-linear optical tomography of turbid media
US6124597A (en) * 1997-07-07 2000-09-26 Cedars-Sinai Medical Center Method and devices for laser induced fluorescence attenuation spectroscopy
US6422994B1 (en) * 1997-09-24 2002-07-23 Olympus Optical Co., Ltd. Fluorescent diagnostic system and method providing color discrimination enhancement
JP2002500907A (ja) * 1998-01-26 2002-01-15 マサチユセツツ・インスチチユート・オブ・テクノロジイ 蛍光画像化用内視鏡
US6592847B1 (en) * 1998-05-14 2003-07-15 The General Hospital Corporation Intramolecularly-quenched near infrared flourescent probes
US6059820A (en) 1998-10-16 2000-05-09 Paradigm Medical Corporation Tissue cooling rod for laser surgery
US7107116B2 (en) * 1999-03-29 2006-09-12 Genex Technologies, Inc. Diffuse optical tomography system and method of use
CN1325022C (zh) * 1999-04-01 2007-07-11 成象诊断系统公司 使用约束肿瘤细胞的生化标记的激光成像装置
US6167297A (en) 1999-05-05 2000-12-26 Benaron; David A. Detecting, localizing, and targeting internal sites in vivo using optical contrast agents
WO2001020306A1 (en) * 1999-09-14 2001-03-22 The Research Foundation Of State University Of New York System and method for tomographic imaging of dynamic properties of a scattering medium
US6795195B1 (en) * 1999-09-14 2004-09-21 Research Foundation Of State University Of New York System and method for tomographic imaging of dynamic properties of a scattering medium
US6915154B1 (en) 1999-09-24 2005-07-05 National Research Council Of Canada Method and apparatus for performing intra-operative angiography
US20050182434A1 (en) 2000-08-11 2005-08-18 National Research Council Of Canada Method and apparatus for performing intra-operative angiography
US7054002B1 (en) 1999-10-08 2006-05-30 The Texas A&M University System Characterization of luminescence in a scattering medium
US7006676B1 (en) 2000-01-21 2006-02-28 Medical Optical Imaging, Inc. Method and apparatus for detecting an abnormality within a host medium utilizing frequency-swept modulation diffusion tomography
US20010032053A1 (en) * 2000-01-24 2001-10-18 Hielscher Andreas H. Imaging of a scattering medium using the equation of radiative transfer
JP2003522578A (ja) * 2000-02-18 2003-07-29 アーゴス インク 不均質組織における空間的に平均された励起−発光マップの生成
EP1290428A1 (en) * 2000-06-02 2003-03-12 Medicometrics APS Method and system for classifying a biological sample
US6748259B1 (en) * 2000-06-15 2004-06-08 Spectros Corporation Optical imaging of induced signals in vivo under ambient light conditions
US6801648B2 (en) * 2000-08-04 2004-10-05 Xuefeng Cheng Optical imaging system with symmetric optical probe
US6587703B2 (en) 2000-09-18 2003-07-01 Photonify Technologies, Inc. System and method for measuring absolute oxygen saturation
US6516209B2 (en) 2000-08-04 2003-02-04 Photonify Technologies, Inc. Self-calibrating optical imaging system
US6597931B1 (en) 2000-09-18 2003-07-22 Photonify Technologies, Inc. System and method for absolute oxygen saturation
AU2001293592A1 (en) 2000-10-06 2002-04-15 Peter R. Herman Multi-spectral fluorescence imaging and spectroscopy device
US7231243B2 (en) 2000-10-30 2007-06-12 The General Hospital Corporation Optical methods for tissue analysis
US9295391B1 (en) 2000-11-10 2016-03-29 The General Hospital Corporation Spectrally encoded miniature endoscopic imaging probe
US6615063B1 (en) * 2000-11-27 2003-09-02 The General Hospital Corporation Fluorescence-mediated molecular tomography
US7383076B2 (en) * 2000-11-27 2008-06-03 The General Hospital Corporation Fluorescence-mediated molecular tomography
US6826424B1 (en) * 2000-12-19 2004-11-30 Haishan Zeng Methods and apparatus for fluorescence and reflectance imaging and spectroscopy and for contemporaneous measurements of electromagnetic radiation with multiple measuring devices
US20030044353A1 (en) * 2001-01-05 2003-03-06 Ralph Weissleder Activatable imaging probes
US6609015B2 (en) * 2001-01-18 2003-08-19 Koninklijke Philips Electronics N.V. Analysis of a composition
AU2002251944A1 (en) * 2001-02-15 2002-09-04 Medtronic Minimed, Inc. Polymers functionalized with fluorescent boronate motifs
NO325061B1 (no) * 2001-03-06 2008-01-28 Photosense As Fremgangsmate og arrangement for bestemmelse av den optiske egenskap av et multisjiktvev
US6930777B1 (en) 2001-04-03 2005-08-16 The Texas A&M University System Method for characterizing particles in suspension from frequency domain photon migration measurements
JP2005509135A (ja) * 2001-04-03 2005-04-07 ザ、テクサス、エイ、アンド、エム、ユーニヴァーサティ、システィム 周波数領域光子伝播計測により懸濁系内の粒子を特徴付けする方法
EP2333523B1 (en) * 2001-04-30 2020-04-08 The General Hospital Corporation Method and apparatus for improving image clarity and sensitivity in optical coherence tomography using dynamic feedback to control focal properties and coherence gating
DE10297689B4 (de) * 2001-05-01 2007-10-18 The General Hospital Corp., Boston Verfahren und Gerät zur Bestimmung von atherosklerotischem Belag durch Messung von optischen Gewebeeigenschaften
ATE336717T1 (de) * 2001-05-17 2006-09-15 Xenogen Corp Verfahren und vorrichtung zur feststellung von zieltiefe, helligkeit und grösse in einer körperregion
US7116354B2 (en) 2001-06-20 2006-10-03 Xenogen Corporation Absolute intensity determination for a light source in low level light imaging systems
US7298415B2 (en) * 2001-07-13 2007-11-20 Xenogen Corporation Structured light imaging apparatus
US7045361B2 (en) 2001-09-12 2006-05-16 Medtronic Minimed, Inc. Analyte sensing via acridine-based boronate biosensors
US6980299B1 (en) * 2001-10-16 2005-12-27 General Hospital Corporation Systems and methods for imaging a sample
US20030109860A1 (en) * 2001-12-12 2003-06-12 Michael Black Multiple laser treatment
US20040082940A1 (en) * 2002-10-22 2004-04-29 Michael Black Dermatological apparatus and method
US20030109787A1 (en) * 2001-12-12 2003-06-12 Michael Black Multiple laser diagnostics
US20030216719A1 (en) * 2001-12-12 2003-11-20 Len Debenedictis Method and apparatus for treating skin using patterns of optical energy
US7310150B2 (en) * 2002-01-11 2007-12-18 The General Hospital Corporation Apparatus and method for low coherence ranging
US7355716B2 (en) * 2002-01-24 2008-04-08 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
US7649185B2 (en) * 2002-02-06 2010-01-19 Xenogen Corporation Fluorescent phantom device
US7629573B2 (en) * 2002-02-06 2009-12-08 Xenogen Corporation Tissue phantom calibration device for low level light imaging systems
US20110201924A1 (en) * 2002-04-30 2011-08-18 The General Hospital Corporation Method and Apparatus for Improving Image Clarity and Sensitivity in Optical Tomography Using Dynamic Feedback to Control Focal Properties and Coherence Gating
EP1514093B1 (en) 2002-06-04 2021-04-28 Visen Medical, Inc. Imaging volumes with arbitrary geometries in non-contact tomography
US7616985B2 (en) * 2002-07-16 2009-11-10 Xenogen Corporation Method and apparatus for 3-D imaging of internal light sources
US7599731B2 (en) * 2002-07-16 2009-10-06 Xenogen Corporation Fluorescent light tomography
AU2003278700A1 (en) * 2002-07-31 2004-02-16 Arryx, Inc. System and method of sorting materials using holographic laser steering
DE10255013B4 (de) * 2002-11-25 2004-12-09 Siemens Ag Verfahren und Vorrichtung zur Lokalisierung von Licht emittierenden Bereichen
US7297962B2 (en) * 2003-01-23 2007-11-20 Horiba Jobin Yvon, Inc. Method for performing spacially coordinated high speed fluorometric measurements
US7582882B2 (en) * 2003-01-23 2009-09-01 Horiba Jobin Yvon, Inc. Solid state multi frequency fluorometric measurements system and method
US7317194B2 (en) * 2003-01-23 2008-01-08 Horiba Jobin Yuon, Inc. Microscope for performing multiple frequency fluorometric measurements
US8054468B2 (en) 2003-01-24 2011-11-08 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
AU2004206998B2 (en) * 2003-01-24 2009-12-17 The General Hospital Corporation System and method for identifying tissue using low-coherence interferometry
EP1593095B1 (en) 2003-02-05 2019-04-17 The General Hospital Corporation Method and system for free space optical tomography of diffuse media
JP2006520638A (ja) * 2003-03-18 2006-09-14 コーニンクレッカ　フィリップス　エレクトロニクス　エヌ　ヴィ 監視による構成要素の分析
ES2441408T3 (es) * 2003-03-27 2014-02-04 The General Hospital Corporation Aparato para tratamiento dermatológico y rejuvenecimiento cutáneo fraccional
AU2004225188B2 (en) 2003-03-31 2010-04-15 The General Hospital Corporation Speckle reduction in optical coherence tomography by path length encoded angular compounding
CN101194270B (zh) * 2003-04-04 2012-07-11 光谱辨识公司 多谱生物统计传感器
US7181219B2 (en) 2003-05-22 2007-02-20 Lucent Technologies Inc. Wireless handover using anchor termination
KR101546024B1 (ko) * 2003-06-06 2015-08-20 더 제너럴 하스피탈 코포레이션 파장 동조 소스용 방법 및 장치
WO2004113889A1 (en) * 2003-06-20 2004-12-29 The Texas A & M University System Method and system for near-infrared fluorescence contrast-enhanced imaging with area illumination and area detection
WO2005002425A2 (en) * 2003-07-02 2005-01-13 U.S. Government As Represented By The Secretary Of The Army Wearable tissue viability diagnostic unit
EP1653876A1 (en) * 2003-07-11 2006-05-10 Reliant Technologies, Inc. Method and apparatus for fractional photo therapy of skin
US7920908B2 (en) * 2003-10-16 2011-04-05 David Hattery Multispectral imaging for quantitative contrast of functional and structural features of layers inside optically dense media such as tissue
EP3009815B1 (en) 2003-10-27 2022-09-07 The General Hospital Corporation Method and apparatus for performing optical imaging using frequency-domain interferometry
JP5214883B2 (ja) * 2003-11-28 2013-06-19 ザ ジェネラル ホスピタル コーポレイション 三次元分光的符号化撮像のための方法と装置
US7330032B2 (en) * 2003-12-30 2008-02-12 The Mitre Corporation Techniques for building-scale electrostatic tomography
US20050165427A1 (en) * 2004-01-22 2005-07-28 Jahns Scott E. Vessel sealing devices
US9011329B2 (en) 2004-04-19 2015-04-21 Searete Llc Lumenally-active device
US8337482B2 (en) * 2004-04-19 2012-12-25 The Invention Science Fund I, Llc System for perfusion management
US8092549B2 (en) * 2004-09-24 2012-01-10 The Invention Science Fund I, Llc Ciliated stent-like-system
US8361013B2 (en) * 2004-04-19 2013-01-29 The Invention Science Fund I, Llc Telescoping perfusion management system
US9801527B2 (en) * 2004-04-19 2017-10-31 Gearbox, Llc Lumen-traveling biological interface device
US20050234440A1 (en) * 2004-04-19 2005-10-20 Searete Llc, A Limited Liability Corporation Of The State Of Delaware System with a sensor for perfusion management
US20070244520A1 (en) * 2004-04-19 2007-10-18 Searete Llc Lumen-traveling biological interface device and method of use
US8024036B2 (en) * 2007-03-19 2011-09-20 The Invention Science Fund I, Llc Lumen-traveling biological interface device and method of use
US20070010868A1 (en) * 2004-04-19 2007-01-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Lumenally-active device
US8353896B2 (en) 2004-04-19 2013-01-15 The Invention Science Fund I, Llc Controllable release nasal system
DE102004024494B4 (de) * 2004-05-16 2019-10-17 Dürr Dental SE Medizinische Kamera
KR101239250B1 (ko) 2004-05-29 2013-03-05 더 제너럴 하스피탈 코포레이션 광간섭 단층촬영 화상 진단에서 반사층을 이용한 색 분산보상을 위한 프로세스, 시스템 및 소프트웨어 배열
US7413572B2 (en) * 2004-06-14 2008-08-19 Reliant Technologies, Inc. Adaptive control of optical pulses for laser medicine
JP4995720B2 (ja) 2004-07-02 2012-08-08 ザ ジェネラル ホスピタル コーポレイション ダブルクラッドファイバを有する内視鏡撮像プローブ
US20060217788A1 (en) * 2004-07-09 2006-09-28 Herron G S Method of using laser induced injury to activate topical prodrugs
EP1782020B1 (en) 2004-08-06 2012-10-03 The General Hospital Corporation Process, system and software arrangement for determining at least one location in a sample using an optical coherence tomography
EP1793730B1 (en) * 2004-08-24 2011-12-28 The General Hospital Corporation Process, system and software arrangement for determining elastic modulus
JP5324095B2 (ja) 2004-08-24 2013-10-23 ザ ジェネラル ホスピタル コーポレイション 血管セグメントを画像化する方法および装置
JP5215664B2 (ja) * 2004-09-10 2013-06-19 ザ ジェネラル ホスピタル コーポレイション 光学コヒーレンス撮像のシステムおよび方法
EP2329759B1 (en) * 2004-09-29 2014-03-12 The General Hospital Corporation System and method for optical coherence imaging
US20060122584A1 (en) * 2004-10-27 2006-06-08 Bommannan D B Apparatus and method to treat heart disease using lasers to form microchannels
EP1819270B1 (en) * 2004-10-29 2012-12-19 The General Hospital Corporation Polarization-sensitive optical coherence tomography
EP1807722B1 (en) * 2004-11-02 2022-08-10 The General Hospital Corporation Fiber-optic rotational device, optical system for imaging a sample
WO2006058049A1 (en) * 2004-11-24 2006-06-01 The General Hospital Corporation Common-path interferometer for endoscopic oct
JP2008521516A (ja) * 2004-11-29 2008-06-26 ザ ジェネラル ホスピタル コーポレイション サンプル上の複数の地点を同時に照射し検出することによって光学画像生成を実行する構成、装置、内視鏡、カテーテル、及び方法
US7966051B2 (en) * 2005-01-11 2011-06-21 Olympus Corporation Fluorescent agent concentration measuring apparatus, dose control apparatus, administration system, fluorescent agent concentration measuring method, and dose control method
US7729750B2 (en) * 2005-01-20 2010-06-01 The Regents Of The University Of California Method and apparatus for high resolution spatially modulated fluorescence imaging and tomography
JP2008538612A (ja) * 2005-04-22 2008-10-30 ザ ジェネラル ホスピタル コーポレイション スペクトルドメイン偏光感受型光コヒーレンストモグラフィを提供することの可能な構成、システム、及び方法
US20060239921A1 (en) 2005-04-26 2006-10-26 Novadaq Technologies Inc. Real time vascular imaging during solid organ transplant
US8351665B2 (en) * 2005-04-28 2013-01-08 The General Hospital Corporation Systems, processes and software arrangements for evaluating information associated with an anatomical structure by an optical coherence ranging technique
US8044996B2 (en) * 2005-05-11 2011-10-25 Xenogen Corporation Surface construction using combined photographic and structured light information
JP2008541096A (ja) * 2005-05-13 2008-11-20 ザ ジェネラル ホスピタル コーポレイション 化学的試料および生体試料の高感度検出用スペクトル領域光コヒーレンス反射計測を実行可能な装置、システム、および方法
JP2008542758A (ja) * 2005-05-31 2008-11-27 ザ ジェネラル ホスピタル コーポレイション スペクトルコード化ヘテロダイン干渉法を画像化に使用可能なシステム、方法、及び装置
US9060689B2 (en) * 2005-06-01 2015-06-23 The General Hospital Corporation Apparatus, method and system for performing phase-resolved optical frequency domain imaging
DE602006017558D1 (de) * 2005-08-09 2010-11-25 Gen Hospital Corp Gerät und verfahren zur durchführung von polarisationsbasierter quadraturdemodulation bei optischer kohärenztomographie
WO2007022220A2 (en) * 2005-08-16 2007-02-22 The General Hospital Corporation Arrangements and methods for imaging in vessels
US20070049996A1 (en) * 2005-08-29 2007-03-01 Reliant Technologies, Inc. Monitoring Method and Apparatus for Fractional Photo-Therapy Treatment
JP2009506835A (ja) * 2005-08-29 2009-02-19 リライアント・テクノロジーズ・インコーポレイテッド 熱誘起組織治療を監視し制御する方法および装置
US20070122344A1 (en) 2005-09-02 2007-05-31 University Of Rochester Medical Center Office Of Technology Transfer Intraoperative determination of nerve location
KR20080066705A (ko) * 2005-09-29 2008-07-16 더 제너럴 하스피탈 코포레이션 점진적으로 증가하는 분해능을 이용하여 하나 이상의 생물학적 샘플을 관찰 및 분석하기 위한 방법 및 장치
US7889348B2 (en) * 2005-10-14 2011-02-15 The General Hospital Corporation Arrangements and methods for facilitating photoluminescence imaging
WO2007056560A2 (en) * 2005-11-09 2007-05-18 Chemimage Corporation System and method for cytological analysis by raman spectroscopic imaging
US20080269617A1 (en) * 2005-11-10 2008-10-30 Koninklijke Philips Electronics, N.V. Absorption and Scattering Map Reconstruction For Optical Fluorescence Tomography
JP2009516847A (ja) * 2005-11-23 2009-04-23 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 混濁媒体の内部を画像化する装置
JP2009517115A (ja) * 2005-11-25 2009-04-30 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 光学蛍光トモグラフィ
WO2007082228A1 (en) * 2006-01-10 2007-07-19 The General Hospital Corporation Systems and methods for generating data based on one or more spectrally-encoded endoscopy techniques
US20070223006A1 (en) * 2006-01-19 2007-09-27 The General Hospital Corporation Systems and methods for performing rapid fluorescence lifetime, excitation and emission spectral measurements
WO2007084903A2 (en) 2006-01-19 2007-07-26 The General Hospital Corporation Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and method for producing one or more optical arrangements
PL1973466T3 (pl) 2006-01-19 2021-07-05 The General Hospital Corporation Balonowy cewnik do obrazowania
US20070171433A1 (en) * 2006-01-20 2007-07-26 The General Hospital Corporation Systems and processes for providing endogenous molecular imaging with mid-infrared light
US20080002211A1 (en) * 2006-01-20 2008-01-03 The General Hospital Corporation System, arrangement and process for providing speckle reductions using a wave front modulation for optical coherence tomography
WO2007084959A1 (en) * 2006-01-20 2007-07-26 The General Hospital Corporation Systems and methods for providing mirror tunnel microscopy
EP1986545A2 (en) * 2006-02-01 2008-11-05 The General Hospital Corporation Apparatus for applying a plurality of electro-magnetic radiations to a sample
JP5524487B2 (ja) * 2006-02-01 2014-06-18 ザ ジェネラル ホスピタル コーポレイション コンフォーマルレーザ治療手順を用いてサンプルの少なくとも一部分に電磁放射を放射する方法及びシステム。
EP1986562B1 (en) * 2006-02-01 2015-04-08 The General Hospital Corporation Apparatus for controlling at least one of at least two sections of at least one fiber
JP5519152B2 (ja) 2006-02-08 2014-06-11 ザ ジェネラル ホスピタル コーポレイション 光学顕微鏡法を用いて解剖学的サンプルに関わる情報を取得するための装置
JP2009527770A (ja) * 2006-02-24 2009-07-30 ザ ジェネラル ホスピタル コーポレイション 角度分解型のフーリエドメイン光干渉断層撮影法を遂行する方法及びシステム
WO2007103721A2 (en) * 2006-03-01 2007-09-13 The General Hospital Corporation System and method for providing cell specific laser therapy of atherosclerotic plaques by targeting light absorbers in macrophages
WO2007109540A2 (en) * 2006-03-17 2007-09-27 The General Hospital Corporation Arrangement, method and computer-accessible medium for identifying characteristics of at least a portion of a blood vessel contained within a tissue using spectral domain low coherence interferometry
CN101466298B (zh) * 2006-04-05 2011-08-31 通用医疗公司 用于样本的偏振敏感光频域成像的方法、装置和系统
US20120035438A1 (en) 2006-04-12 2012-02-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Path selection by a lumen traveling device in a body tub tree based on previous path
US20080058785A1 (en) * 2006-04-12 2008-03-06 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Autofluorescent imaging and target ablation
US20080058786A1 (en) * 2006-04-12 2008-03-06 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Autofluorescent imaging and target ablation
US8755866B2 (en) * 2006-05-03 2014-06-17 Covidien Lp Method and apparatus for lymph node mapping
US8175685B2 (en) * 2006-05-10 2012-05-08 The General Hospital Corporation Process, arrangements and systems for providing frequency domain imaging of a sample
WO2007133964A2 (en) * 2006-05-12 2007-11-22 The General Hospital Corporation Processes, arrangements and systems for providing a fiber layer thickness map based on optical coherence tomography images
CN101484067B (zh) * 2006-07-07 2011-07-06 皇家飞利浦电子股份有限公司 光学成像系统和方法
US20100165335A1 (en) * 2006-08-01 2010-07-01 The General Hospital Corporation Systems and methods for receiving and/or analyzing information associated with electro-magnetic radiation
JP2008043396A (ja) * 2006-08-11 2008-02-28 Olympus Corp 内視鏡システム
US10335038B2 (en) 2006-08-24 2019-07-02 Xenogen Corporation Spectral unmixing for in-vivo imaging
US20080050316A1 (en) * 2006-08-24 2008-02-28 Baylor College Of Medicine Molecular imaging of epithelial cells in lymph
US7875260B2 (en) * 2006-08-24 2011-01-25 Baylor College Of Medicine Imaging agents for functional imaging of lymphatic structures
US10775308B2 (en) * 2006-08-24 2020-09-15 Xenogen Corporation Apparatus and methods for determining optical tissue properties
CN101589301B (zh) * 2006-08-25 2012-11-07 通用医疗公司 利用体积测定过滤技术来增强光学相干断层成像的装置和方法
US20080058782A1 (en) * 2006-08-29 2008-03-06 Reliant Technologies, Inc. Method and apparatus for monitoring and controlling density of fractional tissue treatments
WO2008028298A1 (en) * 2006-09-06 2008-03-13 University Health Network Fluorescence quantification and image acquisition in highly turbid media
US20080161744A1 (en) 2006-09-07 2008-07-03 University Of Rochester Medical Center Pre-And Intra-Operative Localization of Penile Sentinel Nodes
WO2008033909A2 (en) * 2006-09-12 2008-03-20 The General Hospital Corporation Apparatus, probe and method for providing depth assessment in an anatomical structure
