CA2152794C - Diarylalkyl piperidines useful as multi-drug resistant tumor agents - Google Patents
Diarylalkyl piperidines useful as multi-drug resistant tumor agentsInfo
- Publication number
- CA2152794C CA2152794C CA002152794A CA2152794A CA2152794C CA 2152794 C CA2152794 C CA 2152794C CA 002152794 A CA002152794 A CA 002152794A CA 2152794 A CA2152794 A CA 2152794A CA 2152794 C CA2152794 C CA 2152794C
- Authority
- CA
- Canada
- Prior art keywords
- hydrogen
- group
- pharmaceutical composition
- compound
- trimethoxyphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- 229940079593 drug Drugs 0.000 title claims abstract description 14
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- 239000003795 chemical substances by application Substances 0.000 title description 6
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- 125000001424 substituent group Chemical group 0.000 claims description 7
- 125000004414 alkyl thio group Chemical group 0.000 claims description 6
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US656993A | 1993-01-21 | 1993-01-21 | |
| US006,569 | 1993-01-21 | ||
| PCT/US1993/012300 WO1994017040A1 (en) | 1993-01-21 | 1993-12-17 | Diarylalkyl piperidines useful as multi-drug resistant tumor agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2152794A1 CA2152794A1 (en) | 1994-08-04 |
| CA2152794C true CA2152794C (en) | 1999-04-06 |
Family
ID=21721516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002152794A Expired - Fee Related CA2152794C (en) | 1993-01-21 | 1993-12-17 | Diarylalkyl piperidines useful as multi-drug resistant tumor agents |
Country Status (20)
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993016044A1 (en) * | 1992-02-06 | 1993-08-19 | Merrell Dow Pharmaceuticals Inc. | Reversal of multi-drug resistance by triphenyl-azacycloalkane derivatives |
| WO2001007034A1 (en) * | 1999-07-23 | 2001-02-01 | Colorado State University Research Foundation | Multidrug resistance pump inhibitors and uses thereof |
| US6376514B1 (en) | 2000-10-17 | 2002-04-23 | The Procter & Gamble Co. | Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof |
| US6693099B2 (en) | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
| JP2005508990A (ja) * | 2001-11-07 | 2005-04-07 | ファルマシア・コーポレーション | 真核細胞におけるポリアミドの取込みおよび核蓄積を促進する方法 |
| KR100656490B1 (ko) * | 2001-11-26 | 2006-12-12 | 삼성에스디아이 주식회사 | 풀칼라 유기전계 발광표시소자 및 그의 제조방법 |
| US8153184B2 (en) * | 2001-11-26 | 2012-04-10 | Samsung Mobile Display Co., Ltd. | Organic EL display device and method of manufacturing the same |
| EP3732994B1 (en) | 2013-02-08 | 2022-11-09 | General Mills, Inc. | Reduced sodium food products |
| CN110372571B (zh) * | 2018-04-12 | 2022-11-15 | 中国科学院大连化学物理研究所 | 一种2-(2,2-二芳基乙基)-环胺衍生物或盐及合成和应用与组合物 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1049377B (de) * | 1952-04-03 | 1959-01-29 | Abbott Laboratories, North Chicago, 111. (V. St. A.) | Verfahren zur Herstellung von substituierten Vinylpiperidinen |
| US2898339A (en) * | 1957-07-29 | 1959-08-04 | Wm S Merrell Co | N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine |
| US3956296A (en) * | 1974-12-11 | 1976-05-11 | A. H. Robins Company, Incorporated | 1-Substituted-4-benzylpiperidines |
| US4035372A (en) * | 1976-08-13 | 1977-07-12 | G. D. Searle & Co. | 4-{[4-(Diphenylmethyl)-1-piperidinyl]methyl}benzenamines |
| EP0228893A3 (en) * | 1985-12-20 | 1990-01-03 | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) | Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl group in allergy treatment |
| US4851423A (en) * | 1986-12-10 | 1989-07-25 | Schering Corporation | Pharmaceutically active compounds |
| US4990511A (en) * | 1988-08-03 | 1991-02-05 | Takeda Chemical Industries, Ltd. | Amide compounds, their production and use |
| AU650421B2 (en) * | 1989-06-19 | 1994-06-23 | Wellcome Foundation Limited, The | Medicaments useful in cancer therapy and having antihistaminic properties |
| GB9000305D0 (en) * | 1990-01-06 | 1990-03-07 | Pfizer Ltd | Anticholinergic agents |
| EP0467435A3 (en) * | 1990-07-19 | 1992-04-01 | Akzo N.V. | Benzhydryl derivatives having calmodulin inhibitor properties |
| EP0471612B1 (fr) * | 1990-08-14 | 1998-01-28 | Roussel Uclaf | Nouveaux 19-Nor stéroides ayant en position 11béta une chaíne carbonée comportant une fonction amide, leur préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant |
| WO1993016044A1 (en) * | 1992-02-06 | 1993-08-19 | Merrell Dow Pharmaceuticals Inc. | Reversal of multi-drug resistance by triphenyl-azacycloalkane derivatives |
-
1993
- 1993-12-17 DK DK94906446.3T patent/DK0680470T3/da active
- 1993-12-17 KR KR1019950702950A patent/KR100377280B1/ko not_active Expired - Fee Related
- 1993-12-17 DE DE69309310T patent/DE69309310T2/de not_active Expired - Fee Related
- 1993-12-17 CA CA002152794A patent/CA2152794C/en not_active Expired - Fee Related
- 1993-12-17 AU AU60148/94A patent/AU679723B2/en not_active Ceased
- 1993-12-17 AT AT94906446T patent/ATE150748T1/de not_active IP Right Cessation
- 1993-12-17 JP JP51701194A patent/JP3398748B2/ja not_active Expired - Fee Related
- 1993-12-17 ES ES94906446T patent/ES2102830T3/es not_active Expired - Lifetime
- 1993-12-17 NZ NZ261414A patent/NZ261414A/en unknown
- 1993-12-17 EP EP94906446A patent/EP0680470B1/en not_active Expired - Lifetime
- 1993-12-17 US US08/481,538 patent/US5648365A/en not_active Expired - Fee Related
- 1993-12-17 WO PCT/US1993/012300 patent/WO1994017040A1/en active IP Right Grant
- 1993-12-17 HU HU9502195A patent/HUT72078A/hu unknown
-
1994
- 1994-01-17 ZA ZA94317A patent/ZA94317B/xx unknown
- 1994-01-18 TW TW083100396A patent/TW243445B/zh active
- 1994-01-19 IL IL10836994A patent/IL108369A/en not_active IP Right Cessation
- 1994-01-20 MX MX9400563A patent/MX9400563A/es not_active IP Right Cessation
-
1995
- 1995-07-20 FI FI953506A patent/FI112474B/fi active
- 1995-07-20 NO NO952885A patent/NO305166B1/no not_active IP Right Cessation
-
1997
- 1997-04-21 GR GR970400848T patent/GR3023188T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI953506A0 (fi) | 1995-07-20 |
| EP0680470B1 (en) | 1997-03-26 |
| MX9400563A (es) | 1994-07-29 |
| NO305166B1 (no) | 1999-04-12 |
| NZ261414A (en) | 1997-06-24 |
| NO952885L (no) | 1995-09-20 |
| DE69309310D1 (de) | 1997-04-30 |
| IL108369A (en) | 1999-08-17 |
| ZA94317B (en) | 1994-08-18 |
| FI112474B (fi) | 2003-12-15 |
| EP0680470A1 (en) | 1995-11-08 |
| CA2152794A1 (en) | 1994-08-04 |
| WO1994017040A1 (en) | 1994-08-04 |
| ES2102830T3 (es) | 1997-08-01 |
| FI953506L (fi) | 1995-07-20 |
| NO952885D0 (no) | 1995-07-20 |
| GR3023188T3 (en) | 1997-07-30 |
| TW243445B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1995-03-21 |
| DE69309310T2 (de) | 1997-11-06 |
| KR100377280B1 (ko) | 2003-07-18 |
| HUT72078A (en) | 1996-03-28 |
| JP3398748B2 (ja) | 2003-04-21 |
| KR960700230A (ko) | 1996-01-19 |
| JPH08505870A (ja) | 1996-06-25 |
| AU6014894A (en) | 1994-08-15 |
| DK0680470T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1997-04-28 |
| HU9502195D0 (en) | 1995-09-28 |
| US5648365A (en) | 1997-07-15 |
| IL108369A0 (en) | 1994-04-12 |
| AU679723B2 (en) | 1997-07-10 |
| ATE150748T1 (de) | 1997-04-15 |
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