CA1264668C - EXTRUSION TECHNIQUES FOR THE PRODUCTION OF LIPOSOMES - Google Patents

EXTRUSION TECHNIQUES FOR THE PRODUCTION OF LIPOSOMES

Info

Publication number
CA1264668C
CA1264668C CA483485A CA483485A CA1264668C CA 1264668 C CA1264668 C CA 1264668C CA 483485 A CA483485 A CA 483485A CA 483485 A CA483485 A CA 483485A CA 1264668 C CA1264668 C CA 1264668C
Authority
CA
Canada
Prior art keywords
liposomes
extrusion techniques
producing
disclosure
size distribution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA483485A
Other languages
English (en)
French (fr)
Other versions
CA1264668A (en
Inventor
Pieter R Cullis
Michael J Hope
Marcel B Bally
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to CA483485A priority Critical patent/CA1264668C/en
Application granted granted Critical
Publication of CA1264668A publication Critical patent/CA1264668A/en
Publication of CA1264668C publication Critical patent/CA1264668C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/18—Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/08—Flat membrane modules

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Water Supply & Treatment (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
CA483485A 1984-06-20 1985-06-07 EXTRUSION TECHNIQUES FOR THE PRODUCTION OF LIPOSOMES Expired CA1264668C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA483485A CA1264668C (en) 1984-06-20 1985-06-07 EXTRUSION TECHNIQUES FOR THE PRODUCTION OF LIPOSOMES

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US62269084A 1984-06-20 1984-06-20
US62250284A 1984-06-20 1984-06-20
US622,502 1984-06-20
CA483485A CA1264668C (en) 1984-06-20 1985-06-07 EXTRUSION TECHNIQUES FOR THE PRODUCTION OF LIPOSOMES
US622,690 1990-12-05

Publications (2)

Publication Number Publication Date
CA1264668A CA1264668A (en) 1990-01-23
CA1264668C true CA1264668C (en) 1990-01-23

Family

ID=27089214

Family Applications (1)

Application Number Title Priority Date Filing Date
CA483485A Expired CA1264668C (en) 1984-06-20 1985-06-07 EXTRUSION TECHNIQUES FOR THE PRODUCTION OF LIPOSOMES

Country Status (11)

Country Link
EP (1) EP0185756B1 (enExample)
JP (1) JP2537186B2 (enExample)
CA (1) CA1264668C (enExample)
DE (1) DE3579426D1 (enExample)
DK (1) DK173397B1 (enExample)
ES (1) ES8608922A1 (enExample)
GR (1) GR851485B (enExample)
IE (1) IE58630B1 (enExample)
PT (1) PT80678B (enExample)
SG (1) SG21092G (enExample)
WO (1) WO1986000238A1 (enExample)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5231112A (en) 1984-04-12 1993-07-27 The Liposome Company, Inc. Compositions containing tris salt of cholesterol hemisuccinate and antifungal
US5897873A (en) * 1984-04-12 1999-04-27 The Liposome Company, Inc. Affinity associated vaccine
US5736155A (en) * 1984-08-08 1998-04-07 The Liposome Company, Inc. Encapsulation of antineoplastic agents in liposomes
US5077056A (en) * 1984-08-08 1991-12-31 The Liposome Company, Inc. Encapsulation of antineoplastic agents in liposomes
US5059421A (en) * 1985-07-26 1991-10-22 The Liposome Company, Inc. Preparation of targeted liposome systems of a defined size distribution
MX9203291A (es) * 1985-06-26 1992-08-01 Liposome Co Inc Metodo para acoplamiento de liposomas.
US5041278A (en) * 1985-10-15 1991-08-20 The Liposome Company, Inc. Alpha tocopherol-based vesicles
US4737323A (en) * 1986-02-13 1988-04-12 Liposome Technology, Inc. Liposome extrusion method
US6759057B1 (en) 1986-06-12 2004-07-06 The Liposome Company, Inc. Methods and compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs
US5252263A (en) * 1986-06-16 1993-10-12 The Liposome Company, Inc. Induction of asymmetry in vesicles
US5616334A (en) * 1987-03-05 1997-04-01 The Liposome Company, Inc. Low toxicity drug-lipid systems
MX9203808A (es) * 1987-03-05 1992-07-01 Liposome Co Inc Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos.
US6406713B1 (en) 1987-03-05 2002-06-18 The Liposome Company, Inc. Methods of preparing low-toxicity drug-lipid complexes
CA1338702C (en) * 1987-03-05 1996-11-12 Lawrence D. Mayer High drug:lipid formulations of liposomal- antineoplastic agents
EP0414663A4 (en) * 1987-04-16 1991-07-17 The Liposome Company, Inc. Liposome continuous size reduction method and apparatus
US5925375A (en) * 1987-05-22 1999-07-20 The Liposome Company, Inc. Therapeutic use of multilamellar liposomal prostaglandin formulations
US5082664A (en) * 1987-05-22 1992-01-21 The Liposome Company, Inc. Prostaglandin-lipid formulations
US5262168A (en) * 1987-05-22 1993-11-16 The Liposome Company, Inc. Prostaglandin-lipid formulations
MX9203804A (es) * 1987-10-19 1992-07-01 Liposome Co Inc Sistemas farmaceuticos a base de tocoferol.
US5948441A (en) * 1988-03-07 1999-09-07 The Liposome Company, Inc. Method for size separation of particles
DE3812816A1 (de) * 1988-04-16 1989-11-02 Lawaczeck Ruediger Dipl Phys P Verfahren zur solubilisierung von liposomen und/oder biologischer membranen sowie deren verwendung
ATE99544T1 (de) * 1988-11-09 1994-01-15 Evan C Unger Liposomale radiologische kontrastmittel.
US5049392A (en) * 1989-01-18 1991-09-17 The Liposome Company, Inc. Osmotically dependent vesicles
EP0478715B1 (en) * 1989-06-23 1996-04-03 The Liposome Company, Inc. Targeted liposomes and methods for liposome-protein coupling
US5352435A (en) * 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US5542935A (en) * 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US20020150539A1 (en) 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US5469854A (en) * 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5149319A (en) * 1990-09-11 1992-09-22 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids
US5820848A (en) * 1990-01-12 1998-10-13 The Liposome Company, Inc. Methods of preparing interdigitation-fusion liposomes and gels which encapsulate a bioactive agent
US5525232A (en) * 1990-03-02 1996-06-11 The Liposome Company, Inc. Method for entrapment of cationic species in lemellar vesicles
WO1992002244A1 (en) * 1990-07-31 1992-02-20 The Liposome Company, Inc. Accumulation of amino acids and peptides into liposomes
ATE136456T1 (de) * 1990-10-05 1996-04-15 Liposome Co Inc Extrudierverfahren für liposomen
US6623671B2 (en) 1990-10-05 2003-09-23 Royden M. Coe Liposome extrusion process