WO2008049118A2 (en) 2006-10-19 2008-04-24 The General Hospital Corporation Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample and effecting such portion(s)
US8155730B2 (en) 2006-10-24 2012-04-10 The Research Foundation Of State University Of New York Composition, method, system, and kit for optical electrophysiology
WO2008052189A2 (en) * 2006-10-26 2008-05-02 Reliant Technologies, Inc. Micropore delivery of active substances
JP2008148791A (ja) * 2006-12-14 2008-07-03 Olympus Corp 内視鏡システム
EP2102583A2 (en) 2007-01-19 2009-09-23 The General Hospital Corporation Apparatus and method for controlling ranging depth in optical frequency domain imaging
US20080206804A1 (en) * 2007-01-19 2008-08-28 The General Hospital Corporation Arrangements and methods for multidimensional multiplexed luminescence imaging and diagnosis
EP2662673A3 (en) * 2007-01-19 2014-06-18 The General Hospital Corporation Rotating disk reflection for fast wavelength scanning of dispersed broadband light
WO2008116010A1 (en) * 2007-03-19 2008-09-25 The General Hospital Corporation System and method for providing noninvasive diagnosis of compartment syndrome exemplary laser speckle imaging procedure
US20080234567A1 (en) * 2007-03-19 2008-09-25 The General Hospital Corporation Apparatus and method for providing a noninvasive diagnosis of internal bleeding
EP2132840A2 (en) * 2007-03-23 2009-12-16 The General Hospital Corporation Methods, arrangements and apparatus for utlizing a wavelength-swept laser using angular scanning and dispersion procedures
US10534129B2 (en) * 2007-03-30 2020-01-14 The General Hospital Corporation System and method providing intracoronary laser speckle imaging for the detection of vulnerable plaque
US8045177B2 (en) * 2007-04-17 2011-10-25 The General Hospital Corporation Apparatus and methods for measuring vibrations using spectrally-encoded endoscopy
US8224427B2 (en) * 2007-04-25 2012-07-17 Ruder Boscovic Institute Method for real time tumour visualisation and demarcation by means of photodynamic diagnosis
WO2008137637A2 (en) * 2007-05-04 2008-11-13 The General Hospital Corporation Methods, arrangements and systems for obtaining information associated with a sample using brillouin microscopy
US7692160B2 (en) * 2007-05-31 2010-04-06 General Electric Company Method and system of optical imaging for target detection in a scattering medium
US7812945B2 (en) * 2007-06-15 2010-10-12 Art Advanced Research Technologies Inc. Fluorescence tomography using line-by-line forward model
WO2009018456A2 (en) * 2007-07-31 2009-02-05 The General Hospital Corporation Systems and methods for providing beam scan patterns for high speed doppler optical frequency domain imaging
JP5536650B2 (ja) * 2007-08-31 2014-07-02 ザ ジェネラル ホスピタル コーポレイション 自己干渉蛍光顕微鏡検査のためのシステムと方法、及び、それに関連するコンピュータがアクセス可能な媒体
EP2197546A1 (en) * 2007-09-14 2010-06-23 Light Sciences Oncology, Inc. Systems, devices, and methods for photoactive assisted resection
WO2009036453A1 (en) * 2007-09-15 2009-03-19 The General Hospital Corporation Apparatus, computer-accessible medium and method for measuring chemical and/or molecular compositions of coronary atherosclerotic plaques in anatomical structures
JP2011500173A (ja) * 2007-10-12 2011-01-06 ザ ジェネラル ホスピタル コーポレイション 管腔解剖構造の光学イメージングのためのシステムおよびプロセス
WO2009059034A1 (en) * 2007-10-30 2009-05-07 The General Hospital Corporation System and method for cladding mode detection
US20090225324A1 (en) * 2008-01-17 2009-09-10 The General Hospital Corporation Apparatus for providing endoscopic high-speed optical coherence tomography
AU2009205950C1 (en) 2008-01-18 2015-08-06 Visen Medical, Inc. Fluorescent imaging agents
US8406860B2 (en) 2008-01-25 2013-03-26 Novadaq Technologies Inc. Method for evaluating blush in myocardial tissue
US11123047B2 (en) 2008-01-28 2021-09-21 The General Hospital Corporation Hybrid systems and methods for multi-modal acquisition of intravascular imaging data and counteracting the effects of signal absorption in blood
US9332942B2 (en) * 2008-01-28 2016-05-10 The General Hospital Corporation Systems, processes and computer-accessible medium for providing hybrid flourescence and optical coherence tomography imaging
US20090240139A1 (en) * 2008-03-18 2009-09-24 Steven Yi Diffuse Optical Tomography System and Method of Use
US20090240138A1 (en) * 2008-03-18 2009-09-24 Steven Yi Diffuse Optical Tomography System and Method of Use
US20090236541A1 (en) * 2008-03-24 2009-09-24 General Electric Company System and Methods for Optical Imaging
WO2009120228A1 (en) * 2008-03-24 2009-10-01 General Electric Company Image processing systems and methods for surgical applications
US8520921B2 (en) * 2008-03-27 2013-08-27 Koninklijke Philips Electronics N.V. Method for reconstructing a fluorescent image of the interior of a turbid medium and device for imaging the interior of a turbid medium
US10219742B2 (en) 2008-04-14 2019-03-05 Novadaq Technologies ULC Locating and analyzing perforator flaps for plastic and reconstructive surgery
EP2687235A3 (en) 2008-05-02 2014-11-05 Novadaq Technologies Inc. Methods for production and use of substance-loaded erythrocytes (S-LES) for observation and treatment of microvascular hemodynamics
EP2274572A4 (en) * 2008-05-07 2013-08-28 Gen Hospital Corp SYSTEM, METHOD AND COMPUTER MEDIUM FOR TRACKING A VASCULAR MOVEMENT IN A THREE-DIMENSIONAL CORONARTERTERIC MICROSCOPY
JP2011521237A (ja) 2008-05-20 2011-07-21 ユニバーシティー ヘルス ネットワーク 螢光に基づく画像化およびモニタリング用装置ならびにその方法
JP4575474B2 (ja) * 2008-06-11 2010-11-04 国立大学法人東京工業大学 生体組織識別装置および方法
EP2288948A4 (en) * 2008-06-20 2011-12-28 Gen Hospital Corp Fused fiber optic coupler arrangement and method for use thereof
US9254089B2 (en) * 2008-07-14 2016-02-09 The General Hospital Corporation Apparatus and methods for facilitating at least partial overlap of dispersed ration on at least one sample
WO2010042815A2 (en) * 2008-10-09 2010-04-15 Duke University Vhh antibody fragments for use in the detection and treatment of cancer
EP3330696B1 (en) 2008-12-10 2023-07-12 The General Hospital Corporation Systems, apparatus and methods for extending imaging depth range of optical coherence tomography through optical sub-sampling
JP2012515930A (ja) * 2009-01-26 2012-07-12 ザ ジェネラル ホスピタル コーポレーション 広視野の超解像顕微鏡を提供するためのシステム、方法及びコンピューターがアクセス可能な媒体
CN102308444B (zh) 2009-02-04 2014-06-18 通用医疗公司 利用高速光学波长调谐源的设备和方法
US9351642B2 (en) 2009-03-12 2016-05-31 The General Hospital Corporation Non-contact optical system, computer-accessible medium and method for measurement at least one mechanical property of tissue using coherent speckle technique(s)
US10492671B2 (en) 2009-05-08 2019-12-03 Novadaq Technologies ULC Near infra red fluorescence imaging for visualization of blood vessels during endoscopic harvest
US9595028B2 (en) 2009-06-08 2017-03-14 Boku, Inc. Systems and methods to add funds to an account via a mobile communication device
EP2453791B1 (en) 2009-07-14 2023-09-06 The General Hospital Corporation Apparatus for measuring flow and pressure within a vessel
US20110071403A1 (en) * 2009-09-21 2011-03-24 Board Of Regents Of The University Of Texas System Functional near-infrared fluorescence lymphatic mapping for diagnosing, accessing, monitoring and directing therapy of lymphatic disorders
EP2485641A4 (en) * 2009-10-06 2015-10-14 Gen Hospital Corp DEVICE AND METHOD FOR THE IMAGING OF INDIVIDUAL CELLS WITH EOSINOPHILES
US8518405B2 (en) 2009-10-08 2013-08-27 The University Of North Carolina At Charlotte Tumor specific antibodies and uses therefor
US9220412B2 (en) * 2009-11-19 2015-12-29 Modulated Imaging Inc. Method and apparatus for analysis of turbid media via single-element detection using structured illumination
JP5711260B2 (ja) * 2009-12-08 2015-04-30 ザ ジェネラル ホスピタル コーポレイション 光コヒーレンストモグラフィにより声帯襞を分析、診断及び治療モニタリングする方法及び装置
LU91641B1 (en) * 2010-01-21 2011-07-22 Ct De Rech Public Gabriel Lippmann Cancerous or pre-cancerous tissue visualization method and device
RS61066B1 (sr) 2010-03-05 2020-12-31 Massachusetts Gen Hospital Sistemi koji obezbeđuju mikroskopske slike najmanje jedne anatomske strukture na određenoj rezoluciji
JP5566751B2 (ja) * 2010-03-31 2014-08-06 富士フイルム株式会社 光断層情報生成装置、光強度分布算出方法および光強度分布算出プログラム
US9069130B2 (en) 2010-05-03 2015-06-30 The General Hospital Corporation Apparatus, method and system for generating optical radiation from biological gain media
US8681247B1 (en) * 2010-05-12 2014-03-25 Li-Cor, Inc. Field flattening correction method for fluorescence imaging system
EP2575597B1 (en) 2010-05-25 2022-05-04 The General Hospital Corporation Apparatus for providing optical imaging of structures and compositions
US9795301B2 (en) 2010-05-25 2017-10-24 The General Hospital Corporation Apparatus, systems, methods and computer-accessible medium for spectral analysis of optical coherence tomography images
WO2011153434A2 (en) 2010-06-03 2011-12-08 The General Hospital Corporation Apparatus and method for devices for imaging structures in or at one or more luminal organs
GB201011913D0 (en) * 2010-07-15 2010-09-01 Lux Innovate Ltd Detecting device
US8901516B2 (en) 2010-09-01 2014-12-02 Spectral Instruments Imaging, LLC Excitation light source assembly
US9347894B2 (en) 2010-09-01 2016-05-24 Spectral Instruments Imaging, LLC Methods and systems for producing visible light and x-ray image data
CN101975769A (zh) * 2010-09-17 2011-02-16 福建师范大学 一种基于不同波长光源激发的人体组织自体荧光检测系统
US9510758B2 (en) 2010-10-27 2016-12-06 The General Hospital Corporation Apparatus, systems and methods for measuring blood pressure within at least one vessel
US8721077B2 (en) 2011-04-29 2014-05-13 The General Hospital Corporation Systems, methods and computer-readable medium for determining depth-resolved physical and/or optical properties of scattering media by analyzing measured data over a range of depths
JP2014523536A (ja) 2011-07-19 2014-09-11 ザ ジェネラル ホスピタル コーポレイション 光コヒーレンストモグラフィーにおいて偏波モード分散補償を提供するためのシステム、方法、装置およびコンピュータアクセス可能な媒体
US10241028B2 (en) 2011-08-25 2019-03-26 The General Hospital Corporation Methods, systems, arrangements and computer-accessible medium for providing micro-optical coherence tomography procedures
JP2015502562A (ja) 2011-10-18 2015-01-22 ザ ジェネラル ホスピタル コーポレイション 再循環光学遅延を生成および／または提供するための装置および方法
JP5970785B2 (ja) * 2011-11-16 2016-08-17 ソニー株式会社 生体計測装置、生体計測方法、プログラムおよび記録媒体
EP2833776A4 (en) 2012-03-30 2015-12-09 Gen Hospital Corp PICTURE SYSTEM, PROCESS AND DISTAL CONNECTION TO MULTIDIRECTIONAL VISION DOSCOPY
WO2013177154A1 (en) 2012-05-21 2013-11-28 The General Hospital Corporation Apparatus, device and method for capsule microscopy
EP2863801B8 (en) 2012-06-21 2024-06-12 Stryker Corporation Quantification and analysis of angiography and perfusion
JP6227652B2 (ja) 2012-08-22 2017-11-08 ザ ジェネラル ホスピタル コーポレイション ソフトリソグラフィを用いてミニチュア内視鏡を製作するためのシステム、方法、およびコンピュータ・アクセス可能媒体
MX392469B (es) 2012-11-07 2025-03-24 Modulated Imaging Inc Eficiente formacion modulada de imagenes
US10893806B2 (en) 2013-01-29 2021-01-19 The General Hospital Corporation Apparatus, systems and methods for providing information regarding the aortic valve
WO2014121082A1 (en) 2013-02-01 2014-08-07 The General Hospital Corporation Objective lens arrangement for confocal endomicroscopy
JP6378311B2 (ja) 2013-03-15 2018-08-22 ザ ジェネラル ホスピタル コーポレイション 物体を特徴付ける方法とシステム
DE102013008003B4 (de) 2013-05-08 2015-03-19 Freshdetect Gmbh Messgerät zum Messen eines Oberflächenbelags auf einem Messobjekt, insbesondere auf einem Lebensmittel, und dessen Verwendung
EP2997354A4 (en) 2013-05-13 2017-01-18 The General Hospital Corporation Detecting self-interefering fluorescence phase and amplitude
US10117576B2 (en) 2013-07-19 2018-11-06 The General Hospital Corporation System, method and computer accessible medium for determining eye motion by imaging retina and providing feedback for acquisition of signals from the retina
EP4349242A3 (en) 2013-07-19 2024-06-19 The General Hospital Corporation Imaging apparatus and method which utilizes multidirectional field of view endoscopy
EP3910282B1 (en) 2013-07-26 2024-01-17 The General Hospital Corporation Method of providing a laser radiation with a laser arrangement utilizing optical dispersion for applications in fourier-domain optical coherence tomography
WO2015073871A2 (en) * 2013-11-14 2015-05-21 The George Washington University Systems and methods for determining lesion depth using fluorescence imaging
US9733460B2 (en) 2014-01-08 2017-08-15 The General Hospital Corporation Method and apparatus for microscopic imaging
WO2015116986A2 (en) 2014-01-31 2015-08-06 The General Hospital Corporation System and method for facilitating manual and/or automatic volumetric imaging with real-time tension or force feedback using a tethered imaging device
WO2015153982A1 (en) 2014-04-04 2015-10-08 The General Hospital Corporation Apparatus and method for controlling propagation and/or transmission of electromagnetic radiation in flexible waveguide(s)
EP3783034A1 (en) 2014-07-23 2021-02-24 Ohio State Innovation Foundation Methods and compositions related to antibody fragments that bind to tumor-associated glycoprotein 72 (tag-72)
CN115989999A (zh) 2014-07-24 2023-04-21 大学健康网络 用于诊断目的的数据的收集和分析
JP2017525435A (ja) 2014-07-25 2017-09-07 ザ ジェネラル ホスピタル コーポレイション インビボ・イメージングおよび診断のための機器、デバイスならびに方法
AU2015327665B2 (en) 2014-09-29 2018-09-27 Stryker European Operations Limited Imaging a target fluorophore in a biological material in the presence of autofluorescence
AU2014408488B2 (en) 2014-10-09 2019-07-18 Stryker European Operations Limited Quantification of absolute blood flow in tissue using fluorescence-mediated photoplethysmography
US10722301B2 (en) * 2014-11-03 2020-07-28 The George Washington University Systems and methods for lesion assessment
US9626754B2 (en) * 2015-05-28 2017-04-18 Jabil Circuit, Inc. System, apparatus and method for dispensed adhesive material inspection
US10084365B1 (en) 2016-02-04 2018-09-25 Harivallabh Pandya Electromagnetic machinery systems, device, assemblies, methods, processes, uses, and apparatus operable as a motor or generator with one or more stator coils, at least one permanent magnet rotor, and associated circuitry
WO2018145193A1 (en) 2017-02-10 2018-08-16 Novadaq Technologies ULC Open-field handheld fluorescence imaging systems and methods
US10378006B2 (en) 2017-04-19 2019-08-13 The Florida International University Board Of Trustees Near-infrared ray exposure system for biological studies
WO2019109091A1 (en) * 2017-12-03 2019-06-06 Munro Design & Technologies, Llc Digital image processing systems for three-dimensional imaging systems with image intensifiers and methods thereof
CN112449683B (zh) * 2018-04-26 2024-07-23 达特默斯大学托管会 用于确定表面下荧光物体的深度和浓度的装置和方法
DE102018126183B4 (de) * 2018-10-22 2020-08-06 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Bestimmung der Konzentration eines fluoreszierenden und/oder fluoreszenzmarkierten Analyten und Kalibrierverfahren zur Vorbereitung dieser Bestimmung
JP7240995B2 (ja) * 2019-09-17 2023-03-16 株式会社アドバンテスト ファントムおよび蛍光検出装置

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4541438A (en) * 1983-06-02 1985-09-17 The Johns Hopkins University Localization of cancerous tissue by monitoring infrared fluorescence emitted by intravenously injected porphyrin tumor-specific markers excited by long wavelength light
US5353799A (en) * 1991-01-22 1994-10-11 Non Invasive Technology, Inc. Examination of subjects using photon migration with high directionality techniques
