ATE254916T1 - Carbamatanalogen von thiaphysovenin, pharmazeutische zusammensetzungen und verfahren zur hemmung von cholinesterasen - Google Patents
Carbamatanalogen von thiaphysovenin, pharmazeutische zusammensetzungen und verfahren zur hemmung von cholinesterasenInfo
- Publication number
- ATE254916T1 ATE254916T1 AT92919058T AT92919058T ATE254916T1 AT E254916 T1 ATE254916 T1 AT E254916T1 AT 92919058 T AT92919058 T AT 92919058T AT 92919058 T AT92919058 T AT 92919058T AT E254916 T1 ATE254916 T1 AT E254916T1
- Authority
- AT
- Austria
- Prior art keywords
- pharmaceutical compositions
- thiaphysovenin
- carbamat
- analogues
- methods
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical class NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 title 1
- 102000003914 Cholinesterases Human genes 0.000 title 1
- 108090000322 Cholinesterases Proteins 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 108010053652 Butyrylcholinesterase Proteins 0.000 abstract 1
- 102100032404 Cholinesterase Human genes 0.000 abstract 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 abstract 1
- 239000000544 cholinesterase inhibitor Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76576691A | 1991-09-26 | 1991-09-26 | |
| US84508192A | 1992-03-03 | 1992-03-03 | |
| PCT/US1992/007085 WO1993005779A1 (en) | 1991-09-26 | 1992-08-26 | Carbamate analogs of thiaphysovenine, pharmaceutical compositions, and method for inhibiting cholinesterases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE254916T1 true ATE254916T1 (de) | 2003-12-15 |
Family
ID=27117648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92919058T ATE254916T1 (de) | 1991-09-26 | 1992-08-26 | Carbamatanalogen von thiaphysovenin, pharmazeutische zusammensetzungen und verfahren zur hemmung von cholinesterasen |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5378723A (enExample) |
| EP (2) | EP0605474B1 (enExample) |
| JP (1) | JP3193717B2 (enExample) |
| AT (1) | ATE254916T1 (enExample) |
| AU (1) | AU667318B2 (enExample) |
| CA (1) | CA2119782C (enExample) |
| DE (1) | DE69233255T2 (enExample) |
| DK (1) | DK0605474T3 (enExample) |
| ES (1) | ES2206449T3 (enExample) |
| WO (1) | WO1993005779A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999002154A1 (en) * | 1997-07-09 | 1999-01-21 | Axonyx | Highly selective butyrylcholinesterase inhibitors for the treatment and diagnosis of alzheimer's disease and dementias |
| US6534541B1 (en) | 1999-10-19 | 2003-03-18 | Novartis Ag | Treatment of ocular disorders |
| WO2002048150A2 (en) * | 2000-11-02 | 2002-06-20 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Agents useful for reducing amyloid precursor protein and treating demantia and methods of use thereof |
| CA2450073C (en) | 2001-07-25 | 2017-08-29 | Biomarin Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
| WO2005074917A1 (en) * | 2004-01-30 | 2005-08-18 | Axonyx, Inc. | Methods for treatment of complications of diabetes |
| EP2671508B1 (en) | 2005-04-28 | 2020-09-16 | Proteus Digital Health, Inc. | Pharma-informatics system |
| JP2010503710A (ja) | 2006-09-18 | 2010-02-04 | ラプトール ファーマシューティカル インコーポレイテッド | 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置 |
| ES2919563T3 (es) | 2009-02-20 | 2022-07-27 | Enhanx Biopharm Inc | Sistema de administración de medicamentos a base de glutatión |
| KR20180114970A (ko) | 2009-05-06 | 2018-10-19 | 라보라토리 스킨 케어, 인크. | 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법 |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
| KR101667215B1 (ko) | 2014-10-21 | 2016-10-18 | 한밭대학교 산학협력단 | 신규한 트립타민 컨쥬게이트 화합물 및 그의 용도 |
| KR102233120B1 (ko) | 2018-12-18 | 2021-03-29 | 한밭대학교 산학협력단 | 신규한 파에오놀-트립타민 화합물 및 그의 용도 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3133930A (en) * | 1961-08-15 | 1964-05-19 | Ciba Geigy Corp | Ester and amide derivatives of thieno-[3, 2-b] indole 3-carboxylic acids |
| US4900748A (en) * | 1988-03-04 | 1990-02-13 | The United States Of America As Represented By The Department Of Health And Human Services | Carbamates related to (-)-physostigmine as cholinergic agents |
-
1992
- 1992-08-26 EP EP92919058A patent/EP0605474B1/en not_active Expired - Lifetime
- 1992-08-26 JP JP50604593A patent/JP3193717B2/ja not_active Expired - Fee Related
- 1992-08-26 AT AT92919058T patent/ATE254916T1/de not_active IP Right Cessation
- 1992-08-26 DK DK92919058T patent/DK0605474T3/da active
- 1992-08-26 CA CA002119782A patent/CA2119782C/en not_active Expired - Fee Related
- 1992-08-26 AU AU25042/92A patent/AU667318B2/en not_active Ceased
- 1992-08-26 ES ES92919058T patent/ES2206449T3/es not_active Expired - Lifetime
- 1992-08-26 WO PCT/US1992/007085 patent/WO1993005779A1/en not_active Ceased
- 1992-08-26 DE DE69233255T patent/DE69233255T2/de not_active Expired - Fee Related
- 1992-08-28 EP EP02013799A patent/EP1251131A3/en not_active Withdrawn
-
1994
- 1994-01-18 US US08/182,301 patent/US5378723A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP3193717B2 (ja) | 2001-07-30 |
| EP0605474A1 (en) | 1994-07-13 |
| AU667318B2 (en) | 1996-03-21 |
| EP1251131A3 (en) | 2002-10-30 |
| CA2119782C (en) | 2005-08-23 |
| EP0605474B1 (en) | 2003-11-26 |
| US5378723A (en) | 1995-01-03 |
| AU2504292A (en) | 1993-04-27 |
| ES2206449T3 (es) | 2004-05-16 |
| EP1251131A2 (en) | 2002-10-23 |
| CA2119782A1 (en) | 1993-04-01 |
| DE69233255T2 (de) | 2004-05-27 |
| DE69233255D1 (de) | 2004-01-08 |
| EP0605474A4 (enExample) | 1994-08-03 |
| WO1993005779A1 (en) | 1993-04-01 |
| JPH07505120A (ja) | 1995-06-08 |
| DK0605474T3 (da) | 2004-02-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0605474 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |