CA1306261C - 1,4-dihydropyridines, leur procede de preparation et leur application comme medicaments - Google Patents

1,4-dihydropyridines, leur procede de preparation et leur application comme medicaments

Info

Publication number
CA1306261C
CA1306261C CA000573422A CA573422A CA1306261C CA 1306261 C CA1306261 C CA 1306261C CA 000573422 A CA000573422 A CA 000573422A CA 573422 A CA573422 A CA 573422A CA 1306261 C CA1306261 C CA 1306261C
Authority
CA
Canada
Prior art keywords
methyl
carboxylate
ethyl
methylenedioxyphenyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA000573422A
Other languages
English (en)
French (fr)
Inventor
Joaguin Alvaro Galiano Ramos
Carlos Fernandez Torija
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Almirall SA
Original Assignee
Laboratorios Delagrange SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Delagrange SA filed Critical Laboratorios Delagrange SA
Application granted granted Critical
Publication of CA1306261C publication Critical patent/CA1306261C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CA000573422A 1987-08-03 1988-07-29 1,4-dihydropyridines, leur procede de preparation et leur application comme medicaments Expired - Lifetime CA1306261C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP87401799A EP0302980B1 (fr) 1987-08-03 1987-08-03 1,4-Dihydropyridines, leur procédé de préparation et leur application comme médicaments
EP87401799,9 1987-08-03

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA000615848A Division CA1306262C (fr) 1987-08-03 1990-08-28 1,4-dihydropyridines, leur procede de preparation et leur application comme medicaments

Publications (1)

Publication Number Publication Date
CA1306261C true CA1306261C (fr) 1992-08-11

Family

ID=8198243

Family Applications (2)

Application Number Title Priority Date Filing Date
CA000573422A Expired - Lifetime CA1306261C (fr) 1987-08-03 1988-07-29 1,4-dihydropyridines, leur procede de preparation et leur application comme medicaments
CA000615848A Expired - Lifetime CA1306262C (fr) 1987-08-03 1990-08-28 1,4-dihydropyridines, leur procede de preparation et leur application comme medicaments

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA000615848A Expired - Lifetime CA1306262C (fr) 1987-08-03 1990-08-28 1,4-dihydropyridines, leur procede de preparation et leur application comme medicaments

Country Status (34)

Country Link
US (1) US4952592A (show.php)
EP (1) EP0302980B1 (show.php)
JP (1) JPH0733383B2 (show.php)
KR (1) KR960001724B1 (show.php)
CN (1) CN1038587C (show.php)
AT (1) ATE61588T1 (show.php)
BE (1) BE1001055A4 (show.php)
CA (2) CA1306261C (show.php)
CH (1) CH675999A5 (show.php)
CZ (1) CZ282077B6 (show.php)
DD (1) DD282008A5 (show.php)
DE (2) DE3768658D1 (show.php)
DK (1) DK430288A (show.php)
ES (1) ES2007543A6 (show.php)
FI (1) FI91406C (show.php)
GB (1) GB2208861B (show.php)
GR (2) GR880100507A (show.php)
HU (1) HU204523B (show.php)
IE (1) IE60358B1 (show.php)
IL (1) IL87321A (show.php)
IN (1) IN167550B (show.php)
IS (1) IS1549B (show.php)
IT (1) IT1235013B (show.php)
LU (1) LU87297A1 (show.php)
MA (1) MA21344A1 (show.php)
NO (1) NO170934C (show.php)
NZ (1) NZ225661A (show.php)
PH (1) PH25645A (show.php)
PT (1) PT88173B (show.php)
RU (1) RU2036922C1 (show.php)
SK (1) SK278775B6 (show.php)
TN (1) TNSN88081A1 (show.php)
YU (1) YU46547B (show.php)
ZA (1) ZA885684B (show.php)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5242933A (en) * 1990-07-10 1993-09-07 Adir Et Compagnie Piperidine, tetrahydropyridine and pyrrolidine compounds
WO1997004781A1 (en) * 1995-08-02 1997-02-13 Smithkline Beecham Corporation Endothelin receptor antagonists
RU2168987C2 (ru) * 1997-04-15 2001-06-20 Санкт-Петербургская Государственная Химико-Фармацевтическая Академия Гипотензивное средство
RU2155036C2 (ru) * 1998-11-11 2000-08-27 Азад Зияд Оглы Абышев Средство для лечения ишемической болезни сердца
IT1304513B1 (it) * 1998-12-30 2001-03-19 Endura Spa Processo per la sintesi di 5-(alfa-idrossialchil)benzo(1,3)diossoli.
BR0109991A (pt) * 2000-04-11 2003-05-27 Sankyo Co Composição farmacêutica
RU2187303C2 (ru) * 2000-10-12 2002-08-20 Азад Зияд Оглы Абышев Способ получения таблеток диуманкала - forte по 0,01 г
EA200500234A1 (ru) 2002-08-19 2005-08-25 Пфайзер Продактс Инк. Комбинированная терапия гиперпролиферативных болезней
CA2574958A1 (en) * 2004-07-26 2006-02-09 Cotherix, Inc. Treatment of pulmonary hypertension by inhaled iloprost with a microparticle formulation
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
EP2351569B1 (en) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
WO2007050783A2 (en) 2005-10-26 2007-05-03 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
TW200736245A (en) * 2005-11-29 2007-10-01 Sankyo Co Acid addition salts of optically active dihydropyridine derivatives
TW200806648A (en) * 2005-11-29 2008-02-01 Sankyo Co Acid addition salts of dihydropyridine derivatives
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
ATE547394T1 (de) 2006-12-01 2012-03-15 Bristol Myers Squibb Co N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen
WO2012037665A1 (en) 2010-09-24 2012-03-29 Oral Delivery Technology Ltd. Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
CN105143203A (zh) 2013-04-17 2015-12-09 辉瑞大药厂 用于治疗心血管疾病的n-哌啶-3-基苯甲酰胺衍生物
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
WO2020150473A2 (en) 2019-01-18 2020-07-23 Dogma Therapeutics, Inc. Pcsk9 inhibitors and methods of use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3441648A (en) * 1967-02-07 1969-04-29 Smithkline Corp Compositions and methods for lowering blood pressure with 1,4-dihydropyridines
US4031104A (en) * 1972-04-18 1977-06-21 Bayer Aktiengesellschaft 1,4-Dihydropyridine carboxylic acid esters
JPS5978186A (ja) * 1982-10-27 1984-05-04 Yoshitomi Pharmaceut Ind Ltd １，４−ジヒドロピリジン−３，５−ジカルボン酸エステル誘導体
ES531033A0 (es) * 1984-03-27 1985-09-01 Inst Investigacion Desarrollo Un procedimiento para la preparacion de nuevas 1,4-dihidropirinas-4-(polioxialquilfenil)-sustituidas
IE57810B1 (en) * 1984-03-27 1993-04-21 Delagrange Lab 1,4-dihydropyridine derivatives,their preparation and their use
JPH068294B2 (ja) * 1985-02-26 1994-02-02 富山化学工業株式会社 新規な１，４−ジヒドロピリジン誘導体およびその塩
EP0174131A3 (en) * 1984-09-01 1989-06-07 FISONS plc Dihydropyridines, processes and intermediates for their production, and pharmaceutical formulations containing them
JPH01207267A (ja) * 1987-03-05 1989-08-21 Yamanouchi Pharmaceut Co Ltd ピリジン誘導体及び該化合物を含有する肝疾患治療剤

Also Published As

Publication number Publication date
IE882364L (en) 1989-02-03
HU204523B (en) 1992-01-28
YU147088A (en) 1990-04-30
IT8848259A0 (it) 1988-08-02
JPH0733383B2 (ja) 1995-04-12
IT1235013B (it) 1992-06-16
PH25645A (en) 1991-08-21
YU46547B (sh) 1993-11-16
GR880100507A (el) 1989-05-25
US4952592A (en) 1990-08-28
KR890003743A (ko) 1989-04-17
CN1031531A (zh) 1989-03-08
JPH01294675A (ja) 1989-11-28
IN167550B (show.php) 1990-11-10
CZ282077B6 (cs) 1997-05-14
AU606441B2 (en) 1991-02-07
IL87321A0 (en) 1989-01-31
HUT54142A (en) 1991-01-28
GB2208861B (en) 1991-07-17
LU87297A1 (fr) 1989-02-02
EP0302980A1 (fr) 1989-02-15
IS3378A7 (is) 1989-02-04
FI91406C (fi) 1994-06-27
FI883603A7 (fi) 1989-02-04
TNSN88081A1 (fr) 1990-07-10
CA1306262C (fr) 1992-08-11
DD282008A5 (de) 1990-08-29
GR3001984T3 (en) 1992-11-23
IS1549B (is) 1994-06-08
DK430288D0 (da) 1988-08-02
FI91406B (fi) 1994-03-15
PT88173A (pt) 1989-06-30
KR960001724B1 (ko) 1996-02-03
DE3768658D1 (de) 1991-04-18
NO170934B (no) 1992-09-21
RU2036922C1 (ru) 1995-06-09
SK541388A3 (en) 1998-02-04
ZA885684B (en) 1989-04-26
DE3825962A1 (de) 1989-02-16
NO883406L (no) 1989-02-06
IL87321A (en) 1993-04-04
MA21344A1 (fr) 1989-04-01
CH675999A5 (en) 1990-11-30
BE1001055A4 (fr) 1989-06-20
ATE61588T1 (de) 1991-03-15
DK430288A (da) 1989-02-03
CZ541388A3 (en) 1997-01-15
AU2033088A (en) 1989-02-09
GB8818356D0 (en) 1988-09-07
EP0302980B1 (fr) 1991-03-13
CN1038587C (zh) 1998-06-03
NO883406D0 (no) 1988-08-01
IE60358B1 (en) 1994-06-29
NZ225661A (en) 1990-08-28
FI883603A0 (fi) 1988-08-01
SK278775B6 (sk) 1998-02-04
GB2208861A (en) 1989-04-19
NO170934C (no) 1992-12-30
PT88173B (pt) 1995-03-01
ES2007543A6 (es) 1989-06-16

Similar Documents

Publication Publication Date Title
EP0060674B1 (en) Dihydropyridine anti-ischaemic and antihypertensive agents, processes for their production, and pharmaceutical compositions containing them
BE1001055A4 (fr) 1,4-dihydropyridines, leur procede de preparation et leur application comme medicaments.
EP0370901B1 (fr) Nouveaux dérivés du chromanne actifs sur le système nerveux central, leur procédé de préparation et les compositions pharmaceutiques en contenant
CH651561A5 (fr) Derives des nor-tropane et granatane et leur procede de preparation.
JP2637737B2 (ja) 新規な薬剤
DE2943877A1 (de) 3'-substituierte 4- eckige klammer auf (4'-methoxyphenyl)-methyl eckige klammer zu -imidazolidin-2-onderivate, verfahren zur herstellung derselben und diese enthaltende arzneimittel
AU661483B2 (en) Crystalline tiagabine hydrochloride monohydrate, its preparation and use
EP0576619B1 (fr) Compositions therapeutiques a base de derives de 1,2-dithiole-3-thione
EP0021940B1 (fr) Nouveaux dérivés aminés du benzothiazole, leur procédé de préparation et leur application en thérapeutique
FR2595695A1 (fr) Derives de n-(((hydroxy-2 phenyl) (phenyl) methylene) amino-2) ethyl) acetamide, leur preparation et leur application en therapeutique
WO1993020046A1 (fr) Derives d'indane-1,3-dione et d'indane-1,2,3-trione, leurs procedes de preparation et leur application en therapeutique
EP0114850B1 (fr) Nouveaux derives substitues du 2,5-diamino 1,4-diazole, leurs procedes de preparation et les compositions pharmaceutiques en renfermant
EP0002978B1 (fr) Dérivés de thiazolidinedione-2,4, leur préparation et leur application en thérapeutique
FR2496104A1 (fr) Nouveaux produits de la serie de la 3-(piperidin-4-yl) 2h-indol-2-one, et procede pour leur preparation
EP0065295A1 (de) Substituierte Tryptaminderivate von Thienyloxypropanolaminen, Verfahren zu ihrer Herstellung, pharmazeutische Präparate auf Basis dieser Verbindungen sowie ihre Verwendung
FR2547822A1 (fr) Acylpiperazinoquinazolines substituees utiles comme medicaments et procede pour leur preparation
FR2615188A1 (fr) Derives d'hydrazine, procede d'obtention et compositions pharmaceutiques les contenant
CA1076117A (fr) Procede d'obtention de nouveaux ethers aryliques et les produits en resultant
CA1209142A (fr) Procede d'obtention de nouvelles cyanoguanidines et des compositions pharmaceutiques en renfermant
EP0412898A1 (fr) Nouveaux dérivés d'oxazolo pyridines, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
FR2543139A1 (fr) Derives de (1-alcoxy 2-amino) ethyl pyridine ou pyrazine, leur preparation et leur application en therapeutique
EP0099822B1 (fr) Nouveaux 1-(2-carbalkoxy 4-(thiénylalkylamido)phénoxy) 3-amino 2-propanols, leur préparation et leurs applications en thérapeutique
CA2278223C (fr) Derives de la 1,4-dihydropyridine et leur utilisation en therapeutique
CA1095039A (fr) Procede d'obtention de nouveaux ethers aryliques et les produits en resultant
FR2692894A1 (fr) Aryl-1-(o-alcoxy-phényl-4-pipérazinyl-1)-2, 3- ou 4-alcanols, leur procédé de préparation et leur utilisation pour la préparation de médicaments.

Legal Events

Date Code Title Description
MKLA Lapsed