CA1127651A - N-aryl-n'-(2-imidazolidinylidene)-ureas - Google Patents

N-aryl-n'-(2-imidazolidinylidene)-ureas

Info

Publication number
CA1127651A
CA1127651A CA341,351A CA341351A CA1127651A CA 1127651 A CA1127651 A CA 1127651A CA 341351 A CA341351 A CA 341351A CA 1127651 A CA1127651 A CA 1127651A
Authority
CA
Canada
Prior art keywords
urea
imidazolidinylidene
compound
aryl
grams
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA341,351A
Other languages
English (en)
French (fr)
Inventor
Chris R. Rasmussen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
McNeilab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/972,580 external-priority patent/US4239768A/en
Priority claimed from US05/972,579 external-priority patent/US4229462A/en
Application filed by McNeilab Inc filed Critical McNeilab Inc
Application granted granted Critical
Publication of CA1127651A publication Critical patent/CA1127651A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/38—Isothioureas containing any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/42—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA341,351A 1978-12-22 1979-12-06 N-aryl-n'-(2-imidazolidinylidene)-ureas Expired CA1127651A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US972,580 1978-12-22
US972,579 1978-12-22
US05/972,580 US4239768A (en) 1978-12-22 1978-12-22 Method for relieving irritable bowel syndrome symptoms
US05/972,579 US4229462A (en) 1978-12-22 1978-12-22 Method for controlling hypertension and compositions

Publications (1)

Publication Number Publication Date
CA1127651A true CA1127651A (en) 1982-07-13

Family

ID=27130555

Family Applications (1)

Application Number Title Priority Date Filing Date
CA341,351A Expired CA1127651A (en) 1978-12-22 1979-12-06 N-aryl-n'-(2-imidazolidinylidene)-ureas

Country Status (23)

Country Link
AT (1) AT373878B (enrdf_load_html_response)
AU (2) AU532332B2 (enrdf_load_html_response)
CA (1) CA1127651A (enrdf_load_html_response)
CH (1) CH647236A5 (enrdf_load_html_response)
DE (1) DE2951213A1 (enrdf_load_html_response)
DK (1) DK548179A (enrdf_load_html_response)
ES (1) ES487159A0 (enrdf_load_html_response)
FI (1) FI66354C (enrdf_load_html_response)
FR (2) FR2444462B1 (enrdf_load_html_response)
GB (2) GB2040681B (enrdf_load_html_response)
GR (1) GR68018B (enrdf_load_html_response)
HU (1) HU183013B (enrdf_load_html_response)
IL (1) IL59019A (enrdf_load_html_response)
IT (1) IT1126839B (enrdf_load_html_response)
NL (1) NL7909265A (enrdf_load_html_response)
NO (1) NO794249L (enrdf_load_html_response)
NZ (1) NZ192453A (enrdf_load_html_response)
PH (1) PH16571A (enrdf_load_html_response)
PT (1) PT70624A (enrdf_load_html_response)
SE (1) SE7910612L (enrdf_load_html_response)
SU (1) SU971098A3 (enrdf_load_html_response)
YU (1) YU314979A (enrdf_load_html_response)
ZW (1) ZW25379A1 (enrdf_load_html_response)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4673680A (en) * 1985-09-18 1987-06-16 Pendleton Robert G α2 -adrenergic receptor antagonists as modifiers of gastrointestinal motility
US11516649B2 (en) * 2018-10-29 2022-11-29 Apple Inc. Mechanism to activate and manage a standalone device for cellular service

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL267923A (enrdf_load_html_response) * 1960-08-05
FR1296962A (fr) * 1960-08-05 1962-06-22 Geigy Ag J R Nouveaux composés 2-imino-1.3-di-aza et leur préparation

Also Published As

Publication number Publication date
PH16571A (en) 1983-11-18
SE7910612L (sv) 1980-06-23
CH647236A5 (de) 1985-01-15
ES8101558A1 (es) 1980-12-16
HU183013B (en) 1984-04-28
FI794036A7 (fi) 1980-06-23
IT7951164A0 (it) 1979-12-21
FR2445321A1 (enrdf_load_html_response) 1980-07-25
ZW25379A1 (en) 1981-07-22
IL59019A0 (en) 1980-03-31
GB2113204B (en) 1984-02-01
FR2444462B1 (fr) 1986-08-29
FR2444462A1 (fr) 1980-07-18
NO794249L (no) 1980-06-24
FI66354C (fi) 1984-10-10
GR68018B (enrdf_load_html_response) 1981-10-27
AT373878B (de) 1984-02-27
GB2040681B (en) 1983-04-13
YU314979A (en) 1983-02-28
DE2951213A1 (de) 1980-07-10
ES487159A0 (es) 1980-12-16
SU971098A3 (ru) 1982-10-30
FI66354B (fi) 1984-06-29
DK548179A (da) 1980-06-23
GB2040681A (en) 1980-09-03
AU1640083A (en) 1983-11-17
IT1126839B (it) 1986-05-21
AU566013B2 (en) 1987-10-08
FR2445321B1 (enrdf_load_html_response) 1983-08-26
AU532332B2 (en) 1983-09-29
NZ192453A (en) 1982-09-07
IL59019A (en) 1984-05-31
PT70624A (en) 1980-01-01
GB2113204A (en) 1983-08-03
NL7909265A (nl) 1980-06-24
AU5378079A (en) 1980-06-26
ATA808979A (de) 1983-07-15

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Legal Events

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