ES8608922A1 - Un metodo para reducir el caracter laminar de una poblacion de liposomas - Google Patents

Un metodo para reducir el caracter laminar de una poblacion de liposomas

Info

Publication number
ES8608922A1
ES8608922A1 ES544364A ES544364A ES8608922A1 ES 8608922 A1 ES8608922 A1 ES 8608922A1 ES 544364 A ES544364 A ES 544364A ES 544364 A ES544364 A ES 544364A ES 8608922 A1 ES8608922 A1 ES 8608922A1
Authority
ES
Spain
Prior art keywords
liposomes
extrusion techniques
producing
producing liposomes
size distribution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES544364A
Other languages
English (en)
Other versions
ES544364A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elan Pharmaceuticals LLC
Original Assignee
Liposome Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Liposome Co Inc filed Critical Liposome Co Inc
Publication of ES544364A0 publication Critical patent/ES544364A0/es
Publication of ES8608922A1 publication Critical patent/ES8608922A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/18—Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/08—Flat membrane modules

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Water Supply & Treatment (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)

Abstract

METODO PARA LA PRODUCCION DE LIPOSOMAS UNILAMINARES, SIN EL USO DE DISOLVENTES, DETERGENTES U OTROS MATERIALES EXTRAÑOS. COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE PREPARA UNA MEZCLA FORMADA POR UN LIPIDO EN POLVO O EN GLOBULOS Y UN TAMPON ACUOSO; SEGUNDA, LA MEZCLA PREPARADA SE HACE PASAR REPETIDAS VECES, A PRESION, A TRAVES DE UN FILTRO O DE UNA PLURALIDAD DE FILTROS, TODOS LOS CUALES TIENEN EL MISMO TAMAÑO DE POROS; Y POR ULTIMO, OPCIONALMENTE SE SOMETEN LOS LIPOSOMAS OBTENIDOS A UN CICLO DE CONGELACION-DESCONGELACION PARA AUMENTAR LOS VOLUMENES OCLUIDOS.
ES544364A 1984-06-20 1985-06-19 Un metodo para reducir el caracter laminar de una poblacion de liposomas Expired ES8608922A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62250284A 1984-06-20 1984-06-20
US62269084A 1984-06-20 1984-06-20

Publications (2)

Publication Number Publication Date
ES544364A0 ES544364A0 (es) 1986-09-01
ES8608922A1 true ES8608922A1 (es) 1986-09-01

Family

ID=27089214

Family Applications (1)

Application Number Title Priority Date Filing Date
ES544364A Expired ES8608922A1 (es) 1984-06-20 1985-06-19 Un metodo para reducir el caracter laminar de una poblacion de liposomas

Country Status (11)

Country Link
EP (1) EP0185756B1 (es)
JP (1) JP2537186B2 (es)
CA (1) CA1264668A (es)
DE (1) DE3579426D1 (es)
DK (1) DK173397B1 (es)
ES (1) ES8608922A1 (es)
GR (1) GR851485B (es)
IE (1) IE58630B1 (es)
PT (1) PT80678B (es)
SG (1) SG21092G (es)
WO (1) WO1986000238A1 (es)

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US5231112A (en) * 1984-04-12 1993-07-27 The Liposome Company, Inc. Compositions containing tris salt of cholesterol hemisuccinate and antifungal
US5077056A (en) * 1984-08-08 1991-12-31 The Liposome Company, Inc. Encapsulation of antineoplastic agents in liposomes
US5736155A (en) * 1984-08-08 1998-04-07 The Liposome Company, Inc. Encapsulation of antineoplastic agents in liposomes
MX9203291A (es) * 1985-06-26 1992-08-01 Liposome Co Inc Metodo para acoplamiento de liposomas.
US5059421A (en) * 1985-07-26 1991-10-22 The Liposome Company, Inc. Preparation of targeted liposome systems of a defined size distribution
US5041278A (en) * 1985-10-15 1991-08-20 The Liposome Company, Inc. Alpha tocopherol-based vesicles
US4737323A (en) * 1986-02-13 1988-04-12 Liposome Technology, Inc. Liposome extrusion method
US6759057B1 (en) 1986-06-12 2004-07-06 The Liposome Company, Inc. Methods and compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs
US5252263A (en) * 1986-06-16 1993-10-12 The Liposome Company, Inc. Induction of asymmetry in vesicles
CA1338702C (en) * 1987-03-05 1996-11-12 Lawrence D. Mayer High drug:lipid formulations of liposomal- antineoplastic agents
MX9203808A (es) * 1987-03-05 1992-07-01 Liposome Co Inc Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos.
US6406713B1 (en) 1987-03-05 2002-06-18 The Liposome Company, Inc. Methods of preparing low-toxicity drug-lipid complexes
US5616334A (en) * 1987-03-05 1997-04-01 The Liposome Company, Inc. Low toxicity drug-lipid systems
EP0414663A4 (en) * 1987-04-16 1991-07-17 The Liposome Company, Inc. Liposome continuous size reduction method and apparatus
US5262168A (en) * 1987-05-22 1993-11-16 The Liposome Company, Inc. Prostaglandin-lipid formulations
AU617678B2 (en) * 1987-05-22 1991-12-05 Liposome Company, Inc., The Prostaglandin-lipid formulations
US5925375A (en) * 1987-05-22 1999-07-20 The Liposome Company, Inc. Therapeutic use of multilamellar liposomal prostaglandin formulations
MX9203804A (es) * 1987-10-19 1992-07-01 Liposome Co Inc Sistemas farmaceuticos a base de tocoferol.
US5948441A (en) * 1988-03-07 1999-09-07 The Liposome Company, Inc. Method for size separation of particles
DE3812816A1 (de) * 1988-04-16 1989-11-02 Lawaczeck Ruediger Dipl Phys P Verfahren zur solubilisierung von liposomen und/oder biologischer membranen sowie deren verwendung
JPH04501723A (ja) * 1988-11-09 1992-03-26 アンガー，エヴァン，シー． リポソーム性放射線造影剤
US5049392A (en) * 1989-01-18 1991-09-17 The Liposome Company, Inc. Osmotically dependent vesicles
ATE136211T1 (de) * 1989-06-23 1996-04-15 Liposome Co Inc Zielliposomen und verfahren zur kupplung von liposomen-proteinen
US5149319A (en) * 1990-09-11 1992-09-22 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids
US5469854A (en) * 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5352435A (en) * 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US5542935A (en) * 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5820848A (en) * 1990-01-12 1998-10-13 The Liposome Company, Inc. Methods of preparing interdigitation-fusion liposomes and gels which encapsulate a bioactive agent
US5525232A (en) * 1990-03-02 1996-06-11 The Liposome Company, Inc. Method for entrapment of cationic species in lemellar vesicles
CA2087965A1 (en) * 1990-07-30 1992-02-01 Ajoy Chakrabarti Accumulation of amino acids and peptides into liposomes
ES2087315T3 (es) * 1990-10-05 1996-07-16 Liposome Co Inc Procedimiento de extrusion de liposomas.
US6623671B2 (en) 1990-10-05 2003-09-23 Royden M. Coe Liposome extrusion process
EP0804944A3 (en) 1992-05-04 1998-08-26 UNGER, Evan C A method of providing a gas composition in a biological tissue or fluid in vivo
CA2146963A1 (en) * 1992-10-16 1994-04-28 Andreas Sachse Process and device for producing liquid, dispersed systems
DE69429511T2 (de) * 1993-05-21 2002-05-16 The Liposome Co., Inc. Reduzierung von durch liposome induzierte physiologischen gegenreaktionen
US5716526A (en) * 1994-01-14 1998-02-10 The Liposome Company, Inc. Method of separating materials from liposomes or lipid complexes
US6235308B1 (en) 1994-06-10 2001-05-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of treating hypertension
US5622715A (en) * 1994-06-10 1997-04-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of improving renal function
DE19515163C2 (de) * 1995-01-31 2002-11-28 Erich Politsch Vorrichtung zur Extrusion von Suspensionen
US5902604A (en) * 1995-06-06 1999-05-11 Board Of Regents, The University Of Texas System Submicron liposome suspensions obtained from preliposome lyophilizates
NL1001380C2 (nl) * 1995-10-09 1997-04-11 Fuji Photo Film Bv Methode voor het dispergeren van een geëmulgeerd materiaal van het olie-druppeltype in een vloeistoftoevoersysteem en bekledingsmethode waarbij van een dergelijke dispergeermethode gebruik wordt gemaakt.
JPH10508322A (ja) 1995-10-12 1998-08-18 スーパーゲン，インコーポレイティド ５βステロイドのリポソーム配合物
DE19542499A1 (de) * 1995-11-15 1997-05-22 Bayer Ag Verfahren und Vorrichtung zur Herstellung einer parenteralen Arzneistoffzubereitung
IT1289939B1 (it) * 1997-02-20 1998-10-19 Angelini Ricerche Spa Composizione farmaceutica acquosa comprendente un principio attivo altamente insolubile in acqua
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
EP2011517A1 (en) 2001-04-04 2009-01-07 Nordic Vaccine Technology A/S Polynucleotide binding complexes comprising sterols and saponin
CA2502908C (en) 2002-11-14 2011-05-10 K.U.Leuven Research & Development Method for preparing emulsions
JP2005170928A (ja) * 2003-10-21 2005-06-30 Konica Minolta Medical & Graphic Inc リポソーム含有ｘ線造影剤およびその製造方法
JP2005170923A (ja) * 2003-10-21 2005-06-30 Konica Minolta Medical & Graphic Inc リポソーム含有ｘ線造影剤およびその製造方法
JP4654590B2 (ja) * 2004-03-31 2011-03-23 コニカミノルタエムジー株式会社 Ｘ線ｃｔ用造影組成物およびその製造方法
BRPI0710945A2 (pt) 2006-04-28 2012-03-13 Children's Hospital Medical Center Propriedades fusogênicas de saposina c e proteínas e peptídeos relacionados para aplicação a sistemas de distribuição de fármaco transmembrana
KR20080012605A (ko) 2006-08-04 2008-02-12 삼성에스디아이 주식회사 탄성 에너지 장벽을 이용한 생체막 소자
EP1920765A1 (en) * 2006-11-07 2008-05-14 Medigene AG Liposome preparation by single-pass process
US9445975B2 (en) * 2008-10-03 2016-09-20 Access Business Group International, Llc Composition and method for preparing stable unilamellar liposomal suspension
JP5771366B2 (ja) 2009-09-02 2015-08-26 株式会社バイオメッドコア リポソーム製造装置及び方法
EP2646107A2 (en) 2010-12-01 2013-10-09 Spinal Modulation Inc. Agent delivery systems for selective neuromodulation
US20150216998A1 (en) 2012-01-01 2015-08-06 Ramot At Tel-Aviv University Ltd. Endo180-targeted particles for selective delivery of therapeutic and diagnostic agents
CN105188674B (zh) * 2013-03-14 2017-12-08 生物休眠有限公司 脂质体制剂及制造
US9993427B2 (en) 2013-03-14 2018-06-12 Biorest Ltd. Liposome formulation and manufacture
WO2018005657A1 (en) * 2016-06-28 2018-01-04 Verily Life Sciences Llc Serial filtration to generate small cholesterol-containing liposomes
JP6403026B2 (ja) * 2017-06-29 2018-10-10 バイオレスト リミテッド リポソーム、リポソームを含む処方剤、および処方剤の製造方法
WO2024175457A1 (en) * 2023-02-23 2024-08-29 Evonik Operations Gmbh Small scale liposome extruder

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5186117A (en) * 1975-01-27 1976-07-28 Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
US4263428A (en) * 1978-03-24 1981-04-21 The Regents Of The University Of California Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
CA1173360A (en) * 1979-06-22 1984-08-28 Jurg Schrank Pharmaceutical preparations
JPS5782310A (en) * 1980-11-11 1982-05-22 Tanabe Seiyaku Co Ltd Production of liposome preparation

Also Published As

Publication number Publication date
JPS61502452A (ja) 1986-10-30
ES544364A0 (es) 1986-09-01
EP0185756A1 (en) 1986-07-02
DK173397B1 (da) 2000-09-18
CA1264668C (en) 1990-01-23
EP0185756B1 (en) 1990-08-29
PT80678A (en) 1985-07-01
EP0185756A4 (en) 1987-09-02
PT80678B (pt) 1987-08-19
CA1264668A (en) 1990-01-23
DK77986A (da) 1986-02-19
IE851514L (en) 1985-12-20
DK77986D0 (da) 1986-02-19
GR851485B (es) 1985-11-25
JP2537186B2 (ja) 1996-09-25
IE58630B1 (en) 1993-10-20
DE3579426D1 (de) 1990-10-04
WO1986000238A1 (en) 1986-01-16
SG21092G (en) 1992-04-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20060605