CA1182409A - Plasmids constructed by gene manipulation, strains of escherichia coli carrying them, and process of tryptophan production using said strains - Google Patents
Plasmids constructed by gene manipulation, strains of escherichia coli carrying them, and process of tryptophan production using said strainsInfo
- Publication number
- CA1182409A CA1182409A CA000386858A CA386858A CA1182409A CA 1182409 A CA1182409 A CA 1182409A CA 000386858 A CA000386858 A CA 000386858A CA 386858 A CA386858 A CA 386858A CA 1182409 A CA1182409 A CA 1182409A
- Authority
- CA
- Canada
- Prior art keywords
- tryptophan
- strain
- escherichia coli
- strains
- trp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 title claims abstract description 65
- 239000013612 plasmid Substances 0.000 title claims abstract description 33
- 241000588724 Escherichia coli Species 0.000 title claims abstract description 16
- 238000000034 method Methods 0.000 title claims abstract description 13
- 108090000623 proteins and genes Proteins 0.000 title description 6
- 238000004519 manufacturing process Methods 0.000 title description 4
- 230000005764 inhibitory process Effects 0.000 claims abstract description 19
- 108010037870 Anthranilate Synthase Proteins 0.000 claims abstract description 16
- 229960004799 tryptophan Drugs 0.000 claims description 63
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 claims description 16
- 230000002950 deficient Effects 0.000 claims description 7
- 108700034853 E coli TRPR Proteins 0.000 claims description 6
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- 101710136122 Tryptophan 2,3-dioxygenase Proteins 0.000 claims description 4
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
- C12P13/227—Tryptophan
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- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP154,706/80 | 1980-11-05 | ||
| JP55154706A JPS5780398A (en) | 1980-11-05 | 1980-11-05 | Plasmid produced by genetic manipulation, coliform bacillus having the same and preparation of tryptophan with said bacillus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1182409A true CA1182409A (en) | 1985-02-12 |
Family
ID=15590169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000386858A Expired CA1182409A (en) | 1980-11-05 | 1981-09-29 | Plasmids constructed by gene manipulation, strains of escherichia coli carrying them, and process of tryptophan production using said strains |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JPS5780398A (enrdf_load_stackoverflow) |
| AU (1) | AU549686B2 (enrdf_load_stackoverflow) |
| CA (1) | CA1182409A (enrdf_load_stackoverflow) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6180373B1 (en) | 1992-09-28 | 2001-01-30 | Consortium f{umlaut over (u)}r elektrochemische Industrie GmbH | Microorganisms for the production of tryptophan and process for the preparation thereof |
| EP1715056A1 (de) | 2005-04-23 | 2006-10-25 | Degussa AG | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung verbesserter Stämme der Familie Enterobacteriaceae |
| DE102007051024A1 (de) | 2007-03-05 | 2008-09-11 | Evonik Degussa Gmbh | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von Stämmen der Familie Enterobacteriaceae |
| EP1975241A1 (de) | 2007-03-29 | 2008-10-01 | Evonik Degussa GmbH | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
| EP2036979A1 (de) | 2007-09-15 | 2009-03-18 | Evonik Degussa GmbH | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
| EP2055785A1 (de) | 2007-11-02 | 2009-05-06 | Evonik Degussa GmbH | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
| EP2060636A1 (de) | 2007-11-14 | 2009-05-20 | Evonik Degussa GmbH | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
| DE102008040352A1 (de) | 2008-07-11 | 2010-01-14 | Evonik Degussa Gmbh | Verfahren zur Herstellung von L-Tryptophan unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
| DE102008044768A1 (de) | 2008-08-28 | 2010-03-04 | Evonik Degussa Gmbh | Verfahren zur Herstellung von organisch-chemischen Verbindungen unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
| EP2628792A1 (de) | 2012-02-17 | 2013-08-21 | Evonik Industries AG | Zelle mit verringerter ppGppase-Aktivität |
| WO2014117992A1 (de) | 2013-01-30 | 2014-08-07 | Evonik Industries Ag | Mikroorganismus und verfahren zur fermentativen herstellung von aminosäuren |
| EP3385275A1 (de) | 2017-04-07 | 2018-10-10 | Evonik Degussa GmbH | Verfahren zur herstellung von aromatischen l-aminosäuren unter verwendung von verbesserten stämmen der familie enterobacteriaceae |
| US11053526B2 (en) | 2018-08-09 | 2021-07-06 | Evonik Operations Gmbh | Process for preparing L amino acids using improved strains of the enterobacteriaceae family |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA811368B (en) * | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
| JPH074257B2 (ja) * | 1983-06-17 | 1995-01-25 | 三菱油化株式会社 | 新規なプラスミド |
| JPS6043392A (ja) * | 1983-08-20 | 1985-03-07 | Showa Denko Kk | Ｌ−トリプトフアンの製造法 |
| JPS61247392A (ja) * | 1985-02-04 | 1986-11-04 | エンジニツクス インコ−ポレ−テツド | ２種またはより多くのアミノ酸を同時に産生できる組換え微生物 |
| EP0293207A3 (en) * | 1987-05-29 | 1989-11-02 | The Standard Oil Company | Eschericia coli carrying recombinant plasmid for the production of tryptophan |
| JPH0722510B2 (ja) * | 1988-05-09 | 1995-03-15 | 三井東圧化学株式会社 | 耐熱性トリプトファンシンターゼをコードする遺伝子とその利用 |
| US6118047A (en) | 1993-08-25 | 2000-09-12 | Dekalb Genetic Corporation | Anthranilate synthase gene and method of use thereof for conferring tryptophan overproduction |
| EP2987854B1 (en) | 2013-04-16 | 2017-09-27 | CJ Cheiljedang Corporation | Microorganism having l-tryptophan productivity and method for production of l-tryptophan using same |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4371614A (en) * | 1980-08-22 | 1983-02-01 | Ajinomoto Co., Inc. | E.Coli bacteria carrying recombinant plasmids and their use in the fermentative production of L-tryptophan |
-
1980
- 1980-11-05 JP JP55154706A patent/JPS5780398A/ja active Granted
-
1981
- 1981-08-26 AU AU74644/81A patent/AU549686B2/en not_active Withdrawn - After Issue
- 1981-09-29 CA CA000386858A patent/CA1182409A/en not_active Expired
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6180373B1 (en) | 1992-09-28 | 2001-01-30 | Consortium f{umlaut over (u)}r elektrochemische Industrie GmbH | Microorganisms for the production of tryptophan and process for the preparation thereof |
| EP1715056A1 (de) | 2005-04-23 | 2006-10-25 | Degussa AG | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung verbesserter Stämme der Familie Enterobacteriaceae |
| DE102007051024A1 (de) | 2007-03-05 | 2008-09-11 | Evonik Degussa Gmbh | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von Stämmen der Familie Enterobacteriaceae |
| EP1975241A1 (de) | 2007-03-29 | 2008-10-01 | Evonik Degussa GmbH | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
| EP2036979A1 (de) | 2007-09-15 | 2009-03-18 | Evonik Degussa GmbH | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
| DE102007044134A1 (de) | 2007-09-15 | 2009-03-19 | Evonik Degussa Gmbh | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
| EP2055785A1 (de) | 2007-11-02 | 2009-05-06 | Evonik Degussa GmbH | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
| EP2060636A1 (de) | 2007-11-14 | 2009-05-20 | Evonik Degussa GmbH | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
| DE102008040352A1 (de) | 2008-07-11 | 2010-01-14 | Evonik Degussa Gmbh | Verfahren zur Herstellung von L-Tryptophan unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
| EP2147972A1 (de) | 2008-07-11 | 2010-01-27 | Evonik Degussa GmbH | Verfahren zur Herstellung von L-Tryptophan unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
| DE102008044768A1 (de) | 2008-08-28 | 2010-03-04 | Evonik Degussa Gmbh | Verfahren zur Herstellung von organisch-chemischen Verbindungen unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
| EP2163613A2 (de) | 2008-08-28 | 2010-03-17 | Evonik Degussa GmbH | Verfahren zur Herstellung von organisch-chemischen Verbindungen unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
| EP2628792A1 (de) | 2012-02-17 | 2013-08-21 | Evonik Industries AG | Zelle mit verringerter ppGppase-Aktivität |
| WO2014117992A1 (de) | 2013-01-30 | 2014-08-07 | Evonik Industries Ag | Mikroorganismus und verfahren zur fermentativen herstellung von aminosäuren |
| EP3385275A1 (de) | 2017-04-07 | 2018-10-10 | Evonik Degussa GmbH | Verfahren zur herstellung von aromatischen l-aminosäuren unter verwendung von verbesserten stämmen der familie enterobacteriaceae |
| US11053526B2 (en) | 2018-08-09 | 2021-07-06 | Evonik Operations Gmbh | Process for preparing L amino acids using improved strains of the enterobacteriaceae family |
Also Published As
| Publication number | Publication date |
|---|---|
| AU549686B2 (en) | 1986-02-06 |
| AU7464481A (en) | 1982-05-13 |
| JPH0226955B2 (enrdf_load_stackoverflow) | 1990-06-13 |
| JPS5780398A (en) | 1982-05-19 |
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