CA2062437A1 - Derives d'acylaminophenol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Derives d'acylaminophenol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Info

Publication number
CA2062437A1
CA2062437A1 CA002062437A CA2062437A CA2062437A1 CA 2062437 A1 CA2062437 A1 CA 2062437A1 CA 002062437 A CA002062437 A CA 002062437A CA 2062437 A CA2062437 A CA 2062437A CA 2062437 A1 CA2062437 A1 CA 2062437A1
Authority
CA
Canada
Prior art keywords
formula
group
compounds
represent
cis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002062437A
Other languages
English (en)
French (fr)
Inventor
Charles Malen
Jean-Michel Lacoste
Jean-Paul Vilaine
Albert Lenaers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2062437A1 publication Critical patent/CA2062437A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/26—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a saturated carbon skeleton containing rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/27—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA002062437A 1991-03-08 1992-03-06 Derives d'acylaminophenol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Abandoned CA2062437A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9102800A FR2673625B1 (fr) 1991-03-08 1991-03-08 Nouveaux derives d'acylaminophenol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR91.02800 1991-03-08

Publications (1)

Publication Number Publication Date
CA2062437A1 true CA2062437A1 (fr) 1992-09-09

Family

ID=9410501

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002062437A Abandoned CA2062437A1 (fr) 1991-03-08 1992-03-06 Derives d'acylaminophenol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Country Status (13)

Country Link
US (1) US5254590A (ja)
EP (1) EP0508842B1 (ja)
JP (1) JPH07587B2 (ja)
AT (1) ATE109766T1 (ja)
AU (1) AU643368B2 (ja)
CA (1) CA2062437A1 (ja)
DE (1) DE69200311T2 (ja)
DK (1) DK0508842T3 (ja)
ES (1) ES2062870T3 (ja)
FR (1) FR2673625B1 (ja)
IE (1) IE65579B1 (ja)
NZ (1) NZ241864A (ja)
ZA (1) ZA921703B (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014080306A2 (en) * 2012-11-20 2014-05-30 Mahesh Kandula Compositions and methods for the treatment of cardiovascular diseases

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3720395B2 (ja) * 1994-09-20 2005-11-24 京都薬品工業株式会社 新規ヘテロ環誘導体、その製造方法およびその医薬用途
DE69600396T2 (de) * 1995-02-08 1998-10-29 Nippon Shoji Kaisha Ltd Anilinderivate, die einen mehrfach ungesättigten Fettsäurerest tragen und ihre Anwendung
IL123939A (en) 1995-10-05 2001-11-25 Kyoto Pharma Ind The history of the heterocycles and the pharmaceutical preparations containing them
FR2741619B1 (fr) * 1995-11-28 1998-02-13 Pf Medicament Nouveaux derives de 2,3,5-trimethyl-4-hydroxy-anilides, leur preparation et leur application en therapeutique
WO1998002412A1 (fr) * 1996-07-12 1998-01-22 Yamanouchi Pharmaceutical Co., Ltd. Derives de propionanilide ou sels de ceux-ci
IT1309421B1 (it) 1998-09-16 2002-01-23 Med Dia S R L Impiego della batocuproina (acido disolfonico) per la valutazione delpotere antiossidante (pao) nei liquidi e soluzioni.
US7429612B2 (en) 2002-07-17 2008-09-30 Kyoto Pharmaceutical Industries, Ltd. Indoline compound and medicinal use thereof
US7566808B2 (en) * 2004-02-17 2009-07-28 President And Fellows Of Harvard College Management of ophthalmologic disorders, including macular degeneration
US20050288378A1 (en) * 2004-06-21 2005-12-29 Xiaoqiang Yan Cancer chemotherapy
US20050288379A1 (en) * 2004-06-21 2005-12-29 Xiaoqiang Yan Benzoquinone compounds as anti-cancer agents
US20070286906A1 (en) * 2006-04-28 2007-12-13 Hutchison Medipharma Enterprises Limited Dihydrobenzoquinone compounds
FR2973374B1 (fr) * 2011-04-04 2013-08-23 Pf Medicament Nouveaux alkylthioethers, leur preparation et leur application en therapeutique
PL3186046T3 (pl) 2014-08-26 2021-06-28 Kando Innovation Limited Zwiększenie zdolności produkcyjnej piły taśmowej

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2852540A (en) * 1954-08-09 1958-09-16 Exxon Research Engineering Co Oil soluble alkali and alkaline earth metal salts of p-acylamino phenols
US3621043A (en) * 1963-02-06 1971-11-16 Sumitomo Chemical Co N-substituted octadecadienoic acid amides as cholesterol lowering agents
NL130295C (ja) * 1964-04-28
US3479377A (en) * 1965-12-20 1969-11-18 Ashland Oil Inc Hydroxy phenyl fatty amides and polymers thereof,their preparation and use
NL150334B (nl) * 1966-10-04 1976-08-16 Sumito Chemical Werkwijze voor het bereiden van een geneesmiddel met cholesterolspiegel-verlagende werking, alsmede gevormd geneesmiddel.
US3784577A (en) * 1971-10-26 1974-01-08 Sumitomo Chemical Co Fatty acid amide derivatives
US4751026A (en) * 1986-03-24 1988-06-14 Warner-Lambert Company Substituted anilides of oleic, linoleic, or linolenic acid as inhibitors of acyl-coa:cholesterol acyltransferase
US4716175A (en) * 1987-02-24 1987-12-29 Warner-Lambert Company Saturated fatty acid amides as inhibitors of acyl-CoA:cholesterol acyltransferase
WO1991015464A1 (en) * 1990-04-11 1991-10-17 Warner-Lambert Company Amide ester acat inhibitors
JPH0454119A (ja) * 1990-06-20 1992-02-21 Tanabe Seiyaku Co Ltd ５―リポキシゲナーゼ阻害剤

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014080306A2 (en) * 2012-11-20 2014-05-30 Mahesh Kandula Compositions and methods for the treatment of cardiovascular diseases
WO2014080306A3 (en) * 2012-11-20 2014-12-24 Mahesh Kandula Compositions and methods for the treatment of cardiovascular diseases

Also Published As

Publication number Publication date
IE920719A1 (en) 1992-09-09
ZA921703B (en) 1992-11-25
US5254590A (en) 1993-10-19
DE69200311D1 (de) 1994-09-15
FR2673625A1 (fr) 1992-09-11
ATE109766T1 (de) 1994-08-15
ES2062870T3 (es) 1994-12-16
EP0508842A1 (fr) 1992-10-14
JPH04327564A (ja) 1992-11-17
JPH07587B2 (ja) 1995-01-11
DE69200311T2 (de) 1995-03-30
AU1146992A (en) 1992-09-10
NZ241864A (en) 1993-10-26
AU643368B2 (en) 1993-11-11
EP0508842B1 (fr) 1994-08-10
IE65579B1 (en) 1995-11-01
DK0508842T3 (da) 1995-01-02
FR2673625B1 (fr) 1993-05-07

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued