ES8308872A1 - Un procedimiento para la mejoracion de 3-(pirid-3-0,4-ilalquil)indoles - Google Patents

Un procedimiento para la mejoracion de 3-(pirid-3-0,4-ilalquil)indoles

Info

Publication number
ES8308872A1
ES8308872A1 ES507960A ES507960A ES8308872A1 ES 8308872 A1 ES8308872 A1 ES 8308872A1 ES 507960 A ES507960 A ES 507960A ES 507960 A ES507960 A ES 507960A ES 8308872 A1 ES8308872 A1 ES 8308872A1
Authority
ES
Spain
Prior art keywords
indole
processes
preparation
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES507960A
Other languages
English (en)
Other versions
ES507960A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp
Original Assignee
Pfizer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp filed Critical Pfizer Corp
Publication of ES8308872A1 publication Critical patent/ES8308872A1/es
Publication of ES507960A0 publication Critical patent/ES507960A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE 3-(PIRID-3- O 4-ILALQUIL) INDOLES. SE HACE REACCIONAR UN COMPUESTO (II), EN PRESENCIA DE UNA BASE, CON UN AGENTE ALQUILANTE HAL-X-Y TAL COMO EL BROMOCACETATO DE ETILO; COMO BASE SE EMPLEA EL HIDRURO SODICO; EL ESTER OBTENIDO SE HIDROLIZA PARA DAR EL DERIVADO ACETICO CORRESPONDIENTE. SE OBTIENE EL COMPUESTO (I) EN QUE R>1 ES HIDROGENO, ALQUILO, CICLOALQUILO O FENILO; R>2 ES HIDROGENO, ALQUILO, ALCOXI O HALOGENO; R>3 ES HIDROGENO O ALQUILO ; X ES -(CH<2)<N DONDE N ES 1, 2 O 3 O BIEN -CH<2-CH-CH<3 U OTROS; Y ES -COOH, -COO(ALQUILO), -CONH<2, -CN O 5-TETRAZOLILO; Z ES 3- O 4-PIRIDILO.
ES507960A 1980-12-15 1981-12-14 Un procedimiento para la mejoracion de 3-(pirid-3-0,4-ilalquil)indoles Granted ES507960A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8040081 1980-12-15

Publications (2)

Publication Number Publication Date
ES8308872A1 true ES8308872A1 (es) 1983-10-01
ES507960A0 ES507960A0 (es) 1983-10-01

Family

ID=10517993

Family Applications (1)

Application Number Title Priority Date Filing Date
ES507960A Granted ES507960A0 (es) 1980-12-15 1981-12-14 Un procedimiento para la mejoracion de 3-(pirid-3-0,4-ilalquil)indoles

Country Status (22)

Country Link
US (1) US4363912A (es)
EP (1) EP0054417B1 (es)
JP (1) JPS57181082A (es)
KR (1) KR830007552A (es)
AR (1) AR229110A1 (es)
AU (1) AU525296B2 (es)
CA (1) CA1143737A (es)
CS (1) CS228527B2 (es)
DD (1) DD202290A5 (es)
DE (1) DE3167879D1 (es)
DK (1) DK552581A (es)
ES (1) ES507960A0 (es)
FI (1) FI814003L (es)
GR (1) GR76355B (es)
IE (1) IE51949B1 (es)
IL (1) IL64534A0 (es)
NO (1) NO814264L (es)
PH (1) PH17576A (es)
PL (1) PL133634B1 (es)
PT (1) PT74123B (es)
YU (1) YU293481A (es)
ZA (1) ZA818665B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS229934B2 (en) * 1981-07-07 1984-07-16 Pfizer Production method subst.indolylacryte acid derivative
US4478842A (en) * 1981-11-19 1984-10-23 Ciba-Geigy Corporation N-Substituted-2-pyridylindoles
US4460777A (en) * 1981-11-19 1984-07-17 Ciba-Geigy Corporation N-Substituted-2-pyridylindoles
US4536505A (en) * 1983-05-17 1985-08-20 Ciba-Geigy Corporation Certain N-(pyridyl) indoles
US4511573A (en) * 1983-05-17 1985-04-16 Ciba-Geigy Corporation 3-Substituted-2-(heteroaryl) indoles
GB8524157D0 (en) * 1984-10-19 1985-11-06 Ici America Inc Heterocyclic amides
US4609733A (en) * 1984-12-27 1986-09-02 Ciba-Geigy Corporation 3-keto-substituted-N-pyridylindoles
GB8609175D0 (en) * 1986-04-15 1986-05-21 Ici America Inc Heterocyclic carboxamides
CZ300706B6 (cs) * 1998-03-31 2009-07-22 The Institutes For Pharmaceutical Discovery, Inc. Derivát indolalkanové kyseliny a lécivo pro prevenci nebo zmírnení chronických komplikací vznikajících z diabetes mellitus
TNSN99224A1 (fr) * 1998-12-01 2005-11-10 Inst For Pharm Discovery Inc Methodes de reduction des niveaux de glucose et triglyceride en serum et pour suppression de l'antigenese utilisant les acides la indolealkanoique
US20010044437A1 (en) * 2000-01-14 2001-11-22 Dale Robinson Methods for reducing uric acid levels
MXPA05006282A (es) * 2002-12-10 2005-08-19 Wyeth Corp Derivados del acido 1h-indol-1-il acetico de 3-alquilo y 3-arilalquilo sustituido como inhibidores del inhibidor-1 de activador de plasminogeno (pai-1).
GB0324763D0 (en) * 2003-10-23 2003-11-26 Oxagen Ltd Use of compounds in therapy
EP2492268A1 (en) 2006-07-22 2012-08-29 Oxagen Limited Compounds having CRTH2 antagonist activity
EP2203424A1 (en) * 2007-09-24 2010-07-07 Allergan, Inc. Indole compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (s1p) receptor biological activity
RS53142B (en) * 2008-01-18 2014-06-30 Atopix Therapeutics Limited UNITS THAT HAVE ANTAGONISTIC ACTIVITY ON CRTH2
US7750027B2 (en) 2008-01-18 2010-07-06 Oxagen Limited Compounds having CRTH2 antagonist activity
US20100022613A1 (en) * 2008-01-22 2010-01-28 Oxagen Limited Compounds Having CRTH2 Antagonist Activity
EP2240444A1 (en) * 2008-01-22 2010-10-20 Oxagen Limited Compounds having crth2 antagonist activity
GB201322273D0 (en) 2013-12-17 2014-01-29 Atopix Therapeutics Ltd Process
GB201407820D0 (en) * 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form
GB201407807D0 (en) 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5173M (es) * 1966-02-11 1967-06-19
FR7337M (es) * 1968-01-11 1969-10-13
GB2045244B (en) 1979-03-07 1983-01-26 Pfizer Ltd 3-1-(imidazolylalkyl) indoles
US4322533A (en) * 1980-03-17 1982-03-30 Lesher George Y 1H-Indole-2,3-dione derivatives

Also Published As

Publication number Publication date
ZA818665B (en) 1982-10-27
JPS57181082A (en) 1982-11-08
AU525296B2 (en) 1982-10-28
PL234253A1 (en) 1983-05-23
YU293481A (en) 1984-10-31
IE812928L (en) 1982-06-15
AR229110A1 (es) 1983-06-15
DE3167879D1 (en) 1985-01-31
PT74123B (en) 1983-12-19
KR830007552A (ko) 1983-10-21
CA1143737A (en) 1983-03-29
US4363912A (en) 1982-12-14
IE51949B1 (en) 1987-04-29
EP0054417A1 (en) 1982-06-23
AU7848881A (en) 1982-06-24
DK552581A (da) 1982-06-16
FI814003L (fi) 1982-06-16
IL64534A0 (en) 1982-03-31
EP0054417B1 (en) 1984-12-19
PL133634B1 (en) 1985-06-29
NO814264L (no) 1982-06-16
DD202290A5 (de) 1983-09-07
ES507960A0 (es) 1983-10-01
PT74123A (en) 1982-01-01
PH17576A (en) 1984-10-01
GR76355B (es) 1984-08-06
CS228527B2 (en) 1984-05-14

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980203