CA1244020A - Basic esters of benzoic acids and 2-thio- phencarboxylic acids, processes for their preparation and a pharmacological composition containing these esters - Google Patents

Basic esters of benzoic acids and 2-thio- phencarboxylic acids, processes for their preparation and a pharmacological composition containing these esters

Info

Publication number
CA1244020A
CA1244020A CA000435456A CA435456A CA1244020A CA 1244020 A CA1244020 A CA 1244020A CA 000435456 A CA000435456 A CA 000435456A CA 435456 A CA435456 A CA 435456A CA 1244020 A CA1244020 A CA 1244020A
Authority
CA
Canada
Prior art keywords
acid
process according
diethylamino
methyl
ethyl ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000435456A
Other languages
English (en)
French (fr)
Inventor
Edith Rudinger
Xavier Perlia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmaton SA
Original Assignee
Pharmaton SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmaton SA filed Critical Pharmaton SA
Application granted granted Critical
Publication of CA1244020A publication Critical patent/CA1244020A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
CA000435456A 1982-08-27 1983-08-26 Basic esters of benzoic acids and 2-thio- phencarboxylic acids, processes for their preparation and a pharmacological composition containing these esters Expired CA1244020A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH5115/82A CH651014A5 (de) 1982-08-27 1982-08-27 Basische ester von benzoesaeuren und von 2-thiophencarbonsaeuren, verfahren zu deren herstellung und arzneimittel, die diese ester enthalten.
CH5115/82-6 1982-08-27

Publications (1)

Publication Number Publication Date
CA1244020A true CA1244020A (en) 1988-11-01

Family

ID=4288176

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000435456A Expired CA1244020A (en) 1982-08-27 1983-08-26 Basic esters of benzoic acids and 2-thio- phencarboxylic acids, processes for their preparation and a pharmacological composition containing these esters

Country Status (8)

Country Link
JP (1) JPS5998044A (it)
CA (1) CA1244020A (it)
CH (1) CH651014A5 (it)
DE (1) DE3328494A1 (it)
FR (1) FR2532304B1 (it)
GB (1) GB2126219B (it)
IT (1) IT1168211B (it)
SE (1) SE8304457L (it)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL19578C (it) * 1925-01-15
US2173827A (en) * 1936-10-26 1939-09-26 Pitman Moore Company Alkyl thio-substituted benzoic acid alkamine ester salts, intermediate and process of preparing same
GB525199A (en) * 1939-02-15 1940-08-23 Novocol Chemical M F G Co Inc Improvements in or relating to local anaesthetic bases and process of preparing same
US2372116A (en) * 1942-03-24 1945-03-20 Pierce Amino alcohol esters
US2383074A (en) * 1942-04-16 1945-08-21 American Cyanamid Co Alkamine derivatives of o-alkoxymethyl benzoic acid
US2404691A (en) * 1944-08-30 1946-07-23 Squibb & Sons Inc Chemical compounds
US2831016A (en) * 1954-05-27 1958-04-15 Univ Missouri beta-substituted aminoalkyl 2,6-dialkylsubstituted benzoates and method of making the same
US3047574A (en) * 1960-03-28 1962-07-31 Searle & Co 2-cyclohexyl-4-(2-hydroxyethyl)-3-methylmorpholine esters of substituted benzoic acids
FR2432516A1 (fr) * 1978-08-01 1980-02-29 Synthelabo Derives de phenyl-4 piperazino-ethanol et leur application en therapeutique

Also Published As

Publication number Publication date
JPS5998044A (ja) 1984-06-06
SE8304457L (sv) 1984-02-28
GB2126219B (en) 1987-05-28
GB2126219A (en) 1984-03-21
GB8321954D0 (en) 1983-09-14
CH651014A5 (de) 1985-08-30
SE8304457D0 (sv) 1983-08-17
IT8348885A0 (it) 1983-08-26
FR2532304A1 (fr) 1984-03-02
FR2532304B1 (fr) 1989-05-19
IT1168211B (it) 1987-05-20
DE3328494A1 (de) 1984-03-01

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Legal Events

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