ATE99544T1 - Liposomale radiologische kontrastmittel. - Google Patents

Liposomale radiologische kontrastmittel.

Info

Publication number
ATE99544T1
ATE99544T1 AT90900449T AT90900449T ATE99544T1 AT E99544 T1 ATE99544 T1 AT E99544T1 AT 90900449 T AT90900449 T AT 90900449T AT 90900449 T AT90900449 T AT 90900449T AT E99544 T1 ATE99544 T1 AT E99544T1
Authority
AT
Austria
Prior art keywords
liposomal
paramagnetic
contrast agent
radiological contrast
encapsulated
Prior art date
Application number
AT90900449T
Other languages
English (en)
Inventor
Evan C Unger
Colin Tilcock
Original Assignee
Evan C Unger
Colin Tilcock
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26953556&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE99544(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Evan C Unger, Colin Tilcock filed Critical Evan C Unger
Application granted granted Critical
Publication of ATE99544T1 publication Critical patent/ATE99544T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1812—Suspensions, emulsions, colloids, dispersions liposomes, polymersomes, e.g. immunoliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Optical Transform (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
AT90900449T 1988-11-09 1989-11-08 Liposomale radiologische kontrastmittel. ATE99544T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26919088A 1988-11-09 1988-11-09
US42833989A 1989-10-27 1989-10-27
PCT/US1989/005040 WO1990004943A1 (en) 1988-11-09 1989-11-08 Liposomal radiologic contrast agents

Publications (1)

Publication Number Publication Date
ATE99544T1 true ATE99544T1 (de) 1994-01-15

Family

ID=26953556

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90900449T ATE99544T1 (de) 1988-11-09 1989-11-08 Liposomale radiologische kontrastmittel.

Country Status (5)

Country Link
EP (1) EP0442962B1 (de)
JP (1) JPH04501723A (de)
AT (1) ATE99544T1 (de)
DE (1) DE68912139T2 (de)
WO (1) WO1990004943A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020150539A1 (en) 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US5922304A (en) * 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US5352435A (en) * 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US5469854A (en) * 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US5542935A (en) * 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
JPH06505701A (ja) * 1990-09-10 1994-06-30 スクール・オブ・フアーマシー・ユニバーシテイ・オブ・ロンドン リポソーム
WO1992011840A1 (de) * 1991-01-07 1992-07-23 Byk Gulden Lomberg Chemische Fabrik Gmbh Kontrastmittel für die mr-diagnostik
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
US5406950A (en) * 1993-12-23 1995-04-18 Mallinckrodt Medical, Inc. Inhalable contrast agent
ATE219688T1 (de) * 1994-03-28 2002-07-15 Nycomed Imaging As Liposomen enthaltend ein röntgen- oder ultraschallkontrastmittel
JPH10513466A (ja) * 1995-02-09 1998-12-22 シェリング アクチェンゲゼルシャフト 脈管内空間を視覚化するための造影剤を含むリポソーム
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
DE19529922A1 (de) * 1995-08-01 1997-02-06 Schering Ag Verwendung von liposomalen Zubereitungen in der indirekten MRT-Lymphographie
ATE345682T1 (de) 1996-05-01 2006-12-15 Imarx Pharmaceutical Corp In vitro verfahren zum einbringen von nukleinsäuren in eine zelle
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
JP2004528321A (ja) 2001-04-04 2004-09-16 ノルディック ワクチン テクノロジー アクティーゼルスカブ ステロールおよびサポニンを含むポリヌクレオチド結合複合体
US7087212B2 (en) 2001-08-17 2006-08-08 Mallinckrodt, Inc Multicomponent assemblies having enhanced binding properties for diagnosis and therapy
EP1466629A1 (de) * 2003-04-11 2004-10-13 BRACCO IMAGING S.p.A. Adducte zwischen NMR Vershibungsreagenzen und Substraten mit austauschbaren Protonen für die "CEST" Anwendung
WO2006032705A2 (en) * 2004-09-23 2006-03-30 Guerbet Contrast agents encapsulating systems for cest imaging
EP1810688A1 (de) * 2004-11-10 2007-07-25 Konica Minolta Medical & Graphic, Inc. Pharmazeutische zubereitung mit beschichteten magnetischen teilchen und verfahren zu ihrer herstellung und diagnose- und therapiesystem
JP2006335745A (ja) * 2005-06-06 2006-12-14 Fujifilm Holdings Corp リポソームを含むｍｒｉ造影剤
BRPI0710945A2 (pt) 2006-04-28 2012-03-13 Children's Hospital Medical Center Propriedades fusogênicas de saposina c e proteínas e peptídeos relacionados para aplicação a sistemas de distribuição de fármaco transmembrana
FR2914304B1 (fr) 2007-03-28 2012-11-16 Guerbet Sa Composes pour le diagnostic de maladies liees a l'expression de vcam.
FR2914303A1 (fr) 2007-03-28 2008-10-03 Guerbet Sa Composes pour le diagnostic de l'apoptose.
JP2008266324A (ja) * 2007-03-29 2008-11-06 Kose Corp リポソーム組成物及び該リポソーム組成物を含有した皮膚外用剤
FR2939318B1 (fr) * 2008-12-10 2012-07-13 Guerbet Sa Systeme d'encapsulation pour imagerie cest avec quelate q superieur ou egal a 2
US11246832B2 (en) 2016-06-28 2022-02-15 Verily Life Sciences Llc Serial filtration to generate small cholesterol-containing liposomes
JP2021506795A (ja) 2017-12-15 2021-02-22 ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System エキソソーム関連遺伝子編集を用いてがんを処置するための方法および組成物
US12473598B2 (en) 2018-03-28 2025-11-18 Board Of Regents, The University Of Texas System Identification of epigenetic alterations in DNA isolated from exosomes
RU2697802C1 (ru) * 2018-08-23 2019-08-20 Федеральное Государственное Бюджетное Учреждение Науки Институт Биохимической Физики Им. Н.М. Эмануэля Российской Академии Наук (Ибхф Ран) Способ получения магнитных липосом

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4192859A (en) * 1978-09-29 1980-03-11 E. R. Squibb & Sons, Inc. Contrast media containing liposomes as carriers
US4532089A (en) * 1984-01-14 1985-07-30 Northwestern University Method of preparing giant size liposomes
US4728575A (en) * 1984-04-27 1988-03-01 Vestar, Inc. Contrast agents for NMR imaging
CA1264668C (en) * 1984-06-20 1990-01-23 EXTRUSION TECHNIQUES FOR THE PRODUCTION OF LIPOSOMES
US4652257A (en) * 1985-03-21 1987-03-24 The United States Of America As Represented By The Secretary Of The Navy Magnetically-localizable, polymerized lipid vesicles and method of disrupting same
US4675173A (en) * 1985-05-08 1987-06-23 Molecular Biosystems, Inc. Method of magnetic resonance imaging of the liver and spleen
DK175531B1 (da) * 1986-12-15 2004-11-22 Nexstar Pharmaceuticals Inc Leveringsvehikel med amphiphil-associeret aktiv bestanddel

Also Published As

Publication number Publication date
EP0442962A4 (en) 1991-12-18
EP0442962A1 (de) 1991-08-28
EP0442962B1 (de) 1994-01-05
JPH04501723A (ja) 1992-03-26
DE68912139D1 (de) 1994-02-17
DE68912139T2 (de) 1994-04-28
WO1990004943A1 (en) 1990-05-17

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Legal Events

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RZN Patent revoked