US5022757A (en) * 1989-01-23 1991-06-11 Modell Mark D Heterodyne system and method for sensing a target substance
JP2525894B2 (ja) * 1989-04-07 1996-08-21 浜松ホトニクス株式会社 半導体試料の螢光特性検査装置
US5421337A (en) * 1989-04-14 1995-06-06 Massachusetts Institute Of Technology Spectral diagnosis of diseased tissue
US5070455A (en) * 1989-11-22 1991-12-03 Singer Imaging, Inc. Imaging system and method using scattered and diffused radiation
US5142372A (en) * 1990-03-08 1992-08-25 Alfano Robert R Three-dimensional optical imaging of semi-transparent and opaque objects using ultrashort light pulses, a streak camera and a coherent fiber bundle
US5213105A (en) * 1990-12-04 1993-05-25 Research Corporation Technologies, Inc. Frequency domain optical imaging using diffusion of intensity modulated radiation
CA2042075C (en) * 1991-05-08 2001-01-23 Branko Palcic Endoscopic imaging system
US5413098A (en) * 1991-12-24 1995-05-09 Sextant Medical Corporation Path constrained spectrophotometer and method for determination of spatial distribution of light or other radiation scattering and absorbing substances in a radiation scattering medium
JP3107914B2 (ja) * 1992-07-20 2000-11-13 浜松ホトニクス株式会社 散乱吸収体内部の吸収情報計測装置及び方法
US5452723A (en) * 1992-07-24 1995-09-26 Massachusetts Institute Of Technology Calibrated spectrographic imaging
US5421339A (en) * 1993-05-12 1995-06-06 Board Of Regents, The University Of Texas System Diagnosis of dysplasia using laser induced fluoroescence
US5340991A (en) * 1993-05-21 1994-08-23 The Board Of Regents Of The University Of Oklahoma Fluorokinetic analysis of diffusion from a vessel
JPH09504964A (ja) * 1993-10-29 1997-05-20 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア 拡散光を用いた対象物撮像
US5590660A (en) * 1994-03-28 1997-01-07 Xillix Technologies Corp. Apparatus and method for imaging diseased tissue using integrated autofluorescence
US5579773A (en) * 1994-09-30 1996-12-03 Martin Marietta Energy Systems, Inc. Laser-induced differential normalized fluorescence method for cancer diagnosis
US5647368A (en) * 1996-02-28 1997-07-15 Xillix Technologies Corp. Imaging system for detecting diseased tissue using native fluorsecence in the gastrointestinal and respiratory tract

Also Published As

Publication number Publication date
NO980750L (no) 1998-04-23
NO980750D0 (no) 1998-02-23
CN1200174A (zh) 1998-11-25
WO1997008538A1 (en) 1997-03-06
JP2000500228A (ja) 2000-01-11
US5865754A (en) 1999-02-02
MX9801351A (es) 1998-07-31
JP3819032B2 (ja) 2006-09-06
CA2230228A1 (en) 1997-03-06
AU1130797A (en) 1997-03-19
EP0846262A4 (en) 1999-11-03
EP0846262A1 (en) 1998-06-10

Similar Documents

Publication Publication Date Title
CA2230228C (en) Fluorescence lifetime-based imaging and spectroscopy in tissues and other random media
US7328059B2 (en) Imaging of light scattering tissues with fluorescent contrast agents
US7890157B2 (en) Method for fluorescence lifetime imaging microscopy and spectroscopy
US5485530A (en) Method and apparatus for multi-dimensional phase fluorescence lifetime imaging
Schneider et al. Rapid acquisition, analysis, and display of fluorescence lifetime-resolved images for real-time applications
Chang et al. Imaging of fluorescence in highly scattering media
EP1011422B1 (en) Imaging of light scattering tissues with fluorescent contrast agents
Reynolds et al. Multipixel techniques for frequency‐domain photon migration imaging
US7054002B1 (en) Characterization of luminescence in a scattering medium
Petrov et al. Coherent anti-Stokes Raman scattering imaging of microcalcifications associated with breast cancer
Thompson et al. Near-infrared fluorescence contrast-enhanced imaging with intensified charge-coupled device homodyne detection: measurement precision and accuracy
Godavarty et al. Fluorescence‐enhanced optical imaging of large phantoms using single and simultaneous dual point illumination geometries
CN119310057A (zh) 一种快速荧光寿命成像方法及装置
Redford et al. Real-time fluorescence lifetime imaging and FRET using fast gated image intensifiers
CA2346728C (en) Characterization of luminescence in a scattering medium
Hattery et al. Fluorescence measurement of localized deeply embedded physiological processes
Spring et al. Frequency-Domain FILM
Olga et al. A nonparametric method for analysis of fluorescence emission in combined time and wavelength dimensions
Redford Fast fluorescence lifetime imaging using a full-field homodyne system with applications in biology
Sriram et al. Exploring the Capability of Terahertz Imaging for Oral Diagnosis
Fernandez-Seara Digital frequency domain phosphorometer for oxygen measurements in biological systems
Gandjbakhche et al. Fluorescent photon migration theory for turbid biological media
Hawrysz et al. Frequency encoding of source position for multisource reflectance imaging measurements using frequency domain photon migration
Jo et al. Laguerre nonparametric deconvolution technique of time-resolved fluorescence data: application to the prediction of concentrations in a mixture of biochemical components
Maier et al. Quantitative Fluorescence in Tissue-Like Media

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20160823