CA2138021A1 - Coumarin derivative and use thereof - Google Patents

Coumarin derivative and use thereof

Info

Publication number
CA2138021A1
CA2138021A1 CA002138021A CA2138021A CA2138021A1 CA 2138021 A1 CA2138021 A1 CA 2138021A1 CA 002138021 A CA002138021 A CA 002138021A CA 2138021 A CA2138021 A CA 2138021A CA 2138021 A1 CA2138021 A1 CA 2138021A1
Authority
CA
Canada
Prior art keywords
formula
compound
purchased
mmol
lipoxygenase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002138021A
Other languages
English (en)
French (fr)
Inventor
Koichi Hashimoto
Akio Yamada
Hirokazu Hamano
Shigehiro Mori
Hisako Moriuchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Morinaga Milk Industry Co Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP18202893A external-priority patent/JP3166092B2/ja
Priority claimed from JP22210493A external-priority patent/JP3166093B2/ja
Priority claimed from JP24737993A external-priority patent/JP3166094B2/ja
Application filed by Individual filed Critical Individual
Publication of CA2138021A1 publication Critical patent/CA2138021A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002138021A 1993-04-13 1994-04-12 Coumarin derivative and use thereof Abandoned CA2138021A1 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP10876693 1993-04-13
JP5-108766 1993-04-13
JP5-182028 1993-06-28
JP18202893A JP3166092B2 (ja) 1993-04-13 1993-06-28 クマリン誘導体及びそれらの用途
JP5-222104 1993-08-13
JP22210493A JP3166093B2 (ja) 1993-08-13 1993-08-13 クマリン誘導体及びそれらの用途
JP5-247379 1993-09-08
JP24737993A JP3166094B2 (ja) 1993-09-08 1993-09-08 クマリン誘導体及びそれらの用途

Publications (1)

Publication Number Publication Date
CA2138021A1 true CA2138021A1 (en) 1994-10-27

Family

ID=27469661

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002138021A Abandoned CA2138021A1 (en) 1993-04-13 1994-04-12 Coumarin derivative and use thereof

Country Status (6)

Country Link
US (1) US5574062A (ja)
EP (1) EP0645382B1 (ja)
AU (1) AU673916B2 (ja)
CA (1) CA2138021A1 (ja)
DE (1) DE69425210T2 (ja)
WO (1) WO1994024119A1 (ja)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA969363B (en) * 1995-11-08 1997-11-18 Smithkline Beecham Corp An improved process for preparing aromatic ring-fused cyclopentane derivatives.
GB9609024D0 (en) 1996-05-01 1996-07-03 Idg Uk Ltd Compounds
JP2000119181A (ja) * 1998-10-06 2000-04-25 Kureha Chem Ind Co Ltd エスクレチン及びその誘導体の放出制御経口製剤
US6372895B1 (en) 2000-07-07 2002-04-16 3M Innovative Properties Company Fluorogenic compounds
EP1204671B1 (en) * 1999-08-05 2003-12-03 3M Innovative Properties Company Fluorogenic compounds and uses therefor
AU2003245935A1 (en) * 2002-06-13 2003-12-31 Novuspharma S.P.A. Derivatives of chromen-2-one as inhibitors of vegf production in mammalian cells
USRE46558E1 (en) 2005-04-28 2017-09-26 Paloma Pharmaceuticals, Inc. Compositions and methods to treat diseases characterized by cellular proliferation and angiogenesis
US20060257337A1 (en) * 2005-04-28 2006-11-16 David Sherris Compositions and methods to treat skin diseases characterized by cellular proliferation and angiogenesis
US8475776B2 (en) 2005-04-28 2013-07-02 Paloma Pharmaceuticals, Inc. Compositions and methods to treat diseases characterized by cellular proliferation and angiogenesis
US9279082B2 (en) * 2011-01-20 2016-03-08 Merck Patent Gmbh Polymerisable compounds and the use thereof in liquid-crystal displays
WO2012112791A1 (en) 2011-02-16 2012-08-23 Paloma Pharmaceuticals, Inc. Radiation countermeasure agents
US10266488B2 (en) 2013-10-10 2019-04-23 Eastern Virginia Medical School 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase
WO2020130120A1 (ja) * 2018-12-20 2020-06-25 学校法人京都薬科大学 癌転移抑制剤
CN112336757B (zh) * 2020-10-20 2022-12-30 广东一方制药有限公司 含有香豆素类化合物的中药配方颗粒及其制备方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2809201A (en) 1954-07-27 1957-10-08 Koelsch Charles Frederick Benzofurohexahydropyridines and preparation thereof
US2857401A (en) * 1956-12-20 1958-10-21 Searle & Co Acetylated coumarin derivatives
US3351482A (en) * 1961-02-21 1967-11-07 Bayer Ag Synthetic textiles brightened with 3-phenyl-7-hydroxy-coumarin
FR1523317A (fr) * 1967-03-20 1968-05-03 Lipha Nouveaux dérivés hydroxylés de la coumarine et leurs procédés de préparation
US3515721A (en) * 1967-06-26 1970-06-02 Cassella Farbwerke Mainkur Ag 3-tertiary-aminoethyl-4-methyl or phenyl-7-ethoxycarbonylmethoxy - halo or mononitro coumarins and congeners
US3644413A (en) * 1970-03-16 1972-02-22 Upjohn Co 3-phenyl coumarins
US3733338A (en) * 1971-07-29 1973-05-15 Ikeda Pharmaceutical Industry 1-oxo-isochromenes
FR2317922A1 (fr) * 1975-07-15 1977-02-11 Fabre Sa Pierre Isocoumarines de synthese a action anti-allergique utilisables dans le traitement de l'asthme
IT1212882B (it) * 1983-07-29 1989-11-30 Della Valle Francesco Derivati basici della cumarina
US4918092A (en) * 1983-12-21 1990-04-17 Merck Frosst Canada, Inc. Leukotriene antagonists
US5281721A (en) * 1984-08-20 1994-01-25 Georgia Tech Research Corporation Heterocyclic inhibitors of serine proteases
JPH02752A (ja) 1987-12-09 1990-01-05 Kyowa Hakko Kogyo Co Ltd ヒドロキサム酸誘導体
JPH01216961A (ja) 1988-02-25 1989-08-30 Takeda Chem Ind Ltd １２−リポキシゲネース阻害剤
JP2557090B2 (ja) 1988-04-28 1996-11-27 サントリー株式会社 カフェー酸誘導体およびそれを含む医薬組成物
JP2647185B2 (ja) 1989-03-08 1997-08-27 サントリー株式会社 カフェー酸誘導体及びそれを含む医薬組成物
JPH02196767A (ja) 1988-10-11 1990-08-03 Kyowa Hakko Kogyo Co Ltd ヒドロキサム酸誘導体
US5424320A (en) * 1993-06-23 1995-06-13 Merck Frosst Canada, Inc. Heteroaryl coumarins as inhibitors of leukotriene biosynthesis

Also Published As

Publication number Publication date
DE69425210D1 (de) 2000-08-17
AU6438094A (en) 1994-11-08
US5574062A (en) 1996-11-12
AU673916B2 (en) 1996-11-28
EP0645382A1 (en) 1995-03-29
DE69425210T2 (de) 2001-03-01
EP0645382A4 (en) 1995-05-10
EP0645382B1 (en) 2000-07-12
WO1994024119A1 (en) 1994-10-27

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Legal Events

Date Code Title Description
FZDE Discontinued