CA1235120A - Proline derivatives and process for producing the same - Google Patents

Proline derivatives and process for producing the same

Info

Publication number
CA1235120A
CA1235120A CA000404054A CA404054A CA1235120A CA 1235120 A CA1235120 A CA 1235120A CA 000404054 A CA000404054 A CA 000404054A CA 404054 A CA404054 A CA 404054A CA 1235120 A CA1235120 A CA 1235120A
Authority
CA
Canada
Prior art keywords
formula
compound
group
process according
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000404054A
Other languages
English (en)
French (fr)
Inventor
Shun-Ichi Hata
Sadao Tanaka
Kiyonori Kuromaru
Masafumi Fukushima
Junichiro Aono
Hideki Nakano
Yoshikazu Hinohara
Hiroyuki Nabata
Kazushige Sakai
Yasuo Fujimura
Noriko Obatake
Isao Matsunaga
Tomoyasu Iwaoka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP56094002A external-priority patent/JPS57209270A/ja
Priority claimed from JP56137823A external-priority patent/JPS5839661A/ja
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of CA1235120A publication Critical patent/CA1235120A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA000404054A 1981-06-19 1982-05-28 Proline derivatives and process for producing the same Expired CA1235120A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP56094002A JPS57209270A (en) 1981-06-19 1981-06-19 Proline derivative
JP94002/1981 1981-06-19
JP137823/1981 1981-09-03
JP56137823A JPS5839661A (ja) 1981-09-03 1981-09-03 プロリン誘導体の製法

Publications (1)

Publication Number Publication Date
CA1235120A true CA1235120A (en) 1988-04-12

Family

ID=26435270

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000404054A Expired CA1235120A (en) 1981-06-19 1982-05-28 Proline derivatives and process for producing the same

Country Status (19)

Country Link
KR (1) KR890000769B1 (xx)
AT (1) AT377496B (xx)
CA (1) CA1235120A (xx)
CH (1) CH651825A5 (xx)
DE (1) DE3222779A1 (xx)
DK (1) DK156054C (xx)
ES (2) ES8307216A1 (xx)
FI (1) FI75804C (xx)
FR (1) FR2508040B1 (xx)
GB (1) GB2102412B (xx)
HU (1) HU188177B (xx)
IL (1) IL65954A (xx)
IT (1) IT1157053B (xx)
MX (2) MX171888B (xx)
NL (1) NL193282C (xx)
NO (1) NO156408C (xx)
PT (1) PT75076B (xx)
SE (1) SE453595B (xx)
SU (1) SU1316556A3 (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6354321A (ja) * 1985-03-27 1988-03-08 Ajinomoto Co Inc 血糖降下剤
KR870007114A (ko) * 1986-01-21 1987-08-14 우에노 기미오 티올 에스테르 유도체의 안정된 고형제
ZA896851B (en) 1988-09-14 1990-06-27 Hoffmann La Roche Use of ace-inhibitors
DE59409631D1 (de) * 1993-07-15 2001-02-15 Hoffmann La Roche Pharmazeutische Kombination, die einen Hemmer des Renin-Angiotensin-Systems und einen Endothelin-Antagonisten enthält

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA802420B (en) * 1979-05-18 1981-04-29 Squibb & Sons Inc Aminoacyl derivatives of mercaptoacyl amino acids

Also Published As

Publication number Publication date
SU1316556A3 (ru) 1987-06-07
DE3222779A1 (de) 1983-01-27
FI75804B (fi) 1988-04-29
HU188177B (en) 1986-03-28
ES520582A0 (es) 1984-04-01
KR840000488A (ko) 1984-02-22
FR2508040B1 (fr) 1986-07-04
MX171888B (es) 1993-11-23
GB2102412B (en) 1985-01-09
MX155724A (es) 1988-04-20
NO821997L (no) 1982-12-20
AT377496B (de) 1985-03-25
NL193282B (nl) 1999-01-04
NO156408C (no) 1987-09-16
SE453595B (sv) 1988-02-15
PT75076A (en) 1982-07-01
ATA558581A (de) 1984-08-15
IL65954A (en) 1986-03-31
NL193282C (nl) 1999-05-06
SE8203814L (sv) 1982-12-20
IT8267772A0 (it) 1982-06-16
CH651825A5 (de) 1985-10-15
IT1157053B (it) 1987-02-11
DK156054B (da) 1989-06-19
DE3222779C2 (xx) 1991-01-03
FI75804C (fi) 1988-08-08
GB2102412A (en) 1983-02-02
NO156408B (no) 1987-06-09
PT75076B (en) 1984-05-09
DK273082A (da) 1982-12-20
IL65954A0 (en) 1982-09-30
FI822171A0 (fi) 1982-06-16
FI822171L (fi) 1982-12-20
ES8403868A1 (es) 1984-04-01
DK156054C (da) 1989-11-06
ES513277A0 (es) 1983-07-01
ES8307216A1 (es) 1983-07-01
FR2508040A1 (fr) 1982-12-24
NL8202472A (nl) 1983-01-17
KR890000769B1 (ko) 1989-04-05

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Legal Events

Date Code Title Description
MKEX Expiry