CA1264668A - Extrusion techniques for producing liposomes - Google Patents
Extrusion techniques for producing liposomesInfo
- Publication number
- CA1264668A CA1264668A CA000483485A CA483485A CA1264668A CA 1264668 A CA1264668 A CA 1264668A CA 000483485 A CA000483485 A CA 000483485A CA 483485 A CA483485 A CA 483485A CA 1264668 A CA1264668 A CA 1264668A
- Authority
- CA
- Canada
- Prior art keywords
- liposomes
- filter
- population
- pore size
- filters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- 238000000034 method Methods 0.000 title claims abstract description 166
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/18—Apparatus therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/08—Flat membrane modules
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Water Supply & Treatment (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA483485A CA1264668C (en) | 1984-06-20 | 1985-06-07 | EXTRUSION TECHNIQUES FOR THE PRODUCTION OF LIPOSOMES |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62269084A | 1984-06-20 | 1984-06-20 | |
| US62250284A | 1984-06-20 | 1984-06-20 | |
| US622,502 | 1984-06-20 | ||
| CA483485A CA1264668C (en) | 1984-06-20 | 1985-06-07 | EXTRUSION TECHNIQUES FOR THE PRODUCTION OF LIPOSOMES |
| US622,690 | 1990-12-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA1264668A true CA1264668A (en) | 1990-01-23 |
| CA1264668C CA1264668C (en) | 1990-01-23 |
Family
ID=27089214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA483485A Expired CA1264668C (en) | 1984-06-20 | 1985-06-07 | EXTRUSION TECHNIQUES FOR THE PRODUCTION OF LIPOSOMES |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0185756B1 (enExample) |
| JP (1) | JP2537186B2 (enExample) |
| CA (1) | CA1264668C (enExample) |
| DE (1) | DE3579426D1 (enExample) |
| DK (1) | DK173397B1 (enExample) |
| ES (1) | ES8608922A1 (enExample) |
| GR (1) | GR851485B (enExample) |
| IE (1) | IE58630B1 (enExample) |
| PT (1) | PT80678B (enExample) |
| SG (1) | SG21092G (enExample) |
| WO (1) | WO1986000238A1 (enExample) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5231112A (en) * | 1984-04-12 | 1993-07-27 | The Liposome Company, Inc. | Compositions containing tris salt of cholesterol hemisuccinate and antifungal |
| US5897873A (en) * | 1984-04-12 | 1999-04-27 | The Liposome Company, Inc. | Affinity associated vaccine |
| US5736155A (en) * | 1984-08-08 | 1998-04-07 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
| US5077056A (en) * | 1984-08-08 | 1991-12-31 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
| US5059421A (en) * | 1985-07-26 | 1991-10-22 | The Liposome Company, Inc. | Preparation of targeted liposome systems of a defined size distribution |
| MX9203291A (es) * | 1985-06-26 | 1992-08-01 | Liposome Co Inc | Metodo para acoplamiento de liposomas. |
| US5041278A (en) * | 1985-10-15 | 1991-08-20 | The Liposome Company, Inc. | Alpha tocopherol-based vesicles |
| US4737323A (en) * | 1986-02-13 | 1988-04-12 | Liposome Technology, Inc. | Liposome extrusion method |
| US6759057B1 (en) | 1986-06-12 | 2004-07-06 | The Liposome Company, Inc. | Methods and compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs |
| US5252263A (en) * | 1986-06-16 | 1993-10-12 | The Liposome Company, Inc. | Induction of asymmetry in vesicles |
| US6406713B1 (en) | 1987-03-05 | 2002-06-18 | The Liposome Company, Inc. | Methods of preparing low-toxicity drug-lipid complexes |
| US5616334A (en) * | 1987-03-05 | 1997-04-01 | The Liposome Company, Inc. | Low toxicity drug-lipid systems |
| CA1338702C (en) * | 1987-03-05 | 1996-11-12 | Lawrence D. Mayer | High drug:lipid formulations of liposomal- antineoplastic agents |
| MX9203808A (es) * | 1987-03-05 | 1992-07-01 | Liposome Co Inc | Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos. |
| EP0414663A4 (en) * | 1987-04-16 | 1991-07-17 | The Liposome Company, Inc. | Liposome continuous size reduction method and apparatus |
| US5262168A (en) * | 1987-05-22 | 1993-11-16 | The Liposome Company, Inc. | Prostaglandin-lipid formulations |
| KR970005171B1 (ko) * | 1987-05-22 | 1997-04-14 | 더 리포조옴 캄파니, 인코포레이티드 | 아라키돈산 대사물질 관련 리포좀 제조방법 및 그 제제 |
| US5925375A (en) * | 1987-05-22 | 1999-07-20 | The Liposome Company, Inc. | Therapeutic use of multilamellar liposomal prostaglandin formulations |
| MX9203804A (es) * | 1987-10-19 | 1992-07-01 | Liposome Co Inc | Sistemas farmaceuticos a base de tocoferol. |
| US5948441A (en) * | 1988-03-07 | 1999-09-07 | The Liposome Company, Inc. | Method for size separation of particles |
| DE3812816A1 (de) * | 1988-04-16 | 1989-11-02 | Lawaczeck Ruediger Dipl Phys P | Verfahren zur solubilisierung von liposomen und/oder biologischer membranen sowie deren verwendung |
| EP0442962B1 (en) * | 1988-11-09 | 1994-01-05 | UNGER, Evan C | Liposomal radiologic contrast agents |
| US5049392A (en) * | 1989-01-18 | 1991-09-17 | The Liposome Company, Inc. | Osmotically dependent vesicles |
| DE69026380T2 (de) * | 1989-06-23 | 1996-10-17 | The Liposome Co.,Inc., Princeton, N.J. | Zielliposomen und verfahren zur kupplung von liposomen-proteinen |
| US5580575A (en) * | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
| US5149319A (en) * | 1990-09-11 | 1992-09-22 | Unger Evan C | Methods for providing localized therapeutic heat to biological tissues and fluids |
| US5542935A (en) * | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
| US5469854A (en) * | 1989-12-22 | 1995-11-28 | Imarx Pharmaceutical Corp. | Methods of preparing gas-filled liposomes |
| US20020150539A1 (en) | 1989-12-22 | 2002-10-17 | Unger Evan C. | Ultrasound imaging and treatment |
| US5352435A (en) * | 1989-12-22 | 1994-10-04 | Unger Evan C | Ionophore containing liposomes for ultrasound imaging |
| US5820848A (en) * | 1990-01-12 | 1998-10-13 | The Liposome Company, Inc. | Methods of preparing interdigitation-fusion liposomes and gels which encapsulate a bioactive agent |
| US5525232A (en) * | 1990-03-02 | 1996-06-11 | The Liposome Company, Inc. | Method for entrapment of cationic species in lemellar vesicles |
| AU660288B2 (en) * | 1990-07-31 | 1995-06-22 | Transave, Inc. | Accumulation of amino acids and peptides into liposomes |
| US6623671B2 (en) | 1990-10-05 | 2003-09-23 | Royden M. Coe | Liposome extrusion process |
| DE69118708T2 (de) * | 1990-10-05 | 1996-10-31 | The Liposome Co.,Inc., Princeton, N.J. | Extrudierverfahren für liposomen |
| US5205290A (en) | 1991-04-05 | 1993-04-27 | Unger Evan C | Low density microspheres and their use as contrast agents for computed tomography |
| EP0804944A3 (en) | 1992-05-04 | 1998-08-26 | UNGER, Evan C | A method of providing a gas composition in a biological tissue or fluid in vivo |
| EP0665756A1 (de) * | 1992-10-16 | 1995-08-09 | SACHSE, Andreas | Verfahren und vorrichtung zur herstellung flüssiger, disperser systeme |
| DE69429511T2 (de) * | 1993-05-21 | 2002-05-16 | The Liposome Co., Inc. | Reduzierung von durch liposome induzierte physiologischen gegenreaktionen |
| US7083572B2 (en) | 1993-11-30 | 2006-08-01 | Bristol-Myers Squibb Medical Imaging, Inc. | Therapeutic delivery systems |
| US5716526A (en) * | 1994-01-14 | 1998-02-10 | The Liposome Company, Inc. | Method of separating materials from liposomes or lipid complexes |
| US5622715A (en) * | 1994-06-10 | 1997-04-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Method of improving renal function |
| US6235308B1 (en) | 1994-06-10 | 2001-05-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Method of treating hypertension |
| DE19515163C2 (de) * | 1995-01-31 | 2002-11-28 | Erich Politsch | Vorrichtung zur Extrusion von Suspensionen |
| US5902604A (en) * | 1995-06-06 | 1999-05-11 | Board Of Regents, The University Of Texas System | Submicron liposome suspensions obtained from preliposome lyophilizates |
| US6521211B1 (en) | 1995-06-07 | 2003-02-18 | Bristol-Myers Squibb Medical Imaging, Inc. | Methods of imaging and treatment with targeted compositions |
| NL1001380C2 (nl) * | 1995-10-09 | 1997-04-11 | Fuji Photo Film Bv | Methode voor het dispergeren van een geëmulgeerd materiaal van het olie-druppeltype in een vloeistoftoevoersysteem en bekledingsmethode waarbij van een dergelijke dispergeermethode gebruik wordt gemaakt. |
| EP0801557B1 (en) | 1995-10-12 | 2003-07-02 | Supergen, Inc. | Liposome formulations of 5beta steroids |
| DE19542499A1 (de) | 1995-11-15 | 1997-05-22 | Bayer Ag | Verfahren und Vorrichtung zur Herstellung einer parenteralen Arzneistoffzubereitung |
| EP0935415B1 (en) | 1996-05-01 | 2006-11-22 | Imarx Pharmaceutical Corp. | In vitro methods for delivering nucleic acids into a cell |
| US5846517A (en) | 1996-09-11 | 1998-12-08 | Imarx Pharmaceutical Corp. | Methods for diagnostic imaging using a renal contrast agent and a vasodilator |
| IT1289939B1 (it) * | 1997-02-20 | 1998-10-19 | Angelini Ricerche Spa | Composizione farmaceutica acquosa comprendente un principio attivo altamente insolubile in acqua |
| US6537246B1 (en) | 1997-06-18 | 2003-03-25 | Imarx Therapeutics, Inc. | Oxygen delivery agents and uses for the same |
| US7452551B1 (en) | 2000-10-30 | 2008-11-18 | Imarx Therapeutics, Inc. | Targeted compositions for diagnostic and therapeutic use |
| US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
| DE60229118D1 (de) | 2001-04-04 | 2008-11-13 | Nordic Vaccine Technology As | Polynukleotide-bindende komplexe die sterolen und saponine enthalten |
| DK1560641T3 (da) | 2002-11-14 | 2006-07-31 | Leuven K U Res & Dev | Fremgangsmåde til fremstilling af emulsioner |
| JP2005170928A (ja) * | 2003-10-21 | 2005-06-30 | Konica Minolta Medical & Graphic Inc | リポソーム含有ｘ線造影剤およびその製造方法 |
| JP2005170923A (ja) * | 2003-10-21 | 2005-06-30 | Konica Minolta Medical & Graphic Inc | リポソーム含有ｘ線造影剤およびその製造方法 |
| JP4654590B2 (ja) * | 2004-03-31 | 2011-03-23 | コニカミノルタエムジー株式会社 | Ｘ線ｃｔ用造影組成物およびその製造方法 |
| EP2020988B1 (en) | 2006-04-28 | 2017-08-16 | Children's Hospital Medical Center | Compositions comprising fusogenic proteins or polypeptides derived from prosaposin for application in transmembrane drug delivery systems |
| KR20080012605A (ko) | 2006-08-04 | 2008-02-12 | 삼성에스디아이 주식회사 | 탄성 에너지 장벽을 이용한 생체막 소자 |
| EP1920765A1 (en) * | 2006-11-07 | 2008-05-14 | Medigene AG | Liposome preparation by single-pass process |
| US9445975B2 (en) * | 2008-10-03 | 2016-09-20 | Access Business Group International, Llc | Composition and method for preparing stable unilamellar liposomal suspension |
| JP5771366B2 (ja) | 2009-09-02 | 2015-08-26 | 株式会社バイオメッドコア | リポソーム製造装置及び方法 |
| US20120310140A1 (en) | 2010-12-01 | 2012-12-06 | Spinal Modulation, Inc. | Directed delivery of agents to neural anatomy |
| JP2015509085A (ja) | 2012-01-01 | 2015-03-26 | キュービーアイ エンタープライゼズ リミテッドＱｂｉ Ｅｎｔｅｒｐｒｉｓｅｓ Ｌｔｄ． | 治療剤および診断剤の選択的送達のためのｅｎｄｏ１８０を標的とする粒子 |
| ES2874305T3 (es) * | 2013-03-14 | 2021-11-04 | Zuli Holdings Ltd | Formulación y fabricación de liposomas |
| US9993427B2 (en) | 2013-03-14 | 2018-06-12 | Biorest Ltd. | Liposome formulation and manufacture |
| US11246832B2 (en) * | 2016-06-28 | 2022-02-15 | Verily Life Sciences Llc | Serial filtration to generate small cholesterol-containing liposomes |
| JP6403026B2 (ja) * | 2017-06-29 | 2018-10-10 | バイオレスト リミテッド | リポソーム、リポソームを含む処方剤、および処方剤の製造方法 |
| KR102923958B1 (ko) | 2017-12-15 | 2026-02-06 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 엑소좀 관련 유전자 편집을 이용한 암 치료 방법 및 조성물 |
| JP7474702B2 (ja) | 2018-03-28 | 2024-04-25 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | エキソソームから単離されたｄｎａにおけるエピジェネティック変化の同定法 |
| JP6596648B2 (ja) * | 2018-08-29 | 2019-10-30 | ズーリー ホールディングス リミテッド | リポソーム、リポソームを含む処方剤、および処方剤の製造方法 |
| WO2024175457A1 (en) * | 2023-02-23 | 2024-08-29 | Evonik Operations Gmbh | Small scale liposome extruder |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5186117A (en) * | 1975-01-27 | 1976-07-28 | Tanabe Seiyaku Co | Johoseibiryushiseizainoseiho |
| US4263428A (en) * | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| CA1173360A (en) * | 1979-06-22 | 1984-08-28 | Jurg Schrank | Pharmaceutical preparations |
| JPS5782310A (en) * | 1980-11-11 | 1982-05-22 | Tanabe Seiyaku Co Ltd | Production of liposome preparation |
-
1985
- 1985-06-07 CA CA483485A patent/CA1264668C/en not_active Expired
- 1985-06-18 IE IE151485A patent/IE58630B1/en not_active IP Right Cessation
- 1985-06-18 GR GR851485A patent/GR851485B/el unknown
- 1985-06-19 ES ES544364A patent/ES8608922A1/es not_active Expired
- 1985-06-19 EP EP85903513A patent/EP0185756B1/en not_active Expired
- 1985-06-19 JP JP60502838A patent/JP2537186B2/ja not_active Expired - Lifetime
- 1985-06-19 WO PCT/US1985/001161 patent/WO1986000238A1/en not_active Ceased
- 1985-06-19 DE DE8585903513T patent/DE3579426D1/de not_active Expired - Lifetime
- 1985-06-20 PT PT80678A patent/PT80678B/pt unknown
-
1986
- 1986-02-19 DK DK198600779A patent/DK173397B1/da not_active IP Right Cessation
-
1992
- 1992-03-04 SG SG210/92A patent/SG21092G/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES544364A0 (es) | 1986-09-01 |
| WO1986000238A1 (en) | 1986-01-16 |
| DK77986A (da) | 1986-02-19 |
| DK173397B1 (da) | 2000-09-18 |
| DK77986D0 (da) | 1986-02-19 |
| EP0185756B1 (en) | 1990-08-29 |
| ES8608922A1 (es) | 1986-09-01 |
| PT80678B (pt) | 1987-08-19 |
| CA1264668C (en) | 1990-01-23 |
| JP2537186B2 (ja) | 1996-09-25 |
| SG21092G (en) | 1992-04-16 |
| DE3579426D1 (de) | 1990-10-04 |
| IE58630B1 (en) | 1993-10-20 |
| EP0185756A4 (en) | 1987-09-02 |
| JPS61502452A (ja) | 1986-10-30 |
| IE851514L (en) | 1985-12-20 |
| PT80678A (en) | 1985-07-01 |
| GR851485B (enExample) | 1985-11-25 |
| EP0185756A1 (en) | 1986-07-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry | ||
| MKEX | Expiry |
Effective date: 20070123 |