CA2224859A1 - Inhibiteurs de ligands inhibant les proteines de liaison du facteur de croissance du type insuline et leurs procedes d'utilisation - Google Patents
Inhibiteurs de ligands inhibant les proteines de liaison du facteur de croissance du type insuline et leurs procedes d'utilisation Download PDFInfo
- Publication number
- CA2224859A1 CA2224859A1 CA002224859A CA2224859A CA2224859A1 CA 2224859 A1 CA2224859 A1 CA 2224859A1 CA 002224859 A CA002224859 A CA 002224859A CA 2224859 A CA2224859 A CA 2224859A CA 2224859 A1 CA2224859 A1 CA 2224859A1
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- Prior art keywords
- insulin
- growth factor
- igf
- igfbp
- ligand inhibitor
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
Procédés permettant d'augmenter le niveau des protéines libres biologiquement actives, y compris les facteurs de croissance du type insuline (IGF), et de traiter les états sensibles à l'IGF. Ces procédés consistent généralement à administrer un ou plusieurs inhibiteurs de ligands, qui inhibent la liaison de la protéine à une ou plusieurs protéines de liaison du facteur de croissance du type insuline. Les inhibiteurs de ligands appropriés comprennent les analogues de l'IGF-I ou l'IGF-II et les inhibiteurs moléculaires de petite taille.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US63393496A | 1996-04-17 | 1996-04-17 | |
US08/633,934 | 1996-04-17 | ||
PCT/US1997/006503 WO1997039032A1 (fr) | 1996-04-17 | 1997-04-17 | Inhibiteurs de ligands inhibant les proteines de liaison du facteur de croissance du type insuline et leurs procedes d'utilisation |
Publications (1)
Publication Number | Publication Date |
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CA2224859A1 true CA2224859A1 (fr) | 1997-10-23 |
Family
ID=24541756
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CA002224859A Abandoned CA2224859A1 (fr) | 1996-04-17 | 1997-04-17 | Inhibiteurs de ligands inhibant les proteines de liaison du facteur de croissance du type insuline et leurs procedes d'utilisation |
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Country | Link |
---|---|
EP (1) | EP0854884A1 (fr) |
JP (1) | JPH11508608A (fr) |
AU (1) | AU2676297A (fr) |
CA (1) | CA2224859A1 (fr) |
WO (1) | WO1997039032A1 (fr) |
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Publication number | Priority date | Publication date | Assignee | Title |
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EP0965596A1 (fr) | 1996-12-27 | 1999-12-22 | Daiichi Pharmaceutical Co., Ltd. | Procede pour elever la concentration de facteur de croissance libre apparente a l'insuline |
US6121416A (en) | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
US6420518B1 (en) | 1997-04-04 | 2002-07-16 | Genetech, Inc. | Insulin-like growth factor agonist molecules |
US7288516B1 (en) | 1999-09-20 | 2007-10-30 | Celtrix Pharmaceuticals, Inc. | Null IGF for the treatment of cancer |
DK1141014T3 (da) | 1999-01-06 | 2005-04-11 | Genentech Inc | Insulinlignende vækstfaktor (IGF) i mutantvariant |
AU762047B2 (en) | 1999-01-06 | 2003-06-19 | Genentech Inc. | Insulin-like growth factor (IGF) I mutant variants |
ES2266187T3 (es) | 2000-03-24 | 2007-03-01 | Genentech, Inc. | Uso de la insulina para el tratamiento de trastornos del cartilago. |
ATE389416T1 (de) | 2000-05-16 | 2008-04-15 | Genentech Inc | Behandlung von knorpelerkrankungen |
AU2002246619A1 (en) * | 2000-12-08 | 2003-06-23 | Neuronz Limited | Use of insuline-like growth factor-i for promoting remyelination of axons |
US7714020B2 (en) | 2001-05-24 | 2010-05-11 | Neuren Pharmaceuticals Limited | Treatment of non-convulsive seizures in brain injury using G-2-methyl-prolyl glutamate |
US7605177B2 (en) | 2001-05-24 | 2009-10-20 | Neuren Pharmaceuticals Limited | Effects of glycyl-2 methyl prolyl glutamate on neurodegeneration |
AU2002303856A1 (en) | 2001-05-24 | 2002-12-03 | Neuronz Limited | Gpe analogs and peptidomimetics |
EP2425823A1 (fr) * | 2002-04-05 | 2012-03-07 | Euro-Celtique S.A. | Préparation pharmaceutique contenant de l'oxycodone et de la naloxone |
ATE536186T1 (de) | 2003-09-12 | 2011-12-15 | Tercica Inc | Verfahren zur behandlung von igf-1 (insulin-like growth factor 1)-mangel |
BR112012029611A2 (pt) | 2010-05-21 | 2017-07-25 | Merrimack Pharmaceuticals Inc | proteína de fusão biespecífica, composição farmacêutica, método de tratamento de dano ao tecido em um indivíduo, método de promoção da regeração ou sobrevivência do tecido em um indivíduo e molécula de ácido nucleico |
MX2017015700A (es) * | 2015-06-04 | 2018-11-09 | Ospedale San Raffaele Srl | Igfbp3 y sus usos. |
MX367312B (es) * | 2015-06-04 | 2019-08-14 | Ospedale San Raffaele Srl | Inhibidor del eje igrbp3/tmem219 y diabetes. |
EP3865147A1 (fr) | 2015-10-02 | 2021-08-18 | Silver Creek Pharmaceuticals, Inc. | Protéines thérapeutiques bispécifiques pour la réparation de tissus |
WO2021005604A1 (fr) | 2019-07-11 | 2021-01-14 | Opko Biologics Ltd. | Igf-1 ou variants d'igf-1 à action prolongée et procédés de production associés |
WO2022216944A1 (fr) * | 2021-04-07 | 2022-10-13 | Mayo Foundation For Medical Education And Research | Procédés et matériaux d'inversion de l'instabilité de la plaque d'athérome |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1985000831A1 (fr) * | 1983-08-10 | 1985-02-28 | Amgen | Expression microbienne d'un facteur de croissance semblable a l'insuline |
-
1997
- 1997-04-17 WO PCT/US1997/006503 patent/WO1997039032A1/fr not_active Application Discontinuation
- 1997-04-17 JP JP9537398A patent/JPH11508608A/ja active Pending
- 1997-04-17 CA CA002224859A patent/CA2224859A1/fr not_active Abandoned
- 1997-04-17 AU AU26762/97A patent/AU2676297A/en not_active Abandoned
- 1997-04-17 EP EP97918725A patent/EP0854884A1/fr not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP0854884A1 (fr) | 1998-07-29 |
MX9710291A (es) | 1998-08-30 |
JPH11508608A (ja) | 1999-07-27 |
AU2676297A (en) | 1997-11-07 |
WO1997039032A1 (fr) | 1997-10-23 |
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