CA1139222A - Galenical compositions - Google Patents

Galenical compositions

Info

Publication number
CA1139222A
CA1139222A CA000342212A CA342212A CA1139222A CA 1139222 A CA1139222 A CA 1139222A CA 000342212 A CA000342212 A CA 000342212A CA 342212 A CA342212 A CA 342212A CA 1139222 A CA1139222 A CA 1139222A
Authority
CA
Canada
Prior art keywords
composition according
enteric
coating
sterol
ergot alkaloid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000342212A
Other languages
English (en)
French (fr)
Inventor
Joachim Franz
Ludwig Patt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Application granted granted Critical
Publication of CA1139222A publication Critical patent/CA1139222A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA000342212A 1978-12-21 1979-12-19 Galenical compositions Expired CA1139222A (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
CH1301978 1978-12-21
CH13019/78 1978-12-21
CH1302178 1978-12-21
CH13021/78 1978-12-21
CH56779 1979-01-19
CH56679 1979-01-19
CH567/79 1979-01-19
CH566/79 1979-01-19

Publications (1)

Publication Number Publication Date
CA1139222A true CA1139222A (en) 1983-01-11

Family

ID=27427929

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000342212A Expired CA1139222A (en) 1978-12-21 1979-12-19 Galenical compositions

Country Status (23)

Country Link
AT (1) AT372279B (en))
AU (1) AU534051B2 (en))
CA (1) CA1139222A (en))
CH (1) CH642259A5 (en))
CY (1) CY1330A (en))
DE (1) DE2950154A1 (en))
DK (1) DK154607C (en))
FI (1) FI793888A7 (en))
FR (1) FR2444463A1 (en))
GB (1) GB2038181B (en))
HK (1) HK37986A (en))
HU (1) HU182577B (en))
IE (1) IE49323B1 (en))
IL (1) IL59003A (en))
IT (1) IT1164029B (en))
KE (1) KE3617D (en))
MY (1) MY8500129A (en))
NL (1) NL187229C (en))
NZ (1) NZ192457A (en))
PH (1) PH25178A (en))
PT (1) PT70614A (en))
SE (1) SE442265B (en))
WO (1) WO1980001242A1 (en))

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3264867D1 (en) * 1981-04-27 1985-08-29 Haessle Ab New pharmaceutical preparation
US4366145A (en) * 1981-06-24 1982-12-28 Sandoz, Inc. Soft gelatin capsule with a liquid ergot alkaloid center fill solution and method of preparation
DE3413955A1 (de) * 1983-04-22 1984-10-25 Sandoz-Patent-GmbH, 7850 Lörrach Pharmazeutisches praeparat enthaltend co-dergocrine und einen calcium-antagonisten
HU192050B (en) * 1983-04-22 1987-05-28 Sandoz Ag Process for production of medical preparative containing co-dergocrin and one piridin-dicarbonic acid diesthertype calcium-antagonist
HU198844B (en) * 1984-06-14 1989-12-28 Sandoz Ag Process for producing new galenic pharmaceutical composition ensuring retarded release of active ingredient
GB8426922D0 (en) * 1984-10-24 1984-11-28 Sandoz Ltd Galenic formulation
AT388101B (de) * 1985-02-05 1989-05-10 Sandoz Ag Verfahren zur herstellung einer pharmazeutischen zusammensetzung zur oralen verabreichung mit kontrollierter wirkstofffreisetzung
CN1003978B (zh) * 1987-09-05 1989-04-26 广州陈李济药厂 一种补脾益肠丸的制备工艺

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3432593A (en) * 1963-09-18 1969-03-11 Key Pharm Inc Delayed and sustained release type pharmaceutical preparation
DE2528257C2 (de) * 1974-07-04 1986-02-13 Sandoz-Patent-GmbH, 7850 Lörrach Neue galenische Zubereitung
DE2546577B2 (de) * 1975-10-17 1981-04-02 Sandoz-Patent-GmbH, 7850 Lörrach Feste Stoffe aus Polyvinylpyrrolidon und Ergotalkaloiden

Also Published As

Publication number Publication date
MY8500129A (en) 1985-12-31
IE49323B1 (en) 1985-09-18
HU182577B (en) 1984-02-28
GB2038181B (en) 1983-05-11
DK154607B (da) 1988-12-05
IT1164029B (it) 1987-04-08
NZ192457A (en) 1983-06-17
DK154607C (da) 1989-06-05
FI793888A7 (fi) 1981-01-01
PT70614A (fr) 1980-01-01
IL59003A (en) 1982-12-31
GB2038181A (en) 1980-07-23
AU534051B2 (en) 1984-01-05
SE7910227L (sv) 1980-06-22
CH642259A5 (de) 1984-04-13
CY1330A (en) 1986-06-27
AT372279B (de) 1983-09-26
IE792471L (en) 1980-06-21
IT7951153A0 (it) 1979-12-20
FR2444463B1 (en)) 1983-02-25
ATA803679A (de) 1983-02-15
NL187229C (nl) 1991-07-16
KE3617D (en) 1986-04-18
DE2950154A1 (de) 1980-07-10
WO1980001242A1 (en) 1980-06-26
FR2444463A1 (fr) 1980-07-18
HK37986A (en) 1986-05-30
PH25178A (en) 1991-03-27
NL7909105A (nl) 1980-06-24
DE2950154C2 (en)) 1989-05-11
AU5403179A (en) 1980-06-26
DK529879A (da) 1980-06-22
SE442265B (sv) 1985-12-16

Similar Documents

Publication Publication Date Title
US5407686A (en) Sustained release composition for oral administration of active ingredient
KR100535954B1 (ko) 장용 피복된 약학 정제 및 이의 제조방법
US4816264A (en) Sustained release formulations
US4252786A (en) Controlled release tablet
US4666705A (en) Controlled release formulation
US4756911A (en) Controlled release formulation
KR100794427B1 (ko) 직접 압축형 중합체 정제 코어
WO2006070781A1 (ja) 塩基性薬物又はその塩を含有するマトリックス型徐放性製剤およびその製造方法
IE59089B1 (en) Pharmaceutical composition
SK283081B6 (sk) Tuhá perorálna aplikačná forma s regulovaným uvoľňovaním
CA2011919A1 (en) A drug-release controlling coating material for long acting formulations
SK104895A3 (en) Pharmaceutical composition and its use
TWI279232B (en) Delayed-release preparations of quinolone antibiotics and processes for their preparation
WO2006112596A1 (en) Controlled-release formulation containing tamsulosin hydrochloride
US5213806A (en) Pharmaceutical composition comprising calcium polycarbophil
CA1139222A (en) Galenical compositions
KR101246553B1 (ko) 서방성 약제학적 조성물 및 이의 제조방법
IE44540B1 (en) Controlled release tablet
WO1999044614A1 (en) Pharmaceutical composition containing cefuroxime axetil stable for moisture absorption
KR100315618B1 (ko) 베타-페닐프로피오페논유도체의지연방출성미세정제
US4411882A (en) Galenical compositions
WO2004069234A1 (en) Pharmaceutical compositions and process of production thereof
RU2359660C2 (ru) Фармацевтическая композиция, содержащая производное пиримидин-а-она, покрытая кишечнорастворимым полимером
JPS643846B2 (en))
WO2005065662A1 (en) Solid dosage formulations of galantamine

Legal Events

Date Code Title Description
MKEX Expiry