CA2108146A1 - Anti-tumor and anti-psoriatic agents - Google Patents

Anti-tumor and anti-psoriatic agents

Info

Publication number
CA2108146A1
CA2108146A1 CA002108146A CA2108146A CA2108146A1 CA 2108146 A1 CA2108146 A1 CA 2108146A1 CA 002108146 A CA002108146 A CA 002108146A CA 2108146 A CA2108146 A CA 2108146A CA 2108146 A1 CA2108146 A1 CA 2108146A1
Authority
CA
Canada
Prior art keywords
alkyl
formula
compound
water
dried
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002108146A
Other languages
English (en)
French (fr)
Inventor
Stuart W. Mccombie
Bandarpalle B. Shankar
Michael P. Kirkup
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2108146A1 publication Critical patent/CA2108146A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CA002108146A 1991-04-11 1992-04-09 Anti-tumor and anti-psoriatic agents Abandoned CA2108146A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68377091A 1991-04-11 1991-04-11
US683,770 1991-04-11

Publications (1)

Publication Number Publication Date
CA2108146A1 true CA2108146A1 (en) 1992-10-12

Family

ID=24745378

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002108146A Abandoned CA2108146A1 (en) 1991-04-11 1992-04-09 Anti-tumor and anti-psoriatic agents

Country Status (14)

Country Link
EP (2) EP0508792A1 (enExample)
JP (1) JPH06503837A (enExample)
CA (1) CA2108146A1 (enExample)
CZ (1) CZ213693A3 (enExample)
FI (1) FI934461A0 (enExample)
HU (1) HUT70187A (enExample)
IE (1) IE921148A1 (enExample)
IL (1) IL101554A0 (enExample)
MX (1) MX9201643A (enExample)
NO (1) NO933611L (enExample)
NZ (1) NZ242294A (enExample)
SK (1) SK108293A3 (enExample)
TW (1) TW214553B (enExample)
WO (1) WO1992018507A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ245203A (en) * 1991-11-29 1997-07-27 Banyu Pharma Co Ltd 5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates
ES2136103T3 (es) * 1992-06-22 1999-11-16 Kyowa Hakko Kogyo Kk Procedimiento para la preparacion de derivados de estaurosporina.
US5589472A (en) * 1992-09-25 1996-12-31 Vice; Susan F. Diindolo compounds and pharmaceutical compositions containing them
JP3581731B2 (ja) * 1993-12-07 2004-10-27 イーライ・リリー・アンド・カンパニー プロテインキナーゼｃ阻害物質
US5723456A (en) * 1993-12-07 1998-03-03 Eli Lilly & Company Therapeutic treatment for cardiovascular diseases
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
US5843935A (en) * 1993-12-07 1998-12-01 Eli Lilly And Company Protein kinase C inhibitors
AU1911095A (en) * 1994-02-18 1995-09-04 Cephalon, Inc. Aqueous indolocarbazole solutions
WO1997005140A1 (en) * 1995-07-31 1997-02-13 Novartis Ag Trindene compounds
US20040037828A1 (en) 2002-07-09 2004-02-26 Bar-Ilan University Methods and pharmaceutical compositions for healing wounds
FR2826653B1 (fr) * 2001-06-29 2005-10-14 Servier Lab Nouveaux derives de pyrido-pyrido-pyrrolo[3,2-g]pyrrolo [3,4-e]-indole et pyrido-pyrrolo[2,3-a]pyrrolo[3,4-c] carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
TW201041580A (en) 2001-09-27 2010-12-01 Alcon Inc Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
AU2004263009B2 (en) 2003-08-07 2009-12-24 Healor Ltd. Pharmaceutical compositions and methods for accelerating wound healing
WO2007026356A2 (en) 2005-08-29 2007-03-08 Healor Ltd. Methods and compositions for prevention and treatment of diabetic and aged skin
EP2181999A1 (en) 2008-11-03 2010-05-05 Zentiva, A.S. Method of manufacturing ruboxistarin
EP2599494A1 (en) 2010-01-11 2013-06-05 Healor Ltd. PKC inhibitors for the treatment of inflammatory disease or disorder
EP3169337A1 (en) 2014-07-17 2017-05-24 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for treating neuromuscular junction-related diseases
WO2016207366A1 (en) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of viral infections

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4923986A (en) * 1987-03-09 1990-05-08 Kyowa Hakko Kogyo Co., Ltd. Derivatives of physiologically active substance K-252
DE3924538A1 (de) * 1989-07-25 1991-01-31 Goedecke Ag Indolocarbazol und dessen verwendung

Also Published As

Publication number Publication date
EP0508792A1 (en) 1992-10-14
FI934461L (fi) 1993-10-11
HU9302869D0 (en) 1993-12-28
NZ242294A (en) 1993-07-27
MX9201643A (es) 1992-10-01
NO933611D0 (no) 1993-10-08
SK108293A3 (en) 1994-09-07
CZ213693A3 (en) 1994-05-18
NO933611L (no) 1993-10-08
IL101554A0 (en) 1992-12-30
JPH06503837A (ja) 1994-04-28
WO1992018507A1 (en) 1992-10-29
FI934461A7 (fi) 1993-10-11
AU646163B2 (en) 1994-02-10
TW214553B (enExample) 1993-10-11
HUT70187A (en) 1995-09-28
FI934461A0 (fi) 1993-10-11
IE921148A1 (en) 1992-10-21
AU1798292A (en) 1992-11-17
EP0580812A1 (en) 1994-02-02

Similar Documents

Publication Publication Date Title
CA2108146A1 (en) Anti-tumor and anti-psoriatic agents
AU710669B2 (en) Cytotoxic amino sugar and related sugar derivatives of indolopyrrolocarbazoles
FI106864B (fi) Menetelmä terapeuttisesti käyttökelpoisten indolopyrrolokarbatsolijohdannaisten valmistamiseksi
US4268676A (en) Mitomycin analogs
Yu et al. Studies on the synthesis and biological activities of 4′-(R)-hydroxy-5′-(S)-hydroxymethyl-tetrahydrofuranyl purines and pyrimidines
NO303498B1 (no) AnalogifremgangsmÕte for fremstilling av terapeutisk aktive forbindelser
US5589472A (en) Diindolo compounds and pharmaceutical compositions containing them
JP2009532448A (ja) 置換アデニンおよびそれらの使用
Nagamura et al. Synthesis and antitumor activity of duocarmycin derivatives: modification of segment A of duocarmycin B2
JPWO1992012982A1 (ja) ４―デソキシ―４―エピポドフィロトキシン誘導体又はその薬学的に許容される塩
CN118344248A (zh) 具有抗肿瘤活性的20-deoxyingenol醚衍生物及其制备与应用
EP1326874A2 (en) Topoisomerase inhibitors
IL96643A (en) 3 '- Dahmino -'S) - 2 ") - 3 (- Methoxy - 4" - Morpholinyl (-Docsorovicine chirley, its preparation and pharmaceutical preparations containing it
JP3113880B2 (ja) パートリシン誘導体
IE60412B1 (en) New anthracyclines
AU618536B2 (en) Novel 3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives
AU646163C (en) Anti-tumor and anti-psoriatic agents
US4880825A (en) Mitomycin derivatives
US4748251A (en) 7-n-aminomethylenemitomycin derivative
US6686385B2 (en) Anhydro sugar derivatives of indolocarbazoles
EP0376114A2 (en) 9-Dihydro-9-0-alkyldesmycosin derivatives
US4178436A (en) Semi-synthetic oleandomycin derivatives-C8 modifications
EP0449649A2 (en) Antineoplastic quinones and methods of using same
US4188479A (en) Semi-synthetic oleandomycin derivatives-C8 modifications
HK1024177B (en) Cytotoxic amino sugar and related sugar derivatives of indolopyrrolocarbazoles

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued