CA1291131C - 2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8,-inter- m-phenylene pgi _derivatives - Google Patents

2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8,-inter- m-phenylene pgi _derivatives

Info

Publication number
CA1291131C
CA1291131C CA000554050A CA554050A CA1291131C CA 1291131 C CA1291131 C CA 1291131C CA 000554050 A CA000554050 A CA 000554050A CA 554050 A CA554050 A CA 554050A CA 1291131 C CA1291131 C CA 1291131C
Authority
CA
Canada
Prior art keywords
added
mmol
methyl
mixture
inter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA000554050A
Other languages
English (en)
French (fr)
Inventor
Kiyotaka Ohno
Toshiya Takahashi
Shintaro Nishio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Application granted granted Critical
Publication of CA1291131C publication Critical patent/CA1291131C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
CA000554050A 1986-12-11 1987-12-10 2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8,-inter- m-phenylene pgi _derivatives Expired - Fee Related CA1291131C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP295367/86 1986-12-11
JP29536786 1986-12-11

Publications (1)

Publication Number Publication Date
CA1291131C true CA1291131C (en) 1991-10-22

Family

ID=17819706

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000554050A Expired - Fee Related CA1291131C (en) 1986-12-11 1987-12-10 2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8,-inter- m-phenylene pgi _derivatives

Country Status (10)

Country Link
US (1) US4880939A (enExample)
EP (1) EP0274064B1 (enExample)
JP (1) JPS63264475A (enExample)
KR (1) KR930003853B1 (enExample)
AT (1) ATE73768T1 (enExample)
AU (1) AU600054B2 (enExample)
CA (1) CA1291131C (enExample)
DE (1) DE3777590D1 (enExample)
ES (1) ES2032427T3 (enExample)
ZA (1) ZA879186B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5401768A (en) * 1987-10-16 1995-03-28 Toray Industries, Inc. 2,5,6,7-tetranor-4,8-inter-m-phenylene PGI2, derivative, manufacturing process thereof and its use
WO1990010003A1 (en) * 1989-02-27 1990-09-07 Toray Industries, Inc. PREPARATION OF 5,6,7-TRINOR-4,8-INTER-m-PHENYLENE PGI2 DERIVATIVES
US5086071A (en) * 1989-03-14 1992-02-04 Toray Industries, Inc. 2,5,6,7-tetranor-4,8-inter-m-phenylene pgi2 derivatives
US5233059A (en) * 1991-07-25 1993-08-03 Iowa State University Research Foundation, Inc. Synthesis of benzoprostacyclins using palladium catalysis
WO1998040073A1 (fr) * 1997-03-13 1998-09-17 Toray Industries, Inc. Medicament pour traiter les lesions vasculaires diabetiques
WO1999013881A1 (en) * 1997-09-17 1999-03-25 Toray Industries, Inc. Cervical maturing agent
CN105315247B (zh) 2011-06-16 2019-07-26 琅歌生物技术股份有限公司 贝前列素的生产方法
WO2013040068A2 (en) * 2011-09-12 2013-03-21 Irix Pharmaceuticals, Inc. Process for preparing synthetic prostacyclins
US9765047B2 (en) 2015-08-12 2017-09-19 United Therapeutics Corporation Process for making beraprost

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5931510B2 (ja) * 1979-09-03 1984-08-02 東レ株式会社 ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体
DE3041601A1 (de) * 1980-10-31 1982-06-16 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue prostacyclinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3147714A1 (de) * 1981-11-27 1983-06-01 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue prostacycline und verfahren zu ihrer herstellung
JPS58124778A (ja) * 1982-01-20 1983-07-25 Toray Ind Inc ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体

Also Published As

Publication number Publication date
EP0274064A3 (en) 1988-07-27
KR880007453A (ko) 1988-08-27
AU8242087A (en) 1988-06-16
ZA879186B (en) 1988-06-06
KR930003853B1 (ko) 1993-05-14
JPS63264475A (ja) 1988-11-01
JPH0571592B2 (enExample) 1993-10-07
ES2032427T3 (es) 1993-02-16
DE3777590D1 (de) 1992-04-23
EP0274064B1 (en) 1992-03-18
EP0274064A2 (en) 1988-07-13
US4880939A (en) 1989-11-14
ATE73768T1 (de) 1992-04-15
AU600054B2 (en) 1990-08-02

Similar Documents

Publication Publication Date Title
EP0084856B2 (en) 5,6,7-Trinor-4, 8-inter-m-phenylene prostaglandin I2 derivatives
US4822804A (en) 5,6,7,-trinor-4,8-inter-m-phenylene 2-nor PGI2 derivatives and anti-ulcer, anti-thrombotic and anti-hypertensive pharmaceutical compositions containing them
KR890000185B1 (ko) 7-옥사비시클로헵탄 및 7-옥사비시클로헵텐 화합물
CA1291131C (en) 2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8,-inter- m-phenylene pgi _derivatives
EP0232776B1 (en) 2,5,6,7-tetranor-4,8-inter-m-phenylene pgi2 derivatives
EP0365678B1 (en) 2,5,6,7-TETRANOR-4,8-INTER-m-PHENYLENE PGI 2 DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND USE THEREOF
US4585791A (en) Furyl derivatives of 16-substituted prostaglandins
EP0389162B1 (en) 2,5,6,7-Tetranor-4,8-inter-m-phenylene PGI2 derivatives
US4321205A (en) 15-Epi-prostacyclin and analogous prostacyclins
US6555559B1 (en) 5,6,7-trinor-4,8-inter-m-phenylene PGI2, derivative and drugs containing the same
CA1196632A (en) 5,6-dihydro-prostacyclin analogs
US4024181A (en) Analogues of prostanoic acids
US4400393A (en) Novel bicyclooctane compounds
US4211706A (en) 9-Deoxy-9α,6-nitrilo or 6,9α-imino-17,18-didehydro-PGF compounds
JPWO1989003387A1 (ja) ２，５，６，７―テトラノル―４，８―インタ―ｍ―フェニレンＰＧＩ２誘導体ならびにその製造法および用途
FR2515642A1 (fr) Nouvelles (11r)-11-deoxy-11-alkyl-6-oxo-prostaglandines et compositions pharmaceutiques les contenant
US4170596A (en) Novel monoesters of cis-cyclopentenediol, process for preparation thereof, and process for preparation of lactones from the monoesters
JPH0662599B2 (ja) ２，５，６，７―テトラノル―４，８―インタ―ｍ―フェニレンＰＧＩ２誘導体ならびにその製造法および用途
CA1087178A (en) 1,3-benzodioxan-prostandic acid derivatives and process for producing them
NZ243180A (en) Aromatic ether derivatives and antiviral compositions thereof
SE431090B (sv) Optiskt aktiv eller racemisk fluor-prostaglandinforening till anvendning som luteolytiskt och abortivt medel
SU1056899A3 (ru) Способ получени производных 7-оксопростациклина
US4214099A (en) Intermediates for synthesis of precursors for prostaglandins
HU182726B (en) Process for producing the 9-desoxy-9a-methylene-isosteres of pgi2/prostacyclin/
CA1093082A (en) Preparation of optically active cyclopentyl derivatives

Legal Events

Date Code Title Description
MKLA Lapsed