CA1163994A - 3-(1-piperidinylalkyl)-4h-pyrido¬1,2-a|-pyrimidin- 4-one derivatives - Google Patents

3-(1-piperidinylalkyl)-4h-pyrido¬1,2-a|-pyrimidin- 4-one derivatives

Info

Publication number
CA1163994A
CA1163994A CA000372258A CA372258A CA1163994A CA 1163994 A CA1163994 A CA 1163994A CA 000372258 A CA000372258 A CA 000372258A CA 372258 A CA372258 A CA 372258A CA 1163994 A CA1163994 A CA 1163994A
Authority
CA
Canada
Prior art keywords
group
formula
hydrogen
parts
pyrido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000372258A
Other languages
English (en)
French (fr)
Inventor
Josephus C. Mertens
Ludo E.J. Kennis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Priority to CA000430092A priority Critical patent/CA1167843A/en
Application granted granted Critical
Publication of CA1163994A publication Critical patent/CA1163994A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA000372258A 1980-03-28 1981-03-04 3-(1-piperidinylalkyl)-4h-pyrido¬1,2-a|-pyrimidin- 4-one derivatives Expired CA1163994A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA000430092A CA1167843A (en) 1980-03-28 1983-06-09 3-(1-piperidinylalkyl)-4h-pyrido[1,2-a]-pyrimidin- 4-one derivatives

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13484580A 1980-03-28 1980-03-28
US134,845 1980-03-28
US191,632 1980-09-29
US06/191,632 US4342870A (en) 1980-03-28 1980-09-29 Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives

Publications (1)

Publication Number Publication Date
CA1163994A true CA1163994A (en) 1984-03-20

Family

ID=26832744

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000372258A Expired CA1163994A (en) 1980-03-28 1981-03-04 3-(1-piperidinylalkyl)-4h-pyrido¬1,2-a|-pyrimidin- 4-one derivatives

Country Status (22)

Country Link
US (1) US4342870A (h)
EP (1) EP0037265B1 (h)
AU (1) AU537700B2 (h)
BG (1) BG36199A3 (h)
CA (1) CA1163994A (h)
CS (1) CS256366B2 (h)
DE (1) DE3168433D1 (h)
DK (1) DK159390C (h)
ES (1) ES500814A0 (h)
FI (1) FI71737C (h)
GR (1) GR72488B (h)
HU (1) HU187329B (h)
IE (1) IE51319B1 (h)
IL (1) IL62494A (h)
MA (1) MA19107A1 (h)
NO (1) NO156752C (h)
NZ (1) NZ196522A (h)
PH (1) PH16530A (h)
PT (1) PT72740B (h)
RO (1) RO82508A (h)
SU (1) SU1068037A3 (h)
YU (1) YU43010B (h)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4443451A (en) 1981-07-15 1984-04-17 Janssen Pharmaceutica N.V. Bicyclic pyrimidin-5-one derivatives
US4548938A (en) * 1981-07-15 1985-10-22 Janssen Pharmaceutica N.V. 5-H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one compounds
US4355037A (en) * 1981-11-12 1982-10-19 Hoechst-Roussel Pharmaceuticals 3-(4-Piperidyl)-1,2-benzisoxales
US4485107A (en) * 1982-11-01 1984-11-27 Janssen Pharmaceutica N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
US4581171A (en) * 1983-07-27 1986-04-08 Janssen Pharmaceutica, N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders
US4695569A (en) * 1983-11-30 1987-09-22 Janssen Pharmaceutica N.V. Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines
US4888426A (en) * 1983-11-30 1989-12-19 Janssen Pharmaceutica N.V. 1-(5-methyl-furan-2-ylmethyl)-N-(4-piperidinyl)imidazo [4,5-6]pyridine-2-amine
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
US4548939A (en) * 1984-10-01 1985-10-22 Janssen Pharmaceutica N. V. 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
EP0268309B1 (en) * 1986-09-22 1996-12-11 Janssen Pharmaceutica N.V. Serotonin antagonists for treating wounds
IL90879A0 (en) * 1988-09-02 1990-02-09 Janssen Pharmaceutica Nv 3-piperidinyl-indazole derivatives,their preparation and antihypertensive compositions containing them
CA2000786C (en) * 1988-11-07 1999-01-26 Cornelus G. M. Janssen 3-piperidinyl-1,2-benzisoxazoles
HU207310B (en) * 1988-12-02 1993-03-29 Pfizer Process for producing aryl-piperidine derivatives
JPH04504263A (ja) * 1989-03-23 1992-07-30 マリンクロッド・インコーポレイテッド 放射性沃素又は臭素標識ピペリジン化合物、並びに上記化合物の及び上記化合物を含む組成物の製法
DE4138756A1 (de) * 1991-11-26 1993-05-27 Troponwerke Gmbh & Co Kg Kombination mit neuroprotektiver wirkung
US5266571A (en) * 1992-01-09 1993-11-30 Amer Moh Samir Treatment of hemorrhoids with 5-HT2 antagonists
EP0626968B1 (en) * 1992-02-13 2001-09-26 Merrell Pharmaceuticals Inc. Piperidinyl thiacyclic derivatives
CA2137673C (en) 1992-07-13 2005-09-06 Jan Vandenberk Novel 4-[3-benzofuranyl]piperidinyl and 4-[3-benzothienyl]piperidinyl derivatives
SI0729357T1 (en) 1993-11-19 2005-06-30 Janssen Pharmaceutica N.V. Microencapsulated 1,2-benzazoles
ES2085234B1 (es) * 1994-02-24 1997-01-16 Vita Invest Sa Agente activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
TW421649B (en) * 1995-01-31 2001-02-11 Janssen Pharmaceutica Nv 4-(1H-indol-1yl)-1-piperidinyl derivatives
US5753664A (en) * 1995-03-16 1998-05-19 Takeda Chemical Industries, Ltd. Heterocyclic compounds, their production and use
EP1560814A1 (en) * 2002-11-13 2005-08-10 Synthon B.V. Process for making risperidone and intermediates therefor
EP1615923A1 (en) * 2003-04-22 2006-01-18 Synthon B.V. Risperidone monohydrochloride
DK3106166T3 (da) 2008-02-29 2021-01-11 Vm Therapeutics Llc Forbindelser til behandling af smertesyndrom og andre lidelser
US9586955B2 (en) * 2012-02-10 2017-03-07 Ptc Therapeutics, Inc. Compounds for treating spinal muscular atrophy
EP2819519B1 (en) 2012-03-01 2019-10-23 PTC Therapeutics, Inc. Compounds for treating spinal muscular atrophy
MX358514B (es) 2012-03-23 2018-08-24 Ptc Therapeutics Inc Compuestos para tratar la atrofia muscular espinal.
CN105143197A (zh) * 2013-03-15 2015-12-09 Vm医药有限责任公司 新的晶体形式
EP3082820B1 (en) 2013-12-19 2022-07-20 PTC Therapeutics, Inc. Methods for modulating the amount of rna transcripts
EP3310169B1 (en) 2015-05-30 2023-05-17 PTC Therapeutics, Inc. Methods for modulating rna splicing
CN113717154B (zh) 2015-12-10 2024-11-15 Ptc医疗公司 用于治疗亨廷顿病的方法
CA3043755A1 (en) 2016-11-28 2018-05-31 Ptc Therapeutics, Inc. Methods for modulating rna splicing
CN111065626B (zh) 2017-06-05 2024-09-27 Ptc医疗公司 用于治疗亨廷顿氏舞蹈病的化合物
CA3065547A1 (en) 2017-06-14 2018-12-20 Ptc Therapeutics, Inc. Methods for modifying rna splicing
EP3644996B1 (en) 2017-06-28 2023-07-26 PTC Therapeutics, Inc. Methods for treating huntington's disease
BR112019027719A2 (pt) 2017-06-28 2020-07-28 Ptc Therapeutics, Inc. métodos para tratar a doença de huntington
MX2020009957A (es) 2018-03-27 2021-01-15 Ptc Therapeutics Inc Compuestos para el tratamiento de enfermedad de hungtinton.
FI3814357T3 (fi) 2018-06-27 2024-07-26 Ptc Therapeutics Inc Heterosykliset ja heteroaryliyhdisteet huntingtonin taudin hoitoon
CA3104516A1 (en) 2018-06-27 2020-01-02 Ptc Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
EP3814360B8 (en) 2018-06-27 2024-11-06 PTC Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3412094A (en) * 1967-06-21 1968-11-19 Searle & Co 5-alkyl-2-amino-4-azido-6-phenylpyrimidines and congeners
US3960863A (en) * 1974-06-25 1976-06-01 Sankyo Company Limited Pyrido[1,2-a]pyrimidinone derivatives
JPS5146497A (en) * 1974-10-19 1976-04-20 Masato Aiura Hobuban
JPS525795A (en) * 1975-06-28 1977-01-17 Sankyo Co Ltd Preparation of tetrahydro pyridopyrimidinone derivatives
HU173438B (hu) * 1975-11-27 1979-05-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom

Also Published As

Publication number Publication date
AU6842981A (en) 1981-10-01
NO156752C (no) 1987-11-18
YU43010B (en) 1989-02-28
RO82508B (ro) 1983-08-30
HU187329B (en) 1985-12-28
FI810956L (fi) 1981-09-29
EP0037265B1 (en) 1985-01-23
RO82508A (ro) 1983-09-26
PT72740A (en) 1981-04-01
AU537700B2 (en) 1984-07-05
FI71737B (fi) 1986-10-31
IL62494A (en) 1984-08-31
FI71737C (fi) 1987-02-09
IE810706L (en) 1981-09-28
NZ196522A (en) 1985-10-11
CS256366B2 (en) 1988-04-15
PT72740B (en) 1982-11-16
NO811058L (no) 1981-09-29
DK159390B (da) 1990-10-08
GR72488B (h) 1983-11-14
BG36199A3 (en) 1984-09-14
MA19107A1 (fr) 1981-10-01
IE51319B1 (en) 1986-12-10
DE3168433D1 (de) 1985-03-07
SU1068037A3 (ru) 1984-01-15
IL62494A0 (en) 1981-05-20
NO156752B (no) 1987-08-10
US4342870A (en) 1982-08-03
EP0037265A1 (en) 1981-10-07
ES8300763A1 (es) 1982-11-01
ES500814A0 (es) 1982-11-01
PH16530A (en) 1983-11-10
DK138281A (da) 1981-09-29
YU81081A (en) 1983-12-31
DK159390C (da) 1991-03-04

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