ATE73768T1 - 2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8inter-m-phenylene-pgi2-derivate. - Google Patents

2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8inter-m-phenylene-pgi2-derivate.

Info

Publication number
ATE73768T1
ATE73768T1 AT87118053T AT87118053T ATE73768T1 AT E73768 T1 ATE73768 T1 AT E73768T1 AT 87118053 T AT87118053 T AT 87118053T AT 87118053 T AT87118053 T AT 87118053T AT E73768 T1 ATE73768 T1 AT E73768T1
Authority
AT
Austria
Prior art keywords
8inter
tetradehydro
tetranor
phenylene
derivatives
Prior art date
Application number
AT87118053T
Other languages
German (de)
English (en)
Inventor
Kiyotaka Ohno
Toshiya Takahashi
Shintaro Nishio
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries filed Critical Toray Industries
Application granted granted Critical
Publication of ATE73768T1 publication Critical patent/ATE73768T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
AT87118053T 1986-12-11 1987-12-07 2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8inter-m-phenylene-pgi2-derivate. ATE73768T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP29536786 1986-12-11
EP87118053A EP0274064B1 (en) 1986-12-11 1987-12-07 2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8-inter-m-phenylene pgi2 derivatives

Publications (1)

Publication Number Publication Date
ATE73768T1 true ATE73768T1 (de) 1992-04-15

Family

ID=17819706

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87118053T ATE73768T1 (de) 1986-12-11 1987-12-07 2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8inter-m-phenylene-pgi2-derivate.

Country Status (10)

Country Link
US (1) US4880939A (enExample)
EP (1) EP0274064B1 (enExample)
JP (1) JPS63264475A (enExample)
KR (1) KR930003853B1 (enExample)
AT (1) ATE73768T1 (enExample)
AU (1) AU600054B2 (enExample)
CA (1) CA1291131C (enExample)
DE (1) DE3777590D1 (enExample)
ES (1) ES2032427T3 (enExample)
ZA (1) ZA879186B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5401768A (en) * 1987-10-16 1995-03-28 Toray Industries, Inc. 2,5,6,7-tetranor-4,8-inter-m-phenylene PGI2, derivative, manufacturing process thereof and its use
WO1990010003A1 (en) * 1989-02-27 1990-09-07 Toray Industries, Inc. PREPARATION OF 5,6,7-TRINOR-4,8-INTER-m-PHENYLENE PGI2 DERIVATIVES
US5086071A (en) * 1989-03-14 1992-02-04 Toray Industries, Inc. 2,5,6,7-tetranor-4,8-inter-m-phenylene pgi2 derivatives
US5233059A (en) * 1991-07-25 1993-08-03 Iowa State University Research Foundation, Inc. Synthesis of benzoprostacyclins using palladium catalysis
WO1998040073A1 (fr) * 1997-03-13 1998-09-17 Toray Industries, Inc. Medicament pour traiter les lesions vasculaires diabetiques
WO1999013881A1 (en) * 1997-09-17 1999-03-25 Toray Industries, Inc. Cervical maturing agent
CN105315247B (zh) 2011-06-16 2019-07-26 琅歌生物技术股份有限公司 贝前列素的生产方法
WO2013040068A2 (en) * 2011-09-12 2013-03-21 Irix Pharmaceuticals, Inc. Process for preparing synthetic prostacyclins
US9765047B2 (en) 2015-08-12 2017-09-19 United Therapeutics Corporation Process for making beraprost

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5931510B2 (ja) * 1979-09-03 1984-08-02 東レ株式会社 ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体
DE3041601A1 (de) * 1980-10-31 1982-06-16 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue prostacyclinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3147714A1 (de) * 1981-11-27 1983-06-01 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue prostacycline und verfahren zu ihrer herstellung
JPS58124778A (ja) * 1982-01-20 1983-07-25 Toray Ind Inc ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体

Also Published As

Publication number Publication date
CA1291131C (en) 1991-10-22
EP0274064A3 (en) 1988-07-27
KR880007453A (ko) 1988-08-27
AU8242087A (en) 1988-06-16
ZA879186B (en) 1988-06-06
KR930003853B1 (ko) 1993-05-14
JPS63264475A (ja) 1988-11-01
JPH0571592B2 (enExample) 1993-10-07
ES2032427T3 (es) 1993-02-16
DE3777590D1 (de) 1992-04-23
EP0274064B1 (en) 1992-03-18
EP0274064A2 (en) 1988-07-13
US4880939A (en) 1989-11-14
AU600054B2 (en) 1990-08-02

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties