CA2046739A1 - Forme posologique solide enrobee a liberation dans le colon - Google Patents

Forme posologique solide enrobee a liberation dans le colon

Info

Publication number
CA2046739A1
CA2046739A1 CA2046739A CA2046739A CA2046739A1 CA 2046739 A1 CA2046739 A1 CA 2046739A1 CA 2046739 A CA2046739 A CA 2046739A CA 2046739 A CA2046739 A CA 2046739A CA 2046739 A1 CA2046739 A1 CA 2046739A1
Authority
CA
Canada
Prior art keywords
medicament form
releasability
large intestine
active ingredient
solid medicament
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2046739A
Other languages
English (en)
Other versions
CA2046739C (fr
Inventor
Fujio Sekigawa
Yoshiro Onda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shin Etsu Chemical Co Ltd
Original Assignee
Fujio Sekigawa
Yoshiro Onda
Shin-Etsu Chemical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujio Sekigawa, Yoshiro Onda, Shin-Etsu Chemical Co., Ltd. filed Critical Fujio Sekigawa
Publication of CA2046739A1 publication Critical patent/CA2046739A1/fr
Application granted granted Critical
Publication of CA2046739C publication Critical patent/CA2046739C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/286Polysaccharides, e.g. gums; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5036Polysaccharides, e.g. gums, alginate; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
CA002046739A 1990-07-10 1991-07-10 Forme posologique solide enrobee a liberation dans le colon Expired - Fee Related CA2046739C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2-182157 1990-07-10
JP2182157A JP2773959B2 (ja) 1990-07-10 1990-07-10 大腸内放出性固形製剤

Publications (2)

Publication Number Publication Date
CA2046739A1 true CA2046739A1 (fr) 1992-01-11
CA2046739C CA2046739C (fr) 2000-02-29

Family

ID=16113355

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002046739A Expired - Fee Related CA2046739C (fr) 1990-07-10 1991-07-10 Forme posologique solide enrobee a liberation dans le colon

Country Status (8)

Country Link
US (1) US5217720A (fr)
EP (1) EP0466566B1 (fr)
JP (1) JP2773959B2 (fr)
KR (1) KR960006063B1 (fr)
CN (1) CN1037933C (fr)
AU (1) AU633220B2 (fr)
CA (1) CA2046739C (fr)
DE (1) DE69109557T2 (fr)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6764697B1 (en) 1991-06-27 2004-07-20 Alza Corporation System for delaying drug delivery up to seven hours
US5468503A (en) * 1992-08-13 1995-11-21 Teikoku Seiyaku Kabushiki Kaisha Oral pharmaceutical preparation released at infragastrointestinal tract
US5356634A (en) * 1992-11-13 1994-10-18 Eastman Chemical Company Controlled-release delivery system
US5914132A (en) * 1993-02-26 1999-06-22 The Procter & Gamble Company Pharmaceutical dosage form with multiple enteric polymer coatings for colonic delivery
US5843479A (en) * 1993-02-26 1998-12-01 The Procter & Gamble Company Bisacodyl dosage form with multiple enteric polymer coatings for colonic delivery
JP2917799B2 (ja) * 1994-03-11 1999-07-12 田辺製薬株式会社 消化管内適所放出型製剤
US5508276A (en) * 1994-07-18 1996-04-16 Eli Lilly And Company Duloxetine enteric pellets
US5849327A (en) * 1994-07-29 1998-12-15 Advanced Polymer Systems, Inc. Delivery of drugs to the lower gastrointestinal tract
ES2094694B1 (es) * 1995-02-01 1997-12-16 Esteve Quimica Sa Nueva formulacion farmaceuticamente estable de un compuesto de bencimidazol y su proceso de obtencion.
US5637319A (en) * 1995-03-01 1997-06-10 Takada; Kanji Controlled-release preparations
US5686106A (en) * 1995-05-17 1997-11-11 The Procter & Gamble Company Pharmaceutical dosage form for colonic delivery
SG80553A1 (en) * 1995-07-20 2001-05-22 Tanabe Seiyaku Co Pharmaceutical preparation in form of coated capsule releasable at lower part of digestive tract
AU1751997A (en) * 1996-01-30 1997-08-22 Advanced Polymer Systems Inc. Targeted delivery of drugs to the lower gastrointestinal tract
EP0843559A2 (fr) * 1996-06-11 1998-05-27 Zonagen, Inc. Systeme d'administration de medicaments a base de chitosan
US5891474A (en) * 1997-01-29 1999-04-06 Poli Industria Chimica, S.P.A. Time-specific controlled release dosage formulations and method of preparing same
US5788987A (en) * 1997-01-29 1998-08-04 Poli Industria Chimica Spa Methods for treating early morning pathologies
US6248362B1 (en) * 1997-03-26 2001-06-19 Meiji Seika Kaisha, Ltd. Large intestinal delivery composite
DE19732903A1 (de) 1997-07-30 1999-02-04 Falk Pharma Gmbh Pellet-Formulierung zur Behandlung des Intestinaltraktes
WO2000006128A1 (fr) 1998-07-28 2000-02-10 Tanabe Seiyaku Co., Ltd. Preparation capable de liberer un medicament au niveau d'un site cible dans l'intestin
EP1184038B1 (fr) 1999-06-09 2005-12-28 Mochida Pharmaceutical Co., Ltd. Systeme de liberation dans les voies digestives inferieures
KR20020015721A (ko) * 1999-08-09 2002-02-28 도모따께 다께시 키토산 분말 함유 고형 제제 및 그의 제조방법
JP4524009B2 (ja) * 1999-08-09 2010-08-11 大日本住友製薬株式会社 大腸内放出性カプセル製剤
JP2003508422A (ja) 1999-09-02 2003-03-04 ノストラム・ファーマスーティカルズ・インコーポレイテッド 放出制御ペレット製剤
AUPQ672800A0 (en) * 2000-04-06 2000-05-04 Natraherbal Pty Ltd Garlic supplement for deodoriser
TWI241195B (en) * 2000-04-10 2005-10-11 Shionogi & Co Preventive agent for bile acidic diarrhea
CA2412776C (fr) * 2000-06-16 2011-03-15 Mitsubishi Pharma Corporation Compositions permettant de reguler la plage et/ou la vitesse de liberation du ph
CA2359812C (fr) * 2000-11-20 2004-02-10 The Procter & Gamble Company Formes posologiques pharmaceutiques a couches multiples permettant de reduire l'impact des revetement fractures
KR100404769B1 (ko) * 2001-01-31 2003-11-10 주식회사 비에스텍 팬에 부착된 향 송풍장치
IL157634A0 (en) * 2001-03-13 2004-03-28 Penwest Pharmaceuticals Co Chronotherapeutic dosage forms containing glucocorticosteroid
KR100413114B1 (ko) * 2001-03-30 2003-12-31 재단법인서울대학교산학협력재단 키토산으로 표면 코팅된 조직 재생용 생분해성 고분자제제 및 그 제조방법
US6590059B2 (en) 2001-05-11 2003-07-08 Ap Pharma, Inc. Bioerodible polyorthoesters from dioxolane-based diketene acetals
DE102004040243A1 (de) * 2003-08-22 2005-03-17 Heppe, Katja, Dipl.-Biotechnol. Transportsystem auf Chitosanbasis
JP2007519608A (ja) * 2003-09-19 2007-07-19 ペンウェスト ファーマシューティカルズ カンパニー 時間治療用剤形
KR100782918B1 (ko) * 2003-09-19 2007-12-07 펜웨스트 파머슈티칼즈 컴파니 지연 방출성 제형
EP1718621A4 (fr) 2004-01-30 2009-08-19 Univ Johns Hopkins Composes precurseurs de nitroxyle et methodes d'utilisation
EP1727525A4 (fr) * 2004-03-23 2009-12-09 Lytone Enterprise Inc Capsule contenant du chitosane noye ou encapsule
ATE468846T1 (de) * 2004-03-26 2010-06-15 Lek Pharmaceuticals Magenresistente pharmazeutische dosierform mit n- (2-(2-phthalimidoethoxy)-acetyl)-l-alanyl-d- glutaminsäure (lk-423)
US20050220873A1 (en) * 2004-04-02 2005-10-06 Chien-Hsuan Han Pharmaceutical dosage forms having immediate and controlled release properties that contain a GABAB receptor agonist
US20050226927A1 (en) * 2004-04-02 2005-10-13 Impax Laboratories, Inc. Pharmaceutical dosage forms having immediate release and/or controlled release properties that contain a GABAB receptor agonist
US8007827B2 (en) * 2004-04-02 2011-08-30 Impax Laboratories, Inc. Pharmaceutical dosage forms having immediate release and/or controlled release properties
WO2006004795A2 (fr) 2004-06-25 2006-01-12 The Johns Hopkins University Inhibiteurs d'angiogenese
CA2617150C (fr) * 2005-07-29 2016-06-14 Government Of The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Utilisation d'inhibiteurs de la chk2 kinase pour le traitement du cancer
EP2324886A1 (fr) 2005-07-29 2011-05-25 Concert Pharmaceuticals Inc. Nouveaux analogues deutériés de tadalafil
RU2448087C2 (ru) 2006-03-17 2012-04-20 Джонс Хопкинс Юниверсити Скул Оф Медсин Производные n-гидроксилсульфонамида в качестве новых физиологически полезных доноров нитроксила
JP5052051B2 (ja) * 2006-06-16 2012-10-17 トーアエイヨー株式会社 腸溶性顆粒剤及びその製造方法
US20100047323A1 (en) * 2006-12-21 2010-02-25 Aicello Chemical Co., Ltd. Chitosan solution and medical preparation with chitosan coating formed from the solution
WO2008088881A1 (fr) 2007-01-19 2008-07-24 Xcovery, Inc. Composés inhibiteurs de kinase
SG185255A1 (en) 2007-09-26 2012-11-29 Univ Johns Hopkins N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors
KR101115501B1 (ko) * 2007-11-30 2012-02-27 주식회사 키토라이프 시플로플록사신이 담지된 저분자량 수용성 키토산 미립자에고분자가 코팅된 다중입자 및 이의 제조방법
CA2723590C (fr) 2008-05-07 2017-06-27 Cardioxyl Pharmaceuticals Inc. Nouveaux composes nitroses en tant que donneurs de nitroxyle et leurs procedes d'utilisation
US8697866B2 (en) 2008-06-19 2014-04-15 Xcovery Holding Company Llc Substituted pyridazine carboxamide compounds as kinase inhibitor compounds
US8729097B2 (en) 2008-10-06 2014-05-20 The Johns Hopkins University Quinoline compounds as inhibitors of angiogenesis, human methionine aminopeptidase, and SIRT1, and methods of treating disorders
US20110160200A1 (en) * 2009-11-23 2011-06-30 Cardioxyl Pharmaceuticals, Inc. Nitroxyl Progenitors for the Treatment of Pulmonary Hypertension
AU2010328230B2 (en) 2009-12-07 2016-06-02 Cardioxyl Pharmaceuticals, Inc. Bis-acylated hydroxylamine derivatives
CN102753520B (zh) * 2009-12-07 2016-06-08 约翰斯霍普金斯大学 N-酰氧基磺酰胺和n-羟基-n-酰基磺酰胺衍生物
ES2610226T3 (es) 2010-10-08 2017-04-26 Xcovery Holding Company Llc Compuestos de 6-amino-piridazin-3-il-carboxamida sustituidos como moduladores de proteínas cinasas
JP2014529630A (ja) 2011-09-07 2014-11-13 ザウラー−ブロシュ、ローラント 哺乳類の消化管における一つあるいは複数の物質の放出制御製剤
US10653631B2 (en) 2011-09-07 2020-05-19 Roland SAUR-BROSCH Optimal colon targeting technology
CN104053647B (zh) 2011-10-17 2018-06-01 约翰斯霍普金斯大学 作为hno供体的经羟胺取代的米氏酸、巴比妥酸和吡唑啉酮衍生物
WO2014070919A1 (fr) 2012-11-01 2014-05-08 The Johns Hopkins University Libération de hno contrôlée par cyclisation-élimination intramoléculaire
JP5836980B2 (ja) * 2013-01-11 2015-12-24 信越化学工業株式会社 薬物含有粒子、固形製剤及び薬物含有粒子の製造方法
RS59434B1 (sr) 2013-01-18 2019-11-29 Cardioxyl Pharmaceuticals Inc Donori nitroksila sa poboljšanim terapijskim indeksom
AU2014251207B2 (en) 2013-04-07 2019-06-13 Dana-Farber Cancer Institute, Inc. Compositions and methods for personalized neoplasia vaccines
US10801070B2 (en) 2013-11-25 2020-10-13 The Broad Institute, Inc. Compositions and methods for diagnosing, evaluating and treating cancer
US11725237B2 (en) 2013-12-05 2023-08-15 The Broad Institute Inc. Polymorphic gene typing and somatic change detection using sequencing data
CN106456724A (zh) 2013-12-20 2017-02-22 博德研究所 使用新抗原疫苗的联合疗法
