CA2119782C - Carbamate analogs of thiaphysovenine, pharmaceutical compositions, and method for inhibiting cholinesterases - Google Patents

Carbamate analogs of thiaphysovenine, pharmaceutical compositions, and method for inhibiting cholinesterases Download PDF

Info

Publication number
CA2119782C
CA2119782C CA002119782A CA2119782A CA2119782C CA 2119782 C CA2119782 C CA 2119782C CA 002119782 A CA002119782 A CA 002119782A CA 2119782 A CA2119782 A CA 2119782A CA 2119782 C CA2119782 C CA 2119782C
Authority
CA
Canada
Prior art keywords
group
img
compound
alkyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002119782A
Other languages
English (en)
French (fr)
Other versions
CA2119782A1 (en
Inventor
Arnold Brossi
Xiao-shu He
Stanley I. Rapoport
Nigel H. Greig
Malgarzota Brzostowska
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Publication of CA2119782A1 publication Critical patent/CA2119782A1/en
Application granted granted Critical
Publication of CA2119782C publication Critical patent/CA2119782C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
CA002119782A 1991-09-26 1992-08-26 Carbamate analogs of thiaphysovenine, pharmaceutical compositions, and method for inhibiting cholinesterases Expired - Fee Related CA2119782C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US76576691A 1991-09-26 1991-09-26
US765,766 1991-09-26
US84508192A 1992-03-03 1992-03-03
US845,081 1992-03-03
PCT/US1992/007085 WO1993005779A1 (en) 1991-09-26 1992-08-26 Carbamate analogs of thiaphysovenine, pharmaceutical compositions, and method for inhibiting cholinesterases

Publications (2)

Publication Number Publication Date
CA2119782A1 CA2119782A1 (en) 1993-04-01
CA2119782C true CA2119782C (en) 2005-08-23

Family

ID=27117648

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002119782A Expired - Fee Related CA2119782C (en) 1991-09-26 1992-08-26 Carbamate analogs of thiaphysovenine, pharmaceutical compositions, and method for inhibiting cholinesterases

Country Status (10)

Country Link
US (1) US5378723A (enExample)
EP (2) EP0605474B1 (enExample)
JP (1) JP3193717B2 (enExample)
AT (1) ATE254916T1 (enExample)
AU (1) AU667318B2 (enExample)
CA (1) CA2119782C (enExample)
DE (1) DE69233255T2 (enExample)
DK (1) DK0605474T3 (enExample)
ES (1) ES2206449T3 (enExample)
WO (1) WO1993005779A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0949920T3 (da) * 1997-07-09 2006-04-18 Nat Inst Health Höjselektive butyrylcholinesteraseinhibitorer til behandling og diagnose af Alzheimers sygdom og demens
US6534541B1 (en) 1999-10-19 2003-03-18 Novartis Ag Treatment of ocular disorders
CA2465534C (en) * 2000-11-02 2009-10-27 Nigel H. Greig Agents useful for reducing amyloid precursor protein and treating dementia and methods of use thereof
ATE445838T1 (de) 2001-07-25 2009-10-15 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
EP1718294A4 (en) * 2004-01-30 2007-10-03 Axonyx Inc METHODS OF TREATING COMPLICATIONS OF DIABETES
AU2006239221C1 (en) 2005-04-28 2012-08-16 Otsuka Pharmaceutical Co., Ltd. Pharma-informatics system
EP2063905B1 (en) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
PT3395372T (pt) 2009-02-20 2022-05-05 Enhanx Biopharm Inc Sistema de entrega de medicamentos à base de glutationa
TWI556839B (zh) 2009-05-06 2016-11-11 研究室護膚股份有限公司 包含活性劑－磷酸鈣粒子複合物之皮膚遞送組成物及其使用方法
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
KR101667215B1 (ko) 2014-10-21 2016-10-18 한밭대학교 산학협력단 신규한 트립타민 컨쥬게이트 화합물 및 그의 용도
KR102233120B1 (ko) 2018-12-18 2021-03-29 한밭대학교 산학협력단 신규한 파에오놀-트립타민 화합물 및 그의 용도

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3133930A (en) * 1961-08-15 1964-05-19 Ciba Geigy Corp Ester and amide derivatives of thieno-[3, 2-b] indole 3-carboxylic acids
US4900748A (en) * 1988-03-04 1990-02-13 The United States Of America As Represented By The Department Of Health And Human Services Carbamates related to (-)-physostigmine as cholinergic agents

Also Published As

Publication number Publication date
EP0605474B1 (en) 2003-11-26
CA2119782A1 (en) 1993-04-01
DE69233255D1 (de) 2004-01-08
WO1993005779A1 (en) 1993-04-01
DK0605474T3 (da) 2004-02-23
JP3193717B2 (ja) 2001-07-30
JPH07505120A (ja) 1995-06-08
EP0605474A4 (enExample) 1994-08-03
ES2206449T3 (es) 2004-05-16
EP0605474A1 (en) 1994-07-13
DE69233255T2 (de) 2004-05-27
AU667318B2 (en) 1996-03-21
EP1251131A2 (en) 2002-10-23
ATE254916T1 (de) 2003-12-15
US5378723A (en) 1995-01-03
AU2504292A (en) 1993-04-27
EP1251131A3 (en) 2002-10-30

Similar Documents

Publication Publication Date Title
US5998460A (en) Phenylcarbamates of (-)-eseroline, (-)-N1-noreseroline and (-)-N1-benzylnoreseroline: selective inhibitors of acetyl and butyrylcholinesterase, pharmaceutical compositions and method of use thereof
US5929093A (en) Bifunctional acetylcholinesterase reactivators
US6268358B1 (en) Compounds for the treatment of Alzheimer's disease
CA2119782C (en) Carbamate analogs of thiaphysovenine, pharmaceutical compositions, and method for inhibiting cholinesterases
US5171750A (en) Substituted phenserines as specific inhibitors of acetylcholinesterase
CZ279604B6 (cs) 4- a 6-karbamáty, příbuzné fyzostigminu
KR100225927B1 (ko) 콜린에스테라제 저해제로서의 제네세린 유도체
RU2241001C2 (ru) Производные галантамина, способ их получения, лекарственное средство на их основе и способ его получения
EP0154864A1 (en) Physostigmine derivatives with acetylcholinesterase inhibition properties, and the relative production process
SK142495A3 (en) Carbazole derivatives, process for preparing the same, pharmaceutical compositions containing the same and their use
KR19990022572A (ko) 약제로서의 (ｒ)-(ｚ)-1-아자비시클로[2.2.1]헵탄-3-온,ｏ-[3-(3-메톡시페닐)-2-프로피닐]옥심 말레산염
US20020091151A1 (en) Novel macrocycles and uses thereof
EP3753926A1 (en) Spiro compound as indoleamine-2,3-dioxygenase inhibitor
CZ199795A3 (en) Novel pyrrolocarbazoles
US4598080A (en) Certain-2-methyl-6-{4-[1-phenyl-1-hydroxypropyl]-phenoxymethyl}pyridines which inhibit microsonal monoxygenase systems in liver
NO803693L (no) 2,3-indoldion-derivater.
KR0182296B1 (ko) 헥사하이드로피롤로[2,3-b]인돌-카바메이트, -우레아, -아미드 및 관련 화합물과 이를 함유하는 약제학적 조성물
US5026897A (en) Carbaphens: aprophen analogs that are binary antidotes for organophosphate poisoning
NZ238151A (enExample)
EP1910376B1 (fr) Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US4973734A (en) Carbaphens: aprophen analogs that are binary antidotes for organophosphate poisoning
JPH0543579A (ja) フイソスチグミン誘導体

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed