CA1112569A - Methods for preparation of new penicillin esters - Google Patents

Methods for preparation of new penicillin esters

Info

Publication number
CA1112569A
CA1112569A CA140,652A CA140652A CA1112569A CA 1112569 A CA1112569 A CA 1112569A CA 140652 A CA140652 A CA 140652A CA 1112569 A CA1112569 A CA 1112569A
Authority
CA
Canada
Prior art keywords
compound
formula
methyl
ring
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA140,652A
Other languages
English (en)
French (fr)
Other versions
CA140652S (en
Inventor
Wagn O. Godtfredsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leo Pharma AS
Original Assignee
Leo Pharmaceutical Products Ltd AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharmaceutical Products Ltd AS filed Critical Leo Pharmaceutical Products Ltd AS
Priority to CA267,544A priority Critical patent/CA1020158A/en
Application granted granted Critical
Publication of CA1112569A publication Critical patent/CA1112569A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA140,652A 1971-05-05 1972-04-26 Methods for preparation of new penicillin esters Expired CA1112569A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA267,544A CA1020158A (en) 1971-05-05 1976-12-09 Methods for preparation of new penicillin esters

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB13358/1971 1971-05-05
GB1335871 1971-05-05

Publications (1)

Publication Number Publication Date
CA1112569A true CA1112569A (en) 1981-11-17

Family

ID=10021514

Family Applications (1)

Application Number Title Priority Date Filing Date
CA140,652A Expired CA1112569A (en) 1971-05-05 1972-04-26 Methods for preparation of new penicillin esters

Country Status (10)

Country Link
US (1) US3869449A (da)
JP (1) JPS5541240B1 (da)
CA (1) CA1112569A (da)
DE (1) DE2221912A1 (da)
DK (1) DK140481B (da)
FR (1) FR2135339B1 (da)
GB (1) GB1335718A (da)
NL (1) NL7205957A (da)
SE (1) SE417098B (da)
ZA (1) ZA722545B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1579931A (en) * 1976-04-15 1980-11-26 Leo Pharm Prod Ltd Bis-penicillanoyl-oxy-alkanes
US4345071A (en) * 1976-06-29 1982-08-17 Leo Pharmaceutical Products, Ltd. A/S Derivatives of penicillanic acid
LU77362A1 (da) * 1977-05-17 1979-01-19
US4407751A (en) * 1979-02-13 1983-10-04 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Processes for preparing β-lactams
US4325960A (en) * 1979-02-13 1982-04-20 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) 6-Amidinopenicillanic acid derivatives including the radical of a β-lactamase inhibitor
IE49881B1 (en) * 1979-02-13 1986-01-08 Leo Pharm Prod Ltd B-lactam intermediates
US4244951A (en) * 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4309347A (en) * 1979-05-16 1982-01-05 Pfizer Inc. Penicillanoyloxymethyl penicillanate 1,1,1',1'-tetraoxide
US4377524A (en) * 1979-05-16 1983-03-22 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
DE3051044C2 (da) * 1979-06-19 1989-03-30 Leo Pharmaceutical Products Ltd. A/S (Loevens Kemiske Fabrik Produktionsaktieselskab), Ballerup, Dk
US4340539A (en) * 1980-01-21 1982-07-20 Bristol-Myers Company Derivatives of 6-bromo penicillanic acid
US4432903A (en) * 1980-09-08 1984-02-21 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4488994A (en) * 1980-09-08 1984-12-18 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4323499A (en) * 1981-01-05 1982-04-06 Pfizer Inc. 6-(2-Aryl-2-(1,1-dioxopenicillanoyloxy-methoxycarbonyl)acetamido penicillanic acids
US4540687A (en) * 1981-09-09 1985-09-10 Pfizer Inc. Antibacterial 6'-(2-amino-2-[4-acyloxyphenyl]acetamido)penicillanoyloxymethyl penicillanate 1,1-dioxide compounds
US4582829A (en) * 1981-09-09 1986-04-15 Pfizer Inc. Antibacterial 6'-(2-amino-2-[4-acyloxyphenyl]acetamido)penicillanoyloxymethyl penicillanate 1,1-dioxide compounds
CA2379650C (en) * 1999-07-30 2008-09-02 Eisai Co., Ltd. Process for producing a basic antibiotic inorganic acid salt, and oxalate intermediate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3669978A (en) * 1970-05-28 1972-06-13 American Home Prod Process for the production of semi-synthetic penicillin intermediate
US3704290A (en) * 1970-12-09 1972-11-28 American Home Prod 6-(1 - substituted aminocycloalkane-carboxamido)-penicillanic acid and salts
US3770722A (en) * 1971-10-04 1973-11-06 Pfizer 6 - (alpha - (aryl substituted)acylamino-acylamino)penicillanic acidsand derivatives thereof

Also Published As

Publication number Publication date
GB1335718A (en) 1973-10-31
DK140481B (da) 1979-09-10
ZA722545B (en) 1973-01-31
FR2135339A1 (da) 1972-12-15
US3869449A (en) 1975-03-04
FR2135339B1 (da) 1975-06-20
JPS5541240B1 (da) 1980-10-22
DE2221912A1 (de) 1972-11-16
SE417098B (sv) 1981-02-23
NL7205957A (da) 1972-11-07

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Legal Events

Date Code Title Description
MKEX Expiry