ES2734060T3 (es) 2014-01-17 2019-12-04 Cardioxyl Pharmaceuticals Inc Donadores de nitroxilo de N-hidroximetanosulfonamida
EP3148972B1 (fr) 2014-05-27 2019-08-21 Cardioxyl Pharmaceuticals, Inc. Dérivés de pyrazolone utilisés en tant que donneurs de nitroxyle
EP3148983A1 (fr) 2014-05-27 2017-04-05 The Johns Hopkins University Dérivés d'acide n-hydroxylamino-barbiturique utilisés comme donneurs de nitroxyle
US9464061B2 (en) 2014-05-27 2016-10-11 The Johns Hopkins University N-hydroxylamino-barbituric acid derivatives
JP6435179B2 (ja) * 2014-12-08 2018-12-05 フロイント産業株式会社 大腸ドラッグデリバリーシステム錠剤
EP3234130B1 (fr) 2014-12-19 2020-11-25 The Broad Institute, Inc. Procédé pour profiler le répertoire de récepteurs de cellulles t.
EP3234193B1 (fr) 2014-12-19 2020-07-15 Massachusetts Institute of Technology Biomarqueurs moléculaires pour l'immunothérapie d'un cancer
BR112017013593A2 (pt) 2014-12-23 2018-06-19 Cerecor, Inc. compostos, composições e métodos
TWI806815B (zh) 2015-05-20 2023-07-01 美商博德研究所有限公司 共有之gata3相關之腫瘤特異性新抗原
BR112017025742A2 (pt) 2015-06-09 2018-08-07 Rexahn Pharmaceuticals, Inc. métodos de uso de fluorciclopentanilcitosina
EP3344250A2 (fr) 2015-09-04 2018-07-11 Rexahn Pharmaceuticals, Inc. Procédés d'utilisation de quinoxalinyl-pipérazinamide
WO2017184590A1 (fr) 2016-04-18 2017-10-26 The Broad Institute Inc. Prédiction améliorée d'épitope hla
NZ751284A (en) 2016-10-03 2022-09-30 Hangzhou Highlightll Pharmaceutical Co Ltd Novel jak1 selective inhibitors and uses thereof
US11549149B2 (en) 2017-01-24 2023-01-10 The Broad Institute, Inc. Compositions and methods for detecting a mutant variant of a polynucleotide
EP3788147A1 (fr) 2018-05-04 2021-03-10 Tollys Ligands de tlr3 qui activent à la fois des cellules épithéliales et myéloïdes
US20210382068A1 (en) 2018-10-02 2021-12-09 Dana-Farber Cancer Institute, Inc. Hla single allele lines
US20220062394A1 (en) 2018-12-17 2022-03-03 The Broad Institute, Inc. Methods for identifying neoantigens
EP3955923A1 (fr) 2019-04-18 2022-02-23 The Regents Of The University Of Michigan Combinaison d'inhibiteurs de points de contrôle pour le traitement du cancer
EP3962461A1 (fr) * 2019-04-30 2022-03-09 DSM IP Assets B.V. Nouveau système d'administration de vitamines liposolubles
US20220193033A1 (en) * 2019-04-30 2022-06-23 Dsm Ip Assets B.V. New delivery system for specific water-soluble vitamins
US20230203477A1 (en) 2020-05-26 2023-06-29 The Broad Institute, Inc. Nucleic acid artificial mini-proteome libraries
US20240050415A1 (en) 2020-06-05 2024-02-15 Henry Ford Health System Daclatasvir for use in treating lung and prostate cancer
EP4267554A1 (fr) 2020-12-22 2023-11-01 Mekanistic Therapeutics LLC Composés d'hétéroaryle d'aminobenzyle substitués utilisés en tant qu'inhibiteurs d'egfr et/ou de pi3k
WO2022189861A1 (fr) 2021-03-08 2022-09-15 Tollys Conjugués d'hydrates de carbone de ligands tlr3 et leurs utilisations
CN117897156A (zh) 2021-08-10 2024-04-16 贝达药业股份有限公司 恩沙替尼或其盐在治疗携带met 14外显子跳跃突变的疾病中的用途
WO2023076733A1 (fr) 2021-11-01 2023-05-04 Dana-Farber Cancer Institute, Inc. Bibliothèques de mini-protéomes artificiels d'acide nucléique sélectionnées biologiquement
CN115192537B (zh) * 2022-07-27 2024-03-26 康普药业股份有限公司 一种甲磺酸萘莫司他组合物及其制备方法
CN117426267A (zh) * 2023-12-21 2024-01-23 山东科赛基农生物工程有限公司 水稻生产全程健康管理方法及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2471186A1 (fr) * 1979-12-10 1981-06-19 Roussel Uclaf Nouveaux comprimes a delitescence colique, ainsi que leur procede de preparation
US4917899A (en) * 1983-12-22 1990-04-17 Elan Corporation Plc Controlled absorption diltiazem formulation
BR8506634A (pt) * 1984-12-20 1986-09-09 Rhone Poulenc Sante Composicoes para o revestimento de aditivos alimentares destinados aos ruminantes e granulados sob forma de microcapsulas assim revestidos
FR2582909B1 (fr) * 1985-06-07 1991-05-10 Aec Chim Organ Biolog Produit pour l'alimentation des ruminants et sa preparation.
JPH02107060A (ja) * 1988-10-17 1990-04-19 Matsushita Electric Ind Co Ltd 画信号処理方法
IT1230576B (it) * 1988-10-20 1991-10-28 Angeli Inst Spa Formulazioni farmaceutiche per via orale a liberazione selettiva nel colon
JPH0813748B2 (ja) * 1990-04-23 1996-02-14 帝國製薬株式会社 大腸崩壊性ポリペプチド系経口製剤

Also Published As

Publication number Publication date
EP0466566A3 (en) 1992-12-09
US5217720A (en) 1993-06-08
CN1037933C (zh) 1998-04-08
DE69109557D1 (de) 1995-06-14
DE69109557T2 (de) 1995-09-28
EP0466566A2 (fr) 1992-01-15
CN1058904A (zh) 1992-02-26
AU8027291A (en) 1992-01-16
JP2773959B2 (ja) 1998-07-09
EP0466566B1 (fr) 1995-05-10
KR960006063B1 (ko) 1996-05-08
CA2046739C (fr) 2000-02-29
JPH0469333A (ja) 1992-03-04
KR920002135A (ko) 1992-02-28
AU633220B2 (en) 1993-01-21

Similar Documents

Publication Publication Date Title
CA2046739A1 (fr) Forme posologique solide enrobee a liberation dans le colon
KR920702618A (ko) 약제학적 제형
US4789549A (en) Sustained release dosage forms
CA2148465A1 (fr) Preparation pharmaceutique orale, pouvant etre liberee dans la voie digestive inferieure
CA2038245A1 (fr) Micropellets utiles en pharmacologie
CA2153856A1 (fr) Pastilles de duloxetine a delitage enteral
BG100933A (en) Polymer coated tablets comprising amoxycilin and clavulanate
ATE246505T1 (de) Zubereitung enthaltend cefaclor oder cephalexin mit modifizierter freisetzungsmatrix
CA2197941A1 (fr) Comprime pharmaceutique affichant une forte augmentation de volume au contact de liquides biologiques
AU5895596A (en) Treatment of inflammatory bowel disease using oral dosage forms of omega-3 polyunsaturated acids
AU6764390A (en) Pharmaceutical granules and drug dosage units made therefrom
CA2059319A1 (fr) Formulations pour administration par voie orale, applicables en particulier aux ruminants
CA2377916A1 (fr) Formulations pharmaceutiques liquides au gout masque
CA2304110A1 (fr) Comprime de theophylline a liberation prolongee
CA2346988A1 (fr) Formulation pharmaceutique contenant de l'omeprazole
CA2217226A1 (fr) Formulation a liberation lente de medicaments solubles dans l'eau, avec passage incorpore
CA2306103A1 (fr) Nouvelle preparation de sulfonyluree a liberation controlee et a posologie unique
GEP20033014B (en) Enteric Coated Pharmaceutical Composition and Method of Manufacturing
AU6042796A (en) Controlled release formulation having a preformed passageway
AU6541786A (en) Process for producing an administration or dosage form of drugs, reagents or other active ingredients
CA2136411A1 (fr) Comprimes a liberation immediate de medicaments insolubles a revetement pour liberation continue
CA2021574A1 (fr) Preparation pharmaceutique a fragmentation rapide, au gout desagreable masque, pour administration par voie buccale
EP0391518A3 (fr) Préparation pharmaceutique à libération retardée
NZ336251A (en) Composition comprising a core layer (active ingredient, hydroxypropyl cellulose and microcrystalline cellulose), an inner layer (such as hydroxypropylmethyl cellulose, polyvinyl pyrolidore and lubricants; magnesium stearate or talc), an outer layer (hydroxypropylmethyl and hydroxypropyl cellulose)
DE69125619T2 (de) Arzneimittel mit kontrollierter wirkstoffabgabe

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed