CA1143737A - 3-(pyrid-3- or 4-ylalkyl)-indoles - Google Patents

3-(pyrid-3- or 4-ylalkyl)-indoles

Info

Publication number
CA1143737A
CA1143737A CA000392225A CA392225A CA1143737A CA 1143737 A CA1143737 A CA 1143737A CA 000392225 A CA000392225 A CA 000392225A CA 392225 A CA392225 A CA 392225A CA 1143737 A CA1143737 A CA 1143737A
Authority
CA
Canada
Prior art keywords
formula
compound
alkyl
hydrogen
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000392225A
Other languages
English (en)
French (fr)
Inventor
Peter E. Cross
Roger P. Dickinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp SRL
Original Assignee
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp SRL filed Critical Pfizer Corp SRL
Application granted granted Critical
Publication of CA1143737A publication Critical patent/CA1143737A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
CA000392225A 1980-12-15 1981-12-14 3-(pyrid-3- or 4-ylalkyl)-indoles Expired CA1143737A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8040081 1980-12-15
GB8040081 1980-12-15

Publications (1)

Publication Number Publication Date
CA1143737A true CA1143737A (en) 1983-03-29

Family

ID=10517993

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000392225A Expired CA1143737A (en) 1980-12-15 1981-12-14 3-(pyrid-3- or 4-ylalkyl)-indoles

Country Status (22)

Country Link
US (1) US4363912A (enExample)
EP (1) EP0054417B1 (enExample)
JP (1) JPS57181082A (enExample)
KR (1) KR830007552A (enExample)
AR (1) AR229110A1 (enExample)
AU (1) AU525296B2 (enExample)
CA (1) CA1143737A (enExample)
CS (1) CS228527B2 (enExample)
DD (1) DD202290A5 (enExample)
DE (1) DE3167879D1 (enExample)
DK (1) DK552581A (enExample)
ES (1) ES8308872A1 (enExample)
FI (1) FI814003A7 (enExample)
GR (1) GR76355B (enExample)
IE (1) IE51949B1 (enExample)
IL (1) IL64534A0 (enExample)
NO (1) NO814264L (enExample)
PH (1) PH17576A (enExample)
PL (1) PL133634B1 (enExample)
PT (1) PT74123B (enExample)
YU (1) YU293481A (enExample)
ZA (1) ZA818665B (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS229934B2 (en) * 1981-07-07 1984-07-16 Pfizer Production method subst.indolylacryte acid derivative
US4460777A (en) * 1981-11-19 1984-07-17 Ciba-Geigy Corporation N-Substituted-2-pyridylindoles
US4478842A (en) * 1981-11-19 1984-10-23 Ciba-Geigy Corporation N-Substituted-2-pyridylindoles
US4536505A (en) * 1983-05-17 1985-08-20 Ciba-Geigy Corporation Certain N-(pyridyl) indoles
US4511573A (en) * 1983-05-17 1985-04-16 Ciba-Geigy Corporation 3-Substituted-2-(heteroaryl) indoles
GB8524157D0 (en) * 1984-10-19 1985-11-06 Ici America Inc Heterocyclic amides
US4609733A (en) * 1984-12-27 1986-09-02 Ciba-Geigy Corporation 3-keto-substituted-N-pyridylindoles
GB8609175D0 (en) * 1986-04-15 1986-05-21 Ici America Inc Heterocyclic carboxamides
ATE269861T1 (de) * 1998-03-31 2004-07-15 Inst For Pharm Discovery Inc Substituierte indolalkansäure
TNSN99224A1 (fr) * 1998-12-01 2005-11-10 Inst For Pharm Discovery Inc Methodes de reduction des niveaux de glucose et triglyceride en serum et pour suppression de l'antigenese utilisant les acides la indolealkanoique
WO2001051489A2 (en) * 2000-01-14 2001-07-19 The Institutes For Pharmaceutical Discovery, Llc Methods for lowering uric acid levels
ES2268480T3 (es) * 2002-12-10 2007-03-16 Wyeth Derivados del acido 3-alquilo- y 3-arilalquilo-1h-indol-1-il-acetico sustituidos como inhibidores del inhibidor del activador del plasminogeno-1 (pai-1).
GB0324763D0 (en) * 2003-10-23 2003-11-26 Oxagen Ltd Use of compounds in therapy
EP2046740B1 (en) 2006-07-22 2012-05-23 Oxagen Limited Compounds having crth2 antagonist activity
KR20100067677A (ko) * 2007-09-24 2010-06-21 알러간, 인코포레이티드 스핑고신-1-포스페이트 (ｓｐ1) 생물학적 활성을 갖는 아릴 또는 헤테로아릴 기를 함유하는 인돌 화합물
AU2009204700B2 (en) * 2008-01-18 2013-07-04 Atopix Therapeutics Limited Compounds having CRTH2 antagonist activity
US7750027B2 (en) * 2008-01-18 2010-07-06 Oxagen Limited Compounds having CRTH2 antagonist activity
JP2011509991A (ja) * 2008-01-22 2011-03-31 オキサジェン リミテッド Ｃｒｔｈ２アンタゴニスト活性を有する化合物
WO2009093026A1 (en) 2008-01-22 2009-07-30 Oxagen Limited Compounds having crth2 antagonist activity
GB201322273D0 (en) 2013-12-17 2014-01-29 Atopix Therapeutics Ltd Process
GB201407820D0 (en) * 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form
GB201407807D0 (en) * 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5173M (enExample) * 1966-02-11 1967-06-19
FR7337M (enExample) * 1968-01-11 1969-10-13
GB2045244B (en) 1979-03-07 1983-01-26 Pfizer Ltd 3-1-(imidazolylalkyl) indoles
US4322533A (en) * 1980-03-17 1982-03-30 Lesher George Y 1H-Indole-2,3-dione derivatives

Also Published As

Publication number Publication date
DK552581A (da) 1982-06-16
PT74123A (en) 1982-01-01
AR229110A1 (es) 1983-06-15
JPS57181082A (en) 1982-11-08
FI814003L (fi) 1982-06-16
IL64534A0 (en) 1982-03-31
NO814264L (no) 1982-06-16
ZA818665B (en) 1982-10-27
PH17576A (en) 1984-10-01
FI814003A7 (fi) 1982-06-16
ES507960A0 (es) 1983-10-01
AU525296B2 (en) 1982-10-28
CS228527B2 (en) 1984-05-14
PL133634B1 (en) 1985-06-29
EP0054417A1 (en) 1982-06-23
IE51949B1 (en) 1987-04-29
EP0054417B1 (en) 1984-12-19
US4363912A (en) 1982-12-14
PL234253A1 (en) 1983-05-23
DD202290A5 (de) 1983-09-07
DE3167879D1 (en) 1985-01-31
AU7848881A (en) 1982-06-24
YU293481A (en) 1984-10-31
GR76355B (enExample) 1984-08-06
KR830007552A (ko) 1983-10-21
PT74123B (en) 1983-12-19
ES8308872A1 (es) 1983-10-01
IE812928L (en) 1982-06-15

Similar Documents

Publication Publication Date Title
CA1143737A (en) 3-(pyrid-3- or 4-ylalkyl)-indoles
US4273782A (en) Inhibition of thromboxane synthetase by 3-(1-Imidazolylalkyl) indoles
EP0073663B1 (en) Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them
US4636500A (en) N-(phenoxyalkyl)imidazoles as selective inhibitors of the thromboxane synthetase enzyme and pharmaceutical compositions thereof
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US4259345A (en) 2-(Imidazol-1-ylmethyl)pyrroles
JPH05132482A (ja) 置換インドールのｎ−イミダゾリル誘導体
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Legal Events

Date Code Title Description
MKEX Expiry