CA2093826A1 - Procede enzymatique pour la preparation de cyanohydrines optiquement actives - Google Patents

Procede enzymatique pour la preparation de cyanohydrines optiquement actives

Info

Publication number
CA2093826A1
CA2093826A1 CA2093826A CA2093826A CA2093826A1 CA 2093826 A1 CA2093826 A1 CA 2093826A1 CA 2093826 A CA2093826 A CA 2093826A CA 2093826 A CA2093826 A CA 2093826A CA 2093826 A1 CA2093826 A1 CA 2093826A1
Authority
CA
Canada
Prior art keywords
optically active
enzymes
oxynitrilase
enzyme
preparing optically
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2093826A
Other languages
English (en)
Other versions
CA2093826C (fr
Inventor
Stephen Walter Andruski
Bruce Goldberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FMC Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2093826A1 publication Critical patent/CA2093826A1/fr
Application granted granted Critical
Publication of CA2093826C publication Critical patent/CA2093826C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/002—Nitriles (-CN)
    • C12P13/004—Cyanohydrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002093826A 1991-12-17 1992-11-13 Procede enzymatique pour la preparation de cyanohydrines optiquement actives Expired - Fee Related CA2093826C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US809,803 1991-12-17
US07/809,803 US5177242A (en) 1991-12-17 1991-12-17 Process for preparing optically active cyanohydrins with enzymes

Publications (2)

Publication Number Publication Date
CA2093826A1 true CA2093826A1 (fr) 1993-06-18
CA2093826C CA2093826C (fr) 1995-08-29

Family

ID=25202264

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002093826A Expired - Fee Related CA2093826C (fr) 1991-12-17 1992-11-13 Procede enzymatique pour la preparation de cyanohydrines optiquement actives

Country Status (25)

Country Link
US (1) US5177242A (fr)
EP (1) EP0590096B1 (fr)
JP (2) JPH05507736A (fr)
KR (1) KR970009155B1 (fr)
CN (1) CN1075166A (fr)
AR (1) AR247921A1 (fr)
AT (1) ATE135047T1 (fr)
AU (1) AU647982B2 (fr)
BG (1) BG61277B1 (fr)
BR (1) BR9205413A (fr)
CA (1) CA2093826C (fr)
CZ (1) CZ280422B6 (fr)
DE (2) DE69208878T2 (fr)
FI (1) FI931583A (fr)
HU (1) HUT71308A (fr)
IL (1) IL104046A0 (fr)
MW (1) MW4993A1 (fr)
MX (1) MX9206954A (fr)
OA (1) OA09873A (fr)
PL (1) PL170490B1 (fr)
RO (1) RO112765B1 (fr)
RU (1) RU2092558C1 (fr)
SK (1) SK36293A3 (fr)
TW (1) TW242166B (fr)
WO (1) WO1993012072A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT396252B (de) * 1991-10-31 1993-07-26 Chemie Linz Gmbh Enzymatisches verfahren zur enantioselektiven herstellung optisch aktiver cyanhydrine
GB9222253D0 (en) * 1992-10-23 1992-12-09 Celltech Ltd Chemical compounds
AT400035B (de) * 1993-06-01 1995-09-25 Chemie Linz Gmbh Enzymatisches verfahren zur herstellung aliphatischer s-cyanhydrine
DE4322064A1 (de) * 1993-07-02 1995-01-12 Chemie Linz Deutschland Enzymatisches Verfahren zur Herstellung aliphatischer S-Cyanhydrine
DE19529116A1 (de) * 1995-08-08 1997-03-06 Chemie Linz Deutschland Gmbh I (S)-Hydroxynitrillyase aus Hevea brasiliensis
DE59711628D1 (de) * 1996-02-09 2004-06-24 Degussa Verfahren zur Herstellung von (S)-Cyanhydrinen
CN1093531C (zh) * 1998-05-04 2002-10-30 中国科学院上海有机化学研究所 氰醇裂解酶催化合成光学活性氰醇化合物
CN1083009C (zh) * 1999-07-16 2002-04-17 中国科学院上海有机化学研究所 一种新酶源的醇腈裂解酶催化合成光学活性氰醇化合物的方法
ATE241700T1 (de) * 1999-11-25 2003-06-15 Degussa Verfahren zur herstellung von optisch aktiven cyanhydrinen
JP3709317B2 (ja) * 2000-01-12 2005-10-26 株式会社日本触媒 光学活性シアノヒドリンの合成方法
US7078225B2 (en) * 2000-06-02 2006-07-18 Nippon Shokubai Co., Ltd. Method for enzymatically producing an optically active cyanohydrin
WO2007026623A1 (fr) * 2005-08-30 2007-03-08 Sumitomo Chemical Company, Limited Procédé de production de 3-amino-6-chloropyridazine

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3862030A (en) * 1972-12-13 1975-01-21 Amerace Esna Corp Microporous sub-micron filter media
IL46178A (en) * 1974-12-03 1978-10-31 Rehovot Res Prod Method for the performance of enzymatic reactions
US4102746A (en) * 1975-08-29 1978-07-25 Amerace Corporation Immobilized proteins
US4169014A (en) * 1976-08-16 1979-09-25 Amerace Corporation Method of immobilizing proteinaceous substances
US4795704A (en) * 1985-10-11 1989-01-03 Sepracor, Inc. Multiphase asymmetric membrane reactor systems
US4959467A (en) * 1985-11-27 1990-09-25 Allied-Signal Inc. Control of product selectivity in the addition of HCN to arabinose
US4900667A (en) * 1985-12-19 1990-02-13 Allied-Signal Inc. One carbon homologation of carbohydrates by transcyanohydrination
DE3701383A1 (de) * 1987-01-20 1988-07-28 Degussa Verfahren zur herstellung von optisch aktiven cyanhydrinen
US4800162A (en) * 1987-04-01 1989-01-24 Sepracor, Inc. Method for resolution of steroisomers in multiphase and extractive membrane reactors
DE3823864A1 (de) * 1988-01-29 1989-08-10 Kernforschungsanlage Juelich Enymatisches verfahren zur herstellung von optisch aktiven cyanhydrinen
DE3917374A1 (de) * 1988-07-14 1990-12-06 Forschungszentrum Juelich Gmbh Verfahren zur herstellung von s-cyanhydrinen
DE59106876D1 (de) * 1990-03-16 1995-12-21 Forschungszentrum Juelich Gmbh Verfahren zur enzymatischen Herstellung optisch aktiver Cyanhydrine.
AT396252B (de) * 1991-10-31 1993-07-26 Chemie Linz Gmbh Enzymatisches verfahren zur enantioselektiven herstellung optisch aktiver cyanhydrine

Also Published As

Publication number Publication date
HUT71308A (en) 1995-11-28
JPH0832243B2 (ja) 1996-03-29
MX9206954A (es) 1993-06-01
RO112765B1 (ro) 1997-12-30
RU2092558C1 (ru) 1997-10-10
AU647982B2 (en) 1994-03-31
CA2093826C (fr) 1995-08-29
PL170490B1 (pl) 1996-12-31
BG61277B1 (en) 1997-04-30
DE69208878T2 (de) 1996-10-31
CN1075166A (zh) 1993-08-11
HU9301020D0 (en) 1993-11-29
CZ280422B6 (cs) 1996-01-17
FI931583A0 (fi) 1993-04-07
OA09873A (en) 1994-09-15
EP0590096A4 (fr) 1994-02-18
BR9205413A (pt) 1994-05-31
BG97619A (bg) 1994-03-31
JPH06506674A (ja) 1994-07-28
TW242166B (fr) 1995-03-01
IL104046A0 (en) 1993-05-13
MW4993A1 (en) 1994-10-12
JPH05507736A (ja) 1993-11-04
EP0590096B1 (fr) 1996-03-06
US5177242A (en) 1993-01-05
AU3141493A (en) 1993-07-19
FI931583A (fi) 1993-06-18
CZ65193A3 (en) 1994-04-13
AR247921A1 (es) 1995-04-28
KR970009155B1 (ko) 1997-06-07
EP0590096A1 (fr) 1994-04-06
SK36293A3 (en) 1993-10-06
DE69208878D1 (de) 1996-04-11
WO1993012072A1 (fr) 1993-06-24
DE590096T1 (de) 1994-07-28
ATE135047T1 (de) 1996-03-15

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Legal Events

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EEER Examination request
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Effective date: 19981113