CA2223251A1 - Electrostatically depositing a medicament powder - Google Patents

Electrostatically depositing a medicament powder Download PDF

Info

Publication number
CA2223251A1
CA2223251A1 CA002223251A CA2223251A CA2223251A1 CA 2223251 A1 CA2223251 A1 CA 2223251A1 CA 002223251 A CA002223251 A CA 002223251A CA 2223251 A CA2223251 A CA 2223251A CA 2223251 A1 CA2223251 A1 CA 2223251A1
Authority
CA
Canada
Prior art keywords
substrate
charge
medicament
powder
charged
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002223251A
Other languages
English (en)
French (fr)
Inventor
Timothy Allen Pletcher
Pabitra Datta
Randall Eugene Mc Coy
Christopher Just Poux
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Delsys Pharmaceutical Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2223251A1 publication Critical patent/CA2223251A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B5/00—Electrostatic spraying apparatus; Spraying apparatus with means for charging the spray electrically; Apparatus for spraying liquids or other fluent materials by other electric means
    • B05B5/025—Discharge apparatus, e.g. electrostatic spray guns
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/02—Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
    • A61M15/025—Bubble jet droplet ejection devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B5/00—Electrostatic spraying apparatus; Spraying apparatus with means for charging the spray electrically; Apparatus for spraying liquids or other fluent materials by other electric means
    • B05B5/025—Discharge apparatus, e.g. electrostatic spray guns
    • B05B5/047—Discharge apparatus, e.g. electrostatic spray guns using tribo-charging
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03G—ELECTROGRAPHY; ELECTROPHOTOGRAPHY; MAGNETOGRAPHY
    • G03G15/00—Apparatus for electrographic processes using a charge pattern
    • G03G15/04—Apparatus for electrographic processes using a charge pattern for exposing, i.e. imagewise exposure by optically projecting the original image on a photoconductive recording material
    • G03G15/04036—Details of illuminating systems, e.g. lamps, reflectors
    • G03G15/04045—Details of illuminating systems, e.g. lamps, reflectors for exposing image information provided otherwise than by directly projecting the original image onto the photoconductive recording material, e.g. digital copiers
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03G—ELECTROGRAPHY; ELECTROPHOTOGRAPHY; MAGNETOGRAPHY
    • G03G15/00—Apparatus for electrographic processes using a charge pattern
    • G03G15/22—Apparatus for electrographic processes using a charge pattern involving the combination of more than one step according to groups G03G13/02 - G03G13/20
    • G03G15/221—Machines other than electrographic copiers, e.g. electrophotographic cameras, electrostatic typewriters
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03G—ELECTROGRAPHY; ELECTROPHOTOGRAPHY; MAGNETOGRAPHY
    • G03G15/00—Apparatus for electrographic processes using a charge pattern
    • G03G15/22—Apparatus for electrographic processes using a charge pattern involving the combination of more than one step according to groups G03G13/02 - G03G13/20
    • G03G15/32—Apparatus for electrographic processes using a charge pattern involving the combination of more than one step according to groups G03G13/02 - G03G13/20 in which the charge pattern is formed dotwise, e.g. by a thermal head
    • G03G15/321—Apparatus for electrographic processes using a charge pattern involving the combination of more than one step according to groups G03G13/02 - G03G13/20 in which the charge pattern is formed dotwise, e.g. by a thermal head by charge transfer onto the recording material in accordance with the image
    • G03G15/323—Apparatus for electrographic processes using a charge pattern involving the combination of more than one step according to groups G03G13/02 - G03G13/20 in which the charge pattern is formed dotwise, e.g. by a thermal head by charge transfer onto the recording material in accordance with the image by modulating charged particles through holes or a slit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/02—Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Electrostatic Spraying Apparatus (AREA)
CA002223251A 1995-06-06 1996-06-06 Electrostatically depositing a medicament powder Abandoned CA2223251A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/471,889 1995-06-06
US08/471,889 US5714007A (en) 1995-06-06 1995-06-06 Apparatus for electrostatically depositing a medicament powder upon predefined regions of a substrate

Publications (1)

Publication Number Publication Date
CA2223251A1 true CA2223251A1 (en) 1996-12-12

Family

ID=23873389

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002223251A Abandoned CA2223251A1 (en) 1995-06-06 1996-06-06 Electrostatically depositing a medicament powder

Country Status (7)

Country Link
US (5) US5714007A (enExample)
EP (1) EP0828564A4 (enExample)
JP (1) JPH11507272A (enExample)
KR (1) KR19990022213A (enExample)
AU (1) AU711460B2 (enExample)
CA (1) CA2223251A1 (enExample)
WO (1) WO1996039257A1 (enExample)

Families Citing this family (167)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7008668B2 (en) * 1995-05-09 2006-03-07 Phoqus Pharmaceuticals Limited Powder coating composition for electrostatic coating of pharmaceutical substrates
CN1183715A (zh) * 1995-05-09 1998-06-03 科洛康有限公司 适合药物基质静电包衣的粉末包衣物质
US5714007A (en) 1995-06-06 1998-02-03 David Sarnoff Research Center, Inc. Apparatus for electrostatically depositing a medicament powder upon predefined regions of a substrate
US6399143B1 (en) 1996-04-09 2002-06-04 Delsys Pharmaceutical Corporation Method for clamping and electrostatically coating a substrate
GB9623634D0 (en) * 1996-11-13 1997-01-08 Bpsi Holdings Inc Method and apparatus for the coating of substrates for pharmaceutical use
US6433154B1 (en) 1997-06-12 2002-08-13 Bristol-Myers Squibb Company Functional receptor/kinase chimera in yeast cells
US6004752A (en) * 1997-07-29 1999-12-21 Sarnoff Corporation Solid support with attached molecules
US6045753A (en) * 1997-07-29 2000-04-04 Sarnoff Corporation Deposited reagents for chemical processes
FR2768123B1 (fr) * 1997-09-09 1999-11-26 Soc Generale Pour Les Techniques Nouvelles Sgn Procede et dispositif de conditionnement de produits, tel des poudres, notamment magnetiques
ATE286414T1 (de) 1998-03-04 2005-01-15 Sarnoff Corp Spendervorrichtung für einen medizinischen trockenpulver inhalator
US6149774A (en) * 1998-06-10 2000-11-21 Delsys Pharmaceutical Corporation AC waveforms biasing for bead manipulating chucks
US6287595B1 (en) 1998-06-10 2001-09-11 Delsys Pharmaceuticals Corporation Biomedical assay device
AU763869B2 (en) 1998-06-10 2003-07-31 Delsys Pharmaceutical Corporation Pharmaceutical product and methods and apparatus for making same
US6063194A (en) 1998-06-10 2000-05-16 Delsys Pharmaceutical Corporation Dry powder deposition apparatus
US6152130A (en) * 1998-06-12 2000-11-28 Microdose Technologies, Inc. Inhalation device with acoustic control
US6142146A (en) * 1998-06-12 2000-11-07 Microdose Technologies, Inc. Inhalation device
KR100561223B1 (ko) * 1998-06-12 2006-03-15 마이크로도스 테크놀로지즈 인코포레이티드 약제 및 약물의 계량, 포장 및 운송
GB9814368D0 (en) * 1998-07-02 1998-09-02 Reckitt & Colmann Prod Ltd Inhalation of aerosol actives
US6652903B2 (en) 1998-07-09 2003-11-25 Lts Lohmann Therapie-Systeme Ag Dry-copying method for producing flat, individually dosed preparations of active agents
DE19830650C1 (de) * 1998-07-09 1999-08-12 Lohmann Therapie Syst Lts Trockenkopierprozeß zur Herstellung flächiger, einzeldosierter Wirkstoffzubereitungen
SE512386C2 (sv) * 1998-07-30 2000-03-06 Microdrug Ag Förfarande och anordning för klassificering av elektrostatiskt laddat pulverformigt material
WO2000018370A2 (en) 1998-09-25 2000-04-06 Delsys Pharmaceutical Corporation Liquid pharmaceutical for oral delivery
US6378518B1 (en) 1998-10-30 2002-04-30 Richard George Miekka Method for producing uniform small doses of finely divided substances
US6146685A (en) * 1998-11-05 2000-11-14 Delsys Pharmaceutical Corporation Method of deposition a dry powder and dispensing device
US6372246B1 (en) * 1998-12-16 2002-04-16 Ortho-Mcneil Pharmaceutical, Inc. Polyethylene glycol coating for electrostatic dry deposition of pharmaceuticals
US6923979B2 (en) * 1999-04-27 2005-08-02 Microdose Technologies, Inc. Method for depositing particles onto a substrate using an alternating electric field
GB9910505D0 (en) 1999-05-06 1999-07-07 Electrosols Ltd A method and apparatus for manufacturing consumable tablets
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
US7305986B1 (en) * 1999-07-23 2007-12-11 Mannkind Corporation Unit dose capsules for use in a dry powder inhaler
US7464706B2 (en) 1999-07-23 2008-12-16 Mannkind Corporation Unit dose cartridge and dry powder inhaler
US6428809B1 (en) 1999-08-18 2002-08-06 Microdose Technologies, Inc. Metering and packaging of controlled release medication
US6295194B1 (en) 1999-09-10 2001-09-25 Delsys Pharmaceutical Corporation Bead or particle manipulating chucks
US6427688B1 (en) 2000-02-01 2002-08-06 Dura Pharmaceuticals, Icn. Dry powder inhaler
GB0002305D0 (en) * 2000-02-01 2000-03-22 Phoqus Limited Power material for electrostatic application
CN1830536A (zh) * 2000-05-16 2006-09-13 明尼苏达大学评议会 采用多喷嘴喷射产生大批生产量的颗粒
IL153798A0 (en) * 2000-07-06 2003-07-31 Delsys Pharmaceutical Corp Method for formulating healthcare products with enhanced stability
SE516555C2 (sv) * 2000-08-04 2002-01-29 Microdrug Ag Elektropulver
SE0003082L (sv) * 2000-08-31 2002-01-29 Microdrug Ag Uppmätt elektrodos
GB2370243B (en) * 2000-12-21 2004-06-16 Phoqus Ltd Electrostatic application of powder material to solid dosage forms in an elect ric field
US7160432B2 (en) 2001-03-14 2007-01-09 Applied Materials, Inc. Method and composition for polishing a substrate
US20020136772A1 (en) * 2001-03-26 2002-09-26 Tai-Nang Huang Polymer synthesis
US20020168669A1 (en) * 2001-03-26 2002-11-14 Tai-Nang Huang Patterned polymer synthesis
US7247338B2 (en) * 2001-05-16 2007-07-24 Regents Of The University Of Minnesota Coating medical devices
US6588457B2 (en) 2001-05-30 2003-07-08 Richard A. Fotland Method for packaging uniform small doses of finely divided substances
US20040156903A1 (en) * 2002-05-22 2004-08-12 Abrams Andrew L.. Metering and packaging of controlled release medication
US20070087048A1 (en) * 2001-05-31 2007-04-19 Abrams Andrew L Oral dosage combination pharmaceutical packaging
CA2614902A1 (en) 2001-05-31 2002-12-05 Microdose Technologies, Inc. Metering and packaging of controlled release medication
US6702894B2 (en) * 2001-10-24 2004-03-09 Hewlett-Packard Development Company, L.P. Fluid ejection cartridge and system for dispensing a bioactive substance
US20040175331A1 (en) * 2001-06-07 2004-09-09 Figueroa Iddys D. Application of a bioactive agent to a delivery substrate
US6962715B2 (en) * 2001-10-24 2005-11-08 Hewlett-Packard Development Company, L.P. Method and dosage form for dispensing a bioactive substance
WO2003002264A1 (en) * 2001-06-26 2003-01-09 Tiger Microsystems, Inc. Dry powder electrostatic deposition method and apparatus
US6844048B2 (en) * 2001-07-11 2005-01-18 Sarnoff Corporation Substrates for powder deposition containing conductive domains
SE522558C2 (sv) * 2001-07-13 2004-02-17 Microdrug Ag Förfarande och anordning för styrning av överföring av elektriskt laddade partiklar av ett medicinskt pulver till en målarea på ett substratelement vid en dosutformningsprocess
SE522557C2 (sv) * 2001-07-13 2004-02-17 Microdrug Ag Förfarande och anordning för snabb neutralisering av ett skapat elektrostatiskt fält innefattande ett medicinskt pulver deponderad på en målarea vid en dosutformningsprocess
JP4252451B2 (ja) * 2001-08-30 2009-04-08 浜松ホトニクス株式会社 混合液の液滴形成方法及び混合液の液滴形成装置
US6686207B2 (en) 2001-10-12 2004-02-03 Massachusetts Institute Of Technology Manipulating micron scale items
US20030092278A1 (en) * 2001-11-13 2003-05-15 Fink Steven T. Plasma baffle assembly
SI1494732T1 (sl) 2002-03-20 2008-08-31 Mannking Corp Inhalacijski aparat
SE524990C2 (sv) * 2002-04-12 2004-11-09 Microdrug Ag Preparation av terapeutiskt torrt pulver samt förfarande för uppdelning och spridning i luft av medicinskt pulver
SE524957C2 (sv) * 2002-04-12 2004-11-02 Microdrug Ag Förfarande för uppdelning och fördelning i luft av torrt pulvermedikament
SE525027C2 (sv) * 2002-04-12 2004-11-16 Microdrug Ag Anordning utgörande en pulverlufthyvel
US6948537B2 (en) * 2002-05-31 2005-09-27 John Jones Systems and methods for collecting a particulate substance
JP4112935B2 (ja) * 2002-09-30 2008-07-02 浜松ホトニクス株式会社 混合液の液滴形成方法及び液滴形成装置、並びにインクジェット印刷方法及び装置
US20040081689A1 (en) * 2002-10-24 2004-04-29 Dunfield John Stephen Pharmaceutical dosage form and method of making
US6786591B2 (en) * 2002-10-24 2004-09-07 Hewlett-Packard Development Company, L.P. Fluid ejector apparatus and methods
US8999372B2 (en) * 2002-11-14 2015-04-07 Cure Pharmaceutical Corporation Methods for modulating dissolution, bioavailability, bioequivalence and drug delivery profile of thin film drug delivery systems, controlled-release thin film dosage formats, and methods for their manufacture and use
US20040191302A1 (en) 2003-03-28 2004-09-30 Davidson Robert S. Method and apparatus for minimizing heat, moisture, and shear damage to medicants and other compositions during incorporation of same with edible films
US20040131662A1 (en) 2003-11-12 2004-07-08 Davidson Robert S. Method and apparatus for minimizing heat, moisture, and shear damage to medicants and other compositions during incorporation of same with edible films
US9561182B2 (en) * 2003-08-22 2017-02-07 Cure Pharmaceutical Corporation Edible films for administration of medicaments to animals, methods for their manufacture and methods for their use for the treatment of animals
GB0229004D0 (en) * 2002-12-12 2003-01-15 Int Coatings Ltd Powder coating apparatus and process
GB0229003D0 (en) * 2002-12-12 2003-01-15 Int Coatings Ltd Powder coating process
US20040208931A1 (en) * 2002-12-30 2004-10-21 Friend David R Fast dissolving films for oral administration of drugs
US7130178B2 (en) * 2003-03-11 2006-10-31 Sarnoff Corporation Corona charging device and methods
EP1462801A3 (en) * 2003-03-24 2005-01-05 Tepnel Lifecodes Methods for determining the negative control value for multi-analyte assays
GB2420297B (en) * 2003-06-18 2006-11-15 Phoqus Pharmaceuticals Ltd Method and apparatus for the application of powder material to substrates
SE527069C2 (sv) 2003-06-19 2005-12-13 Mederio Ag Förfarande och anordning för administrering av läkemedelspulver
SE527200C2 (sv) * 2003-06-19 2006-01-17 Microdrug Ag Inhalatoranordning samt kombinerade doser av formaterol och fluticason
GB0314832D0 (en) * 2003-06-25 2003-07-30 Phoqus Pharmaceuticals Ltd Production of capsule shells and capsules
SE0303570L (sv) 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
GB0330171D0 (en) * 2003-12-30 2004-02-04 Phoqus Pharmaceuticals Ltd Method and apparatus for the application of powder material to substrates
US7380550B2 (en) 2004-01-30 2008-06-03 Hewlett-Packard Development Company, L.P. Systems and methods for particle detection
GB0407312D0 (en) * 2004-03-31 2004-05-05 Phoqus Pharmaceuticals Ltd Method and apparatus for the application of powder material to substrates
KR101273120B1 (ko) 2004-08-20 2013-06-13 맨카인드 코포레이션 다이케토피페라진 합성의 촉매 작용
BR122019022692B1 (pt) 2004-08-23 2023-01-10 Mannkind Corporation Composição terapêutica em pó seco contendo dicetopiperazina, pelo menos um tipo de cátion e um agente biologicamente ativo
US7325987B2 (en) * 2004-12-14 2008-02-05 Palo Alto Research Center Incorporated Printing method using quill-jet
US7342596B2 (en) * 2004-12-14 2008-03-11 Palo Alto Research Center Incorporated Method for direct xerography
US7325903B2 (en) * 2004-12-14 2008-02-05 Palo Alto Research Center Incorporated Quill-jet printer
US7286149B2 (en) * 2004-12-14 2007-10-23 Palo Alto Research Center Incorporated Direct xerography system
US20060251824A1 (en) * 2005-05-05 2006-11-09 Boulais Dennis R Coating of medical devices with solids
EP1909973B1 (en) 2005-07-15 2018-08-22 Micell Technologies, Inc. Polymer coatings containing drug powder of controlled morphology
US20090062909A1 (en) 2005-07-15 2009-03-05 Micell Technologies, Inc. Stent with polymer coating containing amorphous rapamycin
WO2007021972A2 (en) 2005-08-12 2007-02-22 Yeager Rick B System and method for medical monitoring and treatment through cosmetic monitoring and treatment
KR101486829B1 (ko) 2005-09-14 2015-01-29 맨카인드 코포레이션 결정질 미립자 표면에 대한 활성제의 친화력의 증가를 기반으로 하는 약물 제제의 방법
US9108217B2 (en) 2006-01-31 2015-08-18 Nanocopoeia, Inc. Nanoparticle coating of surfaces
CA2641117C (en) * 2006-01-31 2018-01-02 Nanocopoeia, Inc. Nanoparticle coating of surfaces
US7951428B2 (en) * 2006-01-31 2011-05-31 Regents Of The University Of Minnesota Electrospray coating of objects
EP1986679B1 (en) 2006-02-22 2017-10-25 MannKind Corporation A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
GB0605723D0 (en) 2006-03-23 2006-05-03 3M Innovative Properties Co Powder filling processes
CA2996768C (en) 2006-04-26 2020-12-08 Micell Technologies, Inc. Coatings containing multiple drugs
US9265865B2 (en) * 2006-06-30 2016-02-23 Boston Scientific Scimed, Inc. Stent having time-release indicator
US7976872B2 (en) * 2006-07-24 2011-07-12 L. Perrigo Company Method for distributing a pharmaceutically active compound in an excipient
US20080026062A1 (en) * 2006-07-31 2008-01-31 Isaac Farr Pharmaceutical compositions including nano-sized active agent
US20080026040A1 (en) * 2006-07-31 2008-01-31 Isaac Farr Active agent-releasing dosage forms
US8184901B2 (en) * 2007-02-12 2012-05-22 Tcms Transparent Beauty Llc System and method for applying a reflectance modifying agent to change a person's appearance based on a digital image
US8942775B2 (en) * 2006-08-14 2015-01-27 Tcms Transparent Beauty Llc Handheld apparatus and method for the automated application of cosmetics and other substances
US8636767B2 (en) 2006-10-02 2014-01-28 Micell Technologies, Inc. Surgical sutures having increased strength
US8733274B2 (en) * 2006-10-20 2014-05-27 Hewlett-Packard Development Company, L.P. Tube mounted inkjet printhead die
CN102886326A (zh) 2006-10-23 2013-01-23 米歇尔技术公司 用于在涂覆过程中为基底充电的保持器
US7867548B2 (en) * 2006-10-27 2011-01-11 Hewlett-Packard Development Company, L.P. Thermal ejection of solution having solute onto device medium
US9040816B2 (en) * 2006-12-08 2015-05-26 Nanocopoeia, Inc. Methods and apparatus for forming photovoltaic cells using electrospray
CN101711137B (zh) 2007-01-08 2014-10-22 米歇尔技术公司 具有可生物降解层的支架
US11426494B2 (en) 2007-01-08 2022-08-30 MT Acquisition Holdings LLC Stents having biodegradable layers
CN101641161B (zh) * 2007-02-12 2012-04-18 Tcms剔透美丽有限责任公司 用于向人类皮肤静电施与试剂的系统和方法
US9433516B2 (en) 2007-04-17 2016-09-06 Micell Technologies, Inc. Stents having controlled elution
JP2010527746A (ja) 2007-05-25 2010-08-19 ミセル テクノロジーズ、インコーポレイテッド メディカルデバイスコーティング用ポリマーフィルム
US10092082B2 (en) * 2007-05-29 2018-10-09 Tcms Transparent Beauty Llc Apparatus and method for the precision application of cosmetics
US20090087483A1 (en) * 2007-09-27 2009-04-02 Sison Raymundo A Oral dosage combination pharmaceutical packaging
US8439033B2 (en) 2007-10-09 2013-05-14 Microdose Therapeutx, Inc. Inhalation device
US20100327476A1 (en) * 2008-02-08 2010-12-30 Boehringer Ingelheim International Gmbh Method and device for filling capsules
BRPI0910875B8 (pt) * 2008-03-27 2021-06-22 Mannkind Corp sistema de inalação de pó seco
SG192524A1 (en) 2008-04-17 2013-08-30 Micell Technologies Inc Stents having bioabsorbable layers
JP5448501B2 (ja) * 2008-06-10 2014-03-19 株式会社菊水製作所 粉末圧縮成形機
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
TWI677355B (zh) 2008-06-13 2019-11-21 美商曼凱公司 用於藥物傳輸之乾粉吸入器及系統
ES2421385T3 (es) 2008-06-20 2013-09-02 Mannkind Corp Aparato interactivo y procedimiento para establecer el perfil, en tiempo real, de esfuerzos de inhalación
CA2730995C (en) 2008-07-17 2016-11-22 Micell Technologies, Inc. Drug delivery medical device
TWI614024B (zh) 2008-08-11 2018-02-11 曼凱公司 超快起作用胰島素之用途
US8834913B2 (en) 2008-12-26 2014-09-16 Battelle Memorial Institute Medical implants and methods of making medical implants
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
AU2010220056B2 (en) 2009-03-04 2015-04-02 Regenera Pharma Ltd. Therapeutic uses of mastic gum fractions
EA201492273A1 (ru) 2009-03-04 2015-04-30 Редженера Фарма Лтд. Композиции полимера мирцена
EP2676695A3 (en) 2009-03-11 2017-03-01 MannKind Corporation Apparatus, system and method for measuring resistance of an inhaler
WO2010111232A2 (en) 2009-03-23 2010-09-30 Micell Technologies, Inc. Drug delivery medical device
CA2757276C (en) 2009-04-01 2017-06-06 Micell Technologies, Inc. Coated stents
MY186975A (en) 2009-06-12 2021-08-26 Mannkind Corp Diketopiperazine microparticles with defined specific surface areas
EP2453834A4 (en) 2009-07-16 2014-04-16 Micell Technologies Inc MEDICAL DEVICE DISPENSING MEDICINE
US9016147B2 (en) 2009-11-03 2015-04-28 Mannkind Corporation Apparatus and method for simulating inhalation efforts
JP6017961B2 (ja) 2010-01-05 2016-11-02 マイクロドース セラピューテクス，インコーポレイテッド 吸入デバイスおよび方法
KR101084185B1 (ko) * 2010-01-12 2011-11-17 삼성모바일디스플레이주식회사 패턴 형성 방법 및 유기 발광 소자의 제조방법
US11369498B2 (en) 2010-02-02 2022-06-28 MT Acquisition Holdings LLC Stent and stent delivery system with improved deliverability
US8795762B2 (en) 2010-03-26 2014-08-05 Battelle Memorial Institute System and method for enhanced electrostatic deposition and surface coatings
CA2797110C (en) 2010-04-22 2020-07-21 Micell Technologies, Inc. Stents and other devices having extracellular matrix coating
MX359281B (es) 2010-06-21 2018-09-21 Mannkind Corp Sistema y metodos para suministrar un farmaco en polvo seco.
WO2012009684A2 (en) 2010-07-16 2012-01-19 Micell Technologies, Inc. Drug delivery medical device
WO2012032523A2 (en) 2010-09-07 2012-03-15 Regenera Pharma Ltd. Compositions comprising acidic extracts of mastic gum
CA2810842C (en) 2010-09-09 2018-06-26 Micell Technologies, Inc. Macrolide dosage forms
WO2012092504A2 (en) 2010-12-30 2012-07-05 Micell Technologies, Inc. Nanoparticle and surface-modified particulate coatings, coated balloons, and methods therefore
US8925726B2 (en) 2011-04-01 2015-01-06 Mannkind Corporation Blister package for pharmaceutical cartridges
WO2012166819A1 (en) 2011-05-31 2012-12-06 Micell Technologies, Inc. System and process for formation of a time-released, drug-eluting transferable coating
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
WO2013012689A1 (en) 2011-07-15 2013-01-24 Micell Technologies, Inc. Drug delivery medical device
JP2015501178A (ja) 2011-10-18 2015-01-15 ミセル テクノロジーズ，インク． 薬物送達のための医療用デバイス
US10188772B2 (en) 2011-10-18 2019-01-29 Micell Technologies, Inc. Drug delivery medical device
CA2852536A1 (en) 2011-10-24 2013-05-02 Mannkind Corporation Methods and compositions for treating pain
CA2878457C (en) 2012-07-12 2021-01-19 Mannkind Corporation Dry powder drug delivery systems and methods
MX354365B (es) 2012-07-19 2018-02-28 Adamis Pharmaceuticals Corp Aparato alimentador de polvo.
EP2911690A1 (en) 2012-10-26 2015-09-02 MannKind Corporation Inhalable influenza vaccine compositions and methods
US10702453B2 (en) 2012-11-14 2020-07-07 Xerox Corporation Method and system for printing personalized medication
WO2014089174A2 (en) * 2012-12-06 2014-06-12 Aerodesigns, Inc. Aerosol dispenser with edible cartridge
CN110269959A (zh) 2013-03-12 2019-09-24 脉胜医疗技术公司 可生物吸收的生物医学植入物
EP2970149B1 (en) 2013-03-15 2019-08-21 MannKind Corporation Microcrystalline diketopiperazine compositions and methods
AU2014265460B2 (en) 2013-05-15 2018-10-18 Micell Technologies, Inc. Bioabsorbable biomedical implants
EP3021834A1 (en) 2013-07-18 2016-05-25 MannKind Corporation Heat-stable dry powder pharmaceutical compositions and methods
CN105517607A (zh) 2013-08-05 2016-04-20 曼金德公司 吹入设备和方法
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
EP3159278A1 (en) 2015-10-23 2017-04-26 Arven Ilac Sanayi Ve Ticaret A.S. Blister for tiotropium bromide inhalable formulation

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US30401A (en) * 1860-10-16 Improvement in evaporation of cane-juice
US3831606A (en) * 1971-02-19 1974-08-27 Alza Corp Auto inhaler
US3971377A (en) * 1974-06-10 1976-07-27 Alza Corporation Medicament dispensing process for inhalation therapy
DE2502251A1 (de) * 1975-01-17 1976-07-22 Schering Ag Vorrichtung zur inhalation pulverfoermiger feststoffe
ZA767136B (en) * 1975-12-15 1977-10-26 Hoffmann La Roche Novel dosage form
US4197289A (en) * 1975-12-15 1980-04-08 Hoffmann-La Roche Inc. Novel dosage forms
US4349531A (en) * 1975-12-15 1982-09-14 Hoffmann-La Roche Inc. Novel dosage form
US4088093A (en) * 1976-04-13 1978-05-09 Continental Can Company, Inc. Web coating and powder feed
US4160257A (en) * 1978-07-17 1979-07-03 Dennison Manufacturing Company Three electrode system in the generation of electrostatic images
USRE30401E (en) * 1978-07-07 1980-09-09 Illinois Tool Works Inc. Gasless ion plating
DE2849494A1 (de) * 1978-11-15 1980-05-29 Voss Gunter M Verfahren zur herstellung von arzneimittel-formlingen
US4324812A (en) * 1980-05-29 1982-04-13 Ransburg Corporation Method for controlling the flow of coating material
US4628227A (en) * 1980-10-06 1986-12-09 Dennison Manufacturing Company Mica-electrode laminations for the generation of ions in air
IT1203660B (it) * 1982-10-08 1989-02-15 Glaxo Group Ltd Dispositivi per somministrare farmaci a pazienti e confezione di blister per essi
JPS59150760A (ja) * 1983-02-18 1984-08-29 Fuji Xerox Co Ltd 静電記録ヘツドの製造方法および装置
JPS59152760A (ja) 1983-02-18 1984-08-31 Fujitsu Ltd エラ−検出方式
US4538163A (en) * 1983-03-02 1985-08-27 Xerox Corporation Fluid jet assisted ion projection and printing apparatus
US4570630A (en) * 1983-08-03 1986-02-18 Miles Laboratories, Inc. Medicament inhalation device
GB8328808D0 (en) * 1983-10-28 1983-11-30 Riker Laboratories Inc Inhalation responsive dispensers
DE3345722A1 (de) * 1983-12-17 1985-06-27 Boehringer Ingelheim KG, 6507 Ingelheim Inhalator
GB2178965B (en) * 1985-07-30 1988-08-03 Glaxo Group Ltd Devices for administering medicaments to patients
US5031610A (en) * 1987-05-12 1991-07-16 Glaxo Inc. Inhalation device
US4918468A (en) * 1988-11-14 1990-04-17 Dennison Manufacturing Company Method and apparatus for charged particle generation
US5176132A (en) * 1989-05-31 1993-01-05 Fisons Plc Medicament inhalation device and formulation
US5014076A (en) * 1989-11-13 1991-05-07 Delphax Systems Printer with high frequency charge carrier generation
US5027136A (en) * 1990-01-16 1991-06-25 Dennison Manufacturing Company Method and apparatus for charged particle generation
US4992807A (en) * 1990-05-04 1991-02-12 Delphax Systems Gray scale printhead system
US5115803A (en) * 1990-08-31 1992-05-26 Minnesota Mining And Manufacturing Company Aerosol actuator providing increased respirable fraction
US5328539A (en) * 1990-11-28 1994-07-12 H. B. Fuller Licensing & Financing Inc. Radio frequency heating of thermoplastic receptor compositions
GB2253164B (en) * 1991-02-22 1994-10-05 Hoechst Uk Ltd Improvements in or relating to electrostatic coating of substrates of medicinal products
US5186164A (en) * 1991-03-15 1993-02-16 Puthalath Raghuprasad Mist inhaler
AU650953B2 (en) * 1991-03-21 1994-07-07 Novartis Ag Inhaler
US5243970A (en) * 1991-04-15 1993-09-14 Schering Corporation Dosing device for administering metered amounts of powdered medicaments to patients
US5278588A (en) * 1991-05-17 1994-01-11 Delphax Systems Electrographic printing device
US5327883A (en) * 1991-05-20 1994-07-12 Dura Pharmaceuticals, Inc. Apparatus for aerosolizing powdered medicine and process and using
US5161524A (en) * 1991-08-02 1992-11-10 Glaxo Inc. Dosage inhalator with air flow velocity regulating means
US5124749A (en) * 1991-09-13 1992-06-23 Xerox Corporation Damping electrode wires of a developer unit
GB9123953D0 (en) * 1991-11-12 1992-01-02 Minnesota Mining & Mfg Inhalation device
DE4211475A1 (de) * 1991-12-14 1993-06-17 Asta Medica Ag Pulverinhalator
US5239993A (en) * 1992-08-26 1993-08-31 Glaxo Inc. Dosage inhalator providing optimized compound inhalation trajectory
RO113214B1 (ro) * 1992-10-19 1998-05-29 Dura Pharma Inc Inhalator de pulbere uscata
SE9203743D0 (sv) * 1992-12-11 1992-12-11 Astra Ab Efficient use
DE69413528T2 (de) * 1993-04-06 1999-05-06 Minnesota Mining And Mfg. Co., Saint Paul, Minn. Vorrichtung zum deagglomerieren für trockenpulverinhalatoren
TW402506B (en) * 1993-06-24 2000-08-21 Astra Ab Therapeutic preparation for inhalation
CN1183715A (zh) * 1995-05-09 1998-06-03 科洛康有限公司 适合药物基质静电包衣的粉末包衣物质
US5714007A (en) 1995-06-06 1998-02-03 David Sarnoff Research Center, Inc. Apparatus for electrostatically depositing a medicament powder upon predefined regions of a substrate

Also Published As

Publication number Publication date
KR19990022213A (ko) 1999-03-25
US6074688A (en) 2000-06-13
US5714007A (en) 1998-02-03
EP0828564A4 (en) 2000-05-10
WO1996039257A1 (en) 1996-12-12
US20020176926A1 (en) 2002-11-28
JPH11507272A (ja) 1999-06-29
AU711460B2 (en) 1999-10-14
US6319541B1 (en) 2001-11-20
EP0828564A1 (en) 1998-03-18
AU6382596A (en) 1996-12-24
US6802313B2 (en) 2004-10-12
US6007630A (en) 1999-12-28

Similar Documents

Publication Publication Date Title
US6074688A (en) Method for electrostatically depositing a medicament powder upon predefined regions of a substrate
WO1996039257A9 (en) Electrostatically depositing a medicament powder
US6923979B2 (en) Method for depositing particles onto a substrate using an alternating electric field
AU760126B2 (en) Metering, packaging and delivery of pharmaceuticals and drugs
US6591833B2 (en) Inhaler apparatus with modified surfaces for enhanced release of dry powders
CN1221352A (zh) 用于增强干粉释放的带有电子装置的吸入器设备
CN1192703A (zh) 吸入器装置
US6397840B1 (en) Dry powder dispensing device
US6671161B2 (en) Removing dose electric charge
JP3436542B2 (ja) 乾燥粉末の放出性向上のための修正された表面を備えた吸入装置
US6592930B2 (en) Particle flow control
KR20010072114A (ko) 분말 분류 장치
AU2003231650B2 (en) Metering, packaging and delivery of pharmaceuticals and drugs
US20030010338A1 (en) Particle flow control onto chuck
CA2463663C (en) Inhalation device with acoustic control
AU2002314686A1 (en) Particle flow control

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued