CA1225956A - Process for preparing l-carnitine and chemical intermediates employed therein - Google Patents

Process for preparing l-carnitine and chemical intermediates employed therein

Info

Publication number
CA1225956A
CA1225956A CA000442170A CA442170A CA1225956A CA 1225956 A CA1225956 A CA 1225956A CA 000442170 A CA000442170 A CA 000442170A CA 442170 A CA442170 A CA 442170A CA 1225956 A CA1225956 A CA 1225956A
Authority
CA
Canada
Prior art keywords
carbon atoms
gamma
substituted
radicals
microorganism
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000442170A
Other languages
English (en)
French (fr)
Inventor
Charles J. Sih
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/447,171 external-priority patent/US4642290A/en
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Application granted granted Critical
Publication of CA1225956A publication Critical patent/CA1225956A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA000442170A 1982-12-06 1983-11-29 Process for preparing l-carnitine and chemical intermediates employed therein Expired CA1225956A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US06/447,171 US4642290A (en) 1982-12-06 1982-12-06 Process for preparing a compound for use in the production of L-carnitine
US447,171 1982-12-06
US544,957 1983-10-21
US54495783A 1983-10-24 1983-10-24

Publications (1)

Publication Number Publication Date
CA1225956A true CA1225956A (en) 1987-08-25

Family

ID=27034888

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000442170A Expired CA1225956A (en) 1982-12-06 1983-11-29 Process for preparing l-carnitine and chemical intermediates employed therein

Country Status (23)

Country Link
JP (1) JPH0767674A (tr)
KR (1) KR840008165A (tr)
AT (1) AT393136B (tr)
AU (1) AU566906B2 (tr)
CA (1) CA1225956A (tr)
CH (1) CH661498A5 (tr)
DE (1) DE3344085C2 (tr)
DK (1) DK163917C (tr)
ES (1) ES8601305A1 (tr)
FI (1) FI81115C (tr)
FR (1) FR2537130B1 (tr)
GB (1) GB2132614B (tr)
GR (1) GR78767B (tr)
IE (1) IE56322B1 (tr)
IL (1) IL70352A (tr)
IT (1) IT1167289B (tr)
LU (1) LU85115A1 (tr)
NL (1) NL8304190A (tr)
NO (1) NO159291C (tr)
PH (1) PH20456A (tr)
PT (1) PT77780B (tr)
SE (1) SE455501B (tr)
TR (1) TR23136A (tr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK544284A (da) * 1983-12-06 1985-06-07 Hoffmann La Roche Fremgangsmaade til fremstilling af optisk aktive propionsyrederivater
IT1181908B (it) * 1984-07-12 1987-09-30 Debi Derivati Biologici Procedimento per la preparazione di l-carnitina
IT1181812B (it) * 1984-07-27 1987-09-30 Sigma Tau Ind Farmaceuti Procedimento per la preparazione dell'acido gamma-dimetilammino l-beta-idrossibutirrico
IT1190358B (it) * 1985-05-24 1988-02-16 Sclavo Spa Procedimento per la preparazione di l-carnitina
JPS62126997A (ja) * 1985-11-28 1987-06-09 Nippon Synthetic Chem Ind Co Ltd:The 光学活性のγ−ハロ−βヒドロキシ酪酸エステルの製造法
IT1189070B (it) * 1986-03-14 1988-01-28 Donegani Guido Ist Processo per la preparazione della l(-)-carnitina cloruro a partire da esteri 3,4-epossibutirrici
JPH0678277B2 (ja) * 1988-02-19 1994-10-05 高砂香料工業株式会社 光学活性アルコールおよびその誘導体の製造方法
JP2939646B2 (ja) * 1990-07-17 1999-08-25 チッソ株式会社 ４―置換―２―ヒドロキシブタン酸エステルおよび製造法
US5215919A (en) * 1991-02-25 1993-06-01 Takeda Chemical Industries, Ltd. Process for producing optically active 2-hydroxycycloalkanecarboxylic acid esters using microbially derived reductase
US5324662A (en) 1992-05-15 1994-06-28 E. R. Squibb & Sons, Inc. Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters
JP3155107B2 (ja) * 1993-01-12 2001-04-09 ダイセル化学工業株式会社 光学活性４−ハロ−３−ヒドロキシ酪酸エステルの製造方法
JP2000189170A (ja) * 1998-05-08 2000-07-11 Daicel Chem Ind Ltd 光学活性４―ハロ―３―ヒドロキシ酪酸エステルの製造方法
US6472544B1 (en) 1998-08-05 2002-10-29 Kaneka Corporation Process for the preparation of optically active 2-[6-hydroxymethyl)-1,3-dioxan-4yl]acetic acid derivatives
ATE501264T1 (de) * 2002-08-09 2011-03-15 Codexis Inc Enzymatische verfahren zur herstellung 4- substituierter 3-hydroxybuttersäure-derivate
DE10315760A1 (de) * 2003-04-07 2004-10-21 Basf Ag L-Carnitin Dehydrogenasen, deren Derivate und ein Verfahren zur Herstellung von substituierten (S)-Alkanolen

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3931410A (en) * 1974-02-28 1976-01-06 The Upjohn Company Composition and method of use
CH589604A5 (tr) * 1974-04-26 1977-07-15 Lonza Ag
JPS5139634A (en) * 1974-09-27 1976-04-02 Ono Pharmaceutical Co Ganma amino beeta hidorokishibutansananirido no seizoho
JPS6017776B2 (ja) * 1979-11-07 1985-05-07 電気化学工業株式会社 γ−クロロ−β−ヒドロキシ酪酸アルキルエステルの製法
JPS5950661B2 (ja) * 1980-07-28 1984-12-10 電気化学工業株式会社 γ−アミノ−β−ヒドロキシ酪酸の製造法
JPS5950663B2 (ja) * 1981-04-28 1984-12-10 電気化学工業株式会社 γ−アミノ−β−ヒドロキシ酪酸の製造法

Also Published As

Publication number Publication date
NO834461L (no) 1984-06-07
SE8306714D0 (sv) 1983-12-05
DK559283D0 (da) 1983-12-05
ES527807A0 (es) 1985-11-01
GB2132614A (en) 1984-07-11
ES8601305A1 (es) 1985-11-01
IL70352A0 (en) 1984-02-29
DK559283A (da) 1984-06-07
IT1167289B (it) 1987-05-13
SE8306714L (sv) 1984-06-07
GB8332359D0 (en) 1984-01-11
IE56322B1 (en) 1991-06-19
JPH0767674A (ja) 1995-03-14
SE455501B (sv) 1988-07-18
FR2537130A1 (fr) 1984-06-08
FR2537130B1 (fr) 1988-10-14
GR78767B (tr) 1984-10-02
AU2175883A (en) 1984-06-14
DK163917C (da) 1992-09-14
KR840008165A (ko) 1984-12-13
PT77780A (en) 1984-01-01
NO159291C (no) 1988-12-14
IT8324018A0 (it) 1983-12-05
PT77780B (en) 1986-04-17
DK163917B (da) 1992-04-21
ATA423783A (de) 1991-01-15
DE3344085C2 (de) 1993-10-14
AT393136B (de) 1991-08-26
GB2132614B (en) 1986-03-26
DE3344085A1 (de) 1984-06-07
NO159291B (no) 1988-09-05
PH20456A (en) 1987-01-14
FI81115B (fi) 1990-05-31
LU85115A1 (fr) 1984-04-02
CH661498A5 (it) 1987-07-31
NL8304190A (nl) 1984-07-02
IL70352A (en) 1987-10-20
FI834419A0 (fi) 1983-12-02
FI81115C (fi) 1990-09-10
TR23136A (tr) 1989-04-11
IE832732L (en) 1984-06-06
FI834419A (fi) 1984-06-07
AU566906B2 (en) 1987-11-05

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