CA2095219A1 - Indolizino[1,2-b]quinolinones substituees - Google Patents

Indolizino[1,2-b]quinolinones substituees

Info

Publication number
CA2095219A1
CA2095219A1 CA002095219A CA2095219A CA2095219A1 CA 2095219 A1 CA2095219 A1 CA 2095219A1 CA 002095219 A CA002095219 A CA 002095219A CA 2095219 A CA2095219 A CA 2095219A CA 2095219 A1 CA2095219 A1 CA 2095219A1
Authority
CA
Canada
Prior art keywords
compound
quinolin
lower alkyl
methyl
indolizino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002095219A
Other languages
English (en)
Inventor
Hameed S. Allaudeen
David A. Berges
Robert P. Hertzberg
Randall K. Johnson
William D. Kingsbury
Stephen R. Petteway, Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2095219A1 publication Critical patent/CA2095219A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002095219A 1990-10-31 1991-10-30 Indolizino[1,2-b]quinolinones substituees Abandoned CA2095219A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US60621690A 1990-10-31 1990-10-31
US07/606,216 1990-10-31
US78306391A 1991-10-25 1991-10-25
US07/783,063 1991-10-25

Publications (1)

Publication Number Publication Date
CA2095219A1 true CA2095219A1 (fr) 1992-05-01

Family

ID=27085175

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002095219A Abandoned CA2095219A1 (fr) 1990-10-31 1991-10-30 Indolizino[1,2-b]quinolinones substituees

Country Status (9)

Country Link
EP (1) EP0555347A4 (fr)
JP (1) JPH06502642A (fr)
KR (1) KR930702289A (fr)
AU (1) AU8940491A (fr)
CA (1) CA2095219A1 (fr)
IE (1) IE913790A1 (fr)
NZ (1) NZ240406A (fr)
PT (1) PT99412A (fr)
WO (1) WO1992007856A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5883255A (en) * 1990-10-31 1999-03-16 Smithkline Beecham Corporation Substituted indolizino 1,2-b!quinolinones
AU4288893A (en) * 1992-04-17 1993-11-18 Smithkline Beecham Corporation Substituted indolizino(1,2-b)quinolinones
JPH08509742A (ja) * 1993-05-03 1996-10-15 スミスクライン・ビーチャム・コーポレイション 置換メチレンジオキシ［３’，４’：６，７］インドリジノ［１，２−ｂ］キノリノン
US5491237A (en) * 1994-05-03 1996-02-13 Glaxo Wellcome Inc. Intermediates in pharmaceutical camptothecin preparation
ATE275132T1 (de) * 1995-06-27 2004-09-15 Takeda Chemical Industries Ltd 4-acylamino(halogen)alkyl-chinolin derivate, deren herstellung und deren verwendung als melatonin-agonisten
EP0876373B1 (fr) * 1995-11-02 2005-08-10 OSI Pharmaceuticals, Inc. Procede pour preparer des derives de camptothecine
US6559309B2 (en) 1996-11-01 2003-05-06 Osi Pharmaceuticals, Inc. Preparation of a camptothecin derivative by intramolecular cyclisation
JP3046258B2 (ja) * 1997-04-11 2000-05-29 株式会社ヤクルト本社 １−クロロカルボニル−４−ピペリジノピペリジンまたはその塩酸塩の製造方法
WO2003059884A1 (fr) 2001-12-21 2003-07-24 X-Ceptor Therapeutics, Inc. Modulateurs de lxr
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
WO2003074524A2 (fr) * 2002-03-01 2003-09-12 University Of Pittsburgh Analogues de la mappicine, intermediaires utilises pour la synthese d'analogues de la mappicine et methodes de synthese d'analogues de la mappicine
US7064202B1 (en) * 2003-05-12 2006-06-20 University Of Kentucky Research Foundation Camptothecin intermediates and prodrugs and methods of preparation thereof
US20050267141A1 (en) 2004-05-28 2005-12-01 Phytogen Life Sciences Inc. Process to prepare camptothecin derivatives
US20050272757A1 (en) * 2004-06-04 2005-12-08 Phytogen Life Sciences Inc. Process to prepare camptothecin derivatives and novel intermediate and compounds thereof
WO2006019955A2 (fr) * 2004-07-14 2006-02-23 President And Fellows Of Harvard College Methodes et compositions antivirales
WO2012176145A1 (fr) * 2011-06-22 2012-12-27 Council Of Scientific & Industrial Research Composés insecticides provenant de nothapodites foetida et procédé d'extraction de ceux-ci
KR101721029B1 (ko) 2014-10-16 2017-03-29 연세대학교 산학협력단 인돌리지노[3,2-c]퀴놀린 유도체, 이의 약제학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 낭포성 섬유증 예방 또는 치료용 약학조성물
KR101850607B1 (ko) 2015-07-23 2018-04-19 서울대학교산학협력단 인돌리지노[3,2-ｃ]퀴놀린계 형광 프로브
WO2017014601A1 (fr) * 2015-07-23 2017-01-26 서울대학교 산학협력단 Sonde de fluorescence à base d'indolizino [3,2-c] quinoline

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5829793B2 (ja) * 1975-02-07 1983-06-24 日本ケミフア （株） ７−アルコキシカルボニル−８−メチルインドリジノ〔１，２−ｂ〕キノリン−９（１１Ｈ）−オンの製法

Also Published As

Publication number Publication date
NZ240406A (en) 1994-05-26
EP0555347A1 (fr) 1993-08-18
EP0555347A4 (en) 1995-01-11
JPH06502642A (ja) 1994-03-24
WO1992007856A1 (fr) 1992-05-14
PT99412A (pt) 1992-10-30
KR930702289A (ko) 1993-09-08
IE913790A1 (en) 1992-05-22
AU8940491A (en) 1992-05-26

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead