JPS57181082A - Novel indole compounds, thromvoxane synthetase inhibitor thereof and manufacture - Google Patents

Novel indole compounds, thromvoxane synthetase inhibitor thereof and manufacture

Info

Publication number
JPS57181082A
JPS57181082A JP56201438A JP20143881A JPS57181082A JP S57181082 A JPS57181082 A JP S57181082A JP 56201438 A JP56201438 A JP 56201438A JP 20143881 A JP20143881 A JP 20143881A JP S57181082 A JPS57181082 A JP S57181082A
Authority
JP
Japan
Prior art keywords
thromvoxane
manufacture
indole compounds
synthetase inhibitor
novel indole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56201438A
Other languages
English (en)
Japanese (ja)
Inventor
Edowaado Kurosu Piitaa
Piitaa Deitsukison Rojiyaa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Publication of JPS57181082A publication Critical patent/JPS57181082A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
JP56201438A 1980-12-15 1981-12-14 Novel indole compounds, thromvoxane synthetase inhibitor thereof and manufacture Pending JPS57181082A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8040081 1980-12-15

Publications (1)

Publication Number Publication Date
JPS57181082A true JPS57181082A (en) 1982-11-08

Family

ID=10517993

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56201438A Pending JPS57181082A (en) 1980-12-15 1981-12-14 Novel indole compounds, thromvoxane synthetase inhibitor thereof and manufacture

Country Status (22)

Country Link
US (1) US4363912A (enExample)
EP (1) EP0054417B1 (enExample)
JP (1) JPS57181082A (enExample)
KR (1) KR830007552A (enExample)
AR (1) AR229110A1 (enExample)
AU (1) AU525296B2 (enExample)
CA (1) CA1143737A (enExample)
CS (1) CS228527B2 (enExample)
DD (1) DD202290A5 (enExample)
DE (1) DE3167879D1 (enExample)
DK (1) DK552581A (enExample)
ES (1) ES8308872A1 (enExample)
FI (1) FI814003A7 (enExample)
GR (1) GR76355B (enExample)
IE (1) IE51949B1 (enExample)
IL (1) IL64534A0 (enExample)
NO (1) NO814264L (enExample)
PH (1) PH17576A (enExample)
PL (1) PL133634B1 (enExample)
PT (1) PT74123B (enExample)
YU (1) YU293481A (enExample)
ZA (1) ZA818665B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006514640A (ja) * 2002-12-10 2006-05-11 ワイス プラスミノゲンアクティベータインヒビターのインヒビターとしての置換３−アルキル及び３−アリールアルキル１ｈ−イル酢酸誘導体
JP2010540543A (ja) * 2007-09-24 2010-12-24 アラーガン インコーポレイテッド スフィンゴシン‐１‐リン酸（ｓ１ｐ）レセプター生物学的活性を有するアリールまたはヘテロアリール基を担持するインドール化合物
JP2011509988A (ja) * 2008-01-18 2011-03-31 オキサジェン リミテッド Ｃｒｔｈ２アンタゴニスト活性を有する化合物

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS229934B2 (en) * 1981-07-07 1984-07-16 Pfizer Production method subst.indolylacryte acid derivative
US4460777A (en) * 1981-11-19 1984-07-17 Ciba-Geigy Corporation N-Substituted-2-pyridylindoles
US4478842A (en) * 1981-11-19 1984-10-23 Ciba-Geigy Corporation N-Substituted-2-pyridylindoles
US4536505A (en) * 1983-05-17 1985-08-20 Ciba-Geigy Corporation Certain N-(pyridyl) indoles
US4511573A (en) * 1983-05-17 1985-04-16 Ciba-Geigy Corporation 3-Substituted-2-(heteroaryl) indoles
GB8524157D0 (en) * 1984-10-19 1985-11-06 Ici America Inc Heterocyclic amides
US4609733A (en) * 1984-12-27 1986-09-02 Ciba-Geigy Corporation 3-keto-substituted-N-pyridylindoles
GB8609175D0 (en) * 1986-04-15 1986-05-21 Ici America Inc Heterocyclic carboxamides
ATE269861T1 (de) * 1998-03-31 2004-07-15 Inst For Pharm Discovery Inc Substituierte indolalkansäure
TNSN99224A1 (fr) * 1998-12-01 2005-11-10 Inst For Pharm Discovery Inc Methodes de reduction des niveaux de glucose et triglyceride en serum et pour suppression de l'antigenese utilisant les acides la indolealkanoique
WO2001051489A2 (en) * 2000-01-14 2001-07-19 The Institutes For Pharmaceutical Discovery, Llc Methods for lowering uric acid levels
GB0324763D0 (en) * 2003-10-23 2003-11-26 Oxagen Ltd Use of compounds in therapy
EP2046740B1 (en) 2006-07-22 2012-05-23 Oxagen Limited Compounds having crth2 antagonist activity
US7750027B2 (en) * 2008-01-18 2010-07-06 Oxagen Limited Compounds having CRTH2 antagonist activity
JP2011509991A (ja) * 2008-01-22 2011-03-31 オキサジェン リミテッド Ｃｒｔｈ２アンタゴニスト活性を有する化合物
WO2009093026A1 (en) 2008-01-22 2009-07-30 Oxagen Limited Compounds having crth2 antagonist activity
GB201322273D0 (en) 2013-12-17 2014-01-29 Atopix Therapeutics Ltd Process
GB201407820D0 (en) * 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form
GB201407807D0 (en) * 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5173M (enExample) * 1966-02-11 1967-06-19
FR7337M (enExample) * 1968-01-11 1969-10-13
GB2045244B (en) 1979-03-07 1983-01-26 Pfizer Ltd 3-1-(imidazolylalkyl) indoles
US4322533A (en) * 1980-03-17 1982-03-30 Lesher George Y 1H-Indole-2,3-dione derivatives

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006514640A (ja) * 2002-12-10 2006-05-11 ワイス プラスミノゲンアクティベータインヒビターのインヒビターとしての置換３−アルキル及び３−アリールアルキル１ｈ−イル酢酸誘導体
JP2010540543A (ja) * 2007-09-24 2010-12-24 アラーガン インコーポレイテッド スフィンゴシン‐１‐リン酸（ｓ１ｐ）レセプター生物学的活性を有するアリールまたはヘテロアリール基を担持するインドール化合物
JP2011509988A (ja) * 2008-01-18 2011-03-31 オキサジェン リミテッド Ｃｒｔｈ２アンタゴニスト活性を有する化合物
JP2014159465A (ja) * 2008-01-18 2014-09-04 Oxagen Ltd Ｃｒｔｈ２アンタゴニスト活性を有する化合物

Also Published As

Publication number Publication date
CA1143737A (en) 1983-03-29
DK552581A (da) 1982-06-16
PT74123A (en) 1982-01-01
AR229110A1 (es) 1983-06-15
FI814003L (fi) 1982-06-16
IL64534A0 (en) 1982-03-31
NO814264L (no) 1982-06-16
ZA818665B (en) 1982-10-27
PH17576A (en) 1984-10-01
FI814003A7 (fi) 1982-06-16
ES507960A0 (es) 1983-10-01
AU525296B2 (en) 1982-10-28
CS228527B2 (en) 1984-05-14
PL133634B1 (en) 1985-06-29
EP0054417A1 (en) 1982-06-23
IE51949B1 (en) 1987-04-29
EP0054417B1 (en) 1984-12-19
US4363912A (en) 1982-12-14
PL234253A1 (en) 1983-05-23
DD202290A5 (de) 1983-09-07
DE3167879D1 (en) 1985-01-31
AU7848881A (en) 1982-06-24
YU293481A (en) 1984-10-31
GR76355B (enExample) 1984-08-06
KR830007552A (ko) 1983-10-21
PT74123B (en) 1983-12-19
ES8308872A1 (es) 1983-10-01
IE812928L (en) 1982-06-15

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