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
EP1104678A2 (en) 1992-05-04 2001-06-06 UNGER, Evan C Method for hyperthermic potentiation of tissue
CA2146963A1 (en) * 1992-10-16 1994-04-28 Andreas Sachse Process and device for producing liquid, dispersed systems
CA2160118A1 (en) * 1993-05-21 1994-12-08 Patrick L. Ahl Reduction of liposome-induced adverse physiological reactions
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
US5716526A (en) * 1994-01-14 1998-02-10 The Liposome Company, Inc. Method of separating materials from liposomes or lipid complexes
US6235308B1 (en) 1994-06-10 2001-05-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of treating hypertension
US5622715A (en) * 1994-06-10 1997-04-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of improving renal function
DE19515163C2 (de) * 1995-01-31 2002-11-28 Erich Politsch Vorrichtung zur Extrusion von Suspensionen
US5902604A (en) * 1995-06-06 1999-05-11 Board Of Regents, The University Of Texas System Submicron liposome suspensions obtained from preliposome lyophilizates
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
NL1001380C2 (nl) * 1995-10-09 1997-04-11 Fuji Photo Film Bv Methode voor het dispergeren van een geëmulgeerd materiaal van het olie-druppeltype in een vloeistoftoevoersysteem en bekledingsmethode waarbij van een dergelijke dispergeermethode gebruik wordt gemaakt.
ATE243998T1 (de) 1995-10-12 2003-07-15 Supergen Inc Liposomformulierung von 5-beta steroiden
DE19542499A1 (de) 1995-11-15 1997-05-22 Bayer Ag Verfahren und Vorrichtung zur Herstellung einer parenteralen Arzneistoffzubereitung
AU736301B2 (en) 1996-05-01 2001-07-26 Imarx Therapeutics, Inc. Methods for delivering compounds into a cell
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
IT1289939B1 (it) * 1997-02-20 1998-10-19 Angelini Ricerche Spa Composizione farmaceutica acquosa comprendente un principio attivo altamente insolubile in acqua
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
DE60229118D1 (de) 2001-04-04 2008-11-13 Nordic Vaccine Technology As Polynukleotide-bindende komplexe die sterolen und saponine enthalten
JP2006506229A (ja) 2002-11-14 2006-02-23 カー・イュー・ルーベン・リサーチ・アンド・ディベロップメント 乳濁液調製方法
JP2005170923A (ja) * 2003-10-21 2005-06-30 Konica Minolta Medical & Graphic Inc リポソーム含有ｘ線造影剤およびその製造方法
JP2005170928A (ja) * 2003-10-21 2005-06-30 Konica Minolta Medical & Graphic Inc リポソーム含有ｘ線造影剤およびその製造方法
JP4654590B2 (ja) * 2004-03-31 2011-03-23 コニカミノルタエムジー株式会社 Ｘ線ｃｔ用造影組成物およびその製造方法
CN101583346B (zh) 2006-04-28 2015-08-19 儿童医院医疗中心 用于穿膜药物递送系统的皂化蛋白c和相关蛋白及肽的促融合性质
KR20080012605A (ko) 2006-08-04 2008-02-12 삼성에스디아이 주식회사 탄성 에너지 장벽을 이용한 생체막 소자
EP1920765A1 (en) * 2006-11-07 2008-05-14 Medigene AG Liposome preparation by single-pass process
US9445975B2 (en) 2008-10-03 2016-09-20 Access Business Group International, Llc Composition and method for preparing stable unilamellar liposomal suspension
JP5771366B2 (ja) 2009-09-02 2015-08-26 株式会社バイオメッドコア リポソーム製造装置及び方法
US20120310140A1 (en) 2010-12-01 2012-12-06 Spinal Modulation, Inc. Directed delivery of agents to neural anatomy
WO2013098813A1 (en) 2012-01-01 2013-07-04 Qbi Enterprises Ltd. Endo180-targeted particles for selective delivery of therapeutic and diagnostic agents
US9993427B2 (en) 2013-03-14 2018-06-12 Biorest Ltd. Liposome formulation and manufacture
AU2013382087C1 (en) * 2013-03-14 2017-11-23 Zuli Holdings Ltd. Liposome formulation and manufacture
WO2018005657A1 (en) 2016-06-28 2018-01-04 Verily Life Sciences Llc Serial filtration to generate small cholesterol-containing liposomes
JP6403026B2 (ja) * 2017-06-29 2018-10-10 バイオレスト リミテッド リポソーム、リポソームを含む処方剤、および処方剤の製造方法
CA3084821A1 (en) 2017-12-15 2019-06-20 Board Of Regents, The University Of Texas System Methods and compositions for treating cancer using exosomes-associated gene editing
CA3095134A1 (en) 2018-03-28 2019-10-03 Board Of Regents, The University Of Texas System Identification of epigenetic alterations in dna isolated from exosomes
JP6596648B2 (ja) * 2018-08-29 2019-10-30 ズーリー ホールディングス リミテッド リポソーム、リポソームを含む処方剤、および処方剤の製造方法
IL322828A (en) * 2023-02-23 2025-10-01 Evonik Operations Gmbh Small-scale liposome extrusion facility

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5186117A (en) * 1975-01-27 1976-07-28 Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
US4263428A (en) * 1978-03-24 1981-04-21 The Regents Of The University Of California Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
CA1173360A (en) * 1979-06-22 1984-08-28 Jurg Schrank Pharmaceutical preparations
JPS5782310A (en) * 1980-11-11 1982-05-22 Tanabe Seiyaku Co Ltd Production of liposome preparation

Also Published As

Publication number Publication date
IE851514L (en) 1985-12-20
DK173397B1 (da) 2000-09-18
ES8608922A1 (es) 1986-09-01
ES544364A0 (es) 1986-09-01
WO1986000238A1 (en) 1986-01-16
PT80678A (en) 1985-07-01
DE3579426D1 (de) 1990-10-04
GR851485B (enExample) 1985-11-25
EP0185756A4 (en) 1987-09-02
JPS61502452A (ja) 1986-10-30
DK77986D0 (da) 1986-02-19
PT80678B (pt) 1987-08-19
IE58630B1 (en) 1993-10-20
EP0185756A1 (en) 1986-07-02
JP2537186B2 (ja) 1996-09-25
CA1264668A (en) 1990-01-23
EP0185756B1 (en) 1990-08-29
SG21092G (en) 1992-04-16
DK77986A (da) 1986-02-19

Similar Documents

Publication Publication Date Title
ES8608922A1 (es) Un metodo para reducir el caracter laminar de una poblacion de liposomas
AU580643B2 (en) Retroreflective particles and methods for their production and use
GB2092189B (en) Producing synthetic yarn and yarn-like structures
DE68926758D1 (de) Abriebfeste gesinterte Eisenlegierung, bestehend aus einer Dispersion von harten Legierungsteilchen und Verfahren zu ihrer Herstellung
AU5636080A (en) Sorting objects according to destination
CA2166465A1 (en) Method of controlling the size of liposomes
PT82127A (en) Process for the preparation of phenyl carbamates
GB2086870B (en) High performance carbon fiber process for production thereof and composite materials prepared therewith
AU2534688A (en) Improvements in or relating to fabric production
AU2448984A (en) Sorting particles according to melting point
IT1177783B (it) Materiali amorfi resistenti all'usura ed articoli prodotti con essi,nonche' procedimento per la loro fabbricazione
IT1143247B (it) Procedimento per la preparazione di sospensioni stabili e non gelificabili in particolare per la produzione di detersivi in granuli
GB8312436D0 (en) Producing composite articles
EP0334478A3 (en) Die-upset manufacture to produce high volume fractions of re-fe-b type magnetically-aligned material
GB8425961D0 (en) Producing fine fibres
IT9019174A1 (it) Procedimento per l'arricchimento di polveri, risultanti nel cubilotto, con particelle metalliche
DE3161409D1 (en) 2,4-dialkyl-2,6-heptadienals and -hetadienols, process for their preparation and their use as perfume compounds and flavourings
GB2146015B (en) Process for the improvement of antibiotic production by in vivo genetic recombination
NZ211230A (en) In vitro diagnosis; separating viable cells by magnetism
DE3379788D1 (en) 2(1h)-pyridinones, useful as cardiotonic agents, and their production
DE3367403D1 (en) Single stage production of improved high molecular weight polybenzimidazole
IL73896A (en) Silane-modified ester mixtures,their production and pharmaceutical and cosmetic compositions containing them
USD285609S (en) Suspension rail with sliding block
GB8818794D0 (en) Production of intermetallic particles & products including such
IL61223A (en) Tricyclo(6.2.1.0 1,6)undecanes,their preparation and perfume compositions containing them

Legal Events

Date Code Title Description
MKEX Expiry
MKEX Expiry

Effective date: 